EP0346400A4 - Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof - Google Patents

Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof

Info

Publication number
EP0346400A4
EP0346400A4 EP19880905052 EP88905052A EP0346400A4 EP 0346400 A4 EP0346400 A4 EP 0346400A4 EP 19880905052 EP19880905052 EP 19880905052 EP 88905052 A EP88905052 A EP 88905052A EP 0346400 A4 EP0346400 A4 EP 0346400A4
Authority
EP
European Patent Office
Prior art keywords
cyclic phosphate
chloroadenosine
aminoadenosine
preparation
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19880905052
Other versions
EP0346400A1 (en
Inventor
Roland K. Robins
Ganapathi R. Revankar
Yu-An Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nucleic Acid Research Institute
Original Assignee
Nucleic Acid Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/136,407 external-priority patent/US4861873A/en
Application filed by Nucleic Acid Research Institute filed Critical Nucleic Acid Research Institute
Publication of EP0346400A1 publication Critical patent/EP0346400A1/en
Publication of EP0346400A4 publication Critical patent/EP0346400A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EP19880905052 1987-12-21 1988-04-20 Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof Withdrawn EP0346400A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/136,407 US4861873A (en) 1987-12-21 1987-12-21 8-Chloroadenosine 3', 5'-cyclic monophosphate preparations
US136407 1987-12-21
US18007088A 1988-04-11 1988-04-11
US180070 1988-04-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP19920106624 Division EP0499291A1 (en) 1987-12-21 1988-04-20 Treatment of malignant tumours with 8-chloroadenosine 3'-5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof

Publications (2)

Publication Number Publication Date
EP0346400A1 EP0346400A1 (en) 1989-12-20
EP0346400A4 true EP0346400A4 (en) 1990-11-28

Family

ID=26834271

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19920106624 Withdrawn EP0499291A1 (en) 1987-12-21 1988-04-20 Treatment of malignant tumours with 8-chloroadenosine 3'-5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof
EP19880905052 Withdrawn EP0346400A4 (en) 1987-12-21 1988-04-20 Treatment of malignant tumors with 8-chloroadenosine 3',5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP19920106624 Withdrawn EP0499291A1 (en) 1987-12-21 1988-04-20 Treatment of malignant tumours with 8-chloroadenosine 3'-5'-cyclic phosphate, 8-aminoadenosine 3',5'-cyclic phosphate and preparation thereof

Country Status (10)

Country Link
EP (2) EP0499291A1 (en)
JP (1) JPH02502911A (en)
KR (1) KR900700107A (en)
AU (2) AU1933588A (en)
CA (1) CA1326849C (en)
DK (1) DK406589A (en)
ES (1) ES2019713A6 (en)
MX (1) MX168619B (en)
NZ (1) NZ224307A (en)
WO (2) WO1989005647A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1335572C (en) * 1988-05-23 1995-05-16 Yoon Sang Cho-Chung Derivatives of cyclic amp as treatment for cancer
US4908441A (en) * 1988-07-19 1990-03-13 Warner-Lambert Company Deoxyadenosine compounds and methods of making and using the same
WO1991019728A1 (en) * 1990-06-15 1991-12-26 Nippon Shinyaku Co., Ltd. Nucleotide derivative
CN1037575C (en) * 1993-10-15 1998-03-04 北京市肿瘤防治研究所 Application of 8-chloro-adenosine antineoplastic
GB201820685D0 (en) * 2018-12-19 2019-01-30 NuCana plc Synthesis of 8-chloroadenosine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1336441A (en) * 1969-10-10 1973-11-07 Anvar Derivatives of cyclo adenosine-3,5-phosphoric acid and their preparation
US3849553A (en) * 1973-09-04 1974-11-19 Nelson Res & Dev Cyclic nucleotide therapeutic preparation
US4369181A (en) * 1981-08-05 1983-01-18 Sri International Process for treating proliferative skin diseases using certain 6,8-substituted ribofuranosylpurine-3',5'-cyclic phosphates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO8905648A1 *
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 46, 19th June 1986; E.K. RYU: "New procedure for the chlorination of pyrimidine and purine nucleosides", pages 2819-2823 *

Also Published As

Publication number Publication date
EP0499291A1 (en) 1992-08-19
NZ224307A (en) 1990-03-27
DK406589D0 (en) 1989-08-18
DK406589A (en) 1989-10-12
KR900700107A (en) 1990-08-11
JPH02502911A (en) 1990-09-13
CA1326849C (en) 1994-02-08
AU1932888A (en) 1989-07-19
EP0346400A1 (en) 1989-12-20
AU1933588A (en) 1989-07-19
ES2019713A6 (en) 1991-07-01
MX168619B (en) 1993-06-01
WO1989005648A1 (en) 1989-06-29
WO1989005647A1 (en) 1989-06-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19890821

AK Designated contracting states

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHANG, YU-AN

Inventor name: REVANKAR, GANAPATHI, R.

Inventor name: ROBINS, ROLAND, K.

A4 Supplementary search report drawn up and despatched

Effective date: 19901011

AK Designated contracting states

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19911017

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19920428