EP0118179A1 - Blister pack - Google Patents

Blister pack Download PDF

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Publication number
EP0118179A1
EP0118179A1 EP84300419A EP84300419A EP0118179A1 EP 0118179 A1 EP0118179 A1 EP 0118179A1 EP 84300419 A EP84300419 A EP 84300419A EP 84300419 A EP84300419 A EP 84300419A EP 0118179 A1 EP0118179 A1 EP 0118179A1
Authority
EP
European Patent Office
Prior art keywords
blister
sheet
strip pack
lidding
pack
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84300419A
Other languages
German (de)
French (fr)
Inventor
Gerhard Thomas Schwartz
Bruce Reynolds Inglis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wiggins Teape Group Ltd
Original Assignee
Wiggins Teape Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838303600A external-priority patent/GB8303600D0/en
Application filed by Wiggins Teape Group Ltd filed Critical Wiggins Teape Group Ltd
Publication of EP0118179A1 publication Critical patent/EP0118179A1/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/04—Articles or materials wholly enclosed in single sheets or wrapper blanks
    • B65D75/20—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/22—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding the sheet or blank being recessed to accommodate contents
    • B65D75/24—Articles or materials wholly enclosed in single sheets or wrapper blanks in sheets or blanks doubled around contents and having their opposed free margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding the sheet or blank being recessed to accommodate contents and formed with several recesses to accommodate a series of articles or quantities of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

Definitions

  • This invention relates to a blister pack of the kind which can be used for packing various kinds of articles, and which is particularly although not exclusively applicable for packing medicines in the form of tablets, capsules or the like.
  • blister pack consists of a polyvinyl chloride sheet which has been formed by heat and pressure into blisters.
  • the articles to be packed are then placed in the blisters and a lidding sheet of aluminium foil applied over the flat surface of the blister sheet to seal the blisters.
  • the lidding sheet is sealed to the blister sheet by various means, for example a hot melt adhesive in a heat sealing process. Because of the nature of the pack and the manufacturing process, it is only practicable to manufacture such packs under factory conditions. As a result: production is limited to the packaging of standard packs, for example aspirin tablets.
  • the object of the present invention is to provide a blister pack incorporating a low cost lidding sheet which can be applied without the use of specialised apparatus, and which is cheap to produce.
  • a blister or strip pack comprises a blister sheet which is formed to provide one or more blister cavities and a lidding sheet of paper adhered thereto to seal said cavity or cavities.
  • the lidding sheet is preferably made from papers such as glassine; greaseproof, tracing or vegetable parchment which exhibit high burst and low tear resistance characteristics. Where it is desirable to heighten resistance to moisture transmission, this can be achieved by suitable treatment during manufacture of the paper or by applying coatings subsequently. Certain adhesives with which the paper may be coated for adhesion to the blister sheet may also provide this barrier property.
  • the adhesion between the paper lidding and the blister sheet is such that the paper tears rather than peels from the blister sheet.
  • the residual ruptured lidding fragments remaining when one blister has been opened tear off if attempts are made to peel them back to open another blister.
  • the lidding sheet and the blister sheet are both provided with coatings of mutually adherent high tack dry latex adhesive. A layer of such adhesive will only adhere to another layer of the same adhesive, thus obviating the necessity to'provide protective release sheets.
  • the lidding sheet and the blister sheet are both provided with coatings of high tack self-adhesive, each carrying a release sheet which can be stripped from the adhesive layer when the pack is to be assembled.
  • the pack components do.not require factory conditions for assembly and can be put together by, for example, a pharmacist in a shop or hospital and used for packing tablets in a programmed dosage form.
  • the lidding sheet may carry indicia and may be printed or typed upon prior to assembly so that dosage instructions specific to the patient can be set out on the pack.
  • the lidding sheet of the invention may of course be used in a factory context if required.
  • a hot melt adhesive is applied so that the lidding may be heat sealed, for example to polyvinyl chloride blister packs.
  • a suitably coated lidding sheet according to the invention can be used with many forms of blister sheet material, for example a sheet material made from a blend of cellulose and synthetic wood pulp fibres as set forth in the Applicants co-pending EPA No. filed 24.01.1984 Ref W .87 corresponding to United Kingdom Patent Application No. 83 03600 filed 9th February 1983.
  • the lidding paper can embody a metal layer. This can be provided either by lamination or vacuum deposition and it may for example be of aluminium. Where such a metallic layer is provided, a similar layer may be provided on the blister sheet.
  • the blister sheet may be provided with any number of blister cavities appropriate to the number of articles to be packed.
  • a blister sheet 1 is made from a mixture of cellulosic and fibrillated synthetic thermoplastic fibres as set forth in the Applicants co-pending EPA No. filed 24.01.1984 Ref W.87
  • the synthetic fibres used are those sold under the Trade name SWP by Crown Zellerbach Corporation.
  • the proportion of fibrillated thermoplastic polymer desirable in the paper sheet will vary with the deptch and configuration of the blister cavities to be formed.
  • the thermoplastic polymer therefore is between 75% and 80% and is made up from approximately 75% fibrillated fibres and 25% particulate material.
  • the remainder of the blend comprises the cellulosic and staple fibre material and this can be hardwood sulphate pulp.
  • pigement such as titanium dioxide is also included.
  • An alternative blend of materials suitable for the construction shown in Figures 1 and 2 comprises a blend of synthetic thermoplastic fibre material of the kind sold under the Trade name PULPEX EA by Solvay et Cie.
  • high translucencey is achieved by including thermoplastic polymer amounting to about 85% of the blend, the remainder aqain being hardwood sulphate pulp.
  • at least 60% of the thermoplastic polymer is in fibrillated form, the remainder being particulate.
  • the sheet may be formed on a conventional papermaking machine and when it is to be made up into a blister sheet it is moulded by thermal deformation to provide blisters 2.
  • the blister sheet 1 has coated thereon a layer of high tack dry latex adhesive 3 and contains within its blisters 3 drug tablets 4.
  • a lidding sheet 5 carries thereon a layer 6 of the same high tack dry latex adhesive.
  • the adhesive layers 3 and 6 are mutually adhesive but will not adhere to any other surface.
  • The are sealed together at the locations 7 between the blisters so that each tablet 4 is isolated.
  • the lidding sheet 5 is made of paper, and preferably of a paper having high burst and low tear resistance characteristics. This ensures that inadvertent rupture of the lidding sheet is minimised whilst ensuring that after intentional rupture, it will tear easily to release a selected tablet.
  • Such papers are examplified by glassinge, greaseproof, tracing and vegetable parchment papers, burst and tear characteristics for which are set out in the following table
  • FIG 3 shows a modification of the embodiment of Figures 1 and 2 particularly suited for packing articles 10 which are susceptible to ultra violet and/or hygroscopic degeneration.
  • the construction and assembly of the blister pack is generally as described above with-reference to Figures 1 and 2 and where appropriate, the various parts are designated by the same reference numerals.
  • the outer surfaces of the blister and lidding sheets 1 and 5 are provided with metal layers in 11 and 12 respectively.
  • the metal layers are provided by vacuum deposition.
  • the provision of a metal layer has a further advantage in that it renders both the blister pack and lidding sheet opaque and thus conceals the contents from children who might otherwise identify them as sweets or candies.

Abstract

A blister or strip pack comprising a blister sheet (1) formed to provide one or more blister cavities (2) and a liding sheet (5) of paper adhered thereto to seal said cavity or cavities.

Description

  • This invention relates to a blister pack of the kind which can be used for packing various kinds of articles, and which is particularly although not exclusively applicable for packing medicines in the form of tablets, capsules or the like.
  • One known form of blister pack consists of a polyvinyl chloride sheet which has been formed by heat and pressure into blisters. The articles to be packed are then placed in the blisters and a lidding sheet of aluminium foil applied over the flat surface of the blister sheet to seal the blisters. The lidding sheet is sealed to the blister sheet by various means, for example a hot melt adhesive in a heat sealing process. Because of the nature of the pack and the manufacturing process, it is only practicable to manufacture such packs under factory conditions. As a result: production is limited to the packaging of standard packs, for example aspirin tablets.
  • The object of the present invention is to provide a blister pack incorporating a low cost lidding sheet which can be applied without the use of specialised apparatus, and which is cheap to produce.
  • According to the present invention therefore a blister or strip pack comprises a blister sheet which is formed to provide one or more blister cavities and a lidding sheet of paper adhered thereto to seal said cavity or cavities.
  • The lidding sheet is preferably made from papers such as glassine; greaseproof, tracing or vegetable parchment which exhibit high burst and low tear resistance characteristics. Where it is desirable to heighten resistance to moisture transmission, this can be achieved by suitable treatment during manufacture of the paper or by applying coatings subsequently. Certain adhesives with which the paper may be coated for adhesion to the blister sheet may also provide this barrier property.
  • Where child resistance is an important characteristic required in the blister pack, the adhesion between the paper lidding and the blister sheet is such that the paper tears rather than peels from the blister sheet. As a result, the residual ruptured lidding fragments remaining when one blister has been opened tear off if attempts are made to peel them back to open another blister.
  • In one embodiment, the lidding sheet and the blister sheet are both provided with coatings of mutually adherent high tack dry latex adhesive. A layer of such adhesive will only adhere to another layer of the same adhesive, thus obviating the necessity to'provide protective release sheets. In another embodiment, the lidding sheet and the blister sheet are both provided with coatings of high tack self-adhesive, each carrying a release sheet which can be stripped from the adhesive layer when the pack is to be assembled.
  • Thus the pack components do.not require factory conditions for assembly and can be put together by, for example, a pharmacist in a shop or hospital and used for packing tablets in a programmed dosage form. The lidding sheet may carry indicia and may be printed or typed upon prior to assembly so that dosage instructions specific to the patient can be set out on the pack.
  • Although of particular advantage for use in non- industrial contexts, the lidding sheet of the invention may of course be used in a factory context if required. In this case, a hot melt adhesive is applied so that the lidding may be heat sealed, for example to polyvinyl chloride blister packs.
  • A suitably coated lidding sheet according to the invention can be used with many forms of blister sheet material, for example a sheet material made from a blend of cellulose and synthetic wood pulp fibres as set forth in the Applicants co-pending EPA No. filed 24.01.1984 Ref W.87 corresponding to United Kingdom Patent Application No. 83 03600 filed 9th February 1983.
  • If the articles to be packed are likely to be subject to hygroscopic or ultra violet generation, the lidding paper can embody a metal layer. This can be provided either by lamination or vacuum deposition and it may for example be of aluminium. Where such a metallic layer is provided, a similar layer may be provided on the blister sheet. The blister sheet may be provided with any number of blister cavities appropriate to the number of articles to be packed.
  • The invention will be further described with reference to the accompanying drawings in which
    • Figure 1 is a cross-sectional view of a blister pack according to the invention;
    • Figure 2 is a cross-sectional view on the line II-II of Figure 1; and,
    • Figure 3 is a cross-sectional view through a second embodiment which is suitable for use with tablets susceptible to hygroscopic or ultra violet degeneration.
  • In the construction shown in Figures 1 and 2 a blister sheet 1 is made from a mixture of cellulosic and fibrillated synthetic thermoplastic fibres as set forth in the Applicants co-pending EPA No. filed 24.01.1984 Ref W.87 The synthetic fibres used are those sold under the Trade name SWP by Crown Zellerbach Corporation. The proportion of fibrillated thermoplastic polymer desirable in the paper sheet will vary with the deptch and configuration of the blister cavities to be formed. The thermoplastic polymer therefore is between 75% and 80% and is made up from approximately 75% fibrillated fibres and 25% particulate material. The remainder of the blend comprises the cellulosic and staple fibre material and this can be hardwood sulphate pulp.
  • In order to provide opacity to the sheet a proportion of pigement such as titanium dioxide is also included.
  • An alternative blend of materials suitable for the construction shown in Figures 1 and 2 comprises a blend of synthetic thermoplastic fibre material of the kind sold under the Trade name PULPEX EA by Solvay et Cie. In this blend high translucencey is achieved by including thermoplastic polymer amounting to about 85% of the blend, the remainder aqain being hardwood sulphate pulp. Once again with this embodiment at least 60% of the thermoplastic polymer is in fibrillated form, the remainder being particulate.
  • The sheet may be formed on a conventional papermaking machine and when it is to be made up into a blister sheet it is moulded by thermal deformation to provide blisters 2. The blister sheet 1 has coated thereon a layer of high tack dry latex adhesive 3 and contains within its blisters 3 drug tablets 4.
  • A lidding sheet 5 carries thereon a layer 6 of the same high tack dry latex adhesive. The adhesive layers 3 and 6 are mutually adhesive but will not adhere to any other surface. The are sealed together at the locations 7 between the blisters so that each tablet 4 is isolated.
  • The lidding sheet 5 is made of paper, and preferably of a paper having high burst and low tear resistance characteristics. This ensures that inadvertent rupture of the lidding sheet is minimised whilst ensuring that after intentional rupture, it will tear easily to release a selected tablet. Such papers are examplified by glassinge, greaseproof, tracing and vegetable parchment papers, burst and tear characteristics for which are set out in the following table
    Figure imgb0001
  • In the foregoing embodiment, the use of layers of mutually adherent high tack dry latex adhesive has been proposed. However, it will be'appreciated that self-adhesive layers may be readily substituted, in which case, release sheets, coated for example with silicone release coatings will be applied to the adhesive coatings as a protection, the release sheets being stripped off before the blister and lidding sheets are sealed together. Alternatively, where the lidding sheet is to be sealed to a blister sheet comprising thermoplastic material, such as polyvinyl choride or polyethylene, it may carry a layer of hot melt adhesive. In this case, the lidding sheet will be sealed to the blister sheet by appropriate heat sealing equipment.
  • Referring now to Figure 3, this shows a modification of the embodiment of Figures 1 and 2 particularly suited for packing articles 10 which are susceptible to ultra violet and/or hygroscopic degeneration. The construction and assembly of the blister pack is generally as described above with-reference to Figures 1 and 2 and where appropriate, the various parts are designated by the same reference numerals. In this case however the outer surfaces of the blister and lidding sheets 1 and 5 are provided with metal layers in 11 and 12 respectively. The metal layers are provided by vacuum deposition. The provision of a metal layer has a further advantage in that it renders both the blister pack and lidding sheet opaque and thus conceals the contents from children who might otherwise identify them as sweets or candies.

Claims (12)

1. A blister or strip pack comprising a blister sheet formed to provide one or more blister cavities and a lidding sheet of paper adhered thereto to seal said cavity or cavities.
2. A blister or strip pack as claimed in claim 1 in which the lidding sheet paper is glassine, greaseproof, tracing or vegetable parchment.
3. A blister or strip pack as claimed in claim 1 or claim 2 in which the paper is coated to heighten resistance to moisture.
4. A blister or strip pack as claimed in claims 1 to 3 in which the adhesion of the lidding sheet to the blister sheet is such that the paper tears rather than peels from the blister sheet.
5. A blister or strip pack as claimed in claims 1 to 4 in which the lidding sheet and blister sheet are both provided with mutually adherent high tack dry latex adhesive.
6. A blister or strip pack as claimed in claims 1 to 4 in which the lidding sheet and blister sheet are both provided with coatings or high tack self-adhesive each carrying a release sheet which can be stripped from the adhesive layer when the pack is to be assembled.
7. A blister or strip pack as claimed in claims 1 to 6 in which the lidding sheet carries indicea.
8. A blister or strip pack as claimed in claims 1 to 4 in which the lidding sheet is heat sealed to the blister sheet.
9. A blister or strip pack as claimed in claims 1 to 8 in which the lidding sheet embodies a metal layer.
10. A blister or strip pack as claimed in claim 9 in which the metal layer is applied by lamination or vacuum deposition.
11. A blister or strip pack as claimed in claim 10 in which the metal layer is aluminium.
12. A blister or strip pack as claimed in claims 9 to 11 in which a similar metal layer is also applied to the blister sheet.
EP84300419A 1983-02-09 1984-01-24 Blister pack Withdrawn EP0118179A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8303600 1983-02-09
GB838303600A GB8303600D0 (en) 1983-02-09 1983-02-09 Blister sheet
GB8309231 1983-04-05
GB8309231 1983-04-05

Publications (1)

Publication Number Publication Date
EP0118179A1 true EP0118179A1 (en) 1984-09-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP84300419A Withdrawn EP0118179A1 (en) 1983-02-09 1984-01-24 Blister pack

Country Status (2)

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EP (1) EP0118179A1 (en)
AU (1) AU2420684A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174070A (en) * 1985-04-15 1986-10-29 Boxall Company Blister packs
GB2242134B (en) * 1990-03-02 1994-10-19 Glaxo Group Ltd Inhalation device
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
EP1157682A1 (en) * 2000-05-25 2001-11-28 Cilag AG Blister package for topiramate tablets
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US6792945B2 (en) 1990-03-02 2004-09-21 Glaxo Group Limited Inhalation device
US7225808B2 (en) 1990-03-02 2007-06-05 Glaxo Group Limited Inhalation device

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4653644A (en) * 1984-06-18 1987-03-31 Degesch Gmbh Package for toxic fumigant material in pellet or tablet form and method of making same
US4911304A (en) * 1989-03-20 1990-03-27 Merck & Co., Inc. Sandwich blister package for tablets and similar articles
AUPN673895A0 (en) * 1995-11-23 1995-12-14 Cruse, Peter Alan A dispenser for toothpicks

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3202277A (en) * 1964-03-19 1965-08-24 Lewi William Dual seal package
DE1276993B (en) * 1955-10-13 1968-09-05 Feldmuehle Ag Cellulose-based packaging material that is largely impermeable to light and water vapor
US3630346A (en) * 1970-06-01 1971-12-28 Lilly Co Eli Components for making a strip package
DE3029253A1 (en) * 1980-08-01 1982-03-11 Dixie-Union Verpackungen Gmbh, 8960 Kempten CHILD SAFE MEDICAL PACKAGING

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1276993B (en) * 1955-10-13 1968-09-05 Feldmuehle Ag Cellulose-based packaging material that is largely impermeable to light and water vapor
US3202277A (en) * 1964-03-19 1965-08-24 Lewi William Dual seal package
US3630346A (en) * 1970-06-01 1971-12-28 Lilly Co Eli Components for making a strip package
DE3029253A1 (en) * 1980-08-01 1982-03-11 Dixie-Union Verpackungen Gmbh, 8960 Kempten CHILD SAFE MEDICAL PACKAGING

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2174070A (en) * 1985-04-15 1986-10-29 Boxall Company Blister packs
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
US7225808B2 (en) 1990-03-02 2007-06-05 Glaxo Group Limited Inhalation device
US5860419A (en) * 1990-03-02 1999-01-19 Glaxo Group Limited Inhalation device
US5873360A (en) * 1990-03-02 1999-02-23 Glaxo Group Limited Inhalation device
US6032666A (en) * 1990-03-02 2000-03-07 Glaxo Group Limited Inhalation device
US7389775B2 (en) 1990-03-02 2008-06-24 Glaxo Group Limited Inhalation device
US5590645A (en) * 1990-03-02 1997-01-07 Glaxo Group Limited Inhalation device
GB2242134B (en) * 1990-03-02 1994-10-19 Glaxo Group Ltd Inhalation device
US6792945B2 (en) 1990-03-02 2004-09-21 Glaxo Group Limited Inhalation device
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
WO2001089445A1 (en) * 2000-05-25 2001-11-29 Cilag Ag Blister package for topiramate tablets
AU777753B2 (en) * 2000-05-25 2004-10-28 Cilag A.G. Blister package for topiramate tablets
EP1157682A1 (en) * 2000-05-25 2001-11-28 Cilag AG Blister package for topiramate tablets
EP1284711B2 (en) † 2000-05-25 2012-03-28 Cilag AG Process for making a blister package containing topiramate tablets

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Inventor name: SCHWARTZ, GERHARD THOMAS

Inventor name: INGLIS, BRUCE REYNOLDS