EP0252951A4 - Technetium-antikörper konjugate. - Google Patents

Technetium-antikörper konjugate.

Info

Publication number
EP0252951A4
EP0252951A4 EP19870900623 EP87900623A EP0252951A4 EP 0252951 A4 EP0252951 A4 EP 0252951A4 EP 19870900623 EP19870900623 EP 19870900623 EP 87900623 A EP87900623 A EP 87900623A EP 0252951 A4 EP0252951 A4 EP 0252951A4
Authority
EP
European Patent Office
Prior art keywords
technetium
antibody conjugate
conjugate
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19870900623
Other languages
English (en)
French (fr)
Other versions
EP0252951A1 (de
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Jerry Kanellos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Original Assignee
University of Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Melbourne filed Critical University of Melbourne
Publication of EP0252951A1 publication Critical patent/EP0252951A1/de
Publication of EP0252951A4 publication Critical patent/EP0252951A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
EP19870900623 1986-01-06 1987-01-06 Technetium-antikörper konjugate. Withdrawn EP0252951A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU4103/86 1986-01-06
AUPH410386 1986-01-06

Publications (2)

Publication Number Publication Date
EP0252951A1 EP0252951A1 (de) 1988-01-20
EP0252951A4 true EP0252951A4 (de) 1988-09-07

Family

ID=3771433

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19870900623 Withdrawn EP0252951A4 (de) 1986-01-06 1987-01-06 Technetium-antikörper konjugate.

Country Status (2)

Country Link
EP (1) EP0252951A4 (de)
WO (1) WO1987004164A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
US5078985A (en) * 1989-08-09 1992-01-07 Rhomed, Incorporated Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
EP0486622B1 (de) * 1989-08-09 1998-11-04 Rhomed, Incorporated Direkte radioetikettierung von antikörpern und sonstigen proteinen mittels technetium oder rhenium
US5346687A (en) * 1989-08-09 1994-09-13 Rhomed Incorporated Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US6080384A (en) * 1997-03-25 2000-06-27 American Biogenetic Sciences, Inc. Methods for radionuclide-labeling of biomolecules and kits utilizing the same
DE19845798A1 (de) * 1998-09-29 2000-04-13 Schering Ag Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028092A2 (de) * 1979-10-29 1981-05-06 University Patents, Inc. Zusammensetzung, die einen radiomarkierten Antikörper enthält, Ausrüstung zu ihrer Herstellung und Ausrüstung zur Krebs- oder Tumorbestimmung, die diese Zusammensetzung enthält

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4323546A (en) * 1978-05-22 1982-04-06 Nuc Med Inc. Method and composition for cancer detection in humans
US4486538A (en) * 1978-07-07 1984-12-04 Samuel Bogoch Detection of malignant tumor cells
FR2437213A1 (fr) * 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2523445A1 (fr) * 1982-03-17 1983-09-23 Sanofi Sa Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues
AU565669B2 (en) * 1983-12-29 1987-09-24 Commonwealth Of Australia, The Preparation of 99m-tc radiopharmaceuticals
DE3583278D1 (de) * 1984-04-23 1991-07-25 Boston Biomed Res Inst Doppelspezifische antikoerper-determinanten.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028092A2 (de) * 1979-10-29 1981-05-06 University Patents, Inc. Zusammensetzung, die einen radiomarkierten Antikörper enthält, Ausrüstung zu ihrer Herstellung und Ausrüstung zur Krebs- oder Tumorbestimmung, die diese Zusammensetzung enthält

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 104, No. 18, 5th May 1986, page 449, Abstract No. 155935y, Columbus, Ohio, US, J. BALDAS et al.: "Effect of the technetium-nitrido group on the behavior of technetium-99m-radio-pharmaceuticals". *
International Journal of Applied Radiation and Isotopes, Vol. 36, No. 2, February 1985, pages 133-139, Oxford, GB, J. BALDAS et al.: "Substitution reactions of 99mTcNC14 - a route to a new class of 99mTc-radiopharmaceuticals". *
See also references of WO8704164A1 *

Also Published As

Publication number Publication date
WO1987004164A1 (en) 1987-07-16
EP0252951A1 (de) 1988-01-20

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19870904

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19880907

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19890407

R18W Application withdrawn (corrected)

Effective date: 19890407

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MCKENZIE, IAN, FARQUHAR, CAMPBELL

Inventor name: KANELLOS, JERRY

Inventor name: PIETERSZ, GEOFFREY, ALLAN