EP0107364A3 - 7-anilinoisoquinoline-5,8-quinones - Google Patents

7-anilinoisoquinoline-5,8-quinones Download PDF

Info

Publication number
EP0107364A3
EP0107364A3 EP83305737A EP83305737A EP0107364A3 EP 0107364 A3 EP0107364 A3 EP 0107364A3 EP 83305737 A EP83305737 A EP 83305737A EP 83305737 A EP83305737 A EP 83305737A EP 0107364 A3 EP0107364 A3 EP 0107364A3
Authority
EP
European Patent Office
Prior art keywords
anilinoisoquinoline
quinones
leukotrienes
release
exces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP83305737A
Other languages
German (de)
French (fr)
Other versions
EP0107364A2 (en
Inventor
Jerome Herbert Fleisch
Winston Stanley Marshall
George Joseph Cullinan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0107364A2 publication Critical patent/EP0107364A2/en
Publication of EP0107364A3 publication Critical patent/EP0107364A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

7-Anilinoisoquinoline-5,8-quinones of formula
EP83305737A 1982-09-30 1983-09-26 7-anilinoisoquinoline-5,8-quinones Ceased EP0107364A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US429589 1982-09-30
US06/429,589 US4478820A (en) 1982-09-30 1982-09-30 Anilino-substituted isoquinoline quinones, pharmaceutical compositions and method of use thereof

Publications (2)

Publication Number Publication Date
EP0107364A2 EP0107364A2 (en) 1984-05-02
EP0107364A3 true EP0107364A3 (en) 1985-05-15

Family

ID=23703885

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83305737A Ceased EP0107364A3 (en) 1982-09-30 1983-09-26 7-anilinoisoquinoline-5,8-quinones

Country Status (10)

Country Link
US (1) US4478820A (en)
EP (1) EP0107364A3 (en)
JP (1) JPS5982368A (en)
KR (1) KR860001762B1 (en)
CA (1) CA1234117A (en)
DK (1) DK446583A (en)
GB (1) GB2127813B (en)
GR (1) GR78992B (en)
HU (1) HU190736B (en)
IL (1) IL69817A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2074701A1 (en) * 1991-08-08 1993-02-09 George R. Pettit Cribrostatins 1 and 2
FR2742151B1 (en) * 1995-12-12 1998-03-06 Innothera Lab Sa USE OF DERIVATIVES OF MONO OR DICETONIC BICYCLES, NOVEL COMPOUNDS OBTAINED AND THEIR APPLICATION IN THERAPEUTICS
WO2023240109A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Multispecific molecules for modulating t-cell activity, and uses thereof
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002310A1 (en) * 1977-11-10 1979-06-13 Beecham Group Plc 4,9-Dihydro-4,9-dioxo-1H-naphtho(2,3-d) triazoles, their preparation and antiallergic compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491101A (en) * 1967-05-19 1970-01-20 American Cyanamid Co 5,8-dioxygenated isoquinoline-4-carboxylates
US3857847A (en) * 1968-07-02 1974-12-31 Hoffmann La Roche 6,7 substituted 4 (3{8 3(r) alkyl, 4(s)piperidyl{9 -2-oxopropyl)quinoline and racemates
US4390541A (en) * 1980-12-19 1983-06-28 Lilly Industries Limited Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0002310A1 (en) * 1977-11-10 1979-06-13 Beecham Group Plc 4,9-Dihydro-4,9-dioxo-1H-naphtho(2,3-d) triazoles, their preparation and antiallergic compositions containing them

Also Published As

Publication number Publication date
IL69817A0 (en) 1983-12-30
HU190736B (en) 1986-10-28
KR840006208A (en) 1984-11-22
GB8325677D0 (en) 1983-10-26
JPS5982368A (en) 1984-05-12
GB2127813A (en) 1984-04-18
US4478820A (en) 1984-10-23
KR860001762B1 (en) 1986-10-21
CA1234117A (en) 1988-03-15
DK446583A (en) 1984-03-31
IL69817A (en) 1986-10-31
EP0107364A2 (en) 1984-05-02
GB2127813B (en) 1985-12-11
GR78992B (en) 1984-10-02
DK446583D0 (en) 1983-09-29

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19831003

AK Designated contracting states

Designated state(s): BE CH DE FR GB IT LI LU NL SE

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): BE CH DE FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19870204

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19880421

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CULLINAN, GEORGE JOSEPH

Inventor name: FLEISCH, JEROME HERBERT

Inventor name: MARSHALL, WINSTON STANLEY