EP0469080A4 - Method of inhibiting induction of latent or chronic viral infections - Google Patents

Method of inhibiting induction of latent or chronic viral infections

Info

Publication number
EP0469080A4
EP0469080A4 EP19900907966 EP90907966A EP0469080A4 EP 0469080 A4 EP0469080 A4 EP 0469080A4 EP 19900907966 EP19900907966 EP 19900907966 EP 90907966 A EP90907966 A EP 90907966A EP 0469080 A4 EP0469080 A4 EP 0469080A4
Authority
EP
European Patent Office
Prior art keywords
latent
viral infections
chronic viral
inhibiting induction
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900907966
Other versions
EP0469080A1 (en
Inventor
Jeffrey Laurence
Paul O. P. Ts'o
Paul S. Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Johns Hopkins University
Original Assignee
Cornell Research Foundation Inc
Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc, Johns Hopkins University filed Critical Cornell Research Foundation Inc
Publication of EP0469080A1 publication Critical patent/EP0469080A1/en
Publication of EP0469080A4 publication Critical patent/EP0469080A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
EP19900907966 1989-04-21 1990-04-19 Method of inhibiting induction of latent or chronic viral infections Withdrawn EP0469080A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34150889A 1989-04-21 1989-04-21
US341508 1989-04-21

Publications (2)

Publication Number Publication Date
EP0469080A1 EP0469080A1 (en) 1992-02-05
EP0469080A4 true EP0469080A4 (en) 1992-04-29

Family

ID=23337878

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900907966 Withdrawn EP0469080A4 (en) 1989-04-21 1990-04-19 Method of inhibiting induction of latent or chronic viral infections

Country Status (7)

Country Link
EP (1) EP0469080A4 (en)
JP (1) JPH04505615A (en)
KR (1) KR920700654A (en)
AU (2) AU5551190A (en)
CA (1) CA2014990A1 (en)
WO (1) WO1990012578A1 (en)
ZA (1) ZA902912B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636573B2 (en) * 1988-02-26 1993-05-06 Worcester Foundation For Biomedical Research, Inc. Inhibition of htlv-iii by exogenous oligonucleotides
CA2105595A1 (en) * 1992-09-23 1994-03-24 Ramaswamy Narayanan Antisense polynucleotides
US6776986B1 (en) 1996-06-06 2004-08-17 Novartis Ag Inhibition of HIV-1 replication by antisense RNA expression
US6831057B2 (en) 1997-10-28 2004-12-14 The University Of North Carolina At Chapel Hill Use of NF-κB inhibition in combination therapy for cancer
JP2005525991A (en) * 2001-05-16 2005-09-02 マイジェニックス インコーポレイテッド Nucleic acid based compounds and methods of use thereof
RU2207876C1 (en) * 2001-11-08 2003-07-10 Ткаченко Виталий Васильевич Method for complex- individualized impact upon body at slow viral infection and method for preparing laboratory animal for testing the method of such impact

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
US4757055A (en) * 1980-11-12 1988-07-12 The Johns Hopkins University Method for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4806463A (en) * 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CLINICAL RESEARCH, vol. 37, no. 2, 1989, page 414A; J. LAURENCE et al.: "Anti-sense oligomers and induction of chronic human immunodeficiency virus-1" *
See also references of WO9012578A1 *

Also Published As

Publication number Publication date
AU5551190A (en) 1990-11-16
WO1990012578A1 (en) 1990-11-01
CA2014990A1 (en) 1990-10-21
KR920700654A (en) 1992-08-10
ZA902912B (en) 1991-01-30
AU6465194A (en) 1994-10-06
JPH04505615A (en) 1992-10-01
EP0469080A1 (en) 1992-02-05

Similar Documents

Publication Publication Date Title
HK81597A (en) Physical forms of benzene-sulphonamides
DK0421655T3 (en) induction
ZA896864B (en) Method and composition for the treatment and prevention of viral infections
DK0421656T3 (en) induction
IL89983A (en) Electromagnetic vibrating system
EP0457175A3 (en) Method of purification of alkoxysilanes
EP0608212A4 (en) Method of treating viral infection.
GB9304746D0 (en) Treatment of viral infections
EP0469080A4 (en) Method of inhibiting induction of latent or chronic viral infections
PH24087A (en) Method of inhibiting the transmission of aids virus
FI941705A0 (en) Method for preventing the passage of viral pathogens
EP0546261A3 (en) Method of treating latent herpes viral infections
EP0312839A3 (en) Method for the preparation of an inducer of non-specific immunity
IL95200A0 (en) Method of resolving cis-3-amino-4-(2-(2-furyl)-eth-1-yl)-1-methoxycarbonylmethyl-azetidin-2-one
HUT44439A (en) Process for inhibiting the reproduction of viruses and virus infections
GB9105762D0 (en) Method for the treatment of lamellar or plate-like materials
GB9013653D0 (en) Method of improving magnetic properties
ZW11693A1 (en) Method of treating viral infections
GB9006924D0 (en) Prognosis of hepatitis infection
IE892878L (en) Method of treating viral infections
ZA889496B (en) Method of inhibiting virus
ZA889498B (en) Method of inhibiting virus
ZM7988A1 (en) Method of inhibiting virus
ZM8088A1 (en) Method of inhibiting virus
RU1832331C (en) Method of modelling persistent viral infection

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19911028

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19920310

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19930216

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19941105