EP0154977A3 - Glycerin-ether phosphatides, their preparation and use - Google Patents

Glycerin-ether phosphatides, their preparation and use Download PDF

Info

Publication number
EP0154977A3
EP0154977A3 EP85102830A EP85102830A EP0154977A3 EP 0154977 A3 EP0154977 A3 EP 0154977A3 EP 85102830 A EP85102830 A EP 85102830A EP 85102830 A EP85102830 A EP 85102830A EP 0154977 A3 EP0154977 A3 EP 0154977A3
Authority
EP
European Patent Office
Prior art keywords
glycerin
preparation
phosphatides
ether
ether phosphatides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP85102830A
Other languages
German (de)
Other versions
EP0154977B1 (en
EP0154977A2 (en
Inventor
Manfred Dr. Breuninger
Dieter Dr. Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to AT85102830T priority Critical patent/ATE43131T1/en
Publication of EP0154977A2 publication Critical patent/EP0154977A2/en
Publication of EP0154977A3 publication Critical patent/EP0154977A3/en
Application granted granted Critical
Publication of EP0154977B1 publication Critical patent/EP0154977B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
EP85102830A 1984-03-15 1985-03-12 Glycerin-ether phosphatides, their preparation and use Expired EP0154977B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT85102830T ATE43131T1 (en) 1984-03-15 1985-03-12 GLYCERINAETHER PHOSPHATIDES, THEIR PREPARATION AND USE.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH128784 1984-03-15
CH1287/84 1984-03-15
CH49185 1985-02-04
CH491/85 1985-02-04

Publications (3)

Publication Number Publication Date
EP0154977A2 EP0154977A2 (en) 1985-09-18
EP0154977A3 true EP0154977A3 (en) 1986-02-19
EP0154977B1 EP0154977B1 (en) 1989-05-17

Family

ID=25684726

Family Applications (1)

Application Number Title Priority Date Filing Date
EP85102830A Expired EP0154977B1 (en) 1984-03-15 1985-03-12 Glycerin-ether phosphatides, their preparation and use

Country Status (16)

Country Link
US (1) US4694084A (en)
EP (1) EP0154977B1 (en)
AR (1) AR241022A1 (en)
AU (1) AU574440B2 (en)
CA (1) CA1264162A (en)
DE (1) DE3570239D1 (en)
DK (1) DK117985A (en)
ES (2) ES8606233A1 (en)
FI (1) FI78299C (en)
HU (1) HU195828B (en)
IL (1) IL74540A (en)
MC (1) MC1649A1 (en)
NO (1) NO851006L (en)
NZ (1) NZ211368A (en)
PH (1) PH20750A (en)
PT (1) PT80112B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
EP0284395B1 (en) * 1987-03-24 1993-06-23 Nippon Chemiphar Co., Ltd. Novel glycerol derivative and anti-hypertensive agent
CA2033725C (en) * 1990-01-24 2001-05-29 Folker Pittrof Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
FR2687314A1 (en) * 1992-02-18 1993-08-20 Oreal LIPID VESICLE DISPERSION, COSMETIC AND / OR PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND PROCESS FOR THE PREPARATION OF SAID DISPERSION.
WO1995028146A1 (en) * 1994-04-15 1995-10-26 Hemagen/Pfc Fluorochemical emulsions containing 1,3-dialkylglycerophosphoryl choline surfactants and methods of use
JP2740153B2 (en) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー Mixed micelle
CN1268321C (en) * 2001-07-13 2006-08-09 那野伽利阿株式会社 Lyophilizing composition of drug-encapsulating polymer micelle and method for preparation thereof
AU2002951216A0 (en) * 2002-09-05 2002-09-19 Dbl Australia Pty Ltd Surfactants and lyotropic phases formed therefrom
WO2005021046A1 (en) * 2003-09-01 2005-03-10 Fh Faulding & Co Ltd Compositions and methods for delivery of biologically active agents
DE102005016152A1 (en) * 2005-04-07 2006-10-12 Basf Ag Preparation of (co) surfactants by reaction of polyols with olefins
EP3988537A1 (en) 2011-12-07 2022-04-27 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2016037128A1 (en) 2014-09-04 2016-03-10 Nano Precision Medical, Inc. Polymeric stabilizing formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2020663A (en) * 1978-05-12 1979-11-21 Nattermann A & Cie Phospholipid analogues and their preparation
JPS59163389A (en) * 1983-03-07 1984-09-14 Takeda Chem Ind Ltd Phospholipid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (en) * 1976-07-12 1989-02-09 Hoffmann La Roche INJECTABLE SOLUTIONS IN WHICH THE EMOLITHIC LIFE OF NATURAL MICELLES TRAINING AGENTS IS AVOIDED BY THE ADDITION OF LIPOIDS AND RELATED PRODUCTS
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
DE3011738A1 (en) * 1980-03-26 1981-10-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen NEW GLYCERIN-3-PHOSPHORIC ACID HALOGYL ALTER
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
US4562179A (en) * 1982-04-19 1985-12-31 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, and pharmaceutical composition of the same
JPS59184195A (en) * 1983-04-04 1984-10-19 Takeda Chem Ind Ltd Glycerol derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2020663A (en) * 1978-05-12 1979-11-21 Nattermann A & Cie Phospholipid analogues and their preparation
JPS59163389A (en) * 1983-03-07 1984-09-14 Takeda Chem Ind Ltd Phospholipid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Band 92, Nr. 23, 9. Juni 1980, Seite 635, Nr. 197869u, Columbus, Ohio, US; V.A. VAVER u.a.: "Synthesis of 2,3-di-O-phytanyl-sn-glycero-1-phosphorylcholine", & BIOORG. KHIM. 1980, 6(1), 146-8 *

Also Published As

Publication number Publication date
AU3971085A (en) 1985-09-19
DK117985D0 (en) 1985-03-14
DE3570239D1 (en) 1989-06-22
NO851006L (en) 1985-09-16
ES8606233A1 (en) 1986-04-16
FI78299B (en) 1989-03-31
MC1649A1 (en) 1986-04-07
FI850972A0 (en) 1985-03-12
IL74540A0 (en) 1985-06-30
EP0154977B1 (en) 1989-05-17
PT80112B (en) 1987-03-24
AU574440B2 (en) 1988-07-07
FI78299C (en) 1989-07-10
NZ211368A (en) 1988-11-29
EP0154977A2 (en) 1985-09-18
DK117985A (en) 1985-09-16
ES541242A0 (en) 1986-04-16
PT80112A (en) 1985-04-01
ES550920A0 (en) 1987-02-16
HUT36824A (en) 1985-10-28
FI850972L (en) 1985-09-16
ES8703481A1 (en) 1987-02-16
PH20750A (en) 1987-04-02
IL74540A (en) 1989-02-28
AR241022A2 (en) 1991-04-30
HU195828B (en) 1988-07-28
US4694084A (en) 1987-09-15
AR241022A1 (en) 1991-04-30
CA1264162A (en) 1990-01-02

Similar Documents

Publication Publication Date Title
PT79332A (en) Computeriezed audiometer
IL75906A0 (en) Pyrethroid compositions,their preparation and their use
IL75240A0 (en) 1-heteroaryl-4-aryl-pyrazolin-5-ones,their preparation and their use as microbicides
HK17590A (en) 1-pyrimidinyloxy-3-hetarylalkylamino-2-propanols,preparation,and uses
EP0164018A3 (en) Chromogenic 4,4-diaryl-dihydroquinazolones, their preparation and use
DE3570239D1 (en) Glycerin-ether phosphatides, their preparation and use
ZA85934B (en) Novel substituted imidazoles,their preparation and use
DE3560679D1 (en) 4-hydroxy-2h-1-benzothiopyran-2-one derivatives, their preparation and uses
GB2183638B (en) Polyfluoroalkylisoxazolylamines, their preparation and use
IL77106A0 (en) Homopropargylamines,their preparation and their use as fungicides
DE3563968D1 (en) Phospholipids, their production and use
ZA857272B (en) Vinyltetrazolylphenyl derivatives,their preparation and their use
IL75366A0 (en) Substituted phenylsulphonylureas,their preparation and their use as plant-treatment agents
DE3365480D1 (en) Oxacephalosporin derivatives, their preparation and use
IL68831A (en) 2,2-dimethyl-3-aryl-cyclo-butanones and their preparation
IL76224A0 (en) Substituted carbonylphenylsulphonylguanidines,their preparation and their use as herbicides
IL87779A0 (en) 4-azasaccharines,4-aza-dihydro-and-tetrahydro-saccharines and their preparation
EP0193608A4 (en) Gif-2 and its preparation.
IL76211A0 (en) Fluoroalkoxyphenylsulphonylguanidines,their preparation and their use as herbicides
IL74164A0 (en) Phenoxypropionyloxyalkanephosphonates,their preparation and their use as herbicides
IL76213A0 (en) Substituted arylsulphonylguanidines,their preparation and their use as herbicides
IL63061A (en) 6-arylhydrazono-pyrido(2,1-b)quinazoline-11-ones and their preparation
ZA836469B (en) Substituted 1-pyridyloxy-3-indolylalkylamino-2-propanols,preparation,and use thereof
ZA882852B (en) Pyrrolealdehydes,their preparation and their use
GB2119374B (en) 1,2,4-triazol-1-yl-propionitrile derivatives their preparation and use

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19850312

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19871104

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

REF Corresponds to:

Ref document number: 43131

Country of ref document: AT

Date of ref document: 19890615

Kind code of ref document: T

REF Corresponds to:

Ref document number: 3570239

Country of ref document: DE

Date of ref document: 19890622

ITF It: translation for a ep patent filed

Owner name: BARZANO' E ZANARDO MILANO S.P.A.

ET Fr: translation filed
GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
ITPR It: changes in ownership of a european patent

Owner name: CESSIONE;F. HOFFMANN - LA ROCHE AG

BECH Be: change of holder

Free format text: 890517 F. *HOFFMANN-LA ROCHE A.G.

NLS Nl: assignments of ep-patents

Owner name: F. HOFFMANN-LA ROCHE AG TE BAZEL, ZWITSERLAND.

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19900117

Year of fee payment: 6

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19900228

Year of fee payment: 6

REG Reference to a national code

Ref country code: CH

Ref legal event code: PUE

Owner name: F. HOFFMANN-LA ROCHE AG

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19900307

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19900308

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19900315

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19900322

Year of fee payment: 6

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19900330

Year of fee payment: 6

Ref country code: AT

Payment date: 19900330

Year of fee payment: 6

ITTA It: last paid annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19900331

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19900331

Year of fee payment: 6

26N No opposition filed
REG Reference to a national code

Ref country code: GB

Ref legal event code: 732

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Effective date: 19910312

Ref country code: AT

Effective date: 19910312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19910313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Effective date: 19910331

Ref country code: CH

Effective date: 19910331

Ref country code: BE

Effective date: 19910331

BERE Be: lapsed

Owner name: F. HOFFMANN-LA ROCHE A.G.

Effective date: 19910331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19911001

GBPC Gb: european patent ceased through non-payment of renewal fee
NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19911129

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19920101

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

EUG Se: european patent has lapsed

Ref document number: 85102830.8

Effective date: 19911009