EP0527810A4 - Methods and compositions for reversibly permeabilizing the blood brain barrier - Google Patents

Methods and compositions for reversibly permeabilizing the blood brain barrier

Info

Publication number
EP0527810A4
EP0527810A4 EP19910908404 EP91908404A EP0527810A4 EP 0527810 A4 EP0527810 A4 EP 0527810A4 EP 19910908404 EP19910908404 EP 19910908404 EP 91908404 A EP91908404 A EP 91908404A EP 0527810 A4 EP0527810 A4 EP 0527810A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
brain barrier
blood brain
permeabilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910908404
Other versions
EP0527810A1 (en
Inventor
Alexander Tomasz
Elaine Tuomanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of EP0527810A1 publication Critical patent/EP0527810A1/en
Publication of EP0527810A4 publication Critical patent/EP0527810A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
EP19910908404 1990-04-13 1991-04-12 Methods and compositions for reversibly permeabilizing the blood brain barrier Withdrawn EP0527810A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50931990A 1990-04-13 1990-04-13
US51555290A 1990-04-27 1990-04-27
US515552 1990-04-27
CA002081838A CA2081838A1 (en) 1990-04-13 1992-10-30 Methods and compositions for reversibly permeabilizing the blood brain barrier
US509319 1995-07-26

Publications (2)

Publication Number Publication Date
EP0527810A1 EP0527810A1 (en) 1993-02-24
EP0527810A4 true EP0527810A4 (en) 1993-06-16

Family

ID=27169231

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910908404 Withdrawn EP0527810A4 (en) 1990-04-13 1991-04-12 Methods and compositions for reversibly permeabilizing the blood brain barrier

Country Status (3)

Country Link
EP (1) EP0527810A4 (en)
CA (2) CA2080376A1 (en)
WO (1) WO1991016064A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE228832T1 (en) * 1994-02-28 2002-12-15 Nanopharm Ag SYSTEM FOR THE TARGETED DELIVERY OF ACTIVE INGREDIENTS, METHOD FOR THE PRODUCTION AND USE THEREOF

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866042A (en) * 1987-11-18 1989-09-12 Neuwelt Edward A Method for the delivery of genetic material across the blood brain barrier

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9116064A1 *
THE JOURNAL OF INFECTIOUS DISEASES vol. 151, no. 5, May 1985, CHICAGO, ILL, US pages 859 - 868 E. TUOMANEN ET AL. 'THE INDUCTION OF MENINGEAL INFLAMMATION BY COMPONENTS OF THE PNEUMOCOCCAL CELL WALL.' *

Also Published As

Publication number Publication date
CA2080376A1 (en) 1991-10-14
CA2081838A1 (en) 1994-05-01
EP0527810A1 (en) 1993-02-24
WO1991016064A1 (en) 1991-10-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19921012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RHK1 Main classification (correction)

Ipc: A61K 35/74

A4 Supplementary search report drawn up and despatched

Effective date: 19930427

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19950427

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19950908