EP0226622A4 - Garniture de connexion d'un système de régulation de l'écoulement d'un fluide. - Google Patents

Garniture de connexion d'un système de régulation de l'écoulement d'un fluide.

Info

Publication number
EP0226622A4
EP0226622A4 EP19860903938 EP86903938A EP0226622A4 EP 0226622 A4 EP0226622 A4 EP 0226622A4 EP 19860903938 EP19860903938 EP 19860903938 EP 86903938 A EP86903938 A EP 86903938A EP 0226622 A4 EP0226622 A4 EP 0226622A4
Authority
EP
European Patent Office
Prior art keywords
fluid
aspiration
conduit
irrigation
fluid conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860903938
Other languages
German (de)
English (en)
Other versions
EP0226622A1 (fr
Inventor
Stephen W Haines
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nestle SA
Original Assignee
CooperVision Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CooperVision Inc filed Critical CooperVision Inc
Publication of EP0226622A1 publication Critical patent/EP0226622A1/fr
Publication of EP0226622A4 publication Critical patent/EP0226622A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/00736Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments
    • A61F9/00745Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments using mechanical vibrations, e.g. ultrasonic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71Suction drainage systems
    • A61M1/74Suction control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71Suction drainage systems
    • A61M1/74Suction control
    • A61M1/742Suction control by changing the size of a vent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71Suction drainage systems
    • A61M1/77Suction-irrigation systems
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16LPIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L41/00Branching pipes; Joining pipes to walls
    • F16L41/02Branch units, e.g. made in one piece, welded, riveted
    • F16L41/03Branch units, e.g. made in one piece, welded, riveted comprising junction pieces for four or more pipe members

Definitions

  • This invention relates to fluid control systems for surgical irrigation and aspiration and more par ⁇ ticularly to fluid control systems for use with an ultrasonic surgical tool which includes means for irri- gation of a surgical site and means for aspiration of fluid from the surgical site.
  • the surgical instrument therein disclosed comprises a handpiece which holds an elongated ultra ⁇ sonic surgical tool and contains means for exciting longitudinal ultrasonic vibrations in the tool.
  • the vibrating tool when applied to a tissue such as the crystalline lens of the eye which has developed a cata ⁇ ract is capable of breaking the tissue into small pieces.
  • the tool is provided with means for supplying an irrigating fluid to the surgical site and aspiration means for removing irrigation fluid and fragmented tissue from the surgical site.
  • the aspiration means includes an axial bore through the ultrasonic tool which is connected to a source of suction whereby the tissue fragments are aspirated from the surgical site, together with the irrigation fluid.
  • the incision in the eyeball need be only large enough to insert the tool and is substantially smaller than the incision required for removing the lens in one piece.
  • the surgical wound in the eyeball is only large enough to insert the ultrasonic surgical tool and irri ⁇ gation means, the surgical field is practically entirely enclosed, and controlling the flow of irriga- tion fluid and aspiration fluid is very important.
  • the suction applied to the aspiration means must be limited to a safe value, to avoid the danger of collapsing the eyeball.
  • the fluid control system dis ⁇ closed by Banko et al.
  • the valve is operated by the surgeon and comprises an aspiration pump and electrically operated valve means for connecting and disconnecting the suc ⁇ tion inlet of the pump to the aspiration tubing which conveys fluid away from the surgical field.
  • the valve is controlled by the surgeon by means of a foot switch.
  • An improved fluid control system is disclosed by Kelman, U. S. Patent 3,693,313. This apparatus addresses the problem of maintaining the proper pres ⁇ sure in the enclosed surgical field even with the occurrance of blockages in the aspiration conduit. A blockage or occlusion may occur, for example, when a piece of fragmented tissue which is larger than the axial bore of the surgical tool is drawn against the entrance to the axial bore in the tool.
  • Patent 3,693,613 provides for automatic rapid equaliza ⁇ tion of the pressure in the aspiration conduit when occlusion is removed. This is accomplished by provid ⁇ ing a flow-sensitive transducer in the aspiration con- duit which senses the rate of fluid flow and generates an electrical signal which is sent to a controller. Whenever the flow rate increases suddenly, indicating that a blockage has just been cleared, the controller causes a vent valve in the aspiration conduit to open at once, thus relieving the suction and preventing excessive withdrawal of fluid from the surgical site.
  • the flow control system of Kelman, U. S. Patent 3,693,613 is effective but somewhat complicated. Accordingly, another flow control system for surgical devices of this type was developed by Weiss, et al., U. S.
  • irrigation fluid is supplied to the surgical site from a source of fluid via an irrigation conduit provided with a pres ⁇ sure relief valve to prevent the irrigation pressure from becoming too high.
  • the aspiration conduit is provided with a relief vent valve which opens to the atmosphere at a preset pressure differen ⁇ tial, thereby preventing the suction in the aspiraton conduit from exceeding a preset value. In this way, the suction in the aspiration line never exceeds a predetermined value preset value, and the surgical site is not exposed to excess suction when a blockage is cleared.
  • the apparatus of this invention comprises a source of irrigation fluid, irrigation fluid conduit means for conducting said irrigation fluid to a surgical site, aspiration fluid conduit means for conducting fluid away from the surgical site, suction means in fluid communication with the aspiration fluid conduit means for aspirating fluid from the surgical site, pressure- sensitive control means for removing the source of suction from the aspiration conduit when a predeter- mined value of suction is exceeded, and means for controllably admitting irrigation fluid into the aspir ⁇ ation fluid conduit.
  • the invention also comprises a special modified T-connection fitting for conveniently connecting the fluid conduits used in the fluid flow control system. Accordingly, it is an object of the invention to provide an apparatus for irrigation and aspiration of an enclosed surgical site.
  • a further object is to provide apparatus for con- trollably releasing blockages in a surgical aspiration conduit.
  • a further object is to provide apparatus for rap ⁇ idly releasing suction in the aspiration line of a surgical aspirator.
  • a further object is to provide apparatus for rapidly equalizing pressure in a surgical irrigation- aspiration system in order to remove occluding matter.
  • a further object of the invention is to provide a method for controllably clearing blockages in a surgi- cal irrigation-aspiration system by equalizing pressure in the irrigation and aspiration conduits.
  • a further object is to provide a fluid connecting fixture for conveniently connecting fluid conduits providing irrigation, aspiration, and pressure sensing in a surgical irrigation-aspiration system.
  • Figure 1 illustrates schematically a fluid control system for a surgical irrigator/aspirator.
  • Figure 2 illustrates an electrical control system for operating the fluid control system of the inven- tion.
  • Figure 3 illustrates a fluid connecting fitting specially adapted for connecting aspiration conduit, pressure relief conduit and pressure sensing conduit in the surgical irrigation-aspiration system of this invention.
  • the flow control system is illustrated as associ ⁇ ated with an ultrasonic surgical handpiece 50 of the type described in U. S. Patent 3,589,363, but it will be understood that the flow control system is adaptable to any surgical irrigation-aspiration system and is of great utility wherever occlusion of the aspiration system can occur.
  • the surgical handpiece 50 is provided with an ultrasonic tool 52 having an axial suction passage connected to an aspiration tube 54. Irrigation fluid is supplied through tube 56 and is directed to the surgical site through a passage coaxial with the ultrasonic tool 52 and defined by sheath 58.
  • a source of irrigation fluid 102 supplies fluid through irrigation conduit 104 to the irrigation fluid supply tube 56 of the handpiece 50.
  • the source of irrigation fluid 102 may be a conventional bottle or bag of irrigating fluid, e. g., a conventional ophthal- mological irrigating fluid for ocular surgery, sus ⁇ pended above the surgical site at an elevation to supply the desired irrigation pressure.
  • This pressure will typically range from 10 mm Hg to 100 mm Hg, pref ⁇ erably 30 mm Hg to 60 mm Hg, for surgical procedures in the anterior chamber of the eye.
  • a shut-off valve 106 is provided in the irrigation conduit to control the starting and stopping of the irrigation.
  • this shut-off valve 106 is a remotely controllable valve, e. g., an electrically controlled valve operated by a solenoid 108.
  • the fluid withdrawn from the surgical site through the aspiration tube 54 is drawn through the aspiration conduit 110 of the flow control system by vacuum pump 112 and is discharged through waste conduit 114 to a waste container not shown.
  • the vacuum pump 112 is shown as a peristaltic pump having a pump tube 113 and a rotor 115. Such a pump is preferred in this inven ⁇ tion because of its lack of contamination, its good controllability, its relatively high suction capabil ⁇ ity, and the ease with which the pump may be stopped without special provision for avoiding backflow. How- ever, any appropriate source of vacuum may be used, with the understanding that the control means for dis ⁇ connecting the source of vacuum from the aspiration line, discussed more fully below, will have to be adapted to the needs of each type of pump.
  • a peristaltic type pump may be stopped by simply turning off its drive motor and thereupon inher ⁇ ently prevents backflow
  • other types of pump may require auxiliary valves to disconnect the source of suction from the aspiration conduit.
  • the source of vacuum is immediately stopped or disconnected from the aspiration conduit 110 as soon as the vacuum exceeds a predetermined level, which indicates that an occlusion of the aspiration bore in the ultrasonic tool 52 has occurred.
  • a pressure sensitive transducer 120 is arranged in fluid transmissive contact with the aspiration con ⁇ duit 110.
  • the transducer will be connected to the aspiration conduit 110 by a short length of tubing 122 connected to the aspiration conduit 110 by means of a special connecting fitting 140.
  • a hydro- philic-hydrophobic filter 124 mounted in a filter holder 126 is inserted between the aspiration conduit 110 and the transducer connecting tubing 122 in order to protect the transducer from contamination by contact with tissue particles and the like carried along with the aspiration fluid.
  • the pressure sensitive transducer 120 generates an electrical signal proportional to the vacuum in the aspiration conduit 110 induced by the pump 112. This signal is used to control the pump 112, so that the source of vacuum for the aspiration conduit 110 is quickly removed when the vacuum exceeds the predeter ⁇ mined value, thereby indicating that an occlusion has occured.
  • the pressure-sensitive transducer 120 may be a simple pressure switch which turns off the motor (not shown) of the peristaltic pump 112. When a peristaltic pump is used it is only neces ⁇ sary to turn off the drive motor to stop the pump, maintain the suction vacuum at the level it had reached, and prevent backflow of waste irrigation fluid.
  • shut-off valve between the pump and the aspiration conduit 110.
  • the signal from the pressure sensitive transducer 120 will cause the shut-off valve to be closed, thereby preventing the vacuum from increasing, but also holding the aspiration conduit at the level of vacuum reached before discon ⁇ nection.
  • a shut-off valve may also be necessary if a pump is used which cannot prevent backflow when it is shut off.
  • the pressure equalization is accomplished by means of pressure equalizing conduit 130, which conducts fluid from the source of irrigation fluid 102 to the aspira ⁇ tion conduit 110. Valve 132 in pressure equalizing conduit 130 controls the flow of fluid through conduit 130.
  • Valve 132 is normally closed when the apparatus is being used to aspirate fluid and tissue from a sur ⁇ gical site.
  • a blockage occurs in the aspiration line 110, e. g., when a tissue fragment occludes the axial bore in the ultrasonic tool 52
  • the increased suction in the aspiraton line 110 will be sensed by the pressure-sensitive transducer 120 which will in turn send a signal which shuts off the pump 112.
  • the surgeon can release the vacuum in the aspiration conduit 110 by opening the valve 132 to admit irriga- tion fluid from the source of irrigation fluid 102 to the aspiration fluid conduit 110 via a pressure equal ⁇ izing conduit 130 which is connected to the aspiration conduit 110 through the special fitting 140.
  • the pressure equalization is very rapid, more rapid than in systems which adjust pressure by admitting air to the system.
  • the trans ⁇ ducer 120 will detect the lower level of suction and restart the pump.
  • valve 132 is open fluid will flow directly from the source of irri- gation fluid 102 to suction conduit 110 and no substan ⁇ tial amount of suction will be applied to the surgical site through the suction conduit.
  • the pump 112 will again draw fluid from con ⁇ duit 110 and suction will thereby be reapplied to the surgical site.
  • valve 132 be a remotely controlled valve, for example an electrically controlled valve actuated by a solenoid indicated sche ⁇ matically as 134.
  • the solenoid 134 is energized by a source of electrical power under control of a switch operated by the surgeon.
  • the switch is a foot switch so that the surgeon can easily equalize the pressure and dislodge occluding tissue without having to remove his hands from performing the surgical proce- dure.
  • a check valve 109 is provided in irrigation conduit 56 to prevent a backward surge of fluid in the irrigation conduit 56 when valve 132 is opened to permit irrigation fluid to flow into the aspiration conduit.
  • a schematic electrical circuit which can be used to control the flow control system of the invention is illustrated in Figure 2.
  • Master switch 304 turns on the apparatus and supplies power to footswitch 306, having four positions, desig ⁇ nated as positions zero through three.
  • the foot switch 306 is provided with at least three movable contacts 308, 310 and 330, each having an off position 308a, 310a and 330a respectively, corresponding to position 0 of the footswitch, and each movable contact engaging stationary contacts 308b-d, 310b-d and 330b-d, corre ⁇ sponding to positions 1 - 3, respectively, of the foot ⁇ switch.
  • the footswitch is biased so that when no foot pressure is exerted thereon the switch is in position 0, the position shown, wherein contacts 308, 310 and 330 are in off positions 308a, 310a and 330a, and no power is connected to the control circuitry.
  • solenoids 108 and 134 are not energized and valves 106 and 132 are closed to prevent irrigation fluid flow.
  • contacts 308b and 310b are energized.
  • solenoid 108 is energized to open valve 106 to supply irrigation fluid to the surgical hand ⁇ piece 50.
  • solenoid 134 is not energized because switch 316 is in its normally open position, and therefore valve 132 remains closed.
  • Pump 112 is deactivated in footswitch position 1.
  • contacts 308c and 310c are energized.
  • Solenoid 108 remains ener- gized, and accordingly, valve 106 remains open to sup ⁇ ply irrigation fluid.
  • Solenoid 134 is disconnected, and therefore valve 132 cannot open when the footswitch is in this position.
  • Pump 112 is energized via nor ⁇ mally closed switch 312 which is under the control of pressure transducer 120. This control may be mechani ⁇ cal or electrical as is well known to those skilled in the art. Accordingly, pump action fills aspiration conduit 110 with irrigation fluid.
  • Switch 312 will be normally closed when the suction in the aspiration conduit 110 does not exceed a predetermined value, and will open when that value is exceeded.
  • footswitch 306 will be depressed to position 3 to energize the ultrasonic surgical tool via wire 320 leading to the ultrasonic generator and control circuits for the handpiece which are entirely conventional and are not shown.
  • the sur- geon now proceeds with ultrasonic cutting using the tool 52 in handpiece 50.
  • the switch 312 will be closed so that the pump 112 provides a source of suction for aspirating fluid and fragmented tissue from the surgi ⁇ cal site, while irrigation fluid is supplied through open valve 106.
  • the pressure equalizing conduit 130 remains closed normally.
  • the vacuum in aspiration conduit 110 increases and pres- sure-sensitive transducer 120 causes switch 312 to
  • Triggered controller 324 receives power via contact 308b of the switch 306 and may include a conventional single-pulse circuit, e. g., a one-shot multivibrator, which supplies a single pulse to an actuator, e. g., a relay coil, which momentarily closes switch 316.
  • the single-pulse circuit may be triggered via connection 326 when the footswitch 306 moves from position 2 to position 1.
  • the triggered controller 324 and its circuitry are conventional and readily implemented by one skilled in the art.
  • Sole ⁇ noid 134 is thus momentarily actuated by switch 316 to open valve 132 in pressure equalizing conduit 130 to admit irrigation fluid directly from the source of irrigation fluid 102 into the aspiration conduit 110 to relieve the suction in conduit 110.
  • the suction in aspiration conduit 110 With the removal of the suction in aspiration conduit 110, no suction force holds tissue fragments at the entrance of the axial bore in the ultrasonic tool 52, and the fragments may easily be dislodged. The surgeon may then continue the procedure by depressing the foot switch to posi ⁇ tions 2 and 3.
  • Valve 132 is by this time closed and suction is restored to the aspiration conduit 110. While the described control system represents one cir ⁇ cuit which accomplishes the objects of the invention, it will be recognized that alternate circuits may be employed.
  • the invention also encompasses a special fitting 400 shown in cross section in Figure 3.
  • This connect ⁇ ing fitting is specially adapted to fulfill the func ⁇ tion of connecting together the aspiration conduit, the pressure relief conduit and the pressure-sensitive transducer.
  • the fitting comprises a tubular fluid con- duit 402 having a female connecting member 404 at one end for receiving the aspiration tubing 110 coming from the handpiece 52.
  • This tubing carries aspirated fluid together with fragmented tissue, and the female connec ⁇ tion provides a smooth internal wall for the conduit in order to reduce the chance of clogging.
  • the tubular conduit 402 is provided at its other end with a male connecting member 406 for connecting to the tubing 113 leading to the source of suction, e. g., pump 112.
  • the second fluid conduit 408 has a male tapered connecting member 410 at its free end adapted to mate with a female tapered connecting fitting on the filter housing 126 or with the tubing 122 leading to the pressure-sensitive transducer 120.
  • a third fluid conduit 412 has one end connected to and in fluid communication with the second fluid conduit 408 at a point intermediate between its ends. The other end 414 of the third tubular conduit 412 is tapered to receive the end of the pressure equalizing conduit 130.
  • the third fluid conduit 412 is arranged generally at right angles to the second tubu ⁇ lar conduit 408 and parallel to the first tubular con ⁇ duit 402.
  • This special connecting fitting 400 permits the rapid and convenient connection of all the fluid conducting members associated with the pressure equal ⁇ izing function of the apparatus of this invention.

Abstract

Un appareil de régulation de l'écoulement d'un fluide spécialement adapté à un instrument chirurgical (52) à ultra-sons irrigue un site opératoire et aspire des fluides se trouvant sur le site opératoire. L'appareil comprend une source de fluide d'irrigation (102), une conduite (104) de fluide d'irrigation pour amener le fluide d'irrigation jusqu'au site opératoire, une conduite (54) d'aspiration de fluide pour enlever des fluides du site opératoire, une pompe d'aspiration (112) connectée au site d'aspiration, un système de commande (140, 120) sensible à la pression pour éloigner la source d'aspiration de la conduite d'aspiration lorsqu'une valeur prédéterminée d'aspiration est dépassée, et une soupape (132) d'admission réglable du fluide d'irrigation dans la conduite d'aspiration de fluides. Une vanne d'arrêt (109) agencée dans le conduit d'irrigation empêche l'écoulement en sens inverse lorsque le fluide d'irrigation pénètre dans la conduite d'aspiration. Un connecteur modifié en T (400) avec une première conduite de fluide (402) comprend un bout mâle de connexion (406) et un bout femelle de connexion (404). Un deuxième élément tubulaire rigide (400) en communication fluide avec la première conduite (402) comprend un troisième élément rigide (414) perpendiculaire au deuxième élément rigide (400) et parallèle à la première conduite de fluide (402).
EP19860903938 1985-06-05 1986-06-02 Garniture de connexion d'un système de régulation de l'écoulement d'un fluide. Withdrawn EP0226622A4 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74156585A 1985-06-05 1985-06-05
US741565 1985-06-05
US86536086A 1986-05-21 1986-05-21
US865360 1986-05-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP19920105861 Division EP0494094A3 (en) 1985-06-05 1986-06-02 Fluid flow control system and connecting fitting therefor

Publications (2)

Publication Number Publication Date
EP0226622A1 EP0226622A1 (fr) 1987-07-01
EP0226622A4 true EP0226622A4 (fr) 1988-08-23

Family

ID=27113884

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19920105861 Withdrawn EP0494094A3 (en) 1985-06-05 1986-06-02 Fluid flow control system and connecting fitting therefor
EP19860903938 Withdrawn EP0226622A4 (fr) 1985-06-05 1986-06-02 Garniture de connexion d'un système de régulation de l'écoulement d'un fluide.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP19920105861 Withdrawn EP0494094A3 (en) 1985-06-05 1986-06-02 Fluid flow control system and connecting fitting therefor

Country Status (11)

Country Link
EP (2) EP0494094A3 (fr)
KR (1) KR890004190B1 (fr)
AU (1) AU5998686A (fr)
BR (1) BR8606700A (fr)
CA (1) CA1276094C (fr)
DK (1) DK58287A (fr)
FI (1) FI870475A (fr)
GR (1) GR861431B (fr)
IE (1) IE861484L (fr)
NO (1) NO870388L (fr)
WO (1) WO1986007249A1 (fr)

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Also Published As

Publication number Publication date
FI870475A0 (fi) 1987-02-04
KR890004190B1 (ko) 1989-10-27
BR8606700A (pt) 1987-08-11
EP0494094A3 (en) 1992-10-07
GR861431B (en) 1986-09-19
IE861484L (en) 1986-12-05
AU5998686A (en) 1987-01-07
DK58287D0 (da) 1987-02-04
KR870700326A (ko) 1987-12-28
FI870475A (fi) 1987-02-04
NO870388D0 (no) 1987-01-30
EP0226622A1 (fr) 1987-07-01
NO870388L (no) 1987-01-30
WO1986007249A1 (fr) 1986-12-18
DK58287A (da) 1987-02-04
CA1276094C (fr) 1990-11-13
EP0494094A2 (fr) 1992-07-08

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