EP0049461B1 - Appareil pour l'oxygénation du sang dans un circuit extérieur au corps avec échangeur de chaleur - Google Patents

Appareil pour l'oxygénation du sang dans un circuit extérieur au corps avec échangeur de chaleur Download PDF

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Publication number
EP0049461B1
EP0049461B1 EP81107732A EP81107732A EP0049461B1 EP 0049461 B1 EP0049461 B1 EP 0049461B1 EP 81107732 A EP81107732 A EP 81107732A EP 81107732 A EP81107732 A EP 81107732A EP 0049461 B1 EP0049461 B1 EP 0049461B1
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EP
European Patent Office
Prior art keywords
blood
chamber
oxygen
manifold
pipes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP81107732A
Other languages
German (de)
English (en)
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EP0049461A2 (fr
EP0049461A3 (en
Inventor
Libero Luppi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dideco SpA
Original Assignee
Dideco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT25141/80A external-priority patent/IT1133172B/it
Priority claimed from IT22864/81A external-priority patent/IT1138451B/it
Application filed by Dideco SpA filed Critical Dideco SpA
Priority to AT81107732T priority Critical patent/ATE18853T1/de
Publication of EP0049461A2 publication Critical patent/EP0049461A2/fr
Publication of EP0049461A3 publication Critical patent/EP0049461A3/en
Application granted granted Critical
Publication of EP0049461B1 publication Critical patent/EP0049461B1/fr
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A61M1/322—Antifoam; Defoaming
    • A61M1/325—Surfactant coating; Improving wettability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/03—Heart-lung
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S261/00—Gas and liquid contact apparatus
    • Y10S261/28—Blood oxygenators

Definitions

  • This invention relates to a device for oxygenating blood in extrabodily circulation with heat exchanger.
  • the optimization of the flow is of course achieved with a suitable selection of the cross-section dimensions of the passageways within the oxygenator in accordance with the blood flow rate; this flow rate varying in a directly proportional way to the patient's weight, conventional devices are manufactured in three different sizes, one of which is called “infant” and intended for newly born children, one for pediatric applications, and one for adult applications, in an attempt at approaching as far as possible the optimum condition in each case; however it is evident that the optimization thus achieved can only be a coarse one because each of the three types will have to accommodate widely different flow rates both on account of the different weights of the patients being treated and because any individual patient may involve momentarily different conditions especially when the intervention is carried out in conditions of hypother- my, with attendant greatly reduced blood flow rate.
  • the availability of three sizes of the oxygenator leads to known problems of supplying and inventory, such as arise whenever an article happens to be an assorted one.
  • the priming i.e. the amount of blood which must be retained within the apparatus in order for its operation to be primed, does not follow the flow rate drops proportionally, disproportionately high values constantly being maintained, thus subtracting blood from the amount required by the surgeon to face contingent situations.
  • the task of the invention is to eliminate such prior drawbacks by providing an oxygenating device which can accommodate different blood flow rates in an optimum manner, as required by the varying weights of the patients, from newly born children to adults.
  • Another object of the invention is to provide an oxygenating device of small size and cost.
  • the aforesaid task and objects are achieved by a device for oxygenating blood in extrabodily circulation with heat exchanger, a plurality of selectively operable oxygenating modules, each module comprising at least one diffuser of oxygen (9, 10) through the blood, each diffuser having a closure member (17, 18) for simultaneously shutting off the flow of the two fluids, the diffusers being included in a distributor into which a venous blood manifold (3) and an oxygen manifold (5) open, and a chamber (22) underlying the diffusers, the pipes (24) of the heat exchanger extending through the chamber (22), said oxygenating modules being in communication, via a layer of an antifoaming material (35, 36), with an arterial blood collecting and storing chamber (38) which is provided with outlet fittings (39, 40).
  • the oxygenation module shown cut away in Figure 1, comprises the two oxygen diffusers made up of the stub pipes 9 and 10 communicating, through the holes 11 and 12, with the venous blood manifold 3 and being formed through the walls with holes as at 13 for the diffuser 9 through which oxygen is admitted to mix with blood from wells, as at 14, communicating through holes, as at 15, with the chamber 16 whereinto the oxygen is introduced through the filter 7.
  • the two stub pipes 9 and 10 are equipped with blood and oxygen closure members comprising plungers 17 and 18 made of an elastic material, such as rubber, and being shown in the figures at their stroke bottom end in position to shut off both fluids.
  • the oxygenation module being described which comprises the diffusers 9 and 10, also comprises the underlying chamber 22 whereinto the blood is introduced by gravity from said diffusers to first meet a non-siliconed layer of polyurethane 23 which deadens the impact and homogenizes the blood and oxygen foam to facilitate the mixing, and subsequently the pipes, as at 24, of a heat exchanger adapted for conveying a flow of water, suitably directed by partitions, as at 25, which reaches the manifold 29 through the fitting 28 and leaves through the fitting 29 of the manifold 26 located at the same level as the fitting 28 to prevent the exchanger from becoming emptied;
  • the pipes, as at 24, are arranged in staggered rows along perpendicular directions to the flow of blood sweeping them externally, that is horizontal in the normal operating position of the device, thereby a sort of blood lamination is produced with attendant increase of the contact area thereof with the individual oxygen bubbles.
  • the device in addition to the oxygenation module just described, also includes the module comprising the chamber 30 and overlying diffusers, not shown, the blood and oxygen being introduced into said chamber at all times during the operation because the dif- fuserc are not equipped with closure members, and the modules formed by the chambers 31, 32 and 33 with their related overlying diffusers, not shown, with the shut-off members are operable by manipulating the handles 31a, 32a and 33a, respectively.
  • the foaming blood which leaves the chambers of the modules described hereinabove reaches the space indicated at 34 in Figure 2, and hence, through the layers 35 and 36 of a suitable two- grade siliconed material with antifoaming functions and through the filter screen 37, reaches the collecting and storing chamber 38 equipped with outlet fittings 39 and 40.
  • Said tap comprises the fixed body 45 formed with the passage 46 connected to the small pipe 41 and with the passage 47 connected to the collecting chamber 38, and the rotatable body 48 having the bore 49 which can be brought, by manual operation, onto a syringe inserted into the end 49a, with the end 49b at one of the two passages 46 and 47.
  • the withdrawal is effected by first extracting with the syringe the blood contained in the small pipe 41, considered non-valid for sampling, through the passage 46, and then ejecting said blood, after a suitable rotation of 48, through the passage 47, and thereafter again extracting through 46 the blood renewed in 41, after the return rotation of 48.
  • Indicated at 50 and 51 are then two fittings for the introduction of substances, at 52 a fitting for quick filling, at 53 and 54 two probes for detecting the temperature, at 55 a probe for detecting the level of the blood in the chamber 38, and at 56 an outlet fitting for the gases to be removed from the device interior with an anti-implosion hole.
  • Said connector includes the fitting 57 connected with one end to the manifold 3 and having at its other end the flange 58, formed with seats 58a and 58b and having the gasket 58c at the hole for the fitting 57, which is threaded on the outer edge to match the inside threads of the ring nut 59 which has an abutment 59a for retention and compression against the flange 58 of the disk 60; said disk has three holes at the three stub pipes 60a, 60b and 60c of different diameters, the most suitable one for infant use, or pediatric, or adult applications, being positioned at the hole of the fitting 57.
  • On said fitting 57 there are provided a branching off 57a for connection to a cardiotome and a branch-off 57b for connection to the small pipe 41 for the withdrawal of venous blood samples.
  • heat exchanger is provided with a large width dimension, and ensures, even with the smallest flow rates, a large exchange surface, contrary to what happens in the known devices where the exchangers for the infant or pediatric sizes will be of reduced dimensions.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Claims (17)

1. Dispositif pour l'oxygénation du sang en circulation extracorporelle, comprenant un échangeur de chaleur, une pluralité de modules d'oxygénation à fonctionnement sélectif, chaque module comprenant au moins un diffuseur d'oxygène dans le sang, chaque diffuseur comportant un organe d'obturation pour interrompre simultanément le débit des deux fluides, les diffuseurs étant inclus dans un distributeur dans lequel débouche un collecteur de sang veineux et un collecteur d'oxygène, et une chambre située sous les diffuseurs, des tubes de l'échangeur de chaleur s'étendant à travers la chambre, les modules d'oxygénation étant en communication, par l'intermédiaire d'une couche d'une matière anti-moussage, avec une chambre de collecte et de stockage de sang artétiel qui est munie de raccords de sortie.
2. Dispositif suivant la revendication 1, caractérisé en ce que le diffuseur d'oxygène dans le sang comprend un tube (9, 10) dont l'axe est sensiblement parallèle à l'axe longitudinal de la chambre (22), ce tube étant en communication avec le collecteur (3) de sang veineux, et avec le collecteur (5) d'oxygène par l'intermédiaire de trous inclinés (13) prévus dans la paroi du tube.
3. Dispositif suivant la revendication 2, caractérisé en ce que le collecteur d'oxygène (5) aboutissant au distributeur est défini à l'intérieur d'un couvercle (6) de ce distributeur et est prévu pour bloquer en position une membrane constituant un filtre à oxygène (7).
4. Dispositif suivant la revendication 1, caractérisé en ce que l'organe d'obturation (17, 18) appartenant à chaque diffuseur d'oxygène dans le sang comprend un plongeur (17, 18) en matière élastique telle que le caoutchouc, le plongeur pouvant coulisser et étant en contact avec la paroi intérieure du diffuseur et avec la paroi d'un alésage (9a) coaxial au plongeur dans le corps du distributeur, entre les deux positions extrêmes d'obturation complète du débit des deux fluides et d'admission libre de ces derniers dans la chambre, les plongeurs (17, 18) des diffuseurs appartenant à un même module comportant des éléments de manoeuvre interconnectés (20, 21).
5. Dispositif suivant la revendication 4, caractérisé en ce que l'élément de manoeuvre (20, 21) appartenant à chaque plongeur (17,18) comprend une tige de métal (20, 21) qui s'étend de la face opposée du plongeur à celle en regard de la chambre (22), et qui fait saillie à l'extérieur du distributeur de manière à être reliée à une poignée (19) qui relie elle-même les extrémités des tiges (20, 21) venant des plongeurs (17, 18) qui appartiennent au même module d'oxygénation.
6. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce qu'une couche de polyuréthane non siliconé (23) est prévue dans la région supérieure de la chambre (22).
7. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce que les tubes (24) de l'échangeur de chaleur sont prévus pour la circulation de l'eau qui entre et sort par des raccords (28, 29) situés au même niveau et qui est destinée à fournir de la chaleur au sang ou à en extraire de celui-ci, les tubes étant disposés en rangées décalées, perpendiculairement à la direction d'écoulement du sang dans un espace délimité par des parois qui s'étendent sensiblement verticalement dans la position normale d'utilisation du dispositif et débouchant dans un espace délimité par ladite matière anti-moussage (35, 36).
8. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce que la matière anti-moussage (35, 36), interposée entre les modules d'oxygénation et la chambre (38) de collecte de sang artériel, comprend une double couche (35, 36) d'une matière convenablement siliconée à des degrés différents, délimitée sur le côté de la chambre de collecte (38) par un tamis filtrant (37).
9. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce que le connecteur (2) d'entrée de sang veineux dans le collecteur correspondant (3) comprend un raccord (57) relié à une extrémité à ce collecteur (3) et comportant, à son autre extrémité, une bride (58) à bord fileté prévu pour se visser dans le filetage intérieur d'un écrou annulaire (59) présentant un épaulement (59a) de retenue et de compression, contre la bride (58), d'un disque (60) percé pour le raccordement de tubes (60a, 60b, 60c) de différents diamètres.
10. Dispositif suivant la revendication 9, caractérisé en ce que le raccord (57) comporte un premier branchement (57a), pour la liaison à un cardiotome, et un deuxième branchement (57b) pour la liaison à une petite tuyauterie d'échantillonnage (41).
11. Dispositif suivant la revendication 9, caractérisé en ce que les tubes de différents diamètres sont au nombre de trois, afin de correspondre à l'optimisation du débit pour les trois applications du dispositif, dans ses modes pour enfant, pédiatrique et pour adulte.
12. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce qu'il comprend deux petites tuyauteries (41, 42), dont une extrémité est reliée à l'entrée (2) de sang veineux et à la sortie (38) de sang artériel, respectivement, et dont l'autre extrémité est reliée à un robinet de prélèvement (43, 44).
13. Dispositif suivant la revendication 12, caractérisé en ce que chaque robinet de prélèvement (43, 44) comprend un corps fixe (45), comportant un passage (46) raccordé à une dite petite tuyauterie (41) et un passage (47) raccordé à la chambre (38) de collecte de sang artériel, et un élément tournant (48) comportant un orifice sensiblement diamétral (49) qui peut être amené, par manoeuvre manuelle avec une extrémité (49b) à l'un ou à l'autre des passages (46, 47) à travers le corps fixe (45), l'autre extrémité (49a) étant prévue pour la liaison à une seringue.
14. Dispositif suivant une ou plusieurs des revendications précédentes caractérisé en ce qu'il comprend un connecteur de sortie (56) pour les gaz évacués de l'intérieur, et une soupape de sécurité anti-implosion qui sert à la protection contre les implosions lorsque ledit connecteur (56) est raccordé à une conduite de vide forcé.
15. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce qu'il comprend une sonde (55) de niveau de sang artériel dans la chambre de collecte (38).
16. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce qu'il comprend une sonde (53, 54) de détection de la température du sang à l'entrée de sang veineux et à la sortie de sang artériel.
17. Dispositif suivant une ou plusieurs des revendications précédentes, caractérisé en ce qu'il comprend des raccords (50, 51) pour l'introduction de substances dans le sang et pour le remplissage rapide.
EP81107732A 1980-10-06 1981-09-29 Appareil pour l'oxygénation du sang dans un circuit extérieur au corps avec échangeur de chaleur Expired EP0049461B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT81107732T ATE18853T1 (de) 1980-10-06 1981-09-29 Vorrichtung zur sauerstoffanreicherung von blut in einem kreislauf ausserhalb des koerpers mit waermetauscher.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT25141/80A IT1133172B (it) 1980-10-06 1980-10-06 Dispositivo ossigenatore del sangeu nella circolazione extracorporea con scambiatore di calore
IT2514180 1980-10-06
IT22864/81A IT1138451B (it) 1981-07-10 1981-07-10 Dispositivo ossigenatore del sangue nella circolazione extracorporea con scambiatore di calore
IT2286481 1981-07-10

Publications (3)

Publication Number Publication Date
EP0049461A2 EP0049461A2 (fr) 1982-04-14
EP0049461A3 EP0049461A3 (en) 1982-08-04
EP0049461B1 true EP0049461B1 (fr) 1986-04-02

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EP81107732A Expired EP0049461B1 (fr) 1980-10-06 1981-09-29 Appareil pour l'oxygénation du sang dans un circuit extérieur au corps avec échangeur de chaleur

Country Status (3)

Country Link
US (1) US4440722A (fr)
EP (1) EP0049461B1 (fr)
DE (1) DE3174251D1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431754B2 (en) 2004-07-23 2008-10-07 Terumo Kabushiki Kaisha Artificial lung

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US4663125A (en) * 1985-05-17 1987-05-05 Cobe Laboratories, Inc. Membrane medical device
US4705508A (en) * 1985-09-30 1987-11-10 Regents Of The University Of Minnesota Apparatus and method for rapid infusion of circulatory supportive fluids
US4874581A (en) * 1986-06-13 1989-10-17 Baxter International Inc. O2 /CO2 control in blood oxygenators
US4730936A (en) * 1986-10-10 1988-03-15 The United States Of America As Represented By The Secretary Of The Air Force Gas driven system for preparing large volumes of non-oxidized, pyridoxylated, polymerized stroma-free hemoglobin solution for use as a blood substitute
JPS6411560A (en) * 1987-07-07 1989-01-17 Terumo Corp Blood storage tank
US5061241A (en) * 1989-01-19 1991-10-29 Stephens Jr Harry W Rapid infusion device
US5270004A (en) * 1989-10-01 1993-12-14 Minntech Corporation Cylindrical blood heater/oxygenator
FR2692486A1 (fr) * 1992-06-23 1993-12-24 Abdelmassih Zaki George Procédé et dispositif de stérilisation du sang des malades du SIDA ou d'une autre maladie bactérienne, parasitaire ou virale du sang.
IT1281030B1 (it) * 1995-11-17 1998-02-11 Dideco Spa Agenti anti-schiuma per l'abbattimento di schiume e nebbie nel sangue e suou derivati.
JP4855119B2 (ja) * 2006-03-28 2012-01-18 テルモ株式会社 フィルタ部材および人工肺
US7588549B2 (en) * 2006-08-03 2009-09-15 Terumo Cardiovascular Systems Corporation Thermoelectric temperature control for extracorporeal blood circuit
EP3731892B1 (fr) 2018-03-02 2022-08-24 Spectrum Medical Ltd. Système d'oxygénation
DE102018009062A1 (de) * 2018-11-13 2020-05-14 Moneera Bobaky Vorrichtung und Verfahren zur extrakorporalen Blutoxygenierung mit der Möglichkeit, die Membranoberfläche nach Bedarf zu modifizieren.

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US2652831A (en) * 1952-01-31 1953-09-22 Abraham E Chesler Heart-lung apparatus
US3729377A (en) * 1971-03-12 1973-04-24 Baxter Laboratories Inc Envelope oxygenator for blood having inflatable portions and process of using same
US3827860A (en) * 1972-06-15 1974-08-06 Sherwood Medical Ind Inc Blood oxygenation device
US3994609A (en) * 1975-11-06 1976-11-30 Acme Highway Products Corporation Elastomeric expansion seal
US4183961A (en) * 1976-02-03 1980-01-15 Shiley Incorporated Method of oxygenating blood
US4138288A (en) * 1976-05-10 1979-02-06 Shiley Scientific Incorporated Method and apparatus for oxygenating and regulating the temperature of blood
US4140635A (en) * 1977-04-13 1979-02-20 Esmond William G Purification device
US4160801A (en) * 1977-10-19 1979-07-10 Surgikos Heat exchanger-blood oxygenator combination
US4158693A (en) * 1977-12-29 1979-06-19 Texas Medical Products, Inc. Blood oxygenator
SE7801230L (sv) * 1978-02-02 1979-08-03 Gambro Ab Anordning for diffusion av emnen mellan tva fluida under samtidig temperering av atminstone det ena av dessa fluider
US4205042A (en) * 1978-06-23 1980-05-27 Cobe Laboratories, Inc. Blood oxygenator with a gas filter
US4256692A (en) * 1979-02-01 1981-03-17 C. R. Bard, Inc. Membrane oxygenator
US4280981A (en) * 1979-11-06 1981-07-28 C. R. Bard, Inc. Blood oxygenator

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7431754B2 (en) 2004-07-23 2008-10-07 Terumo Kabushiki Kaisha Artificial lung
US7947113B2 (en) 2004-07-23 2011-05-24 Terumo Kabushiki Kaisha Artificial lung
US8142546B2 (en) 2004-07-23 2012-03-27 Terumo Kabushiki Kaisha Artificial lung

Also Published As

Publication number Publication date
US4440722A (en) 1984-04-03
DE3174251D1 (en) 1986-05-07
EP0049461A2 (fr) 1982-04-14
EP0049461A3 (en) 1982-08-04

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