EP0124363A3 - Photochemical decontamination treatment of whole blood or blood components - Google Patents

Photochemical decontamination treatment of whole blood or blood components Download PDF

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Publication number
EP0124363A3
EP0124363A3 EP84302845A EP84302845A EP0124363A3 EP 0124363 A3 EP0124363 A3 EP 0124363A3 EP 84302845 A EP84302845 A EP 84302845A EP 84302845 A EP84302845 A EP 84302845A EP 0124363 A3 EP0124363 A3 EP 0124363A3
Authority
EP
European Patent Office
Prior art keywords
blood
decontamination treatment
whole blood
photochemical decontamination
components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84302845A
Other versions
EP0124363B1 (en
EP0124363A2 (en
Inventor
Gary P. Wiesehahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Advanced Genetics Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Genetics Research Institute filed Critical Advanced Genetics Research Institute
Priority to AT84302845T priority Critical patent/ATE59145T1/en
Publication of EP0124363A2 publication Critical patent/EP0124363A2/en
Publication of EP0124363A3 publication Critical patent/EP0124363A3/en
Application granted granted Critical
Publication of EP0124363B1 publication Critical patent/EP0124363B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Anesthesiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • External Artificial Organs (AREA)

Abstract

Biological compositions are freed of functional polynucleotides by treatment of the biological composition with psoralen derivatives under irradiation conditions in which the proteins retain their original physiological activities and any polynucleotide present is rendered inactive.
EP84302845A 1983-05-02 1984-04-27 Photochemical decontamination treatment of whole blood or blood components Expired - Lifetime EP0124363B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84302845T ATE59145T1 (en) 1983-05-02 1984-04-27 PHOTOCHEMICAL PURIFICATION TREATMENT OF WHOLE BLOOD OR BLOOD COMPONENTS.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49068183A 1983-05-02 1983-05-02
US490681 1983-05-02

Publications (3)

Publication Number Publication Date
EP0124363A2 EP0124363A2 (en) 1984-11-07
EP0124363A3 true EP0124363A3 (en) 1985-07-03
EP0124363B1 EP0124363B1 (en) 1990-12-19

Family

ID=23949050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84302845A Expired - Lifetime EP0124363B1 (en) 1983-05-02 1984-04-27 Photochemical decontamination treatment of whole blood or blood components

Country Status (7)

Country Link
EP (1) EP0124363B1 (en)
JP (1) JPS6016930A (en)
AT (1) ATE59145T1 (en)
AU (1) AU563557B2 (en)
CA (1) CA1224622A (en)
DE (1) DE3483751D1 (en)
ZA (1) ZA843270B (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK507185A (en) * 1984-11-05 1986-05-06 Du Pont METHOD OF INACTIVATING HUMAN TUMOR LEUKAEMI VIRUS III
JPS61275228A (en) * 1985-03-14 1986-12-05 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテツド Photodynamic inactivity of virus in therapeutical protein composition
US4789545A (en) * 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
US4775625A (en) * 1986-11-21 1988-10-04 The Medical College Of Wisconsin, Inc. Inactivating enveloped viruses with a merocyanine dye
US4878891A (en) † 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US5571666A (en) * 1988-10-28 1996-11-05 Oklahoma Medical Research Foundation Thiazine dyes used to inactivate HIV in biological fluids
IL92996A (en) * 1989-01-10 1996-06-18 Bisaccia Emil Photoactive compounds as medicaments for the treatment of virus infections and method for production of vaccines
WO1991006665A1 (en) * 1989-10-26 1991-05-16 Isaacs Stephen T Activation compounds and methods for nucleic acid sterilization
US5503721A (en) 1991-07-18 1996-04-02 Hri Research, Inc. Method for photoactivation
US6187572B1 (en) 1990-04-16 2001-02-13 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5516629A (en) 1990-04-16 1996-05-14 Cryopharm Corporation Photoinactivation of viral and bacterial blood contaminants using halogenated coumarins
WO1991016060A1 (en) * 1990-04-16 1991-10-31 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5232844A (en) * 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5712086A (en) * 1990-05-15 1998-01-27 New York Blood Center, Inc. Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions
US5981163A (en) 1990-05-15 1999-11-09 New York Blood Center, Inc. Process for the sterilization of biological compositions using irradiation and quenchers of type I and type II photodynamic reactions
DE4136900C1 (en) * 1991-11-09 1993-07-29 Schaper & Bruemmer Gmbh & Co Kg, 3320 Salzgitter, De
EP0633786B1 (en) * 1992-01-27 2001-08-01 Baxter International Inc. Method of inactivation of viral, parasitic and bacterial blood contaminants
US5288605A (en) * 1992-03-02 1994-02-22 Steritech, Inc. Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
CA2141803C (en) * 1992-08-07 2003-06-17 Lily Lin Methods for inactivating bacteria in blood preparations with 8-methoxypsoralen
US5399719A (en) * 1993-06-28 1995-03-21 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US5556993A (en) 1993-06-28 1996-09-17 Steritech, Inc. Compounds for the photodecontamination of pathogens in blood
US6420570B1 (en) 1993-06-28 2002-07-16 Cerus Corporation Psoralen compounds
US6319662B1 (en) 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
US6258577B1 (en) 1998-07-21 2001-07-10 Gambro, Inc. Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers
US7186543B1 (en) 1998-07-21 2007-03-06 Gambro Inc. Preparation of vaccines using a photosensitizer and light
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
US7648699B2 (en) 2000-06-02 2010-01-19 Caridianbct Biotechnologies, Llc Preventing transfusion related complications in a recipient of a blood transfusion
TW590780B (en) 2000-06-02 2004-06-11 Gambro Inc Additive solutions containing riboflavin
US7985588B2 (en) 2000-06-02 2011-07-26 Caridianbct Biotechnologies, Llc Induction of and maintenance of nucleic acid damage in pathogens using riboflavin and light
US9044523B2 (en) 2000-06-15 2015-06-02 Terumo Bct, Inc. Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light
AU2002366708A1 (en) * 2001-12-20 2003-07-09 Gambro, Inc. Preparation of vaccines using photosensitizer and light
NL2000281C2 (en) 2005-11-02 2007-08-07 Pfizer Prod Inc Solid pharmaceutical compositions containing pregabalin.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686395A (en) * 1966-04-06 1972-08-22 Biotest Serum Institut Gmbh Process for preparation of storage stable hepatitis-free serum
EP0030358A2 (en) * 1979-12-11 1981-06-17 Leukocyte Research, Inc. Apparatus for reducing the functioning lymphocyte population in blood
EP0047462A2 (en) * 1980-09-10 1982-03-17 Biotest-Serum-Institut GmbH Method for the cold-sterilisation of preparations containing blood coagulation factor VIII
EP0066886A2 (en) * 1981-06-09 1982-12-15 Lee H. Kronenberg Inactivated target cells, methods of using same and vaccines and diagnostic kits containing same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686395A (en) * 1966-04-06 1972-08-22 Biotest Serum Institut Gmbh Process for preparation of storage stable hepatitis-free serum
EP0030358A2 (en) * 1979-12-11 1981-06-17 Leukocyte Research, Inc. Apparatus for reducing the functioning lymphocyte population in blood
EP0047462A2 (en) * 1980-09-10 1982-03-17 Biotest-Serum-Institut GmbH Method for the cold-sterilisation of preparations containing blood coagulation factor VIII
EP0066886A2 (en) * 1981-06-09 1982-12-15 Lee H. Kronenberg Inactivated target cells, methods of using same and vaccines and diagnostic kits containing same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 87, No. 11, 8 September 12, 1977, page 98, abstract no. 78962f, Columbus, Ohio (US) J.E. HEARST et al.: "The photoinactivation of an RNA animal virus, vesicular stomatiti virus, with the aid of newly synthesized psoralen derivatives"; & Nucleic Acids Res. 1977, 4 (5), 1339-47 *
EXPERIENTIA, Vol. 21, No. 1, January 15, 1965, pages 22-24, Birkhauser Verlag, Basel. (CH) L. MUSAJO et al.: "Photosensitizing furocoumarins: interaction with DNA and photo-inactivation of DNA containing viruses" *

Also Published As

Publication number Publication date
AU2752184A (en) 1984-11-08
JPS6016930A (en) 1985-01-28
ATE59145T1 (en) 1991-01-15
AU563557B2 (en) 1987-07-16
ZA843270B (en) 1984-11-28
CA1224622A (en) 1987-07-28
EP0124363B1 (en) 1990-12-19
JPH0572366B2 (en) 1993-10-12
DE3483751D1 (en) 1991-01-31
EP0124363A2 (en) 1984-11-07

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