EP0514036A3 - Preparation of thionucleosides - Google Patents

Preparation of thionucleosides Download PDF

Info

Publication number
EP0514036A3
EP0514036A3 EP19920303814 EP92303814A EP0514036A3 EP 0514036 A3 EP0514036 A3 EP 0514036A3 EP 19920303814 EP19920303814 EP 19920303814 EP 92303814 A EP92303814 A EP 92303814A EP 0514036 A3 EP0514036 A3 EP 0514036A3
Authority
EP
European Patent Office
Prior art keywords
thionucleosides
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920303814
Other versions
EP0514036A2 (en
Inventor
Robert John Young
John Allen Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of EP0514036A2 publication Critical patent/EP0514036A2/en
Publication of EP0514036A3 publication Critical patent/EP0514036A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
EP19920303814 1991-04-29 1992-04-28 Preparation of thionucleosides Withdrawn EP0514036A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919109186A GB9109186D0 (en) 1991-04-29 1991-04-29 Preparation of thionucleosides
GB9109186 1991-04-29

Publications (2)

Publication Number Publication Date
EP0514036A2 EP0514036A2 (en) 1992-11-19
EP0514036A3 true EP0514036A3 (en) 1993-03-03

Family

ID=10694129

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19920303814 Withdrawn EP0514036A3 (en) 1991-04-29 1992-04-28 Preparation of thionucleosides

Country Status (3)

Country Link
EP (1) EP0514036A3 (en)
JP (1) JPH05170760A (en)
GB (1) GB9109186D0 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591722A (en) * 1989-09-15 1997-01-07 Southern Research Institute 2'-deoxy-4'-thioribonucleosides and their antiviral activity
US5478928A (en) * 1990-04-20 1995-12-26 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides and synthetic precursors thereof
GB9708611D0 (en) * 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409575A1 (en) * 1989-07-17 1991-01-23 The University Of Birmingham Antiviral pyrimidine nucleosides
WO1991004982A1 (en) * 1989-10-04 1991-04-18 University Of Birmingham Further antiviral pyrimidine nucleosides
WO1991016333A1 (en) * 1990-04-20 1991-10-31 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409575A1 (en) * 1989-07-17 1991-01-23 The University Of Birmingham Antiviral pyrimidine nucleosides
WO1991004982A1 (en) * 1989-10-04 1991-04-18 University Of Birmingham Further antiviral pyrimidine nucleosides
WO1991016333A1 (en) * 1990-04-20 1991-10-31 Southern Research Institute 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. C. Dittmer in 'COMPREHENSIVE HETEROCYCLIC CHEMISTRY', Ed. W. Lwowski, Vol. 7, chapter 5.06 GB, Oxford, Pergamon Press, 1984 *
JOURNAL OF MEDICINAL CHEMISTRY. vol. 35, no. 3, 7 February 1992, WASHINGTON US pages 533 - 538 J. A. SECRIST III ET AL 'Synthesis and Anti-HIV Activity of 4'-Thio-2',3'-dideoxynucleosides' *

Also Published As

Publication number Publication date
GB9109186D0 (en) 1991-06-19
JPH05170760A (en) 1993-07-09
EP0514036A2 (en) 1992-11-19

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Effective date: 19970819