EP0127605A3 - Process for obtaining preparations of human blood plasma - Google Patents

Process for obtaining preparations of human blood plasma Download PDF

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Publication number
EP0127605A3
EP0127605A3 EP84890089A EP84890089A EP0127605A3 EP 0127605 A3 EP0127605 A3 EP 0127605A3 EP 84890089 A EP84890089 A EP 84890089A EP 84890089 A EP84890089 A EP 84890089A EP 0127605 A3 EP0127605 A3 EP 0127605A3
Authority
EP
European Patent Office
Prior art keywords
plasma
preparations
human blood
blood plasma
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84890089A
Other languages
German (de)
French (fr)
Other versions
EP0127605A2 (en
Inventor
Johann Dr. Eibl
Günter Prof. Dr. Wöber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oesterreichisches Institut fuer Haemoderivate
Original Assignee
Immuno AG fuer Chemisch Medizinische Produkte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno AG fuer Chemisch Medizinische Produkte filed Critical Immuno AG fuer Chemisch Medizinische Produkte
Publication of EP0127605A2 publication Critical patent/EP0127605A2/en
Publication of EP0127605A3 publication Critical patent/EP0127605A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Es wird ein verfahren zur Herstellung von Präparationen aus menschlichem Blutplasma, wie Gerinnungsfaktor­ präparationen, Globulinpräparationen, Plasmaenzymen und Plasmaenzyminhibitoren beschrieben, wobei der Plasmafrak­ tion zur Inaktivierung etwa vorhandener vermehrungsfähiger Krankheitserreger Verbindungsgemische zugesetzt werden, die in freie Radikale zerfallen. Solche Verbindungen können Alkylperoxide, Acylperoxide, Peroxysäuren, Peroxyester und Peroxycarbonate sein. Es können Katalysatoren mitverwen­ det werden. There is a process for the preparation of preparations from human blood plasma, such as coagulation factor preparations, globulin preparations, plasma enzymes and Plasma enzyme inhibitors described, the plasma fracture tion to inactivate any existing reproductive Pathogen compound mixtures are added that decay into free radicals. Such connections can Alkyl peroxides, acyl peroxides, peroxy acids, peroxy esters and Be peroxycarbonates. Catalysts can be used be det.

In Versuchen, bei welchen Hundehepatitisvirus zu den Plasmafraktionen zugesetzt wird, wird gezeigt, daß nach Behandlung der Plasmafraktionen mit freien Radikalen der Virustiter um mindestens vier Zehnerpotenzen abfällt, während die Aktivität der Plasmafraktionen im wesentlichen erhalten bleibt. In experiments in which canine hepatitis virus If plasma fractions are added, it is shown that after Treatment of plasma fractions with free radicals Virus titer drops by at least four powers of ten, while the activity of the plasma fractions essentially preserved.

EP84890089A 1983-05-31 1984-05-17 Process for obtaining preparations of human blood plasma Withdrawn EP0127605A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT1983/83 1983-05-31
AT0198383A AT382078B (en) 1983-05-31 1983-05-31 METHOD FOR PRODUCING PREPARATIONS FROM HUMAN BLOOD PLASMA

Publications (2)

Publication Number Publication Date
EP0127605A2 EP0127605A2 (en) 1984-12-05
EP0127605A3 true EP0127605A3 (en) 1987-01-28

Family

ID=3525303

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84890089A Withdrawn EP0127605A3 (en) 1983-05-31 1984-05-17 Process for obtaining preparations of human blood plasma

Country Status (6)

Country Link
EP (1) EP0127605A3 (en)
JP (1) JPS606620A (en)
AT (1) AT382078B (en)
CA (1) CA1211709A (en)
DK (1) DK265084A (en)
ES (1) ES532863A0 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805459A1 (en) * 1988-02-22 1989-08-31 Biotest Pharma Gmbh METHOD FOR STERILIZING BLOOD, PLASMA, BLOOD AND PLASMA DERIVATIVES, CELL SUSPENSIONS OR THE LIKE
GB9015910D0 (en) * 1990-07-19 1990-09-05 Univ Bruxelles Novel use
EP0605690A4 (en) * 1992-06-29 1994-12-07 Edward Shanbrom Povidone hydrogen peroxide preservation of blood, tissues and biological fluids.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617500A1 (en) * 1967-03-30 1971-04-08 Gaebelein Klaus Dipl Chem Dr Preservation of blood plasma
FR2400906A1 (en) * 1978-08-22 1979-03-23 Evers Hans Disinfecting and cleaning contact lenses without allergic reaction - with cold soln. contg. ene:diol redox system, water-soluble oxidising agent and opt. heavy metal salt catalyst
EP0037078A2 (en) * 1980-03-27 1981-10-07 Green Cross Corporation Process for heat treatment of aqueous solution containing human blood coagulation factor XIII
WO1982003871A1 (en) * 1981-04-27 1982-11-11 Baxter Travenol Lab Process for making novel blood clotting enzyme compositions
DE3134050A1 (en) * 1981-08-28 1983-03-10 Dr. Franz Köhler Chemie GmbH, 6146 Alsbach Solution for sterilising and removing pyrogens from stainless steel lines and filters in a closed system
EP0139994A1 (en) * 1983-08-25 1985-05-08 Allergan, Inc. Process and kit for disinfection of contact lenses

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617500A1 (en) * 1967-03-30 1971-04-08 Gaebelein Klaus Dipl Chem Dr Preservation of blood plasma
FR2400906A1 (en) * 1978-08-22 1979-03-23 Evers Hans Disinfecting and cleaning contact lenses without allergic reaction - with cold soln. contg. ene:diol redox system, water-soluble oxidising agent and opt. heavy metal salt catalyst
EP0037078A2 (en) * 1980-03-27 1981-10-07 Green Cross Corporation Process for heat treatment of aqueous solution containing human blood coagulation factor XIII
WO1982003871A1 (en) * 1981-04-27 1982-11-11 Baxter Travenol Lab Process for making novel blood clotting enzyme compositions
DE3134050A1 (en) * 1981-08-28 1983-03-10 Dr. Franz Köhler Chemie GmbH, 6146 Alsbach Solution for sterilising and removing pyrogens from stainless steel lines and filters in a closed system
EP0139994A1 (en) * 1983-08-25 1985-05-08 Allergan, Inc. Process and kit for disinfection of contact lenses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS/RRM, Band 13, Zusammenfassung 1724; M. SPROESSIG et al.: "Serum sterilization in cold by per acetic-acid", & JOURNAL OF HYGIENE EPIDEMIOLOGY MICROBIOLOGY AND IMMUNOLOGY (PRAGUE) (CZECHOSLOVAKIA) 1976, Band 20, Nr. 2, Seiten 157-163 *
THE JOURNAL OF IMMUNOLOGY, Band 124, Nr. 3, M{rz 1980, Seiten 1378-1382, The Williams & Wilkins Co., US; E.C. JONG et al.: "Bactericidal activity of eosinophil peroxidase" *

Also Published As

Publication number Publication date
ATA198383A (en) 1986-06-15
AT382078B (en) 1987-01-12
ES8506449A1 (en) 1985-08-01
JPS606620A (en) 1985-01-14
CA1211709A (en) 1986-09-23
DK265084A (en) 1984-12-01
DK265084D0 (en) 1984-05-29
EP0127605A2 (en) 1984-12-05
ES532863A0 (en) 1985-08-01

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Inventor name: EIBL, JOHANN, DR.

Inventor name: WOEBER, GUENTER, PROF. DR.