EP0395382A3 - Macromolecular endoplasmic reticulum - Google Patents

Macromolecular endoplasmic reticulum Download PDF

Info

Publication number
EP0395382A3
EP0395382A3 EP19900304458 EP90304458A EP0395382A3 EP 0395382 A3 EP0395382 A3 EP 0395382A3 EP 19900304458 EP19900304458 EP 19900304458 EP 90304458 A EP90304458 A EP 90304458A EP 0395382 A3 EP0395382 A3 EP 0395382A3
Authority
EP
European Patent Office
Prior art keywords
endoplasmic reticulum
macromolecular endoplasmic
macromolecular
polymerizable
netagive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900304458
Other languages
German (de)
French (fr)
Other versions
EP0395382A2 (en
EP0395382B1 (en
Inventor
Etsuo Hasegawa
Shinji Takeoka
Hiroyuki Ohno
Hiroyuki Nishide
Eishun Tsuchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOF Corp
Original Assignee
Nippon Oil and Fats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2033256A external-priority patent/JPH03291216A/en
Application filed by Nippon Oil and Fats Co Ltd filed Critical Nippon Oil and Fats Co Ltd
Publication of EP0395382A2 publication Critical patent/EP0395382A2/en
Publication of EP0395382A3 publication Critical patent/EP0395382A3/en
Application granted granted Critical
Publication of EP0395382B1 publication Critical patent/EP0395382B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a macromolecular endoplasmic reticulum which comprises a polymer obtained by polymerization of a mixture containing one or more polymerizable phospholipids, cholesterol and one or more polymerizable fatty acid. The macromolecular endoplasmic reticulum in which the surface charge is netagive can be used as a carrier of medicine, enzyme, hemoglobin, etc. in industrial fields or medical fields.
EP90304458A 1989-04-27 1990-04-25 Macromolecular endoplasmic reticulum Expired - Lifetime EP0395382B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP110682/89 1989-04-27
JP11068289 1989-04-27
JP2033256A JPH03291216A (en) 1989-04-27 1990-02-14 Polymeric vesicle
JP33256/90 1990-02-14

Publications (3)

Publication Number Publication Date
EP0395382A2 EP0395382A2 (en) 1990-10-31
EP0395382A3 true EP0395382A3 (en) 1991-10-30
EP0395382B1 EP0395382B1 (en) 1994-03-02

Family

ID=26371932

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90304458A Expired - Lifetime EP0395382B1 (en) 1989-04-27 1990-04-25 Macromolecular endoplasmic reticulum

Country Status (5)

Country Link
US (1) US5160740A (en)
EP (1) EP0395382B1 (en)
CN (1) CN1037492C (en)
CA (1) CA2015291C (en)
DE (1) DE69006896T2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04283207A (en) * 1991-03-13 1992-10-08 Kao Corp Vesicle and polymer vesicle
JPH07503943A (en) * 1991-10-29 1995-04-27 クローバー　コンソリデイテッド，リミテッド Cross-linked polysaccharides, polycations and lipids useful for encapsulation and drug release
EP0615747B1 (en) * 1993-03-18 1999-09-29 Terumo Kabushiki Kaisha Hemoglobin-encapsulating liposome and method for making the same
DE4312970A1 (en) * 1993-04-21 1994-10-27 Juergen Dr Schrezenmeir Microcapsule and process and apparatus for production thereof
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5674528A (en) * 1994-06-15 1997-10-07 Terumo Kabushiki Kaisha Hemoglobin-encapsulated liposome
JP3532692B2 (en) * 1995-04-03 2004-05-31 日本油脂株式会社 Phosphorylcholine group-containing polymer aqueous solution and production method
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US6187335B1 (en) 1997-12-31 2001-02-13 Orasomal Technologies, Inc. Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
DE60231549D1 (en) * 2001-12-03 2009-04-23 Dor Biopharma Inc STABILIZED REVERSE MICRO-COMPOSITIONS AND THEIR USE
US20060210549A1 (en) * 2004-09-10 2006-09-21 Srivastava Devendra K Controlled release liposomes and methods of use
US20080094573A1 (en) * 2006-04-04 2008-04-24 Vermette Patrick Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186211A1 (en) * 1984-12-28 1986-07-02 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Polymerizable liposome-forming lipid, method for production thereof, and use thereof
EP0251229A1 (en) * 1986-06-27 1988-01-07 Terumo Kabushiki Kaisha Polymerizable beta-glycerophospholipid and method for production thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3070993D1 (en) * 1979-12-20 1985-09-19 Dennis Chapman Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions
US4933114A (en) * 1980-08-11 1990-06-12 Eastman Kodak Company Polyacetylenic lipids, radiation-sensitive compositions, photographic elements and processes relating to same
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
FR2547829B1 (en) * 1983-05-28 1988-11-18 Sekimoto Hiroshi COMPOSITIONS CONTAINING UNSATURATED FATTY ACID COMPOUNDS AND METHOD FOR STABILIZING SUCH COMPOUNDS
US4560599A (en) * 1984-02-13 1985-12-24 Marquette University Assembling multilayers of polymerizable surfactant on a surface of a solid material
US4990291A (en) * 1986-04-15 1991-02-05 The United States Of America As Represented By The Secretary Of The Navy Method of making lipid tubules by a cooling process
US5004566A (en) * 1987-02-06 1991-04-02 Geo-Centers, Inc. Process for fabrication of lipid microstructures from dry organic solvent
US4877501A (en) * 1987-02-06 1989-10-31 Schnur Joel M Process for fabrication of lipid microstructures
JPH01180245A (en) * 1988-01-12 1989-07-18 Terumo Corp Liposome
US5061484A (en) * 1988-03-11 1991-10-29 Alpha Therapeutic Corporation Perfluorochemical emulsion with stabilized vesicles
DE19726796A1 (en) * 1997-06-24 1999-01-07 Basf Ag Propylene polymers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186211A1 (en) * 1984-12-28 1986-07-02 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Polymerizable liposome-forming lipid, method for production thereof, and use thereof
EP0251229A1 (en) * 1986-06-27 1988-01-07 Terumo Kabushiki Kaisha Polymerizable beta-glycerophospholipid and method for production thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN, vol. 13, no. 461 (C-645)[3809], 18th October 1989; & JP-A-01 180 245 (TERUMO CORP.) 18-07-1989 *

Also Published As

Publication number Publication date
EP0395382A2 (en) 1990-10-31
EP0395382B1 (en) 1994-03-02
CA2015291A1 (en) 1990-10-27
CN1037492C (en) 1998-02-25
CA2015291C (en) 1996-04-30
US5160740A (en) 1992-11-03
CN1047312A (en) 1990-11-28
DE69006896D1 (en) 1994-04-07
DE69006896T2 (en) 1994-08-18

Similar Documents

Publication Publication Date Title
EP0395382A3 (en) Macromolecular endoplasmic reticulum
AU622967B2 (en) Process for micro-encapsulation
IE891798L (en) Novel ó-glucosidase inhibitors
HUT43488A (en) Process for preparing polymers decomposing by biological process and utilizable for pharmaceutical purposes
HRP940723B1 (en) New thienylcarboxylic acid esters of aminoalcohols, their quarternary products, their preparation and use of the compounds
CA2131316A1 (en) A thrombin blood fraction for use in a medical procedure
ZA9811536B (en) Polymeric products containing modified carbon products and methods of making and using the same.
IL79356A (en) 1-substituted oxindole-3-carboxamides,their preparation and pharmaceutical compositions containing them
PT82575B (en) PROCESS FOR THE PREPARATION OF A CONJUGATE PRODUCT CONSISTING OF AN S.MUTANS ADHESIN OF A PROTEIN NATURE OF A COMPOSITION WITH IMMUNOGEN ACTIVITY AND AN S.MUTANS POLYSACCHARIDE AND USE THEREOF PARTICULARLY IN ANTI-CARIES VACCINES
AU7679587A (en) Pharmaceutical compositions containing dipyridamole or mopidamol and o-acetylsalicylic acid or the physiologically acceptable salts thereof
CA2185119A1 (en) Dosage form for administering drug in liquid formulation
EP0233013A3 (en) Modified enzyme
GB8829835D0 (en) Compounds
EP0451750A3 (en) Use of short chain fatty acid containing lipids to maintain gastrointestinal integrity and function in patients
AU6732190A (en) Use of guanidinoacetic acid to induce an increase of the creatine contents in muscles
AU3927189A (en) N-2,3-butadienyl tri- and tetraaminoalkane derivatives
GR3004253T3 (en)
ATE44950T1 (en) POLYPRENYL COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
CA2064476A1 (en) Podophyllotoxin preparation containing triglycerides
EP0314042A3 (en) Novel copolymers and superoxide dismutase modified with said copolymers
TW246642B (en) Pharmaceutical or vaccinal microcapsule capable of inhibiting activity-reduction caused by gastric acid and protein decomposition enzyme
AU1355488A (en) Calcium lactate-glycerol adduct, a process for its preparation and its use
ATE110393T1 (en) PROCESS FOR THE PREPARATION OF POLYVINYL ALCOHOL MIXTURES IN AQUEOUS SOLUTION AND OBTAINED PRODUCTS.
AU3448189A (en) Process for inhibiting the polymerization of acid monomers
AU1904288A (en) Polyglycerin esters of the degras acid, a process for their preparation, and their use as emulsifying agents

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19900523

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): DE FR GB IT

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): DE FR GB IT

17Q First examination report despatched

Effective date: 19921127

ITF It: translation for a ep patent filed
GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): DE FR GB IT

REF Corresponds to:

Ref document number: 69006896

Country of ref document: DE

Date of ref document: 19940407

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20000411

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20000419

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20000427

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20010425

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: THE PATENT HAS BEEN ANNULLED BY A DECISION OF A NATIONAL AUTHORITY

Effective date: 20010430

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20010425

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20020201

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED.

Effective date: 20050425