EP0269127A3 - Nucleotide sequences which are selectively expressed in pre-b cells and probes therefor - Google Patents

Nucleotide sequences which are selectively expressed in pre-b cells and probes therefor Download PDF

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Publication number
EP0269127A3
EP0269127A3 EP19870117619 EP87117619A EP0269127A3 EP 0269127 A3 EP0269127 A3 EP 0269127A3 EP 19870117619 EP19870117619 EP 19870117619 EP 87117619 A EP87117619 A EP 87117619A EP 0269127 A3 EP0269127 A3 EP 0269127A3
Authority
EP
European Patent Office
Prior art keywords
cells
selectively expressed
nucleotide sequences
probe
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19870117619
Other languages
German (de)
French (fr)
Other versions
EP0269127A2 (en
EP0269127B1 (en
Inventor
Steven R. Dr. Bauer
Akira Dr. Kudo
Georg Friedrich Prof. Dr. Melchers
Nobuo Dr. C/O Dept. Of Immunology Sakaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868628433A external-priority patent/GB8628433D0/en
Priority claimed from GB878724100A external-priority patent/GB8724100D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP0269127A2 publication Critical patent/EP0269127A2/en
Publication of EP0269127A3 publication Critical patent/EP0269127A3/en
Application granted granted Critical
Publication of EP0269127B1 publication Critical patent/EP0269127B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to nucleotide sequences which are selectively expressed in pre-B cells, to a probe comprising a polynucleotide hybridizing specifically to such a nucleotide sequence and to a method for the production of such a probe. Said probe may be used for determining pre-B cells. The invention further relates to polypeptides translated from a transcript comprising a nucleotide sequence which is selectively expressed in pre-B cells or parts thereof, to antibodies against said polypeptides and to methods for the preparation and the use of said polypeptides and the antibodies raised against them.
EP19870117619 1986-11-27 1987-11-27 Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor Expired - Lifetime EP0269127B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB868628433A GB8628433D0 (en) 1986-11-27 1986-11-27 Nucleotide sequence
GB8628433 1986-11-27
GB8716497 1987-07-14
GB878716497A GB8716497D0 (en) 1986-11-27 1987-07-14 Nucleotide sequences
GB878724100A GB8724100D0 (en) 1986-11-27 1987-10-14 Nucleotide sequences
GB8724100 1987-10-14

Publications (3)

Publication Number Publication Date
EP0269127A2 EP0269127A2 (en) 1988-06-01
EP0269127A3 true EP0269127A3 (en) 1991-03-13
EP0269127B1 EP0269127B1 (en) 1994-02-23

Family

ID=27263220

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870117619 Expired - Lifetime EP0269127B1 (en) 1986-11-27 1987-11-27 Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor

Country Status (2)

Country Link
EP (1) EP0269127B1 (en)
DE (1) DE3789138T2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69719726T2 (en) * 1997-03-27 2003-10-16 Council Scient Ind Res Procedure for the detection of leukemia
EP1001020A4 (en) * 1997-07-29 2005-03-02 Sumitomo Electric Industries Antihuman pre-b cell receptor antibodies
MX2009009912A (en) * 2007-03-27 2010-01-18 Sea Lane Biotechnologies Llc Constructs and libraries comprising antibody surrogate light chain sequences.
AU2010249046A1 (en) 2009-05-13 2011-12-01 Sea Lane Biotechnologies, Llc Neutralizing molecules to influenza viruses
CA2764729C (en) 2009-06-26 2019-04-02 Sea Lane Biotechnologies, Llc Expression of surrogate light chains
EP2736928B1 (en) 2011-07-28 2019-01-09 i2 Pharmaceuticals, Inc. Sur-binding proteins against erbb3
US9975956B2 (en) 2011-12-22 2018-05-22 I2 Pharmaceuticals, Inc. Surrogate binding proteins which bind DR4 and/or DR5
JP2018507254A (en) 2015-02-02 2018-03-15 アイツー ファーマシューティカルズ， インコーポレーテッド Anti-alternative light chain antibody

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NATURE, vol. 311, 25th October 1984, pages 727-733; G.D. YANCOPOULOS et al.: "Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines" *
THE EMBO JOURNAL, vol. 5, no. 9, September 1986, pages 2139-2147, IRL Press Ltd, Oxford, GB; N. SAKAGUCHI et al.: "Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells" *
THE EMBO JOURNAL, vol. 6, no. 1, January 1987, pages 103-107, IRL Press Ltd, Oxford, GB; A. KUDO et al.: "Organization of the murine Ig-related lambda5 gene transcribed selectively in pre-B lymphocytes" *
THE EMBO JOURNAL, vol. 6, no. 8, August 1987, pages 2267-2272, IRL Press Ltd, Oxford, GB; A. KUDO et al.: "A second gene, VpreB in the lambda5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes" *

Also Published As

Publication number Publication date
EP0269127A2 (en) 1988-06-01
DE3789138D1 (en) 1994-03-31
EP0269127B1 (en) 1994-02-23
DE3789138T2 (en) 1994-05-26

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