EP0132376B1 - Improvements in fibrous structures - Google Patents
Improvements in fibrous structures Download PDFInfo
- Publication number
- EP0132376B1 EP0132376B1 EP84304891A EP84304891A EP0132376B1 EP 0132376 B1 EP0132376 B1 EP 0132376B1 EP 84304891 A EP84304891 A EP 84304891A EP 84304891 A EP84304891 A EP 84304891A EP 0132376 B1 EP0132376 B1 EP 0132376B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- filaments
- polymeric composition
- composition
- portions
- fibrous structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
- D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
- D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H3/00—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length
- D04H3/08—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating
- D04H3/16—Non-woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
Definitions
- the invention relates to fibrous structures, for example fibrous mats or fibrous tubular structures. More particularly but not exclusively, the invention relates to fibrous synthetic vascular grafts.
- different polymeric composition is intended to cover a variation of the composition of the filaments where the polymer itself does not change across the structure but, for example, an additive is present in the composition at one side of the structure but not present at the opposite side of the structure.
- the structure may comprise a transition area between the sides of the structure, and the portions of the filaments in the transition area may have a polymeric composition comprising a mixture of the first and second polymeric compositions.
- the polymeric composition of the filaments may vary progressively between the two sides of the structure, and the composition of the portions of the filaments in the transition area adjacent the one side of the structure may contain a large proportion of the first polymeric composition and the portions of the filaments adjacent the opposite side of the structure may contain a large proportion of the second polymeric composition.
- the composition of the filaments may change abruptly to provide distinct layers within the structure having different polymeric compositions. There may be more than two layers in the structure.
- the structure may be in the form of a mat, or may be a tubular member.
- the portions of the filaments at the inner surface of the tubular member are preferably of the first polymeric composition to provide compatibility with material with which the inner surface will come into contact, and the portions of the filaments at the outer surface of the tubular member are preferably of the second polymeric composition to provide desirable strength characteristics and other physical properties to the tubular member.
- the tubular member may be cut to provide one or more segmental elements from the tubular wall. If the internal diameter of the tubular member is large enough, for example a few centimetres, the segmental element or elements will tend towards being planar, and may be used as pledgets.
- the invention further provides a method of forming an integral fibrous structure according to the invention, which method comprises the steps of directing filaments of a first polymeric composition at a surface to start building up a fibrous structure of the first polymeric composition, and altering the composition of the filaments during production thereof such that the portions of the filaments at the side of the structure remote from the surface is of the second polymeric composition.
- composition of the filaments may be changed abruptly or may be varied gradually across the structure.
- Figure 1 shows diagrammatically apparatus for electrostatically spinning a synthetic vascular graft.
- Polymer solution is ejected from capillary needles 10 towards an electrostatically charged mandrel 11 rotating at several thousand revolutions per minute, for example 5000 r.p.m.
- the mandrel 11 is at a potential of -12kV with respect to the needles 10.
- polymer solution leaves the needles 10 polymer filaments form and these filaments are attracted to the rotating electrostatically charged mandrel 11 to form a fibrous structure around the mandrel.
- the structure is removed from the mandrel to provide a fibrous tube.
- Mechanical properties of the tubular fibrous structure formed on the mandrel 11 can be controlled by variation of the speed of rotation of the mandrel, the type of polymer used and by altering, the potential of auxiliary electrodes 12.
- the capillary needles 10 are supplied with polymer solution from a manifold 13, the manifold 13 being supplied by tubes 14and 15 meeting in a T connector 16. Both tubes 14 and 15 include a flexible coil 17 and 18 respectively.
- the tube 14 has a valve 19 and the tube 15 has a valve 20 to enable the respective tubes to be closed. Control lines 21 and 22 control opening and closing of the valves 19 and 20.
- the tube 14 is supplied from a first air-ram driven syringe 23 and the tube 15 is fed from a second air-ram driven syringe 24 and the apparatus enables polymer solution from either syringe 23 or syringe 24 to be ejected from the needles 10 towards the mandrel 11.
- a purge line 25 including a closure valve 26 allows purging of the manifold 13.
- the apparatus of Figure 1 allows formation of an integral, uninterrupted fibrous structure of continuous polymeric filaments around the surface of the mandrel 11, the portions of the filaments at the inside surface having a different polymeric composition from the portions of the filaments of the outside surface of the fibrous structure.
- This can be advantageous when the tubular fibrous structures are used for, for example, synthetic vascular grafts.
- different polymers have different haemocompatibilities and that different polymers have different strength characteristics.
- one polyurethane has advantageous haemocompatibility but poor elastic properties, exhibiting high creep.
- a second polyurethane having a higher Young's modulus has satisfactory strength properties but poor haemocompatibility.
- the apparatus of Figure 1 allows production of a synthetic vascular graft having a thin inner lining of the first polyurethane on a wall of the second polyurethane, the graft, however, being formed of fibres spun continuously, with individual fibres changing composition between their ends to provide an integral, uninterrupted, fibrous structure.
- polymers can be used in the electrostatic spinning process.
- polyurethanes such as polyurethanes, polyamides and polyacrylonitrile, all of which can be spun from solution, and polytetrafluorethylene and polyesters which may be spun from dispersion.
- Water soluble polymers such as polyvinyl alcohol, polyvinyl pyrrolidone and polyethylene oxide may be spun from aqueous solution.
- the constraint on the fibrous structure and method of production according to the invention is that the two or more polymers used to vary the composition of the filaments during the spinning process must be either dispersible or alternatively soluble in the same solvent system.
- the two or more polymers used to vary the composition of the filaments during the spinning process must be either dispersible or alternatively soluble in the same solvent system.
- a silicone lubricant could be added to a polyurethane polymer and spun as the inner surface of a graft, the outer surface of the graft being the same polyurethane without the silicone lubricant. Such an example is included in the scope of the invention.
- the advantage of the embodiments of grafts hereinbefore described are that the different layers can be optimised for particular properties, either in its morphology (e.g. porosity, pore shape, fibre size) or in its chemistry (e.g. type of polymer, presence of drug.
- a drug such as heparin or prostacyclin may be included in the inner layer to improve the property with regard to contacting blood). If such layers are built up discontinuously, lines of weakness exist between the contiguous surfaces and delamination is likely to occur at quite low mechanical stresses.
- the advantage of the method hereinbefore described is that it builds different layers into an integrally formed fibrous structure so that the successive wall components are merged in a well controlled way.
- tubular fibrous structures for use as vascular grafts
- the invention is equally applicable to planar fibrous structures such as mats and that such alternative structures would have wide applications.
Landscapes
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Artificial Filaments (AREA)
- Multicomponent Fibers (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Yarns And Mechanical Finishing Of Yarns Or Ropes (AREA)
- Inorganic Fibers (AREA)
- Nonwoven Fabrics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
- The invention relates to fibrous structures, for example fibrous mats or fibrous tubular structures. More particularly but not exclusively, the invention relates to fibrous synthetic vascular grafts.
- In the past, it has been proposed to produce fibrous structures such as mats by a process using electrostatic attraction, where a polymer such as polyurethane in solution is ejected from a fine nozzle towards a surface, between which surface and the nozzle exists an electrostatic potential. Between the nozzle and the surface, fibres of the polymer are formed and the fibres are attracted to the surface. This process has been adapted to make tubular fibrous structures usable as synthetic vascular grafts by providing the surface in the form of a rotating mandrel so that a fibrous tube is gathered around the mandrel.
- The electrostatic spinning process is described in some detail in U.S. Patent Specification No. 4044404 and proposals to use the electrostatic spinning process for making synthetic vascular grafts have been made, for example, in a paper by Annis et al in 1978 (Trans. Am. Soc. Intern. Organs). The microstructure of the fibrous material produced during electrostatic spinning is also described in the Annis et al paper. More recently, developments have been made in matching properties of synthetic vascular grafts to in vivo conditions, as in our British Patent Application No. 8217487 published under No. 2120946A and in controlling anisotropic properties of grafts in our British Patent Application No. 8216066, published under No. 2121286A.
- According to the invention there is provided an integral fibrous structure of a plurality of continuous, polymeric filaments, individual filaments extending from one side of the structure to the opposite side of the structure, the portions of the filaments on one side of the structure being of a first polymeric composition and the portions of the filaments on the opposite side of the structure being of a second polymeric composition different from the first polymeric composition.
- The term "different polymeric composition" is intended to cover a variation of the composition of the filaments where the polymer itself does not change across the structure but, for example, an additive is present in the composition at one side of the structure but not present at the opposite side of the structure.
- The structure may comprise a transition area between the sides of the structure, and the portions of the filaments in the transition area may have a polymeric composition comprising a mixture of the first and second polymeric compositions.
- The polymeric composition of the filaments may vary progressively between the two sides of the structure, and the composition of the portions of the filaments in the transition area adjacent the one side of the structure may contain a large proportion of the first polymeric composition and the portions of the filaments adjacent the opposite side of the structure may contain a large proportion of the second polymeric composition.
- Alternatively, the composition of the filaments may change abruptly to provide distinct layers within the structure having different polymeric compositions. There may be more than two layers in the structure.
- The structure may be in the form of a mat, or may be a tubular member.
- When the structure is a tubular member, the portions of the filaments at the inner surface of the tubular member are preferably of the first polymeric composition to provide compatibility with material with which the inner surface will come into contact, and the portions of the filaments at the outer surface of the tubular member are preferably of the second polymeric composition to provide desirable strength characteristics and other physical properties to the tubular member.
- The tubular member may be cut to provide one or more segmental elements from the tubular wall. If the internal diameter of the tubular member is large enough, for example a few centimetres, the segmental element or elements will tend towards being planar, and may be used as pledgets.
- The invention further provides a method of forming an integral fibrous structure according to the invention, which method comprises the steps of directing filaments of a first polymeric composition at a surface to start building up a fibrous structure of the first polymeric composition, and altering the composition of the filaments during production thereof such that the portions of the filaments at the side of the structure remote from the surface is of the second polymeric composition.
- The composition of the filaments may be changed abruptly or may be varied gradually across the structure.
- By way of example, one embodiment of a fibrous structure and its method of production according to the invention will now be described with reference to the accompanying drawings, in which:
- Figure 1 is a diagrammatic view of apparatus for producing a tubular fibrous structure;
- Figure 2 is a graph illustrating concentration of one polymeric composition in a structure wall; and
- Figure 3 is a part sectional view of a tubular fibrous structure produced by the apparatus of Figure 1.
- Figure 1 shows diagrammatically apparatus for electrostatically spinning a synthetic vascular graft. Polymer solution is ejected from
capillary needles 10 towards an electrostaticallycharged mandrel 11 rotating at several thousand revolutions per minute, for example 5000 r.p.m. Typically, themandrel 11 is at a potential of -12kV with respect to theneedles 10. As polymer solution leaves theneedles 10, polymer filaments form and these filaments are attracted to the rotating electrostaticallycharged mandrel 11 to form a fibrous structure around the mandrel. When the fibrous structure has been built up, the structure is removed from the mandrel to provide a fibrous tube. - Mechanical properties of the tubular fibrous structure formed on the
mandrel 11 can be controlled by variation of the speed of rotation of the mandrel, the type of polymer used and by altering, the potential ofauxiliary electrodes 12. - The
capillary needles 10 are supplied with polymer solution from amanifold 13, themanifold 13 being supplied by tubes 14and 15 meeting in aT connector 16. Bothtubes flexible coil tube 14 has avalve 19 and thetube 15 has avalve 20 to enable the respective tubes to be closed.Control lines valves - The
tube 14 is supplied from a first air-ram drivensyringe 23 and thetube 15 is fed from a second air-ram drivensyringe 24 and the apparatus enables polymer solution from eithersyringe 23 orsyringe 24 to be ejected from theneedles 10 towards themandrel 11. Apurge line 25 including aclosure valve 26 allows purging of themanifold 13. - The apparatus of Figure 1 allows formation of an integral, uninterrupted fibrous structure of continuous polymeric filaments around the surface of the
mandrel 11, the portions of the filaments at the inside surface having a different polymeric composition from the portions of the filaments of the outside surface of the fibrous structure. This can be advantageous when the tubular fibrous structures are used for, for example, synthetic vascular grafts. It has been found that different polymers have different haemocompatibilities and that different polymers have different strength characteristics. In a particular example, one polyurethane has advantageous haemocompatibility but poor elastic properties, exhibiting high creep. A second polyurethane having a higher Young's modulus has satisfactory strength properties but poor haemocompatibility. The apparatus of Figure 1, as will be described in the following example, allows production of a synthetic vascular graft having a thin inner lining of the first polyurethane on a wall of the second polyurethane, the graft, however, being formed of fibres spun continuously, with individual fibres changing composition between their ends to provide an integral, uninterrupted, fibrous structure. - The sequence of operation of the apparatus of Figure 1 in this example is as follows:-
- 1. Fill the
syringe 24 with a first polymer dope and fill thesyringe 23 with a second polymer dope. - 2. Using the
valves tube 14 with the second polymer dope and then prime thetube 15 and themanifold 13 with first polymer dope. - 3. With the
valves syringe 24, thetube 15 and themanifold 13. - 4. After a time, open the
valve 19 and close thevalve 20. After expression of remaining first polymer dope out of theneedles 10, spinning continues in an uninterrupted fashion with second polymer. - 5. The abruptness of the transition from the first polymer dope to the second polymer dope is a function of the rate of flow of second polymer dope into the
manifold 13 and the volume of themanifold 13,needles 10 andT junction 16. This transition can be controlled by the use of thevalve 26 on thepurge line 25 which can be used to vent at a variable rate remaining first polymer dope. The concentration gradient of the two polymers in the graft wall will follow a defined, controllable relationship as illustrated in Figure 2 where the solid line shows an abrupt change where thevalve 26 is used and the chain line shows a slow change. - A further development of the first example arises in that on porosity testing, it was found that the permeability of the bi-layer graft was too high. A situation was envisaged where transmural flow of blood or plasma might lead to excessive blood platelet capture on the inner surface and compromise the thromboresistance of the graft. The solution here would be to include an outer layer of a third polymer, for example one having a high Young's modulus, which when deposited on the second polymer produces a dense matrix with low interstitial volume. In this way, the overall graft wall permeability is determined by this outer layer. Figure 3 shows in cross section part of a bi-layer graft. The further development would mean addition of an outer layer of a third polymer to the graft shown in Figure 3.
- Many different polymers can be used in the electrostatic spinning process. Several examples are given in U.S. Patent Specification No. 4044404, such as polyurethanes, polyamides and polyacrylonitrile, all of which can be spun from solution, and polytetrafluorethylene and polyesters which may be spun from dispersion. Water soluble polymers such as polyvinyl alcohol, polyvinyl pyrrolidone and polyethylene oxide may be spun from aqueous solution.
- The constraint on the fibrous structure and method of production according to the invention is that the two or more polymers used to vary the composition of the filaments during the spinning process must be either dispersible or alternatively soluble in the same solvent system. Thus it would be possible to spin with different polyurethanes, as used in the preferred example, or with different polyesters in dispersion, but it would not be possible to change, for example, from a polyurethane to a polyester.
- It will also be appreciated that the properties of a particular polymeric composition may be varied by the presence of an additive, even if the polymeric composition itself does not vary along the length of a filament. For example, a silicone lubricant could be added to a polyurethane polymer and spun as the inner surface of a graft, the outer surface of the graft being the same polyurethane without the silicone lubricant. Such an example is included in the scope of the invention.
- The advantage of the embodiments of grafts hereinbefore described are that the different layers can be optimised for particular properties, either in its morphology (e.g. porosity, pore shape, fibre size) or in its chemistry (e.g. type of polymer, presence of drug. For example, a drug such as heparin or prostacyclin may be included in the inner layer to improve the property with regard to contacting blood). If such layers are built up discontinuously, lines of weakness exist between the contiguous surfaces and delamination is likely to occur at quite low mechanical stresses. The advantage of the method hereinbefore described is that it builds different layers into an integrally formed fibrous structure so that the successive wall components are merged in a well controlled way.
- An illustration of the advantage of a bi-layer graft according to the example described is that in an initial canine common carotid trial, a 300% improvement in patency over non-laminated, single component grafts were found. Other possibilities, for example pledgets and drug releasing vascular grafts are also quite possible.
- It will be appreciated that while the embodiments described relate to tubular fibrous structures for use as vascular grafts, the invention is equally applicable to planar fibrous structures such as mats and that such alternative structures would have wide applications.
Claims (13)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT84304891T ATE40424T1 (en) | 1983-07-21 | 1984-07-18 | FIBROUS STRUCTURES. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB08319727A GB2145443B (en) | 1983-07-21 | 1983-07-21 | Improvements in fibrous structures |
GB8319727 | 1983-07-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0132376A2 EP0132376A2 (en) | 1985-01-30 |
EP0132376A3 EP0132376A3 (en) | 1986-10-01 |
EP0132376B1 true EP0132376B1 (en) | 1989-01-25 |
Family
ID=10546086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP84304891A Expired EP0132376B1 (en) | 1983-07-21 | 1984-07-18 | Improvements in fibrous structures |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0132376B1 (en) |
JP (1) | JPS60190947A (en) |
AT (1) | ATE40424T1 (en) |
AU (1) | AU558207B2 (en) |
BR (1) | BR8403634A (en) |
CA (1) | CA1248720A (en) |
DE (1) | DE3476432D1 (en) |
DK (1) | DK357184A (en) |
ES (1) | ES534506A0 (en) |
GB (1) | GB2145443B (en) |
HK (2) | HK67187A (en) |
SG (2) | SG6887G (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111317594A (en) * | 2020-02-28 | 2020-06-23 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2195251A (en) * | 1986-09-02 | 1988-04-07 | Ethicon Inc | Improvements in synthetic vascular grafts |
US7780973B2 (en) * | 2003-12-15 | 2010-08-24 | Ethicon Endo-Surgery, Inc. | Method and device for minimally invasive implantation of biomaterial |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1527592A (en) * | 1974-08-05 | 1978-10-04 | Ici Ltd | Wound dressing |
GB1530990A (en) * | 1974-08-05 | 1978-11-01 | Ici Ltd | Electrostatically spun tubular product |
DE2806030C2 (en) * | 1978-02-14 | 1984-02-02 | B. Braun Melsungen Ag, 3508 Melsungen | Process for the production of a tubular blood vessel prosthesis |
-
1983
- 1983-07-21 GB GB08319727A patent/GB2145443B/en not_active Expired
-
1984
- 1984-07-18 AT AT84304891T patent/ATE40424T1/en not_active IP Right Cessation
- 1984-07-18 DE DE8484304891T patent/DE3476432D1/en not_active Expired
- 1984-07-18 EP EP84304891A patent/EP0132376B1/en not_active Expired
- 1984-07-18 JP JP59147749A patent/JPS60190947A/en active Pending
- 1984-07-19 CA CA000459285A patent/CA1248720A/en not_active Expired
- 1984-07-20 AU AU30924/84A patent/AU558207B2/en not_active Ceased
- 1984-07-20 ES ES534506A patent/ES534506A0/en active Granted
- 1984-07-20 BR BR8403634A patent/BR8403634A/en unknown
- 1984-07-20 DK DK357184A patent/DK357184A/en not_active Application Discontinuation
-
1987
- 1987-02-02 SG SG68/87A patent/SG6887G/en unknown
- 1987-09-17 HK HK671/87A patent/HK67187A/en not_active IP Right Cessation
-
1989
- 1989-04-14 SG SG256/89A patent/SG25689G/en unknown
- 1989-08-24 HK HK684/89A patent/HK68489A/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111317594A (en) * | 2020-02-28 | 2020-06-23 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
CN111317594B (en) * | 2020-02-28 | 2023-10-20 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
Also Published As
Publication number | Publication date |
---|---|
DE3476432D1 (en) | 1989-03-02 |
HK68489A (en) | 1989-09-01 |
ATE40424T1 (en) | 1989-02-15 |
DK357184A (en) | 1985-01-22 |
ES8603776A1 (en) | 1986-01-01 |
GB2145443B (en) | 1986-07-23 |
AU3092484A (en) | 1985-01-24 |
HK67187A (en) | 1987-09-25 |
GB2145443A (en) | 1985-03-27 |
ES534506A0 (en) | 1986-01-01 |
AU558207B2 (en) | 1987-01-22 |
SG6887G (en) | 1987-06-05 |
JPS60190947A (en) | 1985-09-28 |
CA1248720A (en) | 1989-01-17 |
DK357184D0 (en) | 1984-07-20 |
EP0132376A2 (en) | 1985-01-30 |
SG25689G (en) | 1989-07-14 |
BR8403634A (en) | 1985-07-02 |
GB8319727D0 (en) | 1983-08-24 |
EP0132376A3 (en) | 1986-10-01 |
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