EP0500776A4 - Poly(alkyl and alkenyl phosphate)s and their thiophosphate and selenophosphate derivatives as antiviral agents - Google Patents

Poly(alkyl and alkenyl phosphate)s and their thiophosphate and selenophosphate derivatives as antiviral agents

Info

Publication number
EP0500776A4
EP0500776A4 EP19910900534 EP91900534A EP0500776A4 EP 0500776 A4 EP0500776 A4 EP 0500776A4 EP 19910900534 EP19910900534 EP 19910900534 EP 91900534 A EP91900534 A EP 91900534A EP 0500776 A4 EP0500776 A4 EP 0500776A4
Authority
EP
European Patent Office
Prior art keywords
selenophosphate
thiophosphate
poly
derivatives
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910900534
Other versions
EP0500776A1 (en
Inventor
Gerald Zon
Makoto Dept. Of Pediatrics Matsukura
Wojciech J. Dept. Of Bioorganic Chemistry Stec
Andrzej Dept. Of Bioorganic Chemistry Wilk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lynx Therapeutics Inc
Original Assignee
Applied Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Biosystems Inc filed Critical Applied Biosystems Inc
Publication of EP0500776A1 publication Critical patent/EP0500776A1/en
Publication of EP0500776A4 publication Critical patent/EP0500776A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C07F9/1411—Esters of phosphorous acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19910900534 1989-11-17 1990-11-13 Poly(alkyl and alkenyl phosphate)s and their thiophosphate and selenophosphate derivatives as antiviral agents Withdrawn EP0500776A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43835589A 1989-11-17 1989-11-17
US438355 1989-11-17

Publications (2)

Publication Number Publication Date
EP0500776A1 EP0500776A1 (en) 1992-09-02
EP0500776A4 true EP0500776A4 (en) 1993-03-24

Family

ID=23740326

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910900534 Withdrawn EP0500776A4 (en) 1989-11-17 1990-11-13 Poly(alkyl and alkenyl phosphate)s and their thiophosphate and selenophosphate derivatives as antiviral agents

Country Status (3)

Country Link
EP (1) EP0500776A4 (en)
JP (1) JPH05501709A (en)
WO (1) WO1991007092A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922857A (en) * 1992-09-28 1999-07-13 Chiron Corporation Methods and compositions for controlling translation of HCV proteins
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288163A2 (en) * 1987-03-25 1988-10-26 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Oligodeoxynucleotides as inhibitors of the replication of retroviruses and the expression of oncogenes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826823A (en) * 1985-02-05 1989-05-02 Warner-Lambert Company Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0288163A2 (en) * 1987-03-25 1988-10-26 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Oligodeoxynucleotides as inhibitors of the replication of retroviruses and the expression of oncogenes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CELLULAR BIOCHEMISTRY vol. SUPPL, no. 14D, March 1990, page 100 W. EGAN ET AL. 'SYNTHESIS AND EVALUATION OF ABASIC OLIGODESOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES AS ANTI-HIV-1 AGENTS' *
NUCLEIC ACIDS RESEARCH vol. 17, no. 20, 1989, pages 8207 - 8219 K. MORI ET AL. 'PHOSPHOROSELENOATE OLIGODEOXYNUCLEOTIDES: SYNTHESIS, PHYSICO-CHEMICAL CHARACTERIZATION, ANTI-SENSE INHIBITORY PROPERTIES AND ANTI-HIV ACTIVITY' *
NUCLEIC ACIDS RESEARCH vol. 18, no. 10, 25 May 1990, pages 2855 - 2859 R.P. LYER ET AL. 'ABASIC OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES: SYNTHESIS AND EVALUATION AS ANTI-HIV-1 AGENTS' *
See also references of WO9107092A1 *

Also Published As

Publication number Publication date
WO1991007092A1 (en) 1991-05-30
JPH05501709A (en) 1993-04-02
EP0500776A1 (en) 1992-09-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19920612

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

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Owner name: LYNX THERAPEUTICS, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19960423