EP0238202A3 - Glycerol derivatives, their preparation and their therapeutic use - Google Patents

Glycerol derivatives, their preparation and their therapeutic use Download PDF

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Publication number
EP0238202A3
EP0238202A3 EP87301283A EP87301283A EP0238202A3 EP 0238202 A3 EP0238202 A3 EP 0238202A3 EP 87301283 A EP87301283 A EP 87301283A EP 87301283 A EP87301283 A EP 87301283A EP 0238202 A3 EP0238202 A3 EP 0238202A3
Authority
EP
European Patent Office
Prior art keywords
sup
sub
group
glycerol derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP87301283A
Other versions
EP0238202B1 (en
EP0238202A2 (en
Inventor
Norio Sankyo Chemical Nakamura
Hiroyuki Sankyo Chemical Koike
Takeshi Sankyo Chemical Ohshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to AT87301283T priority Critical patent/ATE88711T1/en
Publication of EP0238202A2 publication Critical patent/EP0238202A2/en
Publication of EP0238202A3 publication Critical patent/EP0238202A3/en
Application granted granted Critical
Publication of EP0238202B1 publication Critical patent/EP0238202B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Glycerol derivatives having at least one heterocyclic group on the 3 or 2 position and a group of formula -Y-D-Q on the 1 position (in which Y represents oxygen, sulphur, -NR<sup>3</sup>-, -X-CO-R'-, -R<sup>4</sup>-CO-X-, -NR'-CO-, -CO-NR<sup>3</sup>-or -X-P-(O) (OH)-O-, where -NR<sup>3</sup>-is optionally protected imino, R<sup>4</sup> represents a direct bond or -NR<sup>3</sup>; and X represents oxygen or sulphur; D represents optionally substituted C<sub>1</sub>-C<sub>14</sub> alkylene; and Q represents a nitrogen-containing heterocyclic group or an amino group either of which is optionally quatemized) are PAF antagonists which may be used to treat asthma, inflammation and shock. They may be prepared by reacting a glycerol derivative having an active group at the 1-position with an appropriate compound to introduce the desired group.
EP87301283A 1986-02-13 1987-02-13 Glycerol derivatives, their preparation and their therapeutic use Expired - Lifetime EP0238202B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT87301283T ATE88711T1 (en) 1986-02-13 1987-02-13 GLYCEROL DERIVATIVES, THEIR PRODUCTION AND THERAPEUTIC USE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2962486 1986-02-13
JP29624/86 1986-02-13

Publications (3)

Publication Number Publication Date
EP0238202A2 EP0238202A2 (en) 1987-09-23
EP0238202A3 true EP0238202A3 (en) 1988-12-07
EP0238202B1 EP0238202B1 (en) 1993-04-28

Family

ID=12281241

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87301283A Expired - Lifetime EP0238202B1 (en) 1986-02-13 1987-02-13 Glycerol derivatives, their preparation and their therapeutic use

Country Status (8)

Country Link
US (1) US5068340A (en)
EP (1) EP0238202B1 (en)
JP (1) JP2556849B2 (en)
KR (1) KR950005742B1 (en)
AT (1) ATE88711T1 (en)
CA (1) CA1314889C (en)
DE (1) DE3785599T2 (en)
ES (1) ES2054663T3 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301751B1 (en) * 1987-07-31 1993-03-10 Takeda Chemical Industries, Ltd. Pyridinium derivatives, their production and use
US4920134A (en) * 1987-08-07 1990-04-24 Takeda Chemical Industries, Ltd. 2-O-pyrimidinyl glycerol derivatives
EP0356765A3 (en) * 1988-08-19 1991-08-07 Takeda Chemical Industries, Ltd. Carboxylic acid derivatives, their production and use
CA2001532A1 (en) * 1988-10-27 1990-04-27 Hiroaki Nomura Lipids, their production and use
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
ES2010145A6 (en) * 1989-03-02 1989-10-16 Uriach & Cia Sa J 2-picolylamine derivates.
US5192766A (en) * 1989-04-28 1993-03-09 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use as PAF antagonists
US5369106A (en) * 1989-04-28 1994-11-29 Sankyo Company, Limited N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
US5274094A (en) * 1990-08-15 1993-12-28 British Bio-Technology Limited Production of heterobicyclic containing benzene sulfonamides
IE912874A1 (en) * 1990-08-15 1992-02-26 British Bio Technology Compounds
GB9104746D0 (en) * 1991-03-06 1991-04-17 British Bio Technology Compounds
GB9114337D0 (en) * 1991-07-03 1991-08-21 British Bio Technology Compounds
GB9116056D0 (en) * 1991-07-24 1991-09-11 British Bio Technology Compounds
GB9122308D0 (en) * 1991-10-21 1991-12-04 British Bio Technology Compounds
ES2062943B1 (en) * 1993-03-23 1995-11-16 Uriach & Cia Sa J NEW DERIVATIVES OF (2-METHYL-3-PIRIDIL) CYANOMETILPIPERAZINES.
KR100789323B1 (en) * 2005-07-20 2007-12-28 주식회사 엔지켐 Process for the regioselective preparation of glycerol derivatives and their intermediates
TWI385169B (en) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd Heterocyclic substituted pyridine derivatives and antifungal agent containing same
TW200841879A (en) * 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en) * 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
JP2012176900A (en) * 2009-06-24 2012-09-13 Eisai R & D Management Co Ltd Pyridin derivative containing ((phosphonooxy)methyl) pyridinium ring and anti-fungal agent containing these derivative
CA2997474C (en) 2010-11-16 2020-12-15 Texas Heart Institute Agonists that enhance binding of integrin-expressing cells to integrin receptors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146258A2 (en) * 1983-11-10 1985-06-26 Ono Pharmaceutical Co., Ltd. Glycerol derivatives
EP0148777A2 (en) * 1984-01-11 1985-07-17 Takeda Chemical Industries, Ltd. Phospholipids, their production and use
EP0157609A2 (en) * 1984-04-03 1985-10-09 Takeda Chemical Industries, Ltd. Lipid derivatives their production and use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4408052A (en) * 1980-02-27 1983-10-04 Takeda Chemical Industries, Ltd. Phospholipid carbamates
JPS60146894A (en) * 1984-01-11 1985-08-02 Takeda Chem Ind Ltd Phospholipid
JPS61267592A (en) * 1985-01-16 1986-11-27 Sankyo Co Ltd Phosphoric ester derivative, production thereof, and antitumor agent containing same
US4891363A (en) * 1985-07-26 1990-01-02 Sankyo Company Limited Cyclic ether derivatives and their use
GB8713745D0 (en) * 1987-06-12 1987-07-15 Scras Aminoacylates of glycerol

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146258A2 (en) * 1983-11-10 1985-06-26 Ono Pharmaceutical Co., Ltd. Glycerol derivatives
EP0148777A2 (en) * 1984-01-11 1985-07-17 Takeda Chemical Industries, Ltd. Phospholipids, their production and use
EP0157609A2 (en) * 1984-04-03 1985-10-09 Takeda Chemical Industries, Ltd. Lipid derivatives their production and use

Also Published As

Publication number Publication date
JPS62277368A (en) 1987-12-02
JP2556849B2 (en) 1996-11-27
ES2054663T3 (en) 1994-08-16
ATE88711T1 (en) 1993-05-15
DE3785599D1 (en) 1993-06-03
US5068340A (en) 1991-11-26
KR870007926A (en) 1987-09-22
CA1314889C (en) 1993-03-23
EP0238202B1 (en) 1993-04-28
EP0238202A2 (en) 1987-09-23
KR950005742B1 (en) 1995-05-30
DE3785599T2 (en) 1993-11-04

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