EP0489300A3 - New tetralones with pharmacological activity - Google Patents

New tetralones with pharmacological activity Download PDF

Info

Publication number
EP0489300A3
EP0489300A3 EP19910119718 EP91119718A EP0489300A3 EP 0489300 A3 EP0489300 A3 EP 0489300A3 EP 19910119718 EP19910119718 EP 19910119718 EP 91119718 A EP91119718 A EP 91119718A EP 0489300 A3 EP0489300 A3 EP 0489300A3
Authority
EP
European Patent Office
Prior art keywords
tetralones
new
pharmacological activity
pharmacological
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910119718
Other versions
EP0489300A2 (en
Inventor
Carmen Almansa
Ma Carmen Torres
Ma Conception Gonzalez
Elena Carceller
Javier Bartroli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9003308A external-priority patent/ES2024969A6/en
Priority claimed from ES9101242A external-priority patent/ES2033576B1/en
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Publication of EP0489300A2 publication Critical patent/EP0489300A2/en
Publication of EP0489300A3 publication Critical patent/EP0489300A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
EP19910119718 1990-12-05 1991-11-19 New tetralones with pharmacological activity Ceased EP0489300A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES9003308A ES2024969A6 (en) 1990-12-05 1990-12-05 Process for obtaining tetralones
ES9003308 1990-12-05
ES9101242A ES2033576B1 (en) 1991-05-09 1991-05-09 NEW PROCEDURE FOR OBTAINING NEW TETRALONAS.
ES9101242 1991-05-09

Publications (2)

Publication Number Publication Date
EP0489300A2 EP0489300A2 (en) 1992-06-10
EP0489300A3 true EP0489300A3 (en) 1993-03-17

Family

ID=26154508

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910119718 Ceased EP0489300A3 (en) 1990-12-05 1991-11-19 New tetralones with pharmacological activity

Country Status (4)

Country Link
US (1) US5208246A (en)
EP (1) EP0489300A3 (en)
JP (1) JPH07113014B2 (en)
CA (1) CA2056922A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352777A (en) * 1990-12-26 1994-10-04 Pioneer Hi-Bred International, Inc. DNA isolation from animal cells
JP3042156B2 (en) * 1992-02-20 2000-05-15 田辺製薬株式会社 Naphthalene derivative, its production method and its synthetic intermediate
ES2064228B1 (en) * 1992-10-19 1995-09-01 Uriach & Cia Sa J NEW TETRALONES WITH PHARMACOLOGICAL ACTIVITY, COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE FOR THEIR PREPARATION.
US5500442A (en) * 1994-06-10 1996-03-19 American Home Products Corporation Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants
WO2005082343A2 (en) 2004-02-25 2005-09-09 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
CN111333613A (en) * 2020-01-08 2020-06-26 上海孜岚医药科技有限公司 Preparation method of trifluoromethyl tetralone compound

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168619A1 (en) * 1984-06-12 1986-01-22 Beecham Group Plc N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them
EP0321175A1 (en) * 1987-12-14 1989-06-21 Beecham Group Plc Indane derivatives
EP0368160A1 (en) * 1988-11-08 1990-05-16 MERCK PATENT GmbH Tetralin derivatives
EP0376824A1 (en) * 1988-12-26 1990-07-04 Elf Sanofi Process for the preparation of chroman derivatives and synthesis intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839346A (en) * 1972-12-18 1974-10-01 Affiliated Med Res N-substituted pyridone and general method for preparing pyridones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168619A1 (en) * 1984-06-12 1986-01-22 Beecham Group Plc N-acylated di- or tetrahydronaphthalenamines, and antihypertensive compositions containing them
EP0321175A1 (en) * 1987-12-14 1989-06-21 Beecham Group Plc Indane derivatives
EP0368160A1 (en) * 1988-11-08 1990-05-16 MERCK PATENT GmbH Tetralin derivatives
EP0376824A1 (en) * 1988-12-26 1990-07-04 Elf Sanofi Process for the preparation of chroman derivatives and synthesis intermediates

Also Published As

Publication number Publication date
EP0489300A2 (en) 1992-06-10
JPH04308564A (en) 1992-10-30
US5208246A (en) 1993-05-04
JPH07113014B2 (en) 1995-12-06
CA2056922A1 (en) 1992-06-06

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