EP0245942A3 - Process for preparing phosphonic acids - Google Patents

Process for preparing phosphonic acids Download PDF

Info

Publication number
EP0245942A3
EP0245942A3 EP87302983A EP87302983A EP0245942A3 EP 0245942 A3 EP0245942 A3 EP 0245942A3 EP 87302983 A EP87302983 A EP 87302983A EP 87302983 A EP87302983 A EP 87302983A EP 0245942 A3 EP0245942 A3 EP 0245942A3
Authority
EP
European Patent Office
Prior art keywords
phosphonic acids
preparing phosphonic
preparing
oxidizing
struc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87302983A
Other languages
German (de)
French (fr)
Other versions
EP0245942A2 (en
Inventor
John Kurian Thottathil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of EP0245942A2 publication Critical patent/EP0245942A2/en
Publication of EP0245942A3 publication Critical patent/EP0245942A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4087—Esters with arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)

Abstract

A process for preparing phosphonic acids of the struc­ ture wherein R₁ is lower alkyl, aryl, cycloalkyl or arylalkyl, and R₂ is H, benzyl or by oxidizing the corresponding phosphonous acid
EP87302983A 1986-05-12 1987-04-06 Process for preparing phosphonic acids Withdrawn EP0245942A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US861795 1986-05-12
US06/861,795 US4670193A (en) 1986-05-12 1986-05-12 Process for preparing phosphonic acids

Publications (2)

Publication Number Publication Date
EP0245942A2 EP0245942A2 (en) 1987-11-19
EP0245942A3 true EP0245942A3 (en) 1989-12-06

Family

ID=25336785

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87302983A Withdrawn EP0245942A3 (en) 1986-05-12 1987-04-06 Process for preparing phosphonic acids

Country Status (4)

Country Link
US (1) US4670193A (en)
EP (1) EP0245942A3 (en)
JP (1) JPS62273988A (en)
CA (1) CA1297491C (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810878D0 (en) * 1988-05-07 1988-06-08 Lucas Ind Plc Adaptive control system for i c engine
US6479687B2 (en) * 1997-04-15 2002-11-12 Basf Aktiengesellschaft Preparation of vinylphosphonic acid compounds
US6743937B2 (en) * 2000-07-17 2004-06-01 Oxigene, Inc. Efficient method of synthesizing combretastatin A-4 prodrugs
DE10065051A1 (en) * 2000-12-23 2002-07-04 Clariant Gmbh Process for the preparation of ethane bis (alkylphosphinic acids)
DE102008063668A1 (en) * 2008-12-18 2010-07-01 Clariant International Limited Process for the preparation of alkylphosphonic acids, esters and salts by oxidation of alkylphosphonous acids and their use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010872A1 (en) * 1978-10-05 1980-05-14 Ciba-Geigy Ag Process for producing alpha-aminophosphonic acids and their peptides and compounds thus obtained

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
US4168267A (en) * 1978-10-23 1979-09-18 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl prolines
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010872A1 (en) * 1978-10-05 1980-05-14 Ciba-Geigy Ag Process for producing alpha-aminophosphonic acids and their peptides and compounds thus obtained

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS *

Also Published As

Publication number Publication date
JPS62273988A (en) 1987-11-28
CA1297491C (en) 1992-03-17
US4670193A (en) 1987-06-02
EP0245942A2 (en) 1987-11-19

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Inventor name: THOTTATHIL, JOHN KURIAN