EP0385664A3 - Antiinflammatory benzoxazolones - Google Patents

Antiinflammatory benzoxazolones Download PDF

Info

Publication number
EP0385664A3
EP0385664A3 EP19900301941 EP90301941A EP0385664A3 EP 0385664 A3 EP0385664 A3 EP 0385664A3 EP 19900301941 EP19900301941 EP 19900301941 EP 90301941 A EP90301941 A EP 90301941A EP 0385664 A3 EP0385664 A3 EP 0385664A3
Authority
EP
European Patent Office
Prior art keywords
mammal
benzoxazolinones
compounds
methods
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900301941
Other languages
German (de)
French (fr)
Other versions
EP0385664B1 (en
EP0385664A2 (en
Inventor
Kazuo Taito Pfizer Apartment 1 Ando
Nobuko Taito Pfizer Apartment 1-2 Asai
Fumitaka 1-2-206 Sakuragaoka-1 Ito
Takashi Mano
Masami Nakane
Kunio Satake
Kaoru Shimada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of EP0385664A2 publication Critical patent/EP0385664A2/en
Publication of EP0385664A3 publication Critical patent/EP0385664A3/en
Application granted granted Critical
Publication of EP0385664B1 publication Critical patent/EP0385664B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase enzymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in treating allergic and inflam­ matory conditions in a mammal. This invention also relates to methods of inhibiting lipoxygenase and/or cyclooxygenase in a mammal with such benzoxazolinones; methods of treating an allergic condition in a mammal with such compounds; methods of treating an inflammatory condition in a mammal with such compounds; and pharma­ ceutical compositions comprising the benzoxazolinones hereof.
EP90301941A 1989-02-28 1990-02-23 Antiinflammatory benzoxazolones Expired - Lifetime EP0385664B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP47429/89 1989-02-28
JP4742989 1989-02-28

Publications (3)

Publication Number Publication Date
EP0385664A2 EP0385664A2 (en) 1990-09-05
EP0385664A3 true EP0385664A3 (en) 1991-03-06
EP0385664B1 EP0385664B1 (en) 1994-01-12

Family

ID=12774907

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90301941A Expired - Lifetime EP0385664B1 (en) 1989-02-28 1990-02-23 Antiinflammatory benzoxazolones

Country Status (24)

Country Link
US (1) US5086062A (en)
EP (1) EP0385664B1 (en)
JP (1) JPH0730053B2 (en)
KR (1) KR920010641B1 (en)
CN (1) CN1045264A (en)
AT (1) ATE100091T1 (en)
AU (1) AU617041B2 (en)
CA (1) CA2010765A1 (en)
DD (1) DD292256A5 (en)
DE (1) DE69005852T2 (en)
DK (1) DK0385664T3 (en)
ES (1) ES2062332T3 (en)
FI (1) FI900979A0 (en)
HU (1) HUT58328A (en)
IE (1) IE900695L (en)
IL (1) IL93473A0 (en)
MY (1) MY105263A (en)
NO (1) NO900915L (en)
NZ (1) NZ232707A (en)
PL (2) PL163378B1 (en)
PT (1) PT93257A (en)
RU (2) RU2036913C1 (en)
YU (1) YU37490A (en)
ZA (1) ZA901480B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678327B2 (en) * 1989-07-20 1994-10-05 ファイザー製薬株式会社 4,5,6,7, -tetrasubstituted benzoxazolones
JP2807577B2 (en) * 1990-06-15 1998-10-08 エーザイ株式会社 Cyclic amide derivative
DE10210779A1 (en) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclic amides
RU2477283C1 (en) * 2012-02-27 2013-03-10 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) 4,7-DIMETHYL-2-(2,4,5-TRIMETHOXYPHENYL)-3,4,4a,5,8,8a-HEXAHYDRO-2H-4,8-EPOXYCHROMEN POSSESSING ANALGESIC ACTIVITY

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001289A1 (en) * 1983-09-22 1985-03-28 Fujisawa Pharmaceutical Co., Ltd. Benzoxazolone and benzothiazolone derivatives and process for their preparation
EP0249407A2 (en) * 1986-06-09 1987-12-16 Pfizer Corporation Antiallergy and antiinflammatory agents
EP0360566A2 (en) * 1988-09-19 1990-03-28 Pfizer Inc. Lipoxygenase/cyclooxygenase inhibiting benzoxazolones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3017977A1 (en) * 1980-05-10 1981-11-19 Dr. Karl Thomae Gmbh, 7950 Biberach NEW SUBSTITUTED 2 (3H) -ZENZOTHIAZOLONE
FR2491066A1 (en) * 1980-09-29 1982-04-02 Cerm Cent Europ Rech Mauvernay BENZOXAZOLINONES SUBSTITUTED IN 6 BY AN AMINOALCOHOL OR AMINOCETONE CHAIN, THEIR PREPARATION AND THEIR THERAPEUTIC USE
US4835166A (en) * 1986-06-09 1989-05-30 Pfizer Inc. Antiallergy and antiinflammatory agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985001289A1 (en) * 1983-09-22 1985-03-28 Fujisawa Pharmaceutical Co., Ltd. Benzoxazolone and benzothiazolone derivatives and process for their preparation
EP0249407A2 (en) * 1986-06-09 1987-12-16 Pfizer Corporation Antiallergy and antiinflammatory agents
EP0360566A2 (en) * 1988-09-19 1990-03-28 Pfizer Inc. Lipoxygenase/cyclooxygenase inhibiting benzoxazolones

Also Published As

Publication number Publication date
JPH03218368A (en) 1991-09-25
MY105263A (en) 1994-09-30
EP0385664B1 (en) 1994-01-12
KR920010641B1 (en) 1992-12-12
ES2062332T3 (en) 1994-12-16
IL93473A0 (en) 1990-11-29
NO900915L (en) 1990-08-29
YU37490A (en) 1992-05-28
HUT58328A (en) 1992-02-28
RU2024512C1 (en) 1994-12-15
NZ232707A (en) 1991-01-29
RU2036913C1 (en) 1995-06-09
AU5056690A (en) 1990-09-06
HU901063D0 (en) 1990-05-28
PT93257A (en) 1990-08-31
KR910015571A (en) 1991-09-30
PL288077A1 (en) 1991-12-02
US5086062A (en) 1992-02-04
PL284026A1 (en) 1991-04-08
ZA901480B (en) 1991-10-30
CA2010765A1 (en) 1990-08-31
PL163419B1 (en) 1994-03-31
DE69005852T2 (en) 1994-04-28
DD292256A5 (en) 1991-07-25
DK0385664T3 (en) 1994-02-14
ATE100091T1 (en) 1994-01-15
CN1045264A (en) 1990-09-12
NO900915D0 (en) 1990-02-27
PL163378B1 (en) 1994-03-31
DE69005852D1 (en) 1994-02-24
JPH0730053B2 (en) 1995-04-05
AU617041B2 (en) 1991-11-14
EP0385664A2 (en) 1990-09-05
IE900695L (en) 1990-08-28
FI900979A0 (en) 1990-02-27

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