EP0502105A4 - Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens - Google Patents

Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens

Info

Publication number
EP0502105A4
EP0502105A4 EP19910900526 EP91900526A EP0502105A4 EP 0502105 A4 EP0502105 A4 EP 0502105A4 EP 19910900526 EP19910900526 EP 19910900526 EP 91900526 A EP91900526 A EP 91900526A EP 0502105 A4 EP0502105 A4 EP 0502105A4
Authority
EP
European Patent Office
Prior art keywords
immunogens
particles used
antiviral agents
retroviral particles
replicating recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910900526
Other languages
English (en)
Other versions
EP0502105A1 (en
Inventor
Omar K. Haffar
Shiu-Lok Hu
Allen W. Senear
Bruce M. Travis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of EP0502105A1 publication Critical patent/EP0502105A1/en
Publication of EP0502105A4 publication Critical patent/EP0502105A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP19910900526 1989-11-20 1990-11-20 Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens Withdrawn EP0502105A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43920589A 1989-11-20 1989-11-20
US439205 1999-11-12

Publications (2)

Publication Number Publication Date
EP0502105A1 EP0502105A1 (en) 1992-09-09
EP0502105A4 true EP0502105A4 (en) 1993-02-24

Family

ID=23743729

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910900526 Withdrawn EP0502105A4 (en) 1989-11-20 1990-11-20 Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens

Country Status (14)

Country Link
EP (1) EP0502105A4 (cs)
JP (1) JPH05503629A (cs)
KR (1) KR920703639A (cs)
AU (1) AU636944B2 (cs)
CA (1) CA2068713A1 (cs)
ES (1) ES2052478T1 (cs)
FI (1) FI922277A7 (cs)
GR (1) GR930300005T1 (cs)
HU (1) HUT60506A (cs)
NO (1) NO921969L (cs)
OA (1) OA09698A (cs)
TW (1) TW216446B (cs)
WO (1) WO1991007425A1 (cs)
ZA (1) ZA909302B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0431128B1 (en) * 1989-06-01 2003-03-26 Applied Biotechnology, Inc. Vector coding for self-assembled, defective, non-self-propagating viral particles
US5861282A (en) * 1989-10-16 1999-01-19 Whitehead Institute For Biomedical Research Non-infectious HIV particles and uses therefor
WO1991019803A1 (en) * 1990-06-19 1991-12-26 Applied Biotechnology, Incorporated Self assembled, defective, nonself-propagating viral particles
DE4124817A1 (de) * 1991-07-26 1993-01-28 Basf Ag Waessrige polymerisatdispersionen
DE69232650T2 (de) * 1991-11-08 2002-11-28 Pharmacia & Upjohn Co., Kalamazoo Vakzine gegen katzenleukämievirus
CA2118026A1 (en) * 1992-04-14 1993-10-28 Guy T. Layton Induction of ctl responses
EP1473369B1 (en) 1993-01-26 2009-01-07 The Trustees of the University of Pennsylvania (a corporation of Pennsylvania) Compositions and methods for delivery of genetic material
US7001759B1 (en) 1993-01-26 2006-02-21 The Trustees Of The University Of Pennsylvania Compositions and methods for delivery of genetic material
ES2249760T3 (es) 1993-01-26 2006-04-01 The Trustees Of The University Of Pennsylvania (A Corporation Of Pennsylvania) Composiciones y procedimientos de administracion de materias geneticas.
GB9304239D0 (en) * 1993-03-01 1993-04-21 British Bio Technology Viral particles
US6291157B1 (en) 1998-02-23 2001-09-18 Connaught Laboratories Limited Antigenically-marked non-infectious retrovirus-like particles
US5955342A (en) * 1994-08-15 1999-09-21 Connaught Laboratories Limited Non-infectious, replication-defective, self-assembling HIV-1 viral particles containing antigenic markers in the gag coding region
US5858838A (en) 1998-02-23 1999-01-12 Taiwan Semiconductor Manufacturing Company, Ltd. Method for increasing DRAM capacitance via use of a roughened surface bottom capacitor plate
US6080408A (en) 1994-08-22 2000-06-27 Connaught Laboratories Limited Human immunodeficiency virus type 1 nucleic acids devoid of long terminal repeats capable of encoding for non-infectious, immunogenic, retrovirus-like particles
WO1996030523A2 (en) * 1995-03-31 1996-10-03 Hans Wolf Antigen presentation system based on retrovirus-like particles
US6013506A (en) * 1995-06-05 2000-01-11 Wardley; Richard C. Feline leukemia virus vaccines
US6121021A (en) * 1997-12-16 2000-09-19 Connaught Laboratories Limited Constitutive expression of non-infectious HIV-like particles
AU2221600A (en) 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
ES2299276T3 (es) 1998-12-31 2008-05-16 Novartis Vaccines And Diagnostics, Inc. Polipeptidos env del vih modificados.
AU2487300A (en) 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US8623379B2 (en) 2000-03-02 2014-01-07 Emory University Compositions and methods for generating an immune response
CA2401974C (en) 2000-03-02 2013-07-02 Emory University Dna expression vectors and methods of use
EP1372710B1 (en) * 2001-03-08 2009-10-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Mva expressing modified hiv envelope, gag, and pol genes
US7211659B2 (en) 2001-07-05 2007-05-01 Chiron Corporation Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
US20030170614A1 (en) 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
AU2012238351B2 (en) 2011-04-06 2016-11-24 Biovaxim Limited Pharmaceutical compositions for preventing and/or treating an HIV disease in humans
ES2937963T3 (es) 2015-07-21 2023-04-03 Modernatx Inc Vacunas de enfermedad infecciosa
WO2018170256A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Herpes simplex virus vaccine
WO2018170270A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Varicella zoster virus (vzv) vaccine
US12070495B2 (en) 2019-03-15 2024-08-27 Modernatx, Inc. HIV RNA vaccines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241239A2 (en) * 1986-04-07 1987-10-14 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce A cell line producing aids viral antigens without producing infectious virus particles
EP0381146A1 (en) * 1989-02-02 1990-08-08 Banyu Pharmaceutical Co., Ltd. Antigenic noninfectious HIV-producing cloned T cell
EP0386882A1 (en) * 1989-02-06 1990-09-12 Dana Farber Cancer Institute Packaging defective HIV provirus, cell lines, and uses thereof
WO1991005860A1 (en) * 1989-10-16 1991-05-02 Whitehead Institute For Biomedical Research Non-infectious hiv-1 particles and uses therefor
WO1991005864A1 (en) * 1989-10-13 1991-05-02 Connaught Laboratories Limited Production of genetically-engineered vaccines for aids and other retroviral diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0241239A2 (en) * 1986-04-07 1987-10-14 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce A cell line producing aids viral antigens without producing infectious virus particles
EP0381146A1 (en) * 1989-02-02 1990-08-08 Banyu Pharmaceutical Co., Ltd. Antigenic noninfectious HIV-producing cloned T cell
EP0386882A1 (en) * 1989-02-06 1990-09-12 Dana Farber Cancer Institute Packaging defective HIV provirus, cell lines, and uses thereof
WO1991005864A1 (en) * 1989-10-13 1991-05-02 Connaught Laboratories Limited Production of genetically-engineered vaccines for aids and other retroviral diseases
WO1991005860A1 (en) * 1989-10-16 1991-05-02 Whitehead Institute For Biomedical Research Non-infectious hiv-1 particles and uses therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AIDS RES. HUM. RETROVIRUSES vol. 6, no. 1, 1990, page 63 V. KARAKOSTAS 'Assembly of retrovitus particles lacking env protein in cells infected with recombinant vaccinia virus expressing the HIV1' *
J. VIROL. vol. 63, no. 6, 1989, pages 2550 - 2556 C. PENG ET AL. 'Role of hiv type 1 specific protease' *
J. VIROL. vol. 64, no. 6, 1990, pages 2653 - 2659 O. HAFFAR ET AL. 'HIV-like nonreplicating gag-env particles assemble in a recombinant vaccinia virus expression system' *
PROC. NATL. ACAD. SCI. USA vol. 86, no. 22, 1989, pages 8964 - 8967 V. KARAKOSTAS 'HIV-like particles produced by a vaccinia virus expression vector' *
See also references of WO9107425A1 *
VIROLOGY vol. 160, no. 2, 1987, pages 323 - 329 H. GENDELMAN ET AL. 'Molecular characterisation of a polymerase mutant human HIV' *

Also Published As

Publication number Publication date
AU6905591A (en) 1991-06-13
EP0502105A1 (en) 1992-09-09
HU9201659D0 (en) 1992-08-28
NO921969L (no) 1992-06-26
HUT60506A (en) 1992-09-28
CA2068713A1 (en) 1991-05-21
ES2052478T1 (es) 1994-07-16
AU636944B2 (en) 1993-05-13
FI922277A0 (fi) 1992-05-19
JPH05503629A (ja) 1993-06-17
FI922277A7 (fi) 1992-05-19
OA09698A (en) 1993-08-30
KR920703639A (ko) 1992-12-18
ZA909302B (en) 1991-09-25
GR930300005T1 (cs) 1993-04-28
WO1991007425A1 (en) 1991-05-30
TW216446B (cs) 1993-11-21
NO921969D0 (no) 1992-05-19

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Legal Events

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Inventor name: TRAVIS, BRUCE, M.

Inventor name: SENEAR, ALLEN, W.

Inventor name: HU, SHIU-LOK

Inventor name: HAFFAR, OMAR, K.

ITCL It: translation for ep claims filed

Representative=s name: JACOBACCI CASETTA & PERANI S.P.A.

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