EP0132964A3 - 2-Azabicyclo[2.2.2]octane derivatives - Google Patents

2-Azabicyclo[2.2.2]octane derivatives Download PDF

Info

Publication number
EP0132964A3
EP0132964A3 EP84304488A EP84304488A EP0132964A3 EP 0132964 A3 EP0132964 A3 EP 0132964A3 EP 84304488 A EP84304488 A EP 84304488A EP 84304488 A EP84304488 A EP 84304488A EP 0132964 A3 EP0132964 A3 EP 0132964A3
Authority
EP
European Patent Office
Prior art keywords
hydrogen
carbonyl
alkoxy
alkyl
azabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP84304488A
Other languages
German (de)
French (fr)
Other versions
EP0132964A2 (en
Inventor
Elemer Ezer
Laszlo Dr. Szporny
Gyorgy Dr. Hajos
Csaba Dr. Szantay
Tibor Dr. Keve
Gyorgy Dr. Fekete
Gabor Dr. Megyeri
Tibor Acs
Hedvig Dr. Bolcskei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of EP0132964A2 publication Critical patent/EP0132964A2/en
Publication of EP0132964A3 publication Critical patent/EP0132964A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems

Abstract

2-Azabicyclo[2.2.2]octane derivatives of formula (I), wherein
A is hydrogen, (C₁₋₄ alkoxy)carbonyl, phenyl (C₁₋₄ alkoxy)carbonyl, C₁₋₆ alkyl, aryl (C₁₋₄ alkyl) or optionally sub­ stituted aryl (C₂₋₅ alkanoyl),
R₁ is hydrogen or C₁₋₄ alkyl,
Z is hydrogen or halogen, and
either X and Y are each hydrogen or X and Y together repres­ ent a C-C bond and W is (C₁₋₄ alkoxy)carbonyl, cyano, carbox­ amido or haloformyl
or X is halogen and W and Y together represent a --O-

group;
and, where A is hydrogen, acid addition salts thereof, are disclosed which compounds possess interesting anticonvul­ sive, vasodilating, immunosuppressant and/or gastric acid secretion inhibiting properties. They are also of use as inter­ mediates in the preparation of other active compounds.
Process for preparing them and pharmaceutical composi­ tions containing them are also disclosed.
EP84304488A 1983-06-29 1984-06-29 2-Azabicyclo[2.2.2]octane derivatives Ceased EP0132964A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU832343A HU191535B (en) 1983-06-29 1983-06-29 Process for producing 2-azabicyclo/2.2.2/octane derivatives
HU234383 1983-06-29

Publications (2)

Publication Number Publication Date
EP0132964A2 EP0132964A2 (en) 1985-02-13
EP0132964A3 true EP0132964A3 (en) 1985-10-30

Family

ID=10958920

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84304488A Ceased EP0132964A3 (en) 1983-06-29 1984-06-29 2-Azabicyclo[2.2.2]octane derivatives

Country Status (7)

Country Link
US (1) US4563464A (en)
EP (1) EP0132964A3 (en)
JP (1) JPS6045577A (en)
CA (1) CA1252101A (en)
DK (1) DK317184A (en)
FI (1) FI842338A (en)
HU (1) HU191535B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240935A (en) * 1992-11-20 1993-08-31 Sterling Winthrop Inc. Substituted 2-azabicyclo[2.2.2]octane derivatives and compositions and method of use thereof
WO1995032004A1 (en) * 1994-05-20 1995-11-30 Mallinckrodt Medical, Inc. Functionalized bicyclo[2.2.1] heptane and [2.2.2] octane system as preorganized ligands for imaging applications
AU6425498A (en) * 1997-11-05 1999-05-24 Inessa Ivanovna Kritskaya New anticonvulsant drugs
US6248752B1 (en) * 1998-02-27 2001-06-19 Charles Duane Smith Azabicyclooctane compositions and methods for enhancing chemotherapy
WO2017077990A1 (en) 2015-11-05 2017-05-11 日揮ユニバーサル株式会社 Catalyst for use in cleansing of inside of polymer film production furnace, and method for cleansing inside of polymer film production furnace

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3709893A (en) * 1969-07-29 1973-01-09 Farmaceutici It Soc Hydroxyisoquinuclidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3709893A (en) * 1969-07-29 1973-01-09 Farmaceutici It Soc Hydroxyisoquinuclidine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TETRAHEDRON LETTERS, vol. 24, no. 49, 1983, pages 5539-5540, Pergamon Press Ltd., Oxford, GB; C. SZANTAY et al.: "Synthesis of vinca alkaloids and related compounds XVII. Synthesis of deethylcatharanthine" *

Also Published As

Publication number Publication date
HU191535B (en) 1987-03-30
FI842338A0 (en) 1984-06-08
DK317184D0 (en) 1984-06-28
US4563464A (en) 1986-01-07
JPS6045577A (en) 1985-03-12
DK317184A (en) 1984-12-30
FI842338A (en) 1984-12-30
HUT34189A (en) 1985-02-28
EP0132964A2 (en) 1985-02-13
CA1252101A (en) 1989-04-04

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI NL

17P Request for examination filed

Effective date: 19841221

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI NL

17Q First examination report despatched

Effective date: 19870602

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19900521

RIN1 Information on inventor provided before grant (corrected)

Inventor name: FEKETE, GYORGY, DR.

Inventor name: BOLCSKEI, HEDVIG, DR.

Inventor name: SZPORNY, LASZLO, DR.

Inventor name: SZANTAY, CSABA, DR.

Inventor name: KEVE, TIBOR, DR.

Inventor name: HAJOS, GYORGY, DR.

Inventor name: EZER, ELEMER

Inventor name: ACS, TIBOR

Inventor name: MEGYERI, GABOR, DR.

RTI1 Title (correction)

Free format text: 2-AZABICYCLO??2.2.2 OCTANE DERIVATIVES