EP0542867A1 - Methods of preventing or decreasing tissue damage by novel antioxidants and free radical scavengers - Google Patents
Methods of preventing or decreasing tissue damage by novel antioxidants and free radical scavengersInfo
- Publication number
- EP0542867A1 EP0542867A1 EP91915160A EP91915160A EP0542867A1 EP 0542867 A1 EP0542867 A1 EP 0542867A1 EP 91915160 A EP91915160 A EP 91915160A EP 91915160 A EP91915160 A EP 91915160A EP 0542867 A1 EP0542867 A1 EP 0542867A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- amino
- hydrogen
- compound
- aica riboside
- hydrocarbyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 92
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 17
- 230000000451 tissue damage Effects 0.000 title claims abstract description 15
- 231100000827 tissue damage Toxicity 0.000 title claims abstract description 15
- 230000003247 decreasing effect Effects 0.000 title claims description 26
- 229940123457 Free radical scavenger Drugs 0.000 title abstract description 9
- 239000002516 radical scavenger Substances 0.000 title abstract description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 257
- 150000003254 radicals Chemical class 0.000 claims abstract description 32
- 239000007800 oxidant agent Substances 0.000 claims abstract description 30
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 23
- 230000006378 damage Effects 0.000 claims abstract description 18
- 239000001301 oxygen Substances 0.000 claims abstract description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 17
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims abstract description 11
- 230000003647 oxidation Effects 0.000 claims abstract description 7
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 7
- 230000034217 membrane fusion Effects 0.000 claims abstract description 3
- 241000700605 Viruses Species 0.000 claims abstract 2
- -1 substituted-imidazole Chemical class 0.000 claims description 143
- RTRQQBHATOEIAF-UHFFFAOYSA-N AICA riboside Natural products NC1=C(C(=O)N)N=CN1C1C(O)C(O)C(CO)O1 RTRQQBHATOEIAF-UHFFFAOYSA-N 0.000 claims description 107
- RTRQQBHATOEIAF-UUOKFMHZSA-N acadesine Chemical compound NC1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 RTRQQBHATOEIAF-UUOKFMHZSA-N 0.000 claims description 105
- 229910052739 hydrogen Inorganic materials 0.000 claims description 92
- 239000001257 hydrogen Substances 0.000 claims description 87
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 64
- 150000002431 hydrogen Chemical group 0.000 claims description 63
- 150000003857 carboxamides Chemical class 0.000 claims description 61
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 61
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 38
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 37
- 229910052736 halogen Inorganic materials 0.000 claims description 34
- 150000002367 halogens Chemical class 0.000 claims description 34
- 125000003396 thiol group Chemical group [H]S* 0.000 claims description 33
- 241000124008 Mammalia Species 0.000 claims description 29
- 210000001519 tissue Anatomy 0.000 claims description 28
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 125000003118 aryl group Chemical group 0.000 claims description 25
- 230000001590 oxidative effect Effects 0.000 claims description 24
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 23
- 150000002460 imidazoles Chemical class 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 20
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
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- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 15
- 125000001424 substituent group Chemical group 0.000 claims description 15
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- 125000002252 acyl group Chemical group 0.000 claims description 13
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- 125000004423 acyloxy group Chemical group 0.000 claims description 12
- 125000002947 alkylene group Chemical group 0.000 claims description 12
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 12
- 125000004442 acylamino group Chemical group 0.000 claims description 11
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
- 206010002383 Angina Pectoris Diseases 0.000 claims description 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 6
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 6
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims description 6
- 125000003368 amide group Chemical group 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims description 5
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- 238000003860 storage Methods 0.000 claims description 5
- XRNBLQCAFWFFPM-UHFFFAOYSA-N 4-iodobenzamide Chemical group NC(=O)C1=CC=C(I)C=C1 XRNBLQCAFWFFPM-UHFFFAOYSA-N 0.000 claims description 4
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 4
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- 125000001797 benzyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
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- 206010003246 arthritis Diseases 0.000 claims description 3
- 230000003915 cell function Effects 0.000 claims description 3
- 238000000502 dialysis Methods 0.000 claims description 3
- LSBDFXRDZJMBSC-UHFFFAOYSA-N 2-phenylacetamide Chemical group NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 claims description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 2
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- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
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- 125000003545 alkoxy group Chemical group 0.000 claims description 2
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
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- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- QEJALIHYJUJLDQ-UHFFFAOYSA-N N-[(1,4-dichlorocyclohexa-2,4-dien-1-yl)methyl]formamide Chemical group ClC1(CNC=O)CC=C(C=C1)Cl QEJALIHYJUJLDQ-UHFFFAOYSA-N 0.000 claims 1
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- NJCZDNIUWWLVLC-UHFFFAOYSA-N n-[(4-nitrophenyl)methyl]formamide Chemical group [O-][N+](=O)C1=CC=C(CNC=O)C=C1 NJCZDNIUWWLVLC-UHFFFAOYSA-N 0.000 claims 1
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- DVNYTAVYBRSTGK-UHFFFAOYSA-N 5-aminoimidazole-4-carboxamide Chemical compound NC(=O)C=1N=CNC=1N DVNYTAVYBRSTGK-UHFFFAOYSA-N 0.000 abstract description 6
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- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
Definitions
- Ischemia-induced pathological processes are a major cause of cell death and irreversible tissue destruction and make a prime contribution to the morbidity and mortality of heart disease, e.g. acute myocardial infarction and angina, as well as cerebral ischemia, e.g. stroke and neurological dysfunction.
- Prolonged ischemia alone is sufficient to cause cell death but recent evidence suggests that substantial cell injury may occur in settings of reversible ischemia at the time of reperfusion.
- Reperfusion injury or post-ischemic injury has been thought to have limited the success of clinical interventions which allow reperfusion of hypoxic but still viable tissues, most notably in the context of myocardial ischemia, e.g., thrombolysis, percutaneous transluminal coronary angioplasty and coronary artery bypass surgery. Procedures such as organ transplant, reconstructive tissue transplants and dialysis may also result in cell damage due to reversible ischemia. In addition, prolonged or chronic ischemia during angina can lead to myocardial injury termed stunned or hibernating myocardium. These injuries can cause mechanical dysfunction and congestive heart failure or dyspnea.
- a major cause of cell damage mediated by these species has been thought to result from peroxidation of fatty acids in lipid membranes resulting in loss of fluidity and breakdown of the membrane secretory functions and transmembrane ionic gradients. Base hydroxylation, nicking, crosslinking and scission of DNA may also result in mutation and/or inhibition of protein, nucleotide, and fatty acid synthesis. [Ann R. Coll. Surg. Engl. 62:188-194 (1980)]. In addition, production of hypochlorous acid (HOCl) by the action of myeloperoxidase during the respiratory burst of neutrophils may be stimulated during reperfusion.
- hypochlorous acid HOCl
- xanthine dehydrogenase is reported to be converted by a calcium-activated protease to xanthine oxidase and adenosine triphosphate is reported to be catabolized to provide substrate for the enzyme, i.e. xanthine and hypoxanthine.
- xanthine and hypoxanthine adenosine triphosphate
- the activity of the enzyme, and hence its contribution to reperfusion injury has been reported to be low in certain tissues. In some tissues, ischemia alone may be sufficient to cause free radical damage.
- Free radicals which cause direct cell damage have been reported to be produced under non-ischemic conditions, for example, during the course of prostaglandin metabolism [J. Biol. Chem. 257:4764-4768 (1982)], by activated neutrophils during the course of pathogenesis associated with inflammatory diseases or destruction of invading microorganisms [Am. J. Pathol. 107:397-418 (1982); Arthritis Rheum 23:455-463 (1980)] and by activated neutrophils in lung tissue following aspiration, membrane oxygenators and dialysis membrane usage, sepsis, burns, microembolism, pulmonary emphysema, chronic obstructive pulmonary disease and hyperoxia [Mayo Clin. Proc. 63:390 (1988)].
- Free radical-induced platelet aggregation may also result in thrombosis and pulmonary and systemic embolism, as well as contributing to the problem of reocclusion following thrombolysis.
- Thrombolytic therapy represents a major advance in the treatment of cardiovascular disease; however, its success has also been limited by a number of factors which include the resistance of some thrombi to lysis, delays in reperfusion, and reocclusion following successful thrombolysis.
- inhibition of platelet aggregation may comprise an adjunctive thrombolytic therapy.
- SOD superoxide dismutase
- a number of chemical free radical scavengers such as dimethylsulfoxide [Am. J. Path. 109:270-276 (1982], mannitol [J . Thorac. Cardiovasc . Surg. 86 : 262-272 (1983 ) ] , glucose [J. Cardiovasc. Pharmacol. 5:35-43 (1983)] and allopurinol [Am. Heart J. 82:362-370 (1971)] have been reported to show limited beneficial effects in some animal models of ischemic reperfusion injury.
- Allopurinol or its metabolite, oxypurinol has been said to act to limit free radical production indirectly by inhibition of xanthine oxidase and/or directly by scavenging free radicals [Oxygen Radicals in Biology and Medicine, M.G. Simic, K.A. Taylor, J.F. Ward and C. von Stanford, editors, pp. 951-955 (1988)]. Allopurinol has been reported to improve the survival rate of influenza virus infected mice; it was hypothesized that allopurinol inhibited superoxide generation by xanthine oxidase [Akaike et al., J. Clin. Invest. 85:739-745 (1990)].
- N-acetylcysteine presumably acting as a free radical scavenger, has been reported to counteract leukocyte and platelet aggregation in the lung reducing pathophysiological changes in an endotoxin model of ARDS in pigs [Acta Chirurgica Scandinavica 154:169-177 (1988)].
- the natural antioxidants, alpha-tocopherol and vitamin C have also been reported to inhibit platelet aggregation with associated potential therapeutic benefits [Naunyn-Schmiedebergs, Archives of Pharmacology 338:74-81 (1988); Medical Hypothesis 19:345-357 (1986)].
- Cardioplegia refers to the process of cooling and arresting the heart to protect it during the ischemia encountered in a number of cardiac surgical procedures. It may be achieved by perfusing the coronary arteries after cross clamping the aorta with a blood solution containing a high concentration of potassium. This results in myocardial cell membrane depolarization and immediate cessation of electrical and mechanical activity. Although established as a method of choice for myocardial protection during open heart surgery, its success is limited by the duration of ischemia and there is hence a need to develop better protection when the ischemic period exceeds three hours.
- U.S. Patent 4,912,092 is said to describe a method for increasing extracellular concentrations of adenosine by therapeutic intervention with the purine precursor 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) and the advantages of such intervention in the management of the treatment of diseases associated with ischemia and inflammation.
- AICA riboside 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide
- U.S. Patent 4,575,498 is said to demonstrate enhanced nucleotide synthesis and concomitant repletion of ATP pools with AICA riboside to enable the amelioration of tissue damage in ischemic canine hearts.
- U.S. Patent No. 4,115,641 to Fischer et al. is directed to certain ribofuranosyl derivatives which are said to have cardiac and circulatory-dynamic properties.
- Fischer et al. are directed to certain compounds which are said to have intrinsic adenosine-like modes of action as determined by measuring decreased heart rate and blood pressure.
- Adenine has been utilized to increase the shelf life of packed red blood cells (RBC's) presumably by increasing ATP pools; however, AICA riboside does not appear to be metabolized to adenine in human red blood cells.
- the present invention is directed to methods of decreasing tissue damage in a mammal following a period of diminished or interrupted blood flow to that tissue, including that caused by conditions such as ischemia, surgery, cardioplegia or the like by administering to the mammal or to cells, tissues or organs of the mammal an antioxidant effective amount or a free-radical scavenging effective amount of AICA riboside (1- ⁇ -D-ribofuranosyl-5-amino-imidazole-4-carboxamide or 5-amino-4-imidazole carboxamide riboside) or a substituted-imidazole analog of AICA riboside.
- the present invention is directed to certain new substituted imidazole analogs of AICA riboside which exhibit surprisingly advantageous activity in decreasing post-ischemic and reperfusion tissue damage, and in increasing post-ischemic cardiac function.
- These compounds can be used to treat diseases which arise from, or are aggravated by free radical or oxidant damage caused by insufficient blood flow through a particular organ or portion thereof or other biological sources of free radicals and oxidants. Certain of these compounds have also demonstrated antiplatelet and antiviral properties.
- post-ischemic damage to cardiac tissue resulting from hypoperfusion or interrupted perfusion is prevented or decreased by the administration of AICA riboside or substituted-imidazole analogs of AICA riboside.
- the cardioprotective effects include decreased tissue damage mediated by oxygen-related free radicals and oxidants and improved post-ischemic cardiac function.
- AICA riboside and these substituted-imidazole analogs of AICA riboside when added to collected whole blood or packed red blood cells, act to maintain cellular viability and function of red blood cells, platelets or white blood cells during storage such as for blood banking, blood collection and prolonged storage.
- AICA riboside does not appear to be metabolized to adenine in red blood cells.
- hydrocarbyl refers to an organic radical comprised of primarily carbon and hydrogen and includes alkyl, alkenyl and alkynyl groups as well as aromatic groups such as aryl and aralkyl groups and groups which have a mixture of saturated and unsaturated bonds, alicyclic (carbocyclic or cycloalkyl) groups or such groups substituted with aryl (aromatic) groups or combinations thereof and may refer to straight-chain, branched-chain or cyclic structures or to radicals having a combination thereof.
- alkyl refers to saturated aliphatic groups, including straight, branched and carbocyclic groups.
- lower alkyl refers to both straight- and branched-chain alkyl groups having a total of from 1 to 6 carbon atoms and includes primary, secondary and tertiary alkyl groups. Typical lower alkyls include, for example, methyl, ethyl, n-propyl,, isopropyl, n-butyl, isobutyl, t-butyl, n-pentyl, n-hexyl, and the like.
- aryl refers tc aromatic groups having form about 6 to 14 carbon atoms and includes cyclic aromatic systems such as phenyl and naphthyl.
- aralkyl refers to an alkyl group of about 1 to 4 carbon atoms substituted with an aryl group of form 6 to 10 carbon atoms and includes, for example, benzyl, p-chlorobenzyl, p-methylbenzyl and 2-phenylethyl.
- alkynyl refers to unsaturated groups having at least one triple bond [e.g. CH 3 C ⁇ C(CH 2 ) 2 -] and includes both straight chain and branched-chain groups.
- halo or halogen refers to fluorine, chlorine, bromine and iodine.
- acyl refers to the group wherein R' is hydrocarbyl.
- acyloxy refers to the group wherein R' is hydrocarbyl.
- alkylene refers to straight and branched-chain alkylene groups which are biradicals, and includes, for example, groups such as ethylene, propylene, 2-methylpropylene 3-methylpentylene
- amide or “amido” refers to the group wherein each R" is independently hydrogen or hydrocarbyl, or to compounds having at least one such group.
- carboxamide refers to the group wherein each R" is independently hydrogen or hydrocarbyl.
- unsubstituted carboxamide refers to the group
- acylamino refers to the group wherein R' is hydrocarbyl.
- lower acylamino refers to acylamino groups wherein R' is alkyl of 1 to 6 carbon atoms.
- carbonate ester refers to the group wherein R' is hydrocarbyl or to compounds having at least one such group.
- acyl ester refers to the group wherein R' is hydrocarbyl or to compounds having at least one such group.
- phosphate ester refers to the group
- R" is independently hydrogen or hydrocarbyl and/or to compounds having at least one such group, and includes salts thereof.
- mixed ester refers to compounds having at least one carbonate ester group and at least one acyl ester group or to compounds having combinations of different acyl ester or carbonate ester groups.
- carboxylic acid ester refers to the group wherein R' is hydrocarbyl or to compounds having at least one such group.
- Carboxyl refers to the group
- Carbocyclic AICA riboside refers to an analog of AICA riboside wherein the oxygen atom of the ribosyl ring has been replaced by a methylene (-CH 2 -) group.
- hydrocarbyloxy refers to the group R'O- wherein R' is hydrocarbyl.
- alkoxy refers to the group R'O- wherein R1 is alkyl.
- hydrocarbylthio refers to the group having the formula R'S- wherein R' is hydrocarbyl.
- hydrocarbylamino refers to the groups -NHR' or -NR' 2 where R' is an independently selected hydrocarbyl group.
- hydrocarbylimidate refers to the group wherein R' is hydrocarbyl.
- hydrocarbyloxyamidine refers to the group wherein R' is hydrocarbyl.
- hydrocarbyloxycarbonyl refers to the group
- R wherein R' is hydrocarbyl.
- hydrocarbyloxycarboxy refers to the group wherein R' is hydrocarbyl.
- substituted imidazole analog of AICA riboside includes the compounds set forth in formulas I, II and III described herein in the Detailed Description of the Invention as "Preferred Substituted Imidazole Analogs of AICA Riboside” and "Preferred Novel Substituted Imidazole Analogs of AICA Riboside.”
- FIG. 1 depicts the effects of AICA riboside administered at reperfusion alone on cardiac function.
- preferred substituted-imidazole analogs of AICA riboside include compounds of the formula (I) are useful free radical scavengers and antioxidants:
- R 1 is hydrogen or hydrocarbyl of about 1 to about 18 carbon atoms, optionally substituted with from 1 to about 4 substituents independently selected from hydroxy, sulfhydryl, hydrocarbyloxy, hydrocarbylthio, halogen, amino, hydrocarbylamino, aryl; or carboxylic acid or an ester, thioester, amide and salt thereof; then R 2 is amino, R 3 is hydrogen, cyano, or carboxylic acid or an amide, ester, thioester, or salt thereof; and R 4 is hydrogen, hydrocarbyl, halogen, hydroxy, (including tantomeric imidazolones) hydrocarbyloxy, sulfhydryl (including tautomeric imidazolthiones), hydrocarbylthio, amino, or hydrocarbylamino; or
- R 5 and R 6 are independently hydrogen, hydrocarbyl, acyl or hydrocarbyloxycarbonyl;
- R 7 is hydrogen, halogen, hydroxy, hydrocarbyloxy, sulfhydryl, hydrocarbylthio, sulfamyloxy, amino, hydrocarbylamino, azido, hydrocarbyl, acyloxy, hydrocarbyloxycarboxy or phosphate ester group or salts thereof;
- R 2 is hydrogen, amino, hydrocarbylamino, acylamino, amido or dihydrocarbylaminoalkyleneimino;
- R 3 is hydrogen, cyano, h y d r o c a r b y l i m i d a t e , c a r b o x a m i d o x i m e , hydrocarbyloxyamidine,
- R 3 may be a group of formula:
- alk is an alkylene group of from 2 to 8 carbon atoms. Suitable alk groups include n-hexylene and 1,4-cyclohexylene.
- Preferred compounds of Formula I according to subparagraph (a) include those wherein R 1 is hydrogen, R 2 is amino, R 3 is carboxamide and R 4 is hydrogen and pharmaceutically acceptable salts thereof.
- Preferred compounds of formula I according to subparagraph (b) include those wherein R 2 is amino, R 3 is carboxamide wherein one of the amide hydrogens is optionally replaced by an optionally substituted hydrocarbyl, more preferably an aralkyl group, R 4 is hydrogen, R 5 is hydrogen, R 6 is hydrogen and R 7 is hydroxy or amino.
- preferred compounds include compound Nos. 21 (1-227), 23 (1-343), 25 (1-360), 27 (1-395), 29 (1-349), 32 (1-262, 43 (1-432), 47 (1-450), 52 (1-467), 53 (1-468), 66 (1-531) and 79 (1-607) of Tables VIII and IX.
- One preferred group of compounds of formula I include certain novel substituted-imidazole analogs of AICA riboside of which will be more fully described hereinafter.
- Preferred novel substituted imidazole analogs of the present invention include those of formula I wherein R 1 is
- R 5 and R 6 are independently hydrogen, alkyl (of 1 to about 18 carbon atoms), acyl or hydrocarbyloxy-carbonyl; and R 7 is hydrogen, hydrocarbyl, hydroxy, hydrocarbyloxy, sulfhydryl, hydrocarbylthio, sulfamyloxy, amino, hydrocarbylamino, azido, acyloxy, hydrocarbyloxycarboxy or phosphate ester or salt thereof; R 2 is amino, hydrocarbylamino, acylamino or dihydrocarbylaminoalkyleneimino; R 3 is carboxamide wherein one of the amide hydrogens (attached to the nitrogen atom) is optionally replaced by alkyl, cycloalkyl, aryl or aralkyl, optionally substituted with 1 to 3 substituents independently selected from halogen, alkyl, aryl, nitro, amino, hydrocarbylamino
- Preferred compounds of formula I include those wherein R 2 is amino, R 3 is carboxamide substituted with an aralkyl group, more preferably a benzyl group, having from 1 to 3 ring substitutions as described above, or cycloalkyl.
- Preferred dihydrocarbylaminoalkyleneimino groups include dimethylaminomethyleneimino.
- preferred compounds include compound Nos. 21 (1-27), 23 (1-343), 25 (1-360), 27 (1-395), 29 (1-349), 32 (1-262), 43 (1-432), 47 (1-450), 52 (1-467), 53 (1-468), 66 (1-531), and 79 (1-607) of Tables VIII and IV.
- One example of an especially preferred compound is a compound where X is oxygen, R 1 is amino, R 2 is p-chlorobenzylcarboxamide, R 3 , R 4 and R 5 are hydrogen and R 6 is amino and salts, thereof.
- One particularly preferred salt is the hydrochloride salt.
- novel substituted imidazole analogs of the present invention can be synthesized by well known chemical reactions as demonstrated in the examples which follow.
- compounds of formula I where R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl or the fragment described by formula II can be prepared from 4-methyl-5-nitro-1H-imidazole by the route described by Baker et al. (Baker D., J. Org. Chem. 47: 3457 (1982)) to prepare 1-benzyl-5-nitro-1H-imidazole-4-carboxylic acid followed by the additional step of reduction of the nitro group to give the desired amino group at R 2 .
- the elegant synthesis of AICA riboside reported by Ferris et al.
- R 2 substituent is acylamino
- R 2 is hydrocarbylamino
- R 2 is hydrocarbylamino
- Compounds according to formula II where R 7 is acylamino can be prepared from the corresponding 5-amino-5'-deoxy-imidazole riboside by acylation with the desired hydrocarbyl acid anhydride followed by de-O-acylation with ammonia or sodium methoxide.
- Compounds according to formula II where R 7 is hydrocarbyl can be prepared from the 1-(2,3-O-isopropylidene- ⁇ -D-ribo-pento-1,5-dialdo-14,-furanosyl)imidazoles by the Wittig reaction modification of nucleosides described by Montgomery et al. (J. Het. Chem., 11: 211 (1974)).
- R 7 is phosphate or a phosphate ester
- R 7 is phosphate or a phosphate ester
- 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide and analogs and prodrugs thereof can increase post-ischemic function in isolated buffer perfused rat and guinea pig hearts (Langendorff model) subject to hypoperfusion or interruption of perfusion.
- related compounds provide protection from free radical and oxidant damage in a buffer perfused guinea pig heart.
- Another aspect of the present invention comprises the inclusion of AICA riboside or a substituted-imidazole analog of AICA riboside in the cardioplegia solution to afford better protection from tissue damage due to the prolonged ischemia during cardioplegia.
- AICA riboside or a substituted-imidazole analog of AICA riboside is administered to decrease platelet aggregation and preserve platelet function.
- Preservation of platelet function during hypercoaguable states resulting from diseases such as cancer, thrombocytopenia purpura, anemia, shock and hemorrhagic fever virus infection may serve to mitigate the shock of these diseases.
- the inhibition of platelet aggregation and preservation of platelet function may be used as an adjunct to thrombolytic therapy.
- AICA riboside acts to maintain cellular viability and function in stored whole blood.
- AICA riboside 0.1 ⁇ M to 1000 ⁇ M final concentration
- citrate citrate
- Addition of AICA riboside may increase red blood cell shelf life to about 45 days or more.
- AICA riboside and its analogs may be used in blood-banking to prolong the shelf-life of stored blood and packed red blood cells, platelets or white blood cells for transfusion, and also cross-match samples.
- AICA riboside or its analogs is added to the whole blood or packed red blood cells, platelets, white blood cells or cross-match sample soon after the blood is drawn, prior to storage.
- Another aspect of the present invention is directed to the use of these substituted imidazole analogs of AICA riboside as antiviral agents. These agents may be administered either prophylactically (i.e. before viral infection) or post-infection. These analogs are useful in treating retroviral infections including human immunodeficiency virus (HIV) infections. The antioxidant activity of these analogs may result in prevention of membrane fusion events and viral entry due to neutralization of oxidants.
- HIV human immunodeficiency virus
- Particularly preferred substituted imidazole analogs of AICA riboside include those compounds which cannot be phosphorylated.
- Compounds of the invention are administered to the affected tissue at the rate of from 0.01 to 3.0 ⁇ mole/min/kg, preferably from 0.1 to 1.0 ⁇ mole/min/kg. Such rates are easily maintained when these compounds are intravenously administered as discussed below. When other methods are used (e.g., oral administration), use of time-release preparations to control the rate of release of the active ingredient may be preferred. These compounds are administered in a dose of about 0.01 mg/kg/day to about 200 mg/kg/day, preferably from about 0.5 mg/kg/day to about 100 mg/kg/day.
- the compounds of the invention may be administered by a variety of means including orally, parenterally, by inhalation spray, topically, or rectally in formulations containing conventional non-toxic pharmaceutically acceptable carriers, adjuvants and vehicles.
- parenteral as used herein includes subcutaneous, intravenous, intramuscular, and intraarterial injections with a variety of infusion techniques.
- Intraarterial and intravenous injection as used herein includes administration through catheters. Preferred for certain indications are methods of administration which allow rapid access to the tissue or organ being treated, such as intravenous injections for the treatment of myocardial infarction. When an organ outside a body is being treated, perfusion is preferred.
- compositions containing the active ingredient may be in any form suitable for the intended method of administration.
- tablets, troches, lozenges, aqueous or oil suspensions, dispersible powders or granules, emulsions, hard or soft capsules, syrups or elixirs may be prepared.
- Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents including those from the group consisting of sweetening agents, flavoring agents, coloring agents and preserving agents, in order to provide a palatable preparation.
- Tablets containing the active ingredient in admixture with non-toxic pharmaceutically acceptable excipient which are suitable for manufacture of tablets are acceptable.
- excipients may be, for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, such as maize starch, or alginic acid; binding agents, such as starch, gelatin or acacia; and lubricating agents, such as magnesium stearate, stearic acid or talc. Tablets may be uncoated or may be coated by known techniques including microencapsulation to delay disintegration and adsorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate alone or with a wax may be employed.
- inert diluents such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate
- granulating and disintegrating agents such as maize starch, or alginic acid
- Formulations for oral use may be also presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent, for example calcium phosphate or kaolin, or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium, such as peanut oil, liquid paraffin or olive oil.
- an inert solid diluent for example calcium phosphate or kaolin
- an oil medium such as peanut oil, liquid paraffin or olive oil.
- Aqueous suspensions of the invention contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions.
- excipients include a suspending agent, such as sodium c a r b o x y m e t h y l c e l l u l o s e , m e t h y l c e l l u l o s e , hydroxypropylmethylcelluose, sodium alginate, polyvmylpyrrolidone, gum tragacanth and gum acacia, and dispersing or wetting agents such as a naturally occurring phosphatide (e.g., lecithin), a condensation product of an alkylene oxide with a fatty acid (e.g., polyoxyethylene stearate), a condensation product of ethylene oxide with a long chain aliphatic alcohol (e.g., hepta
- the aqueous suspension may also contain one or more preservative such as ethyl of n-propyl p-hydroxybenzoate, one or more coloring agent, one or more flavoring agent and one or more sweetening agent, such as sucrose or saccharin.
- Oil suspensions may be formulated by suspending the active ingredient in a vegetable oil, such as arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as liquid paraffin.
- the oral suspensions may contain a thickening agent, such as beeswax, hard paraffin or cetyl alcohol.
- Sweetening agents, such as those set forth above, and flavoring agents may be added to provide a palable oral preparation.
- These compositions may be preserved by the addition of an antioxidant such as ascorbic acid.
- Dispersible powders and granules of the invention suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, a suspending agent, and one or more preservatives.
- a dispersing or wetting agent e.g., sodium tartrate
- suspending agent e.g., sodium EDTA
- preservatives e.g., sodium bicarbonate, sodium bicarbonate, sodium bicarbonate, sodium bicarbonate
- the pharmaceutical compositions of the invention may also be in the form of oil-in-water emulsions.
- the oily phase may be a vegetable oil, such as olive oil or arachis oil, a mineral oil, such as liquid paraffin, or a mixture of these.
- Suitable emulsifying agents include naturally-occurring gums, such as gum acacia and gum tragacanth, naturally occurring phosphatides, such as soybean lecithin, esters or partial esters derived from fatty acids and hexitol anhydrides, such as sorbitan mono-oleate, and condensation products of these partial esters with ethylene oxide, such as polyoxyethylene sorbitan mono-oleate.
- the emulsion may also contain sweetening and flavoring agents.
- Syrups and elixirs may be formulated with sweetening agents, such as glycerol, sorbitol or sucrose. Such formulations may also contain a demulcent, a preservative, a flavoring or a coloring agent.
- sweetening agents such as glycerol, sorbitol or sucrose.
- Such formulations may also contain a demulcent, a preservative, a flavoring or a coloring agent.
- compositions of the invention may be in the form of a sterile injectable preparation, such as a sterile injectable aqueous or oleaginous suspension.
- a sterile injectable preparation such as a sterile injectable aqueous or oleaginous suspension.
- This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above.
- the sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, such as a solution in 1,3-butanediol or prepared as a lyophylized powder.
- acceptable vehicles and solvents that may be employed are water, Ringer's solution and isotonic sodium chloride solution.
- sterile fixed oils may conventionally be employed as a solvent or suspending medium.
- any bland fixed oil may be employed including synthetic mono- or diglycerides.
- fatty acids such as oleic acid may likewise be used in the preparation of inje ⁇ tables.
- a time-release formulation intended for oral administration to humans may contain 20 to 200 ⁇ moles of active material compounded with an appropriate and convenient amount of carrier material which may vary from about 5 to about 95% of the total compositions. It is preferred that pharmaceutical composition be prepared which provides easily measurable amounts for administration.
- an aqueous solution intended for intravenous infusion should contain from about 20 to about 50 ⁇ moles of the active ingredient per milliliter of solution in order that infusion of a suitable volume at a rate of about 30 ml/hr can occur.
- the specific dose level for any particular patient will depend on a variety of factors including the activity of the specific compound employed; the age, body weight, general health, sex and diet of the individual being treated; the time and route of administration; the rate of excretion; other drugs which have previously been administered; and the severity of the particular disease undergoing therapy, as is well understood by those skilled in the art.
- the method may be used following thrombolysis for coronary occlusion.
- the compound would be given as a sterile injectable preparation with water or isotonic sodium chloride as the solvent.
- the solution can be administered intravenously or directly into the coronary artery at the time of left heart catheterization or into a carotid artery.
- the rate of administration could vary from 0.2 to 1 ⁇ mole/min/kg with, for example, an infusion volume of 30 ml/hr. Duration of therapy would typically be about 96 hours.
- Angina and early myocardial infarcts can be treated by intravenous administration using a sterile injectable preparation using the rates discussed above.
- Compounds of the invention can also be administered to patients intravenously during cardiac bypass surgery or to other surgical patients at risk for a myocardial infarct.
- the compound can be added directly to the solution administered by the membrane oxygenation, or to the cardiac preservation solution, at the rates discussed above.
- Organs can be preserved using the method of the invention by perfusing the organ with a solution containing a compound of the invention.
- the dosage administered would vary with the rate of perfusion of the organ, as is well understood to those skilled in the art.
- This method is particularly applicable to organs and tissues used in organ transplantation.
- test compound Solutions of the test compound were prepared in water to a final concentration of 10 mM. 100 ⁇ l of this solution was added to 1 ml of approximately 1 mM sodium hypochlorite aqueous solution. The resulting solutions were mixed for approximately two seconds and immediately thereafter tested for oxidizing strength with starch-iodide paper. Compounds which showed no detectable oxidation of starch-iodide paper, i.e., detectable purple color resulting from the formation of a starch-iodine complex, are scored as positive antioxidants. The results are given in Table I.
- the compounds imidazole, ribavirin, tiazofurin, 5-amino-1-beta-D-ribofuranosylpyrazole-4-carboxamide and adenosine which do not act as antioxidants in this test are included to demonstrate the surprising selective antioxidant properties of AICA riboside and these substituted imidazole analogs of AICA riboside (see Formula I).
- COMPOUND NO. 1 RESULT water (control) neg 5-amino-1-beta-D-ribofuranosylimidazole-4- 1(1-110) poscarboxamide
- Compound No refers to the Compound No. as set forth in Tables VIII and IX. TABLE I (Continued)
- AICA riboside and these substituted- imidazole AICA riboside analogs were demonstrated in a model of electrolysis-induced myocardial dysfunction [See, J. Pharmacol. Meth. 15:305-320 (1986)].
- Isolated guinea pig hearts were cannulated via the ascending aorta and attached to a perfusion apparatus according to the method of Langendorff.
- the hearts were perfused at a constant pressure of 60 cm water using a modified Krebs-Henseleit buffer (pH 7.4) at 37 degrees C.
- LVDP left ventricular developed pressure
- Electrolysis was performed by inserting platinum electrodes directly into the inflowing perfusion buffer above the heart. Following equilibration of the hearts for a period of 30 minutes, the perfusion buffer was subjected to electrolysis for a period of 1 minute at 1 mA. This resulted in a decrease in LVDP to approximately 25% of control values at 10 minutes post-electrolysis.
- Isolated rat hearts were prepared as described in Example 2. Developed pressures (LVDP) were continuously monitored and coronary flows also measured gravimetrically. After equilibrating the hearts at a constant perfusion pressure of 100 cm water for 30 minutes, the hearts were subjected to low flow ischemia by reducing the perfusion pressure to 10 cm water for a period of 30 minutes and then reperfused by restoring the pressure to its original level (100 cm water) for a further 30 minutes. Addition of 10 ⁇ M, 20 ⁇ M or 100 ⁇ M 5-amino-1- ⁇ -D-ribofuranosylimidazole-4-carboxamide to the perfusion buffer at reperfusion alone significantly improved the recovery of LVDP at 30 minutes reperfusion. (See Figure 1) Selected compounds according to formula (I) were evaluated for their ability to reduce post-ischemic injury. The results are summarized in Table III.
- Hearts were then stored for 150 minutes at 20 °C immersed in the same cardioplegic solution. Following the termination of ischaemia, all hearts were reperfused normothermically for 15 minutes in the Langendorff mode with or without AICA riboside (20 ⁇ mol/1) added to the perfusion fluid. Hearts were then converted to the working mode for a further 20 minutes. At the end of this period heart rate (HR), coronary flow
- CF aortic flow
- AF cardiac output
- CO cardiac output
- SV stroke volume
- SW stroke work
- Cardiac output was calculated as the sum of coronary flow and aortic flow
- stroke volume as cardiac output divided by heart rate
- stroke work as the stroke volume multiplied by the peak systolic pressure.
- Hearts not subjected to ischaemia were perfused for the same period (15 minutes Langendorff plus 20 minutes working heart) to serve as time-matched aerobic controls for comparative purposes.
- AICA riboside analogs to inhibit platelet aggregation was examined in human whole blood.
- Whole blood was drawn from healthy donors and collected in 0.1 volume of sodium citrate to prevent coagulation.
- Platelet aggregation was measured by the impedance technique using a Whole Blood Aggregometer. The test compounds were incubated in whole blood for 10 minutes at 37oC and 10 ⁇ M adenosine was added 5 minutes before eliciting aggregation. Aggregation was induced by addition of ADP (6-25 ⁇ M) at the minimum concentration inducing full aggregation in untreated controls.
- AICA riboside 50 g was dissolved in pyridine (450 ml) and then cooled in an ice bath. Acetic anhydride (80 ml) was added and the ice bath removed. The reaction mixture was stirred for 3 hrs. TLC on silica gel, eluting with 9:1 methylene chloride:methanol, showed the reaction to be complete. Methanol (5 ml) was added to neutralize unreacted acetic anhydride. The solvents were removed by evaporation under high vacuum (bath temperature less than 40 °C). The residue was coevaporated with dimethylformamide (3 ⁇ 150 ml). The residue was crystallized from ethanol using seed crystals. The yield of the triacetate 62 g of white solid; melting point 128-129°C.
- the compound from the preceeding preparation was dissolved in 60% formic acid (20 ml) and the resulting solution was stirred at room temperature for 48 hours. The solvent was removed by evaporation under high vacuum. The residue was coevaporated with water. The product was crystallized from aqueous ethanol. Yield was 1.0 g of the above-identified product, melting point 174-175°C.
- Yield was 5.0 g, of the above-identified product, melting point 138-139oC.
- the supernatant from the above crystallization was concentrated and applied to a 200 ml column of silica gel.
- the 5:1 eluate contained a major product and was evaporated and residue dissolved in 10 ml of methanol.
- N-Succinimidyl-5-amino-1- 2 , 3 , 5-tri-O-acetyl- ⁇ -D-ribofuranosyl ) imidazole-4-carboxylate 4 ( 0. 50 g) ,
- the foam was dissolved in methanol (20 ml) and methanolic sodium methoxide solution was added (0.3 ml of 0.25 M solution). The solution was stirred under an argon atmosphere for 15 min. TLC indicated the reaction was complete. The solution was neutralized to pH 6 with ion exchange resin. The resin was filtered and the solution concentrated under high vacuum to yield a yellow foam (0.23 g).
- AICA riboside (1.00 g) , triphenylphosphine (3.05 g) and carbon tetrachloride (1.15 ml) were stirred in dimethyl formamide (38 ml) at room temperature for 3 hours.
- the solution was diluted with methanol (15 ml), then concentrated under reduced pressure.
- the resulting yellow tar was chromatographed on silica gel, eluting with 4:1 methylene chloride:methanol. The like fractions were combined and concentrated under reduced pressure to afford a purple foam.
- a solution of approximately 30 mmol diazoethane in 40 ml of ether was prepared by slow addition of 7 g (44 mmol) of 1-ethyl-3-nitro-1-nitrosoguanidine to a mixture of 8 g of potassium hydroxide, 9 ml water and 60 ml of ether followed by distillation. This was slowly added to a solution of 3.2 g (12 mmol) of 5-amino-1- ⁇ -D-ribofuranosylimidazole-4-carboxamide (AICA riboside) in 35 ml dimethylformamide containing 50 mg of tin(II) chloride dihydrate. During the addition approximately 20 ml of methanol was added to maintain solubility.
- AICA riboside 5-amino-1- ⁇ -D-ribofuranosylimidazole-4-carboxamide
- Diazobutane was prepared by treatment of 16.5 g of N-nitroso-N-n-butylmethane [Wilds, A.L. and Meeder, A.L., SOC 13 (1948)] in ethyl ether (100ml) with potassium hydroxide (55 g) in water (60 ml). The ethereal diazobutane was used without distillation. The supernatant from the above crystallization was concentrated under reduced pressure to give 125 mg of a pink foam. HPL analysis showed a 14/71 mixture. 1 H NMR decoupling and exchange experiments showed the major product to be the 3'-O-n-butyl ether.
- the residue was dissolved in methanol (15 ml) and the pH was adjusted to about 10 using a sodium methoxide solution. After stirring at room temperature for 45 mintues, the solution was neutralized with Dowex 50-resin. The resin was filtered off and washed with methanol (2 ⁇ 5 ml). The combined filtrate and the washings were evaporated to dryness.
- the residue which was in the form of a foam was dissolved in absolute ethanol (10 ml). The pH of the solution was adjusted to about 5 with an ethanolic-HCl solution. Solvent was evaporated to dryness and the residue was treated with anhydrous ether. The amorphous solid that separated was collected by filtration and washed with ether (2 ⁇ 10 ml), and dried under high vacuum to yield 250 mg. The compound obtained was highly hygroscopic; no melting point could be obtained.
- This compound was prepared according to the procedures described in Example J for the 4-p-nitrobenzyl derivative, substituting 3-iodobenzylamine hydrochloride for 4-nitrobenzylamine hydrochloride.
- N4-benzyl carboxamide 3.6 (m, 2H, 5'-CH 2 ), 3.9-4.3 (m, 3H, 2'-CH, 3'-CH, 4'-CH), 5.1 (m, 1H, methine proton on
- Step C The product of Step C, as obtained, was dissolved in 150 ml of 80% trifluoracetic acid and warmed to 50°C for 30 minutes. The solution was evaporated to a syrup at 40°C under vacuum and the residue evaporated twice from 25 ml of water. The syrupy residue was dissolved in 100 ml of ethyl acetate and gently stirred over 100 ml of saturated sodium bicarbonate. Crystallization began in the ethyl acetate phase and after 1 hour crystals were collected by filtration. These crystals were combined with two additional crops or crystals obtained by concentration of the ethyl acetate phase to yield 15.7 g (77% yield based on the product of Step B). Melting point of an analytical sample was 182-183°C.
- Step E The product of Step E (theoretically 159 mmole) was dissolved in 100 ml of ethanol and 3.5 ml of 6 N hydrochloric acid added (pH to wet pH paper approximately 3). The solution was evaporated to a hard syrup. This syrup was dissolved in 50 ml of hot ethanol and diluted with 150 ml of ethyl ether. The resulting gummy precipitate was stirred sealed for 12 hours and the resulting white precipitate collected by filtration and washed with ether. Drying under vacuum at 40oC yielded 6.0 g of the above-identified compound (90% yield based on the compound from Step D).
- This compound was prepared by the same reaction sequence described in Example AH for compound 53 (1-468), substituting the 4-N-cyclopentylamide, compound 10 (1-186), of Table XII for the 4-N-p-chlorobenzylamide compound 29 (1-349) of Table XII.
- the intermediate, 5-amino-1-(5-chloro-5-deoxy- ⁇ -D- ribofuranosyl)imidazole-4-carboxamide was prepared according to the procedures described in Example Al for compound 5 1 (1-466), substituting 5-amino-1- ⁇ -D-ribofuranosylimidazole-4-carboxamide for 5-amino-1- ⁇ -D-r i b o f u r a n o s y l i m i d a z o l e - 4 - N - [ ( 4-nitrophenylmethyl ] carboxamide .
- Triethylamine (approximately 0.75 ml) was added until the solution was basic. The solution was stirred at ambient temperature under a drying tube for 2 hours. The solution was washed with water, dried with magnesium sulfate, and concentrated under reduced pressure to give a yellow foam. The foam was dissolved in methanol (35 ml). A sodium methoxide methanol solution (approximately 0.75 ml of a 0.5 N solution) was added and the resulting solution stirred at ambient temperature under a drying tube, for 30 minutes. The solution was neutralized with methanol-washed Dowex 50 (strongly acidic ion-exchange resin). The mixture was filtered and concentrated under reduced pressure to give a pale yellow residue.
- Dowex 50 strongly acidic ion-exchange resin
- step B 5-Amino-1-(5-iodo-5-deoxy-2,3-isopropylidene- ⁇ -D-ribofuranosyl)imidazole-4-N-[(4-chlorophenyl)methyl]carboxamide (see procedures described in Example AH for preparation of Compound 53 (1-468), step B) (0.64 g) was stirred in 30 ml of 50% formic acid overnight. The excess solvent was evaporated under reduced pressure. The resulting residue was co-evaporated with water (25 ml) and methanol (25 ml). The resulting yellow foam was chromatographed on silica gel, using 9:1 methylene chloride:methanol as eluting solvent.
- the mixture was shaken for an additional 48 hours.
- the reaction mixture contained 30% starting material.
- the mixture was filtered through Celite, and concentrated under reduced pressure.
- the resulting residue was chromatographed on silica gel, using ethyl acetate (400 ml) and 5% methanol in ethyl acetate
- Example AK 5-Amino-1-(5-deoxy-5-methylthio- ⁇ -D-ribofuranosyl ) imidazole-4-carboxamide (compound 54 (1-483)) of Example AK (0.40 g) was dissolved in water (20 ml). Hydrogen peroxide, 30 weight percent, (0.42 ml), was added and the solution stirred for 30 minutes. TLC (6/1, methylene chloride/methanol) indicated some starting material present. An additional 1.0 ml of hydrogen peroxide was added and the solution stirred for 15 minutes. TLC indicated no starting material. The solvent was evaporated under reduced pressure to give a yellow foam. The foam was chromatographed on silica gel, using 3/1, methylene chloride/methanol, as eluting solvent. The appropriate fractions were combined and concentrated in vacuo to give 75 mg of the above-identified compound as a yellow foam.
- Postassium sulfate (3.7 g) was heated at reflux in ethanol (20 ml) for 15 minutes. The mixture was filtered. To the filtrate was added 5'-deoxy-2',3'-isopropylidene-2-bromo AICA riboside (from step A). The mixture was heated at 100°C in a steel bomb for 5.5 hours. The mixture was cooled and filtered. The pH of the filtrate was adjusted to about 5-6 with acetic acid, and the solvent evaporated under reduced pressure. The resulting residue was passed through a column of silica gel, eluting with 7/1, methylene chloride/methanol. The fractions containing the product were combined and concentrated under reduced pressure to give a dark brown foam.
- N-succinimidyl-5-amino-1- (2,3, 5-tri-O-acetyl- ⁇ -D-ribofuranosyl-imidazole-4-carboxylate (2.50 g) (ref: Srivastava, P.C, et al., J. Med. Chem. 12:1207 (1974)), 1,6-hexane diamine (0.300 g) , triethylamine (0.5 ml), and methylene chloride (35 ml) were combined and stirred at room temperature for 18 hours.
- the title compound was prepared according to the procedures described in Example J. The final product was crystallized from methanol to yield 0.32 g of the above-identified compound. Mp - 181- 185oC.
- the glass was dissolved in 80% of trifluoroacetic acid (8 ml) and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure to give a yellow solid. The solid was stirred in diethylether/ethanol (10 ml of 95/5), then filtered and dried to yield a yellow solid (55 mg).
- This compound was prepared according to the procedures described in Example J for the p-nitrobenzyl derivative, substituting 4-(aminomethyl)benzene sulfonamide hydrochloride for 4-nitrobenzylamine hydrochloride.
- the microscopic solid was collected, and the combined solid material was dissolved in water (20 ml) and neutralized with Dowex 50W strongly acidic ion exchange resin. The solvent was evaporated under reduced pressure to give a dark tar. The tar was dissolved in 80% acetic acid (20 ml) and gently heated (60oC). The solvent was evaporated under reduced presure to give a dark tar. The tar was co-evaporated with methanol (2 ⁇ 15 ml). The resulting residue was chromatographed on silica gel, using 3/1, methylene chloride/methanol, as eluting solvent. The appropriate fractions were combined and concentrated under reduced pressure to yield a dark tar. The tar was co-evaporated with tolune (3 ⁇ 20 ml), then vacuum dried to yield a dark brown, hygroscopic foam (110 mg).
Abstract
Les procédés décrits permettent de traiter diverses affections corporelles entraînant des lésions tissulaires dont les médiateurs sont des radicaux libres dérivés de l'oxygène et des oxydants, en administrant aux patients du riboside AICA ou des promédicaments et des analogues de ceux-ci comme antioxydants et comme piégeurs de radicaux libres. L'invention se rapporte également à l'utilisation de ces composés pour inhiber l'agrégation plaquettaire lors d'une thérapie thrombolytique et pour inhiber les situations de fusion des membranes qui sont une condition préalable à l'entrée des virus, cette capacité inhibitrice étant due au pouvoir qu'ont ces composés de neutraliser la destruction par oxydation des membranes cellulaires.The methods described make it possible to treat various bodily conditions resulting in tissue damage, the mediators of which are free radicals derived from oxygen and oxidants, by administering to patients riboside AICA or prodrugs and analogs thereof as antioxidants and as free radical scavengers. The invention also relates to the use of these compounds for inhibiting platelet aggregation during thrombolytic therapy and for inhibiting the situations of membrane fusion which are a prerequisite for the entry of viruses, this inhibitory capacity being due to the power of these compounds to neutralize the destruction by oxidation of cell membranes.
Description
Claims
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US56619790A | 1990-08-10 | 1990-08-10 | |
US566197 | 1990-08-10 | ||
US73218191A | 1991-07-17 | 1991-07-17 | |
US732181 | 1991-07-17 |
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IL103294A0 (en) * | 1991-09-30 | 1993-05-13 | Gensia Pharma | Pharmaceutical compositions for preventing tissue damage associated with decreased blood flow |
AU2003213628A1 (en) * | 2002-02-28 | 2003-09-16 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
SG160425A1 (en) * | 2005-03-28 | 2010-04-29 | Pericor Therapeutics Inc | Methods, compositions, and formulations for preventing or reducing adverse effects in a patient |
US8461192B2 (en) | 2007-09-13 | 2013-06-11 | The University Of South Florida | Method of selectively inhibiting PKCiota |
CA2739463C (en) | 2008-10-03 | 2018-07-03 | Pericor Therapeutics, Inc. | Methods and compositions for treatment of acute heart failure |
BR112014014740B1 (en) | 2011-12-22 | 2021-08-24 | Alios Biopharma, Inc | NUCLEOSIDE COMPOUNDS, NUCLEOTIDES AND THEIR ANALOGUES, THEIR USE AND PHARMACEUTICAL COMPOSITION |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
Citations (2)
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EP0301900A2 (en) * | 1987-07-29 | 1989-02-01 | The Regents Of The University Of California | L'utilisation de riboside ou ribotide de l'AICA pour la fabrication d'un médicament contre la crise cardiaque ou l'infarctus du myocarde aux patients souffrant d'athérosclerosis. |
WO1990008550A1 (en) * | 1989-01-24 | 1990-08-09 | Gensia Pharmaceuticals, Inc. | Antivirals and methods for increasing the antiviral activity of azt |
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AT350735B (en) * | 1976-08-06 | 1979-06-11 | Hoffmann La Roche | METHOD FOR PRODUCING NEW RIBO-FURANOSYL IMIDAZOLE DERIVATIVES |
US4575498A (en) * | 1983-07-21 | 1986-03-11 | Duke University | Method for restoring depleted purine nucleotide pools |
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1991
- 1991-08-08 IL IL99125A patent/IL99125A0/en unknown
- 1991-08-09 IE IE283491A patent/IE912834A1/en unknown
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- 1991-08-09 AU AU84062/91A patent/AU651131B2/en not_active Ceased
- 1991-08-09 JP JP3514158A patent/JPH06500101A/en active Pending
- 1991-08-09 CA CA002089145A patent/CA2089145A1/en not_active Abandoned
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EP0301900A2 (en) * | 1987-07-29 | 1989-02-01 | The Regents Of The University Of California | L'utilisation de riboside ou ribotide de l'AICA pour la fabrication d'un médicament contre la crise cardiaque ou l'infarctus du myocarde aux patients souffrant d'athérosclerosis. |
WO1990008550A1 (en) * | 1989-01-24 | 1990-08-09 | Gensia Pharmaceuticals, Inc. | Antivirals and methods for increasing the antiviral activity of azt |
Non-Patent Citations (6)
Title |
---|
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY vol. 309, no. A, 1991, page 347 METZNER E.K. ET AL 'ACADESINE (AICA RIBOSIDE) ATTENUATES REPERFUSION INJURY AND OXIDANT -INDUCED DAMAGE OF THE HEART' * |
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY vol. 309, no. A, 1991, pages 275 - 278 BARANKIEWICZ J. ET AL 'REGULATION OF ADENOSINE CONCENTRATIONS BY ACADESINE (AICA RIBOSIDE) IN HUMAN B-LYMPHOBLASTS' * |
AMERICAN COLLEGE OF SURGEONS SURGICAL FORUM vol. 34, 1983, pages 330 - 331 ROSENKRANZ E.R. ET AL 'IMPROVED ADENOSINE TRIPHOSPHATE RECOVERY IN ENERGY DEPLETED HEARTS TREATED WITH 5-AMINO-4-IMIDAZOLE CARBOXAMIDE RIBOSIDE (AICAR)' * |
CIRCULATION vol. 80, no. 5, 1989, pages 1400 - 1411 GRUBER H.E. ET AL 'INCREASED ADENOSINE CONCENTRATION IN BLOOD FROM ISCHEMIC MYOCARDIUM BY AICA RIBOSIDE.' * |
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH vol. 10, no. 8/9, 1984, pages 549 - 562 FEHER J. ET AL 'IMMUNOMODULATORY EFFECT OF NEW RADICAL SCAVENGERS' * |
See also references of WO9202213A1 * |
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FI930553A0 (en) | 1993-02-09 |
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CA2089145A1 (en) | 1992-02-11 |
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