EP0057700A4 - Nitrosourea derivatives having antitumour activity and pharmaceutical compositions containing the same. - Google Patents

Nitrosourea derivatives having antitumour activity and pharmaceutical compositions containing the same.

Info

Publication number
EP0057700A4
EP0057700A4 EP19810902235 EP81902235A EP0057700A4 EP 0057700 A4 EP0057700 A4 EP 0057700A4 EP 19810902235 EP19810902235 EP 19810902235 EP 81902235 A EP81902235 A EP 81902235A EP 0057700 A4 EP0057700 A4 EP 0057700A4
Authority
EP
European Patent Office
Prior art keywords
same
pharmaceutical compositions
compositions containing
antitumour activity
nitrosourea derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19810902235
Other languages
German (de)
French (fr)
Other versions
EP0057700A1 (en
Inventor
Andrew Welebir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIONAL FOUNDATION FOR CANCER RESEARCH, INC.
Original Assignee
National Foundation for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Foundation for Cancer Research filed Critical National Foundation for Cancer Research
Publication of EP0057700A1 publication Critical patent/EP0057700A1/en
Publication of EP0057700A4 publication Critical patent/EP0057700A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP19810902235 1980-08-14 1981-08-14 Nitrosourea derivatives having antitumour activity and pharmaceutical compositions containing the same. Ceased EP0057700A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17794080A 1980-08-14 1980-08-14
US177940 2002-06-21

Publications (2)

Publication Number Publication Date
EP0057700A1 EP0057700A1 (en) 1982-08-18
EP0057700A4 true EP0057700A4 (en) 1982-11-17

Family

ID=22650546

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19810902235 Ceased EP0057700A4 (en) 1980-08-14 1981-08-14 Nitrosourea derivatives having antitumour activity and pharmaceutical compositions containing the same.
EP19810902234 Withdrawn EP0057699A4 (en) 1980-08-14 1981-08-14 5,6-o-isoalkylidene ascorbic acid derivatives.

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19810902234 Withdrawn EP0057699A4 (en) 1980-08-14 1981-08-14 5,6-o-isoalkylidene ascorbic acid derivatives.

Country Status (6)

Country Link
EP (2) EP0057700A4 (en)
JP (2) JPS57501580A (en)
DK (2) DK167182A (en)
HU (1) HU185969B (en)
NO (2) NO821220L (en)
WO (2) WO1982000642A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60130582A (en) * 1983-12-19 1985-07-12 Takeda Chem Ind Ltd Antioxidant for food, ascorbic acid derivative and its production
JPS60139619A (en) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Antitumor agent comprising o-bnezylidene-ascorbic acid or its salt
US5405412A (en) * 1994-04-13 1995-04-11 The Procter & Gamble Company Bleaching compounds comprising N-acyl caprolactam and alkanoyloxybenzene sulfonate bleach activators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2539483A (en) * 1945-03-28 1951-01-30 Simon L Ruskin Urea ascorbate and complexes containing the same and process for their manufacture
US3074998A (en) * 1959-12-10 1963-01-22 Shell Oil Co Enol carbamates
CH495980A (en) * 1967-02-25 1970-09-15 Bayer Ag Process for the preparation of benzodioxane-N-methylcarbamates
DE2346305A1 (en) * 1973-09-14 1975-04-03 Basf Ag NEW CARBAMATES AND THEIR USE AS A MEDICINAL PRODUCT
US4111958A (en) * 1977-06-03 1978-09-05 Pfizer Inc. Ascorbic acid synthesis
US4148921A (en) * 1977-07-13 1979-04-10 Suami T Antitumor agents
NL7904249A (en) * 1978-06-20 1979-12-27 Cancer Res Nat Found NEW CYCLIC ACETALS WITH CYTOSTATIC, BLOOD PRESSURE REDUCING AND PAIN-ANTI-PAIN ACTIONS, METHOD OF PREPARING THESE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING SUCH COMPOUND.
JPS554324A (en) * 1978-06-26 1980-01-12 Kaken Pharmaceut Co Ltd Novel glycopyranosidoamine derivative, its preparation, and antitumor agent comprising it as active constituent
JP2811964B2 (en) * 1990-12-20 1998-10-15 富士通株式会社 Connection partner designation method

Also Published As

Publication number Publication date
WO1982000642A1 (en) 1982-03-04
DK167182A (en) 1982-04-14
EP0057700A1 (en) 1982-08-18
EP0057699A1 (en) 1982-08-18
WO1982000644A1 (en) 1982-03-04
NO821220L (en) 1982-04-14
EP0057699A4 (en) 1982-11-08
JPS57501580A (en) 1982-09-02
DK167282A (en) 1982-04-14
NO821221L (en) 1982-04-14
JPS57501581A (en) 1982-09-02
HU185969B (en) 1985-04-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19820419

AK Designated contracting states

Designated state(s): AT CH DE FR GB LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NATIONAL FOUNDATION FOR CANCER RESEARCH, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19850201

RIN1 Information on inventor provided before grant (corrected)

Inventor name: WELEBIR, ANDREW