EP0249736A3 - Ointment for the treatment of skin diseases - Google Patents

Ointment for the treatment of skin diseases Download PDF

Info

Publication number
EP0249736A3
EP0249736A3 EP87106773A EP87106773A EP0249736A3 EP 0249736 A3 EP0249736 A3 EP 0249736A3 EP 87106773 A EP87106773 A EP 87106773A EP 87106773 A EP87106773 A EP 87106773A EP 0249736 A3 EP0249736 A3 EP 0249736A3
Authority
EP
European Patent Office
Prior art keywords
ointment
treatment
skin diseases
ebselen
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87106773A
Other languages
German (de)
French (fr)
Other versions
EP0249736A2 (en
Inventor
Axel Dr. Römer
Jörg Dr. Hager
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of EP0249736A2 publication Critical patent/EP0249736A2/en
Publication of EP0249736A3 publication Critical patent/EP0249736A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

the invention relates to formulations for the topical application of ebselen, a process for the preparation of the ointment, and its use in the treatment of inflammatory and allergic skin diseases.
EP87106773A 1986-06-20 1987-05-08 Ointment for the treatment of skin diseases Withdrawn EP0249736A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19863620674 DE3620674A1 (en) 1986-06-20 1986-06-20 Ointment for the treatment of skin diseases
DE3620674 1986-06-20

Publications (2)

Publication Number Publication Date
EP0249736A2 EP0249736A2 (en) 1987-12-23
EP0249736A3 true EP0249736A3 (en) 1989-03-29

Family

ID=6303316

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87106773A Withdrawn EP0249736A3 (en) 1986-06-20 1987-05-08 Ointment for the treatment of skin diseases

Country Status (6)

Country Link
US (1) US4784994A (en)
EP (1) EP0249736A3 (en)
JP (1) JPS635022A (en)
DE (1) DE3620674A1 (en)
DK (1) DK254887A (en)
PT (1) PT84899B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3720493A1 (en) * 1987-06-20 1989-01-26 Nattermann A & Cie MEDICINAL PREPARATIONS WITH MICRONIZED EBSELEN CRYSTALS
US5288734A (en) * 1988-10-29 1994-02-22 A. Nattermann & Cie Gmbh Stable parenteral solution of 2-phenyl-1.2-benzisoselenazol-3(2H)-one and process for producing the same
US5385726A (en) * 1990-08-06 1995-01-31 Rhone-Poulenc Rorer Gmbh Use of 2-phenyl-1,2-benzisoselenazol-3-(2H)-one
US5340813A (en) * 1992-11-09 1994-08-23 Cell Therapeutics, Inc. Substituted aminoalkyl xanthine compounds
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US6335036B1 (en) * 1993-10-27 2002-01-01 Daiichi Pharmaceutical Co., Ltd. Granular pharmaceutical preparation of ebselen
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
FR2730930B1 (en) * 1995-02-27 1997-04-04 Oreal USE OF NO-SYNTHASE INHIBITORS TO REDUCE THE IRRITANT SKIN EFFECT OF PRODUCTS USED IN THE COSMETIC OR PHARMACEUTICAL FIELD
EP0826371A4 (en) * 1995-04-27 2000-11-15 Akzo Nobel Nv EXTERNAL PREPARATION CONTAINING EMEDASTINE
FR2740339B1 (en) * 1995-10-26 1997-12-05 Oreal USE OF AT LEAST ONE NO-SYNTHASE INHIBITOR IN THE TREATMENT OF SENSITIVE SKIN
AU3457300A (en) 1999-03-31 2000-10-16 Daiichi Pharmaceutical Co., Ltd. Substrates for thioredoxin reductase
CA2432136A1 (en) * 2000-12-28 2002-07-11 Kiyoshi Ebihara Pharmaceutical emulsion preparation
DE10111050A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Use of substances which prevent the NO-synthase of the warm-blooded organism from exerting its effect, for the preparation of cosmetic or dermatological preparations for the treatment and / or prophylaxis of undesired skin pigmentation
DE10111052A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Cosmetic or dermatological preparations for increasing ceramide biosynthesis, e.g. to prevent dryness, containing agents inhibiting the onset of nitrogen monoxide synthase activity
DE10111049A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Cosmetic or dermatological preparations for combating inflammatory disorders or dryness of the skin, containing agents inhibiting the onset of nitrogen monoxide synthase activity
DE10111054A1 (en) * 2001-03-06 2002-09-12 Beiersdorf Ag Cosmetic or dermatological preparations for reinforcing skin barrier function, e.g. to prevent dryness, containing agents inhibiting the onset of nitrogen monoxide synthase activity
US20030086916A1 (en) * 2001-10-12 2003-05-08 Goligorsky Michael S. Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence
KR100991054B1 (en) * 2002-08-26 2010-10-29 에스.엘.에이. 파르마 에이지 Topical formulations containing at least 5% metronidazole in white petrolatum and its use in the anus and rectal area
ATE519756T1 (en) * 2007-05-25 2011-08-15 Santen Pharmaceutical Co Ltd PROPHYLACTIC OR THERAPEUTIC FOR AGE-RELATED MACULAR DEGENERATION
IL184620A0 (en) * 2007-07-15 2008-01-20 Can Fite Biopharma Ltd Composition for the treatment of inflammation
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263313A (en) * 1977-02-24 1981-04-21 Kali-Chemie Pharma Gmbh Topical pharmaceutical formulations, carrier compositions therefor, and preparation thereof
EP0044971A1 (en) * 1980-07-17 1982-02-03 A. Nattermann & Cie. GmbH 2-Phenyl-1.2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and their use
GB2128087A (en) * 1982-10-07 1984-04-26 Ciba Geigy Ag Topically administrable anti-inflammatory pharmaceutical compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525347A (en) * 1978-06-17 1985-06-25 Kowa Company Limited Antiinflammatory analgesic gelled ointment
JPS57171912A (en) * 1981-04-14 1982-10-22 Sumitomo Chem Co Ltd Cream
CH643138A5 (en) * 1983-08-29 1984-05-30 Mepha Ag INDOMETHACIN CONTAINING, gelatinous OINTMENT.
US4543251A (en) * 1983-12-09 1985-09-24 Toko Yakuhin Industry Co., Ltd. Gel preparations for external application
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263313A (en) * 1977-02-24 1981-04-21 Kali-Chemie Pharma Gmbh Topical pharmaceutical formulations, carrier compositions therefor, and preparation thereof
EP0044971A1 (en) * 1980-07-17 1982-02-03 A. Nattermann & Cie. GmbH 2-Phenyl-1.2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and their use
GB2128087A (en) * 1982-10-07 1984-04-26 Ciba Geigy Ag Topically administrable anti-inflammatory pharmaceutical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 103, 1985, Columbus, Ohio, USA H. SAFAYHI et al. "A Novel Biologically Active Selenoorganic Compound - V. Inhibition by Ebselen (PZ 51) of Rat Peritoneal Neutrophil Lipoxygenase" page 28, column 2, Abstract No. 98 448v & Biochem. Pharmacol. 1985, 34(15), 2691-2694 *
E. JUCKER "Fortschritte der Arznei-Mittelforschung", Vol. 28, 1984 Birkhauser Verlag, Basel, Boston, Stuttgart W.J. WECHTER, B.E. LOUGHMAN "Immunology in Drug Research" pages 261-265 *

Also Published As

Publication number Publication date
EP0249736A2 (en) 1987-12-23
US4784994A (en) 1988-11-15
JPS635022A (en) 1988-01-11
PT84899A (en) 1987-06-01
DK254887A (en) 1987-12-21
DK254887D0 (en) 1987-05-19
PT84899B (en) 1990-02-08
DE3620674A1 (en) 1987-12-23

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Effective date: 19910114

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Inventor name: HAGER, JOERG, DR.

Inventor name: ROEMER, AXEL, DR.