EP0316345A4 - Liposomes with enhanced retention on mucosal tissue. - Google Patents

Liposomes with enhanced retention on mucosal tissue.

Info

Publication number
EP0316345A4
EP0316345A4 EP19870905136 EP87905136A EP0316345A4 EP 0316345 A4 EP0316345 A4 EP 0316345A4 EP 19870905136 EP19870905136 EP 19870905136 EP 87905136 A EP87905136 A EP 87905136A EP 0316345 A4 EP0316345 A4 EP 0316345A4
Authority
EP
European Patent Office
Prior art keywords
liposomes
mucosal tissue
enhanced retention
retention
enhanced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870905136
Other languages
German (de)
French (fr)
Other versions
EP0316345A1 (en
Inventor
Luke S S Guo
Carl T Redemann
Ramachandran Radhakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liposome Technology Inc
Original Assignee
Liposome Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/890,817 external-priority patent/US4804539A/en
Priority claimed from US06/890,815 external-priority patent/US4839175A/en
Application filed by Liposome Technology Inc filed Critical Liposome Technology Inc
Publication of EP0316345A4 publication Critical patent/EP0316345A4/en
Publication of EP0316345A1 publication Critical patent/EP0316345A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
EP87905136A 1986-07-28 1987-07-28 Liposomes with enhanced retention on mucosal tissue Withdrawn EP0316345A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US890817 1986-07-28
US06/890,817 US4804539A (en) 1986-07-28 1986-07-28 Ophthalmic liposomes
US06/890,815 US4839175A (en) 1986-07-28 1986-07-28 Liposomes with enhanced retention on mucosal tissue
US890815 1986-07-28

Publications (2)

Publication Number Publication Date
EP0316345A4 true EP0316345A4 (en) 1989-05-16
EP0316345A1 EP0316345A1 (en) 1989-05-24

Family

ID=27128959

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87905136A Withdrawn EP0316345A1 (en) 1986-07-28 1987-07-28 Liposomes with enhanced retention on mucosal tissue

Country Status (3)

Country Link
EP (1) EP0316345A1 (en)
JP (1) JPH02500360A (en)
WO (1) WO1988000824A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4914088A (en) * 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4921644A (en) * 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
US5064655A (en) * 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
KR920700691A (en) * 1989-04-04 1992-08-10 존.에프.맥인티리 Use of liposomes for the administration of therapeutic agents to wounds, incisions and abrasions
IT1240353B (en) * 1990-03-30 1993-12-07 Poli Ind Chimica Spa LIPOSOMAL FORMULATIONS OF IMMUNOMODULATING DRUGS FOR LOCAL AND AEROSOL APPLICATION
DE69115990T2 (en) * 1990-05-29 1996-05-30 Ocular Res Of Bonton Inc Composition for the treatment of dry eye diseases
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
JP3407072B2 (en) * 1991-02-14 2003-05-19 バクスター、インターナショナル、インコーポレイテッド Binding of recognition substance to liposome
SE9102340D0 (en) * 1991-08-13 1991-08-13 Astra Ab PHARMACEUTICAL COMPOSITION CONTAINING CARBACHOL AND OTHERCHOLINERGIC SUBSTANCES
US6509032B1 (en) 1991-08-28 2003-01-21 Mcmaster University Cationic amphiphiles
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
PT101422B (en) * 1993-12-06 1997-06-30 Ineti Inst Biotec Q F E Tecnol LIPOSOMAL FORMULATIONS CONTAINING VIDARABINE AND / OR DERIVATIVES, WITH A HIGH THERAPEUTIC INDEX AND PROCESS FOR THEIR PREPARATION
US5719131A (en) * 1994-12-09 1998-02-17 Genzyme Corporation Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
US5948767A (en) * 1994-12-09 1999-09-07 Genzyme Corporation Cationic amphiphile/DNA complexes
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US6383814B1 (en) 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5767099A (en) * 1994-12-09 1998-06-16 Genzyme Corporation Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
US5910487A (en) * 1994-12-09 1999-06-08 Genzyme Corporation Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
US5747471A (en) * 1994-12-09 1998-05-05 Genzyme Corporation Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules
US5840710A (en) * 1994-12-09 1998-11-24 Genzyme Corporation Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules
US5650096A (en) * 1994-12-09 1997-07-22 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US6331524B1 (en) 1994-12-09 2001-12-18 Genzyme Corporation Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
DE19511322C2 (en) 1995-03-28 1999-09-02 Mann Gerhard Chem Pharm Fab Sterile eye gels containing medium chain triglycerides and process for their preparation
US5935936A (en) * 1996-06-03 1999-08-10 Genzyme Corporation Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
US5925628A (en) * 1997-03-31 1999-07-20 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5912239A (en) * 1997-04-04 1999-06-15 Genzyme Corporation Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
US5948925A (en) * 1997-05-06 1999-09-07 Genzyme Corporation Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
US5952516A (en) * 1997-05-08 1999-09-14 Genzyme Corporation Cationic amphiphiles containing multiplesteroid lipophilic groups
US5942634A (en) * 1997-05-09 1999-08-24 Genzyme Corporation Cationic amphiphiles for cell transfections
US6372720B1 (en) * 1998-02-05 2002-04-16 Kenneth J. Longmuir Liposome fusion and delivery vehicle
US6290987B1 (en) * 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US6861060B1 (en) * 2000-04-21 2005-03-01 Elena Luriya Personal care formulations
US20050220742A1 (en) * 2004-03-31 2005-10-06 Breen Ed V Compositions and methods for maintaining eyelid hygiene
JP4669665B2 (en) * 2004-04-12 2011-04-13 正彦 阿部 Polycation-modified liposome having no cytotoxicity and method for producing the same
CN100566810C (en) 2005-01-18 2009-12-09 国立大学法人北海道大学 Method with coating particle with lipid film
PL2350043T3 (en) * 2008-10-09 2014-09-30 Tekmira Pharmaceuticals Corp Improved amino lipids and methods for the delivery of nucleic acids
JP5914418B2 (en) * 2013-06-26 2016-05-11 富士フイルム株式会社 Lipid particle, nucleic acid delivery carrier, composition for producing nucleic acid delivery carrier, lipid particle production method and gene introduction method
CN110404080B (en) * 2019-07-09 2021-06-22 南京大学 Mitochondrion targeted phospholipid and application thereof
CN112043670B (en) * 2019-10-08 2021-10-29 中国药科大学 Mitochondria-targeted external medicinal preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235792A (en) * 1977-04-14 1980-11-25 The Governing Council Of The University Of Toronto Immunological materials
WO1983002069A1 (en) * 1981-12-10 1983-06-23 Univ California Thiol reactive liposomes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH621479A5 (en) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4350676A (en) * 1981-05-21 1982-09-21 Laties Alan M Ophthalmic use of carboxyfluorescein
US4480041A (en) * 1982-07-09 1984-10-30 Collaborative Research, Inc. Use of phosphotriester intermediates for preparation of functionalized liposomes
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4619913A (en) * 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235792A (en) * 1977-04-14 1980-11-25 The Governing Council Of The University Of Toronto Immunological materials
WO1983002069A1 (en) * 1981-12-10 1983-06-23 Univ California Thiol reactive liposomes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 14, 1st October 1984, page 349, abstract no. 116680e, Columbus, Ohio, US; K. SINGH et al.: "Liposomal ophthalmic drug delivery system. II. Dihydrostreptomycin sulfate", & INT. J. PHARM. 1984 19(3), 263-9 *
See also references of WO8800824A1 *

Also Published As

Publication number Publication date
EP0316345A1 (en) 1989-05-24
JPH02500360A (en) 1990-02-08
WO1988000824A1 (en) 1988-02-11

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19890116

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19890516

17Q First examination report despatched

Effective date: 19900618

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19901229