EP0358724A4 - Compound, composition and method for the reduction of lipids the modification of the affinity of hemoglobin for oxygen and the prevention of platelet aggregation. - Google Patents
Compound, composition and method for the reduction of lipids the modification of the affinity of hemoglobin for oxygen and the prevention of platelet aggregation.Info
- Publication number
- EP0358724A4 EP0358724A4 EP19880906435 EP88906435A EP0358724A4 EP 0358724 A4 EP0358724 A4 EP 0358724A4 EP 19880906435 EP19880906435 EP 19880906435 EP 88906435 A EP88906435 A EP 88906435A EP 0358724 A4 EP0358724 A4 EP 0358724A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- hemoglobin
- lipids
- affinity
- prevention
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6223687A | 1987-06-15 | 1987-06-15 | |
US62236 | 1998-04-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0358724A1 EP0358724A1 (en) | 1990-03-21 |
EP0358724A4 true EP0358724A4 (en) | 1990-06-05 |
Family
ID=22041101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19880906435 Withdrawn EP0358724A4 (en) | 1987-06-15 | 1988-06-15 | Compound, composition and method for the reduction of lipids the modification of the affinity of hemoglobin for oxygen and the prevention of platelet aggregation. |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0358724A4 (en) |
JP (1) | JPH02503797A (en) |
AU (1) | AU616674B2 (en) |
WO (1) | WO1988010113A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4921997A (en) * | 1988-06-15 | 1990-05-01 | Montefiore Medical Center | Method of synthesis and novel compounds for pharmaceutical uses |
US5382680A (en) * | 1990-12-07 | 1995-01-17 | The Center For Innovative Technology | Allosteric hemoglobin modifier compounds |
US5049695A (en) * | 1990-02-12 | 1991-09-17 | Center For Innovative Technology | Allosteric hemoglobin modifiers |
GB9027023D0 (en) * | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
DE69410193T2 (en) * | 1993-03-17 | 1998-09-03 | Meiji Seika K.K., Tokio/Tokyo | NEW CONNECTIONS WITH BLOOD PLAGUE AGGREGATING ACTIVITY |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2614045A1 (en) * | 1976-04-01 | 1977-10-06 | Boehringer Mannheim Gmbh | Hypolipaemic ureido-alkyl-phenoxy-alkanoic aid derivs. prepn. - by reacting (4)-hydroxy-aralkylamines with phosgene, amine and halo-alkanoic acid deriv. |
-
1988
- 1988-06-15 JP JP63505967A patent/JPH02503797A/en active Pending
- 1988-06-15 EP EP19880906435 patent/EP0358724A4/en not_active Withdrawn
- 1988-06-15 WO PCT/US1988/002092 patent/WO1988010113A1/en not_active Application Discontinuation
- 1988-06-15 AU AU19986/88A patent/AU616674B2/en not_active Ceased
Non-Patent Citations (3)
Title |
---|
J. MED. CHEM., vol. 32, no. 12, December 1989, pages 2352-2357, American Chemical Society; I. LALEZARI et al.: "Synthesis and investigation of effects of 2-[4-[[(Arylamino)carbonyl]amino]phenoxy]-2-methylpropionic acids on the affinity of hemoglobin for oxygen: Structure-activity relationships" * |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, vol. 85, August 1988, pages 6117-6121; I. LALEZARI et al.: "LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholestrol, and on low density lipoprotein" * |
See also references of WO8810113A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU616674B2 (en) | 1991-11-07 |
AU1998688A (en) | 1989-01-19 |
EP0358724A1 (en) | 1990-03-21 |
WO1988010113A1 (en) | 1988-12-29 |
JPH02503797A (en) | 1990-11-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19891207 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19900605 |
|
17Q | First examination report despatched |
Effective date: 19910524 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19930101 |