Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
  • A61N1/00—Electrotherapy; Circuits therefor
  • A61N1/18—Applying electric currents by contact electrodes
  • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
  • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
  • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye

Definitions

• the present invention relates to transmission of ' sensory information obtained by a prosthetic device to the brain to create a sensory perception.
• the present invention relates to the transmission of visual, audile, or tactile information to the brain in an encoded form that causes a functionally related perception on the part of the subject.
• a healthy human being receives a stimulus from the external environment that is detected by the appropriate type of receptor. For example, photoreceptors within the eye detect light with each photoreceptor converting the received stimulus into neuron impulses. This conversion of the stimulus energy into neuron impulses takes place in one or more neurons that are associated with the receptor. Each neuron then emits a neuron spike sequence that is used by the brain to obtain sensory perception. The combination of many neurons, each transmitting many neuron spike trains provide a complete or global sensory perception.
• a simulated neuron spike or pulse train can produce a sensory perception in a subject when applied to selected areas of the brain, spinal column, or nerves of a subject. Additionally, the brain has been
• Placement of an electrode at an appropriate location and stimulated with electrical pulses will produce a sensory perception.
• an electrode placed on the striate cortex and to which a single simulation neuron impulse is transmitted will cause some type of visual
• the present invention provides an apparatus and method for transmitting prosthetic information to the brain in the form of simulated neuron impulses that contain a time varying component.
• This time varying component corresponds to the time varying component that exists during consecutive neuron impulses in an individual neuron and allows information concerning multiple dimensions of a sense to be contained in the simulated neuron impulse train.
• the apparatus and method of the present invention sense an external stimulus with an array of sensors.
• the output of each of these sensors is used to determine simulated neuron impulses associated with each sensor.
• Each sensor acts as a channel that sends its simulated neuron impulses to the appropriate sensory location so that the sense can be perceived.
• the array of channels transmits simulated neuron impulses in parallel to allow sensory perception.
• the present invention utilizes a series of characteristic sensory functions in combination with respective temporal neural filters. Processing of sensory perceived parameters via these characteristic functions and neural filters results in simulated neural impulses, or a spike train, containing the properly time varying components that allow the brain to sense the external stimulus.
• the present invention advantageously allows a person to perceive environmental parameters, such as light, sound, or touch, via simulated neural spike trains that emulate naturally occurring spike trains with a temporal modulation scheme in such a way that the perception based
• SUB STATUTESHEET on the simulated spike train will be functionally related to the external stimuli or parameter.
• FIG. 1 is a partial schematic block diagram of a system for generating a simulated neural impulse for stimulating the-visual cortex of the human brain;
• FIG. 2 is a partial schematic block diagram of the system of the present invention.
• FIG. 3 is a legend indicating the manner by which FIGS. 1 and 2 are to be read;
• FIG. 4 is a graphical illustration of a first neural transform in which the abscissa represents time and the ordinate represents magnitude;
• FIG. 5 is a table providing quantitative data as to the neural transform of FIG. 4 in which the left column represents time in milliseconds from zero to 315 ms. and the right column presents the corresponding magnitude value;
• FIG. 6 is a graphical illustration of a second neural transform in which the abscissa represents time and the ordinate represents magnitude;
• FIG. 7 is a table providing quantitative data as to the neural transform of FIG. 6 in which the left column represents time in milliseconds from zero to 315 ms. and the right column presents the corresponding magnitude value;
• FIG. 8 is a graphical illustration of a third neural transform in which the abscissa represents time and the ordinate represents magnitude;
• FIG. 9 is a table providing quantitative data as to the neural transform of FIG. 8 in which the left column represents time in milliseconds from zero to 315 ms. and the right column presents the corresponding magnitude value;
• FIG. 10 is a schematic block diagram of a stored- program controlled processor for effecting various transformations in a digital manner
• FIG. 11 is a flow diagram illustrating a control sequence for converting digital values into a temporally modulated spike train suitable for stimulating the striate cortex to effect a visual perception in a subject;
• FIG. 12 is an illustration of an image pattern, its corresponding temporal encoding, and its corresponding temporally modulated spike train suitable for stimulating the visual cortex to provide a perception that is a function of the image pattern;
• FIG. 13 is an illustration of another image pattern, its corresponding temporal encoding, and its corresponding temporally modulated spike train suitable for stimulating the visual cortex to provide a perception that is a function of the image pattern.
• FIGS. 1 and 2 An exemplary system in accordance with the present invention for generating simulated neural impulses from an environmental parameter and providing a functionally related -spike' train for stimulating the brain to effect a functionally related perception of the environmental parameter is shown in FIGS. 1 and 2 and is designated generally therein by the reference character 10.
• the system 10 is designed to sense an environmental parameter in the form of variations in light that define an image and provide a corresponding spike train that is
• SUBSTITUTESHEET temporally modulated, i.e., pulse position modulated, and which, when used to stimulate a portion of the brain of a subject, produces a perception that is functionally related to the sensed light or image.
• the exemplary embodiment of the system 10 includes an array 8 of individual photoreceptors 14.
• sixteen photoreceptors 14 are shown in solid-line illustration and represent an input sub-array 12 for one sub-image information channel for transducing environmental light into corresponding electrical signals presented on respective output lines, indicated generally at 18.
• other photoreceptors 14 are similarly arrayed as the input transducers for other sub-image information channels (not specifically shown in FIGS.
• the photoreceptors 14 can be individual planar photocells, photodiodes, or phototransistors arranged in an array or can take the form of a subset of the photoreceptors on a planar integrated device. If desired, an optical system can be provided to image subjects of principal and secondary interest within a selected field of view onto the array 12.
• a scale-factor conditioner 20 is provided to accept the outputs of the array 12 and introduce a scaling factor that is a function of the light-to-signal input/output function of the particular photoreceptors 14.
• the scaling factors are determined empirically and vary, for example, as a function of the sensitivity and spectral response of the particular photoreceptors 14.
• the scale-factor conditioner 20 can introduce a logarithmic function (typically log e ) to compensate for the functional response characteristics of
• the appropriately scaled output of the scale-factor conditioner 20 is provided via an appropriate bus 22 connection to each of three signal-weighting filters 24, 26, and 28.
• Each of the signal-weighting filters accepts all the scale-factored signal outputs of the scale-factor conditioner 20 and multiplies the respective outputs by a specific weighting value to provide a spatial filter effect that is related to respective neural transforms described more fully below.
• weight values for the signal- weighting filters 24, 26, and 28 for the preferred embodiment are as listed, respectively, in Tables I, II, and III below and presented in the four-by-four array format corresponding to the input sub-array 12.
• the summing amplifiers can be fabricated from conventional operational amplifiers configured in a summing mode, and the cubic function generators 36, 38, and 40 can be fabricated from conventional analog multiplier devices.
• Sample-and-hold circuits 42, 44, and 46 are provided respectively at the outputs of the cube function generators 36, 38, and 40 and are designed to continuously sample the output voltage values.
• the system 10 is designed to generate output simulated neural impulses on a frame-by-frame basis, with the simulated neural impulses generated subsequent to each frame and prior to the subsequent frame.
• Each sample-and-hold circuit 42, 44, 46 can be defined by a series-connected capacitor and switch, such as a MOSFET.
• Neural transform function units 48, 50, and 52 are provided, respectively, at the outputs of the sample-and- hold circuits 42, 44, and 46.
• Each neural transform function unit 48, 50, and 52 includes an empirically determined, time-dependent neural transfer function that is multiplied by the value stored in the respective sample-and-hold circuits 42, 44, and 46.
• the transforms are determined by measuring biological neuron responses to mathematically complete sets of stimuli, e.g., Walsh
• the neural waveform for the neural waveform unit 48 is reproduced on an enlarged scale in FIG. 4 in which the abscissa represents time, and the ordinate represents magnitude.
• the neural waveform of FIG. 4 is also presented in a quantitative manner in FIG. 5 with the left column representing time in milliseconds between zero and 315 ms. and the right column representing the corresponding magnitude.
• the neural waveform of neural waveform units 50 and 52 are shown in enlarged scale in FIGS. 6 and 8, respectively, and their quantitative data in FIGS. 7 and 9. While 64 time and corresponding data values are shown in FIGS. 5, 7, and 9, it is preferred that data values at one millisecond intervals be utilized in the signal processing, these values provided by interpolation of the data values presented in FIGS.
• the neural waveform units 48, 50, and 52 are shown in functional block form in FIGS. 1 and 2 and are preferably implemented in a digital manner with a stored-program controlled processor. For example and as shown in FIG.
• the functions performed by the neural waveform units 48, 50, and 52 and the summing amplifier 54 are performed by a microprocessor 100 that is coupled to a read-only- memory (ROM) 102 and a random-access-memory (RAM) 104.
• ROM read-only- memory
• RAM random-access-memory
• a multiplexer 106 accepts the inputs from the sample-and- hold circuits 42, 44, and 46 and, in response to
• A/D coverter 108 which, in turn provides the corresponding digitized sample-and-hold value to the microprocessor 100.
• a clock 110 provides the necessary timing and control signals to the various devices to effect synchronized operation.
• the ROM 102 includes the data tables of FIGS. 5, 7, and 9.
• the clock 110 provides the timing and control signal to the multiplexer 106 to select one of the sample-and-hold values which is digitized and stored in one of the general purpose registers in the microprocessor 100 with the procedure repeated until three digital values representative of the three sample- and-hold values are stored in digital form.
• FIG. 10 provides a circuit that implements
• the digital output is converted to a spike train the spacing of which encodes information functionally related to that sensed by the input sub-array 12.
• the digital output of the analog-to-digital converter 56 which represents a succession of digital values representative of the processed neural waveform values, is presented to a stored-program controlled microprocessor 58 that is coupled to read-only-memory (ROM) 60 that contains a program sequence, as presented in FIG. 11, and a random-access-memory (RAM) 62 for storing various intermediate and other values.
• ROM read-only-memory
• RAM random-access-memory
• a clock 64 provides timing pulses while a controller 66 provides the necessary select, enable, and control signals to provide synchronous operation of the various devices.
• the microprocessor 58 is coupled, along with appropriate control lines, to a counter 68 that is periodically parallel-loaded with a preset threshold value X from a register 70.
• the output of the counter 68 is provided to a one-shot monostable multi-vibrator 72 that provides, in response to an appropriate trigger signal, a pulse or spike of selected pulse amplitude and duration. As explained below, a succession of such spikes are provided with an inter-spike temporal spacing that contains the encoded information from the image sensed by the input sub-array 12.
• the output of the one-shot 72 is provided through a conditioning amplifier 74 which controls the voltage output to provide a spike train of appropriate voltage level (typically 10 to 500 microvolts with a 50
• the microprocessor 58 of FIG. 2 operates in .- accordance with the control sequence of FIG. 11 to produce a temporally modulated spike train as a function of the digital values presented from the analog-to- digital converter 56.
• the system initializes, in part, by storing 1 to the data pointer - variable, N, with N having a maximum value N ⁇ that represents the total number of digital data values for that frame and which must be converted into a spike train representative of that frame.
• N- ⁇ 300 digital values determined by interpolation of the 64 times values shown in FIGS. 5, 7, and 9, each value of which is the sum of the products of the corresponding values of the neural waveforms (FIGS., 4-9) and the sample-and-hold values.
• the one-shot 72 is triggered to provide an initial spike, have a pulse duration or spike width of between 50 and 100 microseconds and a selected voltage amplitude.
• a query is presented to determine if the accumulated contents of the counter 68 are greater than a selected value X (i.e., 1000), and, if not, the data pointer N is incremented by 1 and the program loops to add the next data value to the counter 68, provided that N is not equal to N max . If the counter sum is greater that X, the counter is decremented by X by effecting a parallel load from the register 70, and, substantially
• SUBSTITUTE SHEET concurrently, triggering the one-shot 72 to produce the next successive spike. Thereafter, the data pointer N is incremented by one with the program looping to continue to successively add the digital data values to the counter 68, decrement by X when X is exceeded, and issue the next successive spike.
• the time duration between each spike is a function of the rate at which the digital value accumulates to exceed X so that a temporally modulated spike train is generated, i.e., a spike train in which the inter-spike timing is varied as a function of the products of the corresponding values of the neural waveforms (FIGS. 4-9) with the sample-and-hold values that are a function of the image sensed by the input sub-array 12.
• the spike train output of the one-shot 72 is provided to an amplifier 74 which provides a buffered output, typically no more than 10 - 100 microvolts, that is provided to a neural probe that is placed in a selected location on an appropriately mapped visual cortex of the brain of a subject to stimulate a neuron(s) to cause perception of an image or light pattern that is functionally related to that sensed by the input sub- array 12.
• the other adjacent channels (not specifically shown in FIGS. 1 and 2) similarly drive other neural electrodes place in an electrode grid pattern corresponding to the visual maps of the entire input array 8.
• Exemplary temporally modulated spike trains, their corresponding waveforms, and the corresponding Walsh patterns are shown in FIGS., 12 and 13, and, as shown, the inter-spike spacing and the rate of changes thereof varies as a function of the waveform to produce a temporally modulated spike train. In practice, it has been found that inter-spike spacing varies between one
• the present invention has been disclosed as useful in providing a simulated spike train responsive to a sensed optical image; as can be appreciated, a different input sensor, such as an array of sound-responsive devices or pressure responsive devices can likewise be utilized to provide a simulated spike train responsive to a sensed sound or pressure.
• the present invention advantageously allows a person to perceive environmental parameters via temporally modulated simulated neural spike trains that emulate naturally occurring spike trains in such a way that a perception based on the simulated spike train will be functionally related to the external stimuli or parameter.
• various changes and modifications may be made to the illustrated apparatus and method for transmitting prosthetic information to the brain of the present invention without departing from the spirit and scope of the invention as determined in the appended claims and their legal equivalent.

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• Health & Medical Sciences (AREA)
• Ophthalmology & Optometry (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Radiology & Medical Imaging (AREA)
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• Veterinary Medicine (AREA)
• Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
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• Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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Citations (3)

• 1988
  • 1988-07-22 US US07/222,882 patent/US5037376A/en not_active Expired - Lifetime
• 1989
  • 1989-07-06 CA CA000604979A patent/CA1325079C/en not_active Expired - Fee Related
  • 1989-07-12 IL IL9094889A patent/IL90948A/en not_active IP Right Cessation
  • 1989-07-14 EP EP19890908955 patent/EP0425575A4/en not_active Withdrawn
  • 1989-07-14 AU AU40395/89A patent/AU625459B2/en not_active Ceased
  • 1989-07-14 JP JP1508412A patent/JPH04501517A/ja active Pending
  • 1989-07-14 WO PCT/US1989/003070 patent/WO1990000912A1/en not_active Application Discontinuation

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