EP0068740A3 - Recombinant dna cloning vectors and the eukaryotic and prokaryotic transformants thereof - Google Patents

Recombinant dna cloning vectors and the eukaryotic and prokaryotic transformants thereof Download PDF

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Publication number
EP0068740A3
EP0068740A3 EP82303155A EP82303155A EP0068740A3 EP 0068740 A3 EP0068740 A3 EP 0068740A3 EP 82303155 A EP82303155 A EP 82303155A EP 82303155 A EP82303155 A EP 82303155A EP 0068740 A3 EP0068740 A3 EP 0068740A3
Authority
EP
European Patent Office
Prior art keywords
eukaryotic
recombinant dna
cloning vectors
dna cloning
transformants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82303155A
Other versions
EP0068740B1 (en
EP0068740A2 (en
Inventor
Ramachandra Nagaraja Rao
Robert Frank Santerre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0068740A2 publication Critical patent/EP0068740A2/en
Publication of EP0068740A3 publication Critical patent/EP0068740A3/en
Application granted granted Critical
Publication of EP0068740B1 publication Critical patent/EP0068740B1/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP82303155A 1981-06-22 1982-06-17 Recombinant dna cloning vectors and the eukaryotic and prokaryotic transformants thereof Expired EP0068740B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27644581A 1981-06-22 1981-06-22
US276445 1981-06-22
US36221582A 1982-03-26 1982-03-26
US362215 1982-03-26

Publications (3)

Publication Number Publication Date
EP0068740A2 EP0068740A2 (en) 1983-01-05
EP0068740A3 true EP0068740A3 (en) 1984-02-15
EP0068740B1 EP0068740B1 (en) 1989-03-22

Family

ID=26957974

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82303155A Expired EP0068740B1 (en) 1981-06-22 1982-06-17 Recombinant dna cloning vectors and the eukaryotic and prokaryotic transformants thereof

Country Status (10)

Country Link
EP (1) EP0068740B1 (en)
AU (2) AU555574B2 (en)
CA (1) CA1195626A (en)
DE (1) DE3279566D1 (en)
DK (1) DK172716B1 (en)
GB (2) GB2100738B (en)
GR (1) GR76152B (en)
HU (1) HU195248B (en)
IE (1) IE53521B1 (en)
IL (1) IL66065A (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727028A (en) * 1981-06-22 1988-02-23 Eli Lilly And Company Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof
CA1209501A (en) * 1982-09-16 1986-08-12 Nikos Panayotatos Expression vector
US4634678A (en) * 1982-12-13 1987-01-06 Molecular Genetics Research And Development Limited Partnership Plasmid cloning and expression vectors for use in microorganisms
US4670399A (en) * 1983-01-31 1987-06-02 Stauffer Chemical Co. Hybrid plasmid with marker
DK172882B1 (en) * 1983-02-07 1999-09-06 Rothwell Property Ltd DNA containing expression control region from a eukaryotic heat shock gene, vector and eukaryotic cell containing DNAs
US4960704A (en) * 1983-07-22 1990-10-02 Eli Lilly And Company Modified antibiotic resistance gene
CA1278540C (en) * 1983-07-22 1991-01-02 Eli Lilly And Company Modified antibiotic resistance gene
IL72666A0 (en) * 1983-08-15 1984-11-30 Stauffer Chemical Co Plasmid vector
JPS60160887A (en) * 1984-02-02 1985-08-22 Green Cross Corp:The Vector
US4784949A (en) * 1984-04-19 1988-11-15 Cetus Corporation Universal dominant selectable marker cassette
WO1985003522A1 (en) * 1984-02-08 1985-08-15 Cetus Corporation Monitoring and control systems for recombinant manipulations
US5683909A (en) * 1984-03-02 1997-11-04 Van Den Bergh Foods Company, Division Of Conopco, Inc. Plasmids replicatable in Bacillus subtilis, E. coli and lactic acid streptococcus bacteria
NL8400687A (en) * 1984-03-02 1985-10-01 Unilever Nv RECOMBINANT PLASMIDS; RECOMBINANT PLASMID CONTAINING BACTERIA; METHOD FOR PREPARING OR MANUFACTURING A MILK PRODUCT; PROCESS FOR PREPARING A PROTEIN.
US4663281A (en) * 1984-03-22 1987-05-05 Mass Institute Of Technology Enhanced production of proteinaceous materials in eucaryotic cells
US4870013A (en) * 1984-04-19 1989-09-26 Cetus Corporation SV40 early and RSV promoters useful in saccharomyces expression
IL75210A0 (en) * 1984-05-22 1985-09-29 Bioteknika International Yeast vector
US6214577B1 (en) 1984-05-22 2001-04-10 Robert Rogers Yocum Yeast vectors conferring antibiotic resistance
US4843002A (en) * 1984-09-27 1989-06-27 Eli Lilly And Company Method of selecting recombinant DNA-containing streptomyces
US4762786A (en) * 1984-09-27 1988-08-09 Eli Lilly And Company Vectors and conditions which allow genetic transformation of cephalosporium
DE3579788D1 (en) * 1984-11-07 1990-10-25 Antibioticos Sa CEPHALOSPORIUM ACREMONIUM, THAT IS TRANSFORMED WITH AN AMINOGLYCOSIDE RESISTANCE.
US5668298A (en) * 1984-12-24 1997-09-16 Eli Lilly And Company Selectable marker for development of vectors and transformation systems in plants
CA1340766C (en) 1984-12-24 1999-09-28 Clive Waldron Selectable marker for development of vectors and transformation systems in plants
AU582288B2 (en) * 1986-03-07 1989-03-16 Damon Biotech Inc. Vector and method for achieving high level expression in eukaryotic cells
FR2601965B1 (en) * 1986-07-25 1989-12-08 Pasteur Institut DNA FRAGMENT COMPRISING AT LEAST A PART OF A DETERMINANT ENCODING ACETYLTRANSFERASE 6'-AMINO-GLYCOSIDE AND / OR PHOSPHOTRANSFERASE 2 '' - AMINOGLYCOSIDE ITS PROCESS FOR OBTAINING AND ITS BIOCHEMICAL APPLICATIONS.
JPH01108995A (en) * 1987-10-23 1989-04-26 Hoechst Japan Kk Gene amplification for increasing production of protein by culturing mammalian cells
JPH02261386A (en) * 1989-03-31 1990-10-24 Kyowa Hakko Kogyo Co Ltd Recombinant vector
JPH07163368A (en) * 1993-12-15 1995-06-27 Hayashibara Biochem Lab Inc Recombinant dna and transformant containing the same recombinant dna
US6265186B1 (en) 1997-04-11 2001-07-24 Dsm N.V. Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003087A1 (en) * 1981-03-02 1982-09-16 Garapin Florence Selective genetic markers for eucaryotic cells,method for implementing such markers and application of cells containing such marker to the production of proteins determined after their transformation by a corresponding dna

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003087A1 (en) * 1981-03-02 1982-09-16 Garapin Florence Selective genetic markers for eucaryotic cells,method for implementing such markers and application of cells containing such marker to the production of proteins determined after their transformation by a corresponding dna

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 92, no. 11, 17th March 1980, page 287, no. 90712k, Columbus, Ohio, US *
CHEMICAL ABSTRACTS, vol. 94, no. 13, 30th March 1981, page 169, no. 96942y, Columbus, Ohio, US *
NATURE, vol. 287, 30th October 1980, pages 869-871, Basingstoke, GB *

Also Published As

Publication number Publication date
HU195248B (en) 1988-04-28
GB2146031B (en) 1985-10-23
EP0068740B1 (en) 1989-03-22
EP0068740A2 (en) 1983-01-05
AU5798086A (en) 1986-10-16
CA1195626A (en) 1985-10-22
AU555574B2 (en) 1986-10-02
GB2146031A (en) 1985-04-11
AU582653B2 (en) 1989-04-06
DE3279566D1 (en) 1989-04-27
GR76152B (en) 1984-08-03
DK270982A (en) 1982-12-23
AU8494982A (en) 1983-01-06
IE821442L (en) 1982-12-22
DK172716B1 (en) 1999-06-14
GB8424454D0 (en) 1984-10-31
IL66065A0 (en) 1982-09-30
IL66065A (en) 1989-06-30
GB2100738B (en) 1985-10-16
GB2100738A (en) 1983-01-06
IE53521B1 (en) 1988-12-07

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