EP0493470A4 - Assays and reagents for amyloid deposition - Google Patents

Assays and reagents for amyloid deposition

Info

Publication number
EP0493470A4
EP0493470A4 EP19900914284 EP90914284A EP0493470A4 EP 0493470 A4 EP0493470 A4 EP 0493470A4 EP 19900914284 EP19900914284 EP 19900914284 EP 90914284 A EP90914284 A EP 90914284A EP 0493470 A4 EP0493470 A4 EP 0493470A4
Authority
EP
European Patent Office
Prior art keywords
assays
reagents
amyloid deposition
amyloid
deposition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19900914284
Other languages
English (en)
Other versions
EP0493470A1 (fr
Inventor
Barbara Cordell
David Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scios LLC
Original Assignee
California Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Biotechnology Inc filed Critical California Biotechnology Inc
Publication of EP0493470A1 publication Critical patent/EP0493470A1/fr
Publication of EP0493470A4 publication Critical patent/EP0493470A4/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
EP19900914284 1989-09-18 1990-09-12 Assays and reagents for amyloid deposition Ceased EP0493470A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40876789A 1989-09-18 1989-09-18
US408767 1989-09-18

Publications (2)

Publication Number Publication Date
EP0493470A1 EP0493470A1 (fr) 1992-07-08
EP0493470A4 true EP0493470A4 (en) 1992-11-25

Family

ID=23617679

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900914284 Ceased EP0493470A4 (en) 1989-09-18 1990-09-12 Assays and reagents for amyloid deposition

Country Status (5)

Country Link
EP (1) EP0493470A4 (fr)
JP (1) JPH05502368A (fr)
AU (1) AU641434B2 (fr)
CA (1) CA2065404C (fr)
WO (1) WO1991004339A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3249793A (en) 1991-12-24 1993-07-28 Isis Pharmaceuticals, Inc. Compositions and methods for modulating beta -amyloid
US6610493B1 (en) 1993-06-17 2003-08-26 Brigham And Women's Hospital Screening compounds for the ability to alter the production of amyloid-β peptide
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
US7799535B1 (en) * 1997-12-09 2010-09-21 Arch Development Corporation Methods for identifying factors that control the folding of amyloid proteins of diverse origin
ATE382704T1 (de) 2001-02-15 2008-01-15 Univ Chicago Verfahren zum nachweis in hefe für mittels die proteinfaltung beeinflussen
EP1793001B1 (fr) * 2001-02-15 2011-11-09 The University of Chicago Cribles à base de levure pour agents affectant le repliement de protéines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274826A1 (fr) * 1986-11-17 1988-07-20 California Biotechnology, Inc. Protéine recombinante amyloide d'alzheimer
WO1989006242A1 (fr) * 1987-10-08 1989-07-13 The Mclean Hospital Corporation Anticorps agissant sur un peptide de l'amyloide de sequence a4
WO1989006693A1 (fr) * 1988-01-13 1989-07-27 The Mclean Hospital Corporation Sequences genetiques codant pour l'amyloide cerebrale d'alzheimer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2403557A1 (fr) * 1977-09-19 1979-04-13 Beljanski Mirko Procede et reactifs de detection des substances cancerigenes et des substances anticancereuses
US4666829A (en) * 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
US4919915A (en) * 1987-03-03 1990-04-24 Paul Averback Method for detecting the ability to prevent red-to-green congophilic birefringence
US4912206A (en) * 1987-02-26 1990-03-27 The United States Of America As Represented By The Department Of Health And Human Services CDNA clone encoding brain amyloid of alzheimer's disease
CA1340802C (fr) * 1987-08-15 1999-10-26 Yasuyuki Takahashi Proteine precurseur de l'amyloide senile et anticorps specifique pour cette proteine
WO1989007657A1 (fr) * 1988-02-10 1989-08-24 The Children's Medical Center Corporation Precurseurs de proteines amyloides, sondes genetiques, anticorps, et modes d'utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274826A1 (fr) * 1986-11-17 1988-07-20 California Biotechnology, Inc. Protéine recombinante amyloide d'alzheimer
WO1989006242A1 (fr) * 1987-10-08 1989-07-13 The Mclean Hospital Corporation Anticorps agissant sur un peptide de l'amyloide de sequence a4
WO1989006693A1 (fr) * 1988-01-13 1989-07-27 The Mclean Hospital Corporation Sequences genetiques codant pour l'amyloide cerebrale d'alzheimer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9104339A1 *

Also Published As

Publication number Publication date
CA2065404A1 (fr) 1991-03-19
CA2065404C (fr) 2002-12-24
EP0493470A1 (fr) 1992-07-08
AU6431190A (en) 1991-04-18
AU641434B2 (en) 1993-09-23
JPH05502368A (ja) 1993-04-28
WO1991004339A1 (fr) 1991-04-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19920317

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19921005

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19940520

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SCIOS NOVA INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19960311