EP0077759A3 - Phenyl urea - Google Patents

Phenyl urea Download PDF

Info

Publication number
EP0077759A3
EP0077759A3 EP82810428A EP82810428A EP0077759A3 EP 0077759 A3 EP0077759 A3 EP 0077759A3 EP 82810428 A EP82810428 A EP 82810428A EP 82810428 A EP82810428 A EP 82810428A EP 0077759 A3 EP0077759 A3 EP 0077759A3
Authority
EP
European Patent Office
Prior art keywords
phenyl urea
urea
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82810428A
Other languages
German (de)
Other versions
EP0077759A2 (en
EP0077759B1 (en
Inventor
Manfred Boger
Josef Dr. Ehrenfreund
Pierre Dr. Martin
Eginhard Dr. Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to AT82810428T priority Critical patent/ATE31298T1/en
Publication of EP0077759A2 publication Critical patent/EP0077759A2/en
Publication of EP0077759A3 publication Critical patent/EP0077759A3/en
Application granted granted Critical
Publication of EP0077759B1 publication Critical patent/EP0077759B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C07D213/643—2-Phenoxypyridines; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
EP82810428A 1981-10-20 1982-10-14 Phenyl urea Expired EP0077759B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82810428T ATE31298T1 (en) 1981-10-20 1982-10-14 PHENYLUREAS.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH669181 1981-10-20
CH6691/81 1981-10-20
CH323182 1982-05-26
CH3231/82 1982-05-26
CH524882 1982-09-03
CH5248/82 1982-09-03

Publications (3)

Publication Number Publication Date
EP0077759A2 EP0077759A2 (en) 1983-04-27
EP0077759A3 true EP0077759A3 (en) 1984-03-07
EP0077759B1 EP0077759B1 (en) 1987-12-09

Family

ID=27174204

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82810428A Expired EP0077759B1 (en) 1981-10-20 1982-10-14 Phenyl urea

Country Status (10)

Country Link
US (1) US4511571A (en)
EP (1) EP0077759B1 (en)
AU (2) AU555936B2 (en)
BR (1) BR8206089A (en)
CA (1) CA1244442A (en)
DE (1) DE3277810D1 (en)
ES (1) ES8402575A1 (en)
IL (1) IL67079A0 (en)
NZ (1) NZ202225A (en)
TR (1) TR21387A (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3275720D1 (en) * 1981-11-10 1987-04-23 Ciba Geigy Ag PHENYLBENZOYL UREAS AS PESTICIDES
EP0167491A3 (en) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Thiobarbituric-acid derivatives
EP0177455A3 (en) * 1984-10-05 1987-07-15 Ciba-Geigy Ag N-benzoylphenyl urea
DE3584433D1 (en) * 1984-12-20 1991-11-21 Ciba Geigy Ag Benzoylphenylharnstoffe.
US5135953A (en) * 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
DE3545570A1 (en) * 1985-12-21 1987-06-25 Hoechst Ag NEW PYRIDINE DERIVATIVES AND THEIR N-OXIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS INTERMEDIATE PRODUCTS
DE3626503A1 (en) * 1986-08-05 1988-02-11 Celamerck Gmbh & Co Kg METHOD FOR PRODUCING BENZOYL UREA
EP0264904A3 (en) * 1986-10-23 1988-08-17 Ishihara Sangyo Kaisha, Ltd. Pharmaceutical compositions containing benzoyl urea derivatives
DE3852621D1 (en) * 1987-12-07 1995-02-09 Ciba Geigy Ag 3-aminobenzoylphenylureas.
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) * 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1158985B1 (en) * 1999-01-13 2011-12-28 Bayer HealthCare LLC OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS
ME00275B (en) 1999-01-13 2011-02-10 Bayer Corp ?-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2400070T3 (en) * 2001-12-03 2013-04-05 Bayer Healthcare Llc Aryl urea compounds in combination with other cytostatic or cytotoxic agents for the treatment of human cancers
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
PT1478358E (en) 2002-02-11 2013-09-11 Bayer Healthcare Llc Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
WO2003068229A1 (en) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
WO2003068223A1 (en) * 2002-02-11 2003-08-21 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
CN1318404C (en) 2002-02-11 2007-05-30 拜耳制药公司 Aryl ureas as kinase inhibitors
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
DE602004011340T2 (en) * 2003-05-20 2008-11-06 Bayer Healthcare Llc DIARYL-UREA SUBSTANCES WITH CHINESE-INHIBITING EFFECT
UA84156C2 (en) * 2003-07-23 2008-09-25 Байер Фармасьютикалс Корпорейшн Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003733A (en) * 1974-01-22 1977-01-18 The Dow Chemical Company Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives
DE2748636A1 (en) * 1976-10-29 1978-05-03 Ishihara Mining & Chemical Co N-BENZOYL-N'-PYRIDYLOXY-PHENYLURA AND METHOD FOR PREPARING THE SAME
EP0028870A1 (en) * 1977-08-12 1981-05-20 Imperial Chemical Industries Plc Phenoxypyridine compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2450955C2 (en) * 1974-10-26 1976-09-29 Ofenbaugesellschaft Berg & Co Method and device for patenting steel wire coiled into coils
US4173637A (en) * 1976-10-29 1979-11-06 Ishihara Sangyo Kaisha Ltd. N-Benzoyl-N'-pyridyloxy phenyl urea and insecticidal compositions thereof
DE3584433D1 (en) * 1984-12-20 1991-11-21 Ciba Geigy Ag Benzoylphenylharnstoffe.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4003733A (en) * 1974-01-22 1977-01-18 The Dow Chemical Company Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives
DE2748636A1 (en) * 1976-10-29 1978-05-03 Ishihara Mining & Chemical Co N-BENZOYL-N'-PYRIDYLOXY-PHENYLURA AND METHOD FOR PREPARING THE SAME
EP0028870A1 (en) * 1977-08-12 1981-05-20 Imperial Chemical Industries Plc Phenoxypyridine compound

Also Published As

Publication number Publication date
AU596370B2 (en) 1990-05-03
NZ202225A (en) 1985-11-08
EP0077759A2 (en) 1983-04-27
EP0077759B1 (en) 1987-12-09
AU6184886A (en) 1987-04-09
DE3277810D1 (en) 1988-01-21
ES516648A0 (en) 1984-03-01
AU8960282A (en) 1983-04-28
IL67079A0 (en) 1983-02-23
ES8402575A1 (en) 1984-03-01
TR21387A (en) 1984-05-10
AU555936B2 (en) 1986-10-16
CA1244442A (en) 1988-11-08
US4511571A (en) 1985-04-16
BR8206089A (en) 1983-09-13

Similar Documents

Publication Publication Date Title
DE3277810D1 (en) Phenyl urea
DE3261757D1 (en) Novel urea derivatives
MY8700843A (en) N-phenylsulfonyl-n-primidinyl and-triazinyl ureas
GB2102186B (en) Disc-accommodating case
GB2095239B (en) Novel amidine compounds
JPS57150694A (en) Compound
CS82782A2 (en) Zpusob odstranovani kyslicnikovych okuji z povrchu kovovych predmetu
ZA821339B (en) 1-benzoyl-3-(arylpyridyl)urea compounds
GB2109372B (en) Urea synthesis
GB2107714B (en) Phenyl ketones
DE3160929D1 (en) Phenyl ureas
ZA82264B (en) Hexahydro-trans- and tetrahydropyridoindole neutroleptic agents
DE3173924D1 (en) Phenyl ureas
ZA827550B (en) Pest-combating agents
DE3161279D1 (en) Phenyl ureas
JPS57145863A (en) Biscyclic urea
JPS5772955A (en) Urea manufacture
GB2096598B (en) Novel amidine compounds
ZW5581A1 (en) Phenyl quinolizidines
JPS56166166A (en) Urea manufacture
PH18596A (en) Substituted guanidines
JPS57180973A (en) Case
ZA812285B (en) Phenyl quinolizidines
ZA821887B (en) New phenyl-perhydroazepines
GB2113219B (en) Herbicidal phenyl urea derivatives

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19821016

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI NL

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Designated state(s): AT BE CH DE FR GB IT LI NL

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE FR GB IT LI NL

REF Corresponds to:

Ref document number: 31298

Country of ref document: AT

Date of ref document: 19871215

Kind code of ref document: T

ITF It: translation for a ep patent filed

Owner name: BARZANO' E ZANARDO MILANO S.P.A.

REF Corresponds to:

Ref document number: 3277810

Country of ref document: DE

Date of ref document: 19880121

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19900817

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 19900830

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19900903

Year of fee payment: 9

Ref country code: AT

Payment date: 19900903

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19901005

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19901026

Year of fee payment: 9

ITTA It: last paid annual fee
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19901031

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Effective date: 19911014

Ref country code: AT

Effective date: 19911014

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Effective date: 19911031

Ref country code: CH

Effective date: 19911031

Ref country code: BE

Effective date: 19911031

BERE Be: lapsed

Owner name: CIBA-GEIGY A.G.

Effective date: 19911031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19920501

GBPC Gb: european patent ceased through non-payment of renewal fee
NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19920630

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Effective date: 19920701

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST