EP0503748A3 - Method and apparatus for generating ions, specially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally instable, non-volatile, large molecules - Google Patents

Method and apparatus for generating ions, specially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally instable, non-volatile, large molecules Download PDF

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Publication number
EP0503748A3
EP0503748A3 EP19920250055 EP92250055A EP0503748A3 EP 0503748 A3 EP0503748 A3 EP 0503748A3 EP 19920250055 EP19920250055 EP 19920250055 EP 92250055 A EP92250055 A EP 92250055A EP 0503748 A3 EP0503748 A3 EP 0503748A3
Authority
EP
European Patent Office
Prior art keywords
mass spectrometer
specially
volatile
time
large molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19920250055
Other languages
German (de)
Other versions
EP0503748A2 (en
EP0503748B1 (en
Inventor
Ruediger Dr. Frey
Armin Dr. Holle
Gerhard Weiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bruker Daltonics GmbH and Co KG
Original Assignee
Bruken Franzen Analytik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bruken Franzen Analytik GmbH filed Critical Bruken Franzen Analytik GmbH
Priority to EP95104288A priority Critical patent/EP0669638A1/en
Publication of EP0503748A2 publication Critical patent/EP0503748A2/en
Publication of EP0503748A3 publication Critical patent/EP0503748A3/en
Application granted granted Critical
Publication of EP0503748B1 publication Critical patent/EP0503748B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/147—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers with electrons, e.g. electron impact ionisation, electron attachment

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
EP92250055A 1991-03-13 1992-03-07 Method for generating ions, specially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally instable, non-volatile, large molecules Expired - Lifetime EP0503748B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP95104288A EP0669638A1 (en) 1991-03-13 1992-03-07 Method and apparatus for generating ions, especially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally unstable, non-volatile, large molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4108462 1991-03-13
DE4108462A DE4108462C2 (en) 1991-03-13 1991-03-13 Method and device for generating ions from thermally unstable, non-volatile large molecules
DE4108463 1991-03-13
DE4108463 1991-03-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP95104288.6 Division-Into 1992-03-07

Publications (3)

Publication Number Publication Date
EP0503748A2 EP0503748A2 (en) 1992-09-16
EP0503748A3 true EP0503748A3 (en) 1993-04-28
EP0503748B1 EP0503748B1 (en) 1996-12-11

Family

ID=25901910

Family Applications (2)

Application Number Title Priority Date Filing Date
EP92250055A Expired - Lifetime EP0503748B1 (en) 1991-03-13 1992-03-07 Method for generating ions, specially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally instable, non-volatile, large molecules
EP95104288A Withdrawn EP0669638A1 (en) 1991-03-13 1992-03-07 Method and apparatus for generating ions, especially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally unstable, non-volatile, large molecules

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP95104288A Withdrawn EP0669638A1 (en) 1991-03-13 1992-03-07 Method and apparatus for generating ions, especially for a mass spectrometer such as a time-of-flight mass spectrometer, from thermally unstable, non-volatile, large molecules

Country Status (3)

Country Link
US (1) US5294797A (en)
EP (2) EP0503748B1 (en)
DE (2) DE4108462C2 (en)

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DE4322102C2 (en) * 1993-07-02 1995-08-17 Bergmann Thorald Time-of-flight mass spectrometer with gas phase ion source
DE19608963C2 (en) * 1995-03-28 2001-03-22 Bruker Daltonik Gmbh Process for ionizing heavy molecules at atmospheric pressure
GB2310950A (en) * 1996-03-08 1997-09-10 Bruker Franzen Analytik Gmbh Method for the ionization of heavy molecules at atmospheric pressure
DE19630547C2 (en) * 1996-07-17 1998-05-28 Forschungsverbund Berlin Ev Process for matrix-assisted laser desorption and ionization of analyte molecules, especially fragile or unstable molecules
US5742050A (en) * 1996-09-30 1998-04-21 Aviv Amirav Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis
DE19649201A1 (en) * 1996-11-27 1998-05-28 Max Planck Gesellschaft Electron beam analysis
DE19705762C2 (en) * 1997-02-14 2001-06-07 Rainer Edmund Weinkauf Method and device for generating gas jets
DE19734460A1 (en) * 1997-08-11 1999-02-18 Gsf Forschungszentrum Umwelt Method and device for the analytical detection of traces
DE19822674A1 (en) * 1998-05-20 1999-12-09 Gsf Forschungszentrum Umwelt Gas inlet for an ion source
DE19822672B4 (en) * 1998-05-20 2005-11-10 GSF - Forschungszentrum für Umwelt und Gesundheit GmbH Method and device for producing a directional gas jet
US7119342B2 (en) * 1999-02-09 2006-10-10 Syagen Technology Interfaces for a photoionization mass spectrometer
US6630664B1 (en) 1999-02-09 2003-10-07 Syagen Technology Atmospheric pressure photoionizer for mass spectrometry
US7109476B2 (en) 1999-02-09 2006-09-19 Syagen Technology Multiple ion sources involving atmospheric pressure photoionization
US6211516B1 (en) * 1999-02-09 2001-04-03 Syagen Technology Photoionization mass spectrometer
DE19911801C1 (en) 1999-03-17 2001-01-11 Bruker Daltonik Gmbh Method and device for matrix-assisted laser desorption ionization of substances
DE10014847A1 (en) * 2000-03-24 2001-10-04 Gsf Forschungszentrum Umwelt Method and device for the detection of connections in a gas stream
DE10042394B4 (en) * 2000-08-29 2006-06-29 Dräger Safety AG & Co. KGaA Ion source for ion mobility spectrometer with optical and Teilchenstrahlun gsionisation
US6737642B2 (en) 2002-03-18 2004-05-18 Syagen Technology High dynamic range analog-to-digital converter
JP4646920B2 (en) * 2003-12-12 2011-03-09 セメクイップ， インコーポレイテッド Method and apparatus for extending equipment operational time in ion implantation
US20080223409A1 (en) * 2003-12-12 2008-09-18 Horsky Thomas N Method and apparatus for extending equipment uptime in ion implantation
DE102004002729B4 (en) * 2004-01-20 2008-11-27 Bruker Daltonik Gmbh Ionization of desorbed analyte molecules at atmospheric pressure
DE102005005333B4 (en) * 2005-01-28 2008-07-31 Deutsches Zentrum für Luft- und Raumfahrt e.V. Method for sampling and aerosol analysis
US7291845B2 (en) * 2005-04-26 2007-11-06 Varian, Inc. Method for controlling space charge-driven ion instabilities in electron impact ion sources
JP4825028B2 (en) 2006-03-17 2011-11-30 浜松ホトニクス株式会社 Ionizer
JP4958258B2 (en) * 2006-03-17 2012-06-20 株式会社リガク Gas analyzer
EP2017875A1 (en) * 2007-07-16 2009-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and apparatus for providing a sample for a subsequent analysis
WO2009039382A1 (en) * 2007-09-21 2009-03-26 Semequip. Inc. Method for extending equipment uptime in ion implantation
US7750291B2 (en) * 2008-02-25 2010-07-06 National Sun Yat-Sen University Mass spectrometric method and mass spectrometer for analyzing a vaporized sample
US8742335B2 (en) * 2009-12-18 2014-06-03 Sri International Rotator sample introduction interface
CN102903597A (en) * 2012-10-19 2013-01-30 山东省科学院海洋仪器仪表研究所 Ion source combining thermal desorption with electron bombardment
GB2518122B (en) * 2013-02-19 2018-08-08 Markes International Ltd An electron ionisation apparatus
EP3690923A1 (en) * 2013-04-17 2020-08-05 Fluidigm Canada Inc. Sample analysis for mass cytometry
GB201721700D0 (en) 2017-12-22 2018-02-07 Micromass Ltd Ion source
JP7039439B2 (en) * 2018-10-26 2022-03-22 株式会社堀場製作所 Gas analyzer and gas analysis method
CN116031138A (en) * 2023-01-10 2023-04-28 中国科学院大学 Gas-phase pollutant all-species high-sensitivity online mass spectrometer and detection method

Family Cites Families (8)

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FR1024654A (en) * 1950-09-16 1953-04-03 Csf Transit time selection mass spectrometer using frequency modulation
US3182190A (en) * 1962-07-31 1965-05-04 Gulf Research Development Co Magnetic field free ion source with adjustable electron gun
US3296434A (en) * 1964-05-26 1967-01-03 Martin H Studier Method of operating an ion source for a time of flight mass spectrometer
DE3224801C2 (en) * 1982-07-02 1986-04-30 Edward William Prof. Dr. 8000 München Schlag Method and device for generating pulsed molecular beams containing large, thermally unstable molecules
US4740692A (en) * 1985-06-13 1988-04-26 Mitsubishi Denki Kabushiki Kaisha Laser mass spectroscopic analyzer and method
DE3809504C1 (en) * 1988-03-22 1989-09-21 Bruker - Franzen Analytik Gmbh, 2800 Bremen, De
DE3920566A1 (en) * 1989-06-23 1991-01-10 Bruker Franzen Analytik Gmbh MS-MS FLIGHT TIME MASS SPECTROMETER
GB8928917D0 (en) * 1989-12-21 1990-02-28 Vg Instr Group Method and apparatus for surface analysis

Non-Patent Citations (4)

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Title
ANALYTICAL INSTRUMENTATION, Band 16, Nr. 1, 1987, Seiten 93-115, New York, US; J.K. OLTHOFF et al.: "Modification of Wiley-McLaren TOF analysers for laser desorption" *
APPLIED PHYSICS B. PHOTOPHYSICS AND CHEMISTRY, Band B41, Nr. 6, Dezember 1990, Seiten 395-403, Heidelberg, DE; G. MEIJER et al.: "Laser desorption jet-cooling of organic molecules" *
PHYSICAL REVIEW, B. CONDENSED MATTER, Band 38, Nr. 5, 15. August 1988, Seiten 3517-3520, New York, US; C.W.S. CONOVER et al.: "Laser vaporisation of solids into an inert gas: a measure of high-temperature cluster stability" *
REVIEW OF SCIENTIFIC INSTRUMENTS, Band 59, Nr. 4, April 1988, Seiten 557-561, New York, US; L. LI et al.: "Pulsed laser desorption method for volatilizing thermally labile molecules for supersonic jet spectroscopy" *

Also Published As

Publication number Publication date
US5294797A (en) 1994-03-15
DE4108462C2 (en) 1994-10-13
DE59207642D1 (en) 1997-01-23
EP0669638A1 (en) 1995-08-30
EP0503748A2 (en) 1992-09-16
DE4108462A1 (en) 1992-09-17
EP0503748B1 (en) 1996-12-11

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