EP0030688A3 - Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them - Google Patents

Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them Download PDF

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Publication number
EP0030688A3
EP0030688A3 EP80107648A EP80107648A EP0030688A3 EP 0030688 A3 EP0030688 A3 EP 0030688A3 EP 80107648 A EP80107648 A EP 80107648A EP 80107648 A EP80107648 A EP 80107648A EP 0030688 A3 EP0030688 A3 EP 0030688A3
Authority
EP
European Patent Office
Prior art keywords
thiophene
hydroxy
preparation
carboxylic acid
acid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP80107648A
Other languages
German (de)
Other versions
EP0030688A2 (en
EP0030688B1 (en
Inventor
Fritz-Frieder Dr. Frickel
Gerda Dr. Von Philipsborn
Claus D. Dr. Mueller
Dieter Dr. Lenke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to AT80107648T priority Critical patent/ATE4808T1/en
Publication of EP0030688A2 publication Critical patent/EP0030688A2/en
Publication of EP0030688A3 publication Critical patent/EP0030688A3/en
Application granted granted Critical
Publication of EP0030688B1 publication Critical patent/EP0030688B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Substituted piperidino-alkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.
EP80107648A 1979-12-13 1980-12-05 Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them Expired EP0030688B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT80107648T ATE4808T1 (en) 1979-12-13 1980-12-05 PIPERIDINE DERIVATIVES OF 3-HYDROXY-THIOPHEN-2CARBONS[UREESTERS, THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2950064 1979-12-13
DE19792950064 DE2950064A1 (en) 1979-12-13 1979-12-13 PIPERIDE DERIVATIVES OF 3-HYDROXYTHIOPHEN-2-CARBONIC ACIDS AND ESTERS, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Publications (3)

Publication Number Publication Date
EP0030688A2 EP0030688A2 (en) 1981-06-24
EP0030688A3 true EP0030688A3 (en) 1981-07-15
EP0030688B1 EP0030688B1 (en) 1983-09-28

Family

ID=6088313

Family Applications (1)

Application Number Title Priority Date Filing Date
EP80107648A Expired EP0030688B1 (en) 1979-12-13 1980-12-05 Piperidine derivatives of 3-hydroxy-thiophene-2-carboxylic acid esters, their preparation, and pharmaceutical preparations containing them

Country Status (7)

Country Link
US (1) US4329352A (en)
EP (1) EP0030688B1 (en)
JP (1) JPS5695187A (en)
AT (1) ATE4808T1 (en)
CA (1) CA1155851A (en)
DE (2) DE2950064A1 (en)
ZA (1) ZA807789B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0076072B1 (en) * 1981-09-24 1987-05-13 BEECHAM - WUELFING GmbH & Co. KG Sulphonamides
AT376436B (en) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg METHOD FOR PRODUCING NEW THIOPHENE-2CARBONS [UREDERIVATIVES AND PHARMACEUTICALLY COMPATIBLE ACID OR BASE ADDITION SALTS THEREOF
CA1297109C (en) * 1986-01-17 1992-03-10 Dieter Binder 2-pyridinyl or 2-quinolinyl-methoxy-thiophene derivatives
WO1990006303A1 (en) * 1988-12-02 1990-06-14 Pfizer Inc. Arylpiperidine derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1935558A1 (en) * 1969-07-12 1971-01-28 Hoechst Ag Tiophenaethers and methods for their preparation
DE2242629A1 (en) * 1971-09-06 1973-03-15 Fahlberg List Veb Aryloxypropanol-piperidines as circulatory agents - from aryloxyepoxides and hydroxypiperidines
DE2630152A1 (en) * 1976-07-05 1978-01-19 Cassella Farbwerke Mainkur Ag (N)-Phenoxy-hydroxypropyl 4-pyridyl-piperidinol derivs. - useful as antiarrhythmic agents
DE2720613A1 (en) * 1977-05-07 1978-11-16 Basf Ag Beta-sympatholytic 1-amino-3-thienyl:oxy-2-propanol derivs. - prepd. e.g. by reacting a 1-thienyl:oxy-2,3-epoxypropane with an amine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2973363A (en) * 1959-03-26 1961-02-28 Paul Adriaan J Janssen 1-(2-thenoyl)alkyl-4-arylpiperidin-4-ols
BE615410A (en) * 1961-03-22
US3171838A (en) * 1961-10-10 1965-03-02 Res Lab Dr C Janssen N V Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds
DE1935558U (en) 1965-08-20 1966-03-31 Siemens Ag SPRING GROUND PLATE.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1935558A1 (en) * 1969-07-12 1971-01-28 Hoechst Ag Tiophenaethers and methods for their preparation
DE2242629A1 (en) * 1971-09-06 1973-03-15 Fahlberg List Veb Aryloxypropanol-piperidines as circulatory agents - from aryloxyepoxides and hydroxypiperidines
DE2630152A1 (en) * 1976-07-05 1978-01-19 Cassella Farbwerke Mainkur Ag (N)-Phenoxy-hydroxypropyl 4-pyridyl-piperidinol derivs. - useful as antiarrhythmic agents
DE2720613A1 (en) * 1977-05-07 1978-11-16 Basf Ag Beta-sympatholytic 1-amino-3-thienyl:oxy-2-propanol derivs. - prepd. e.g. by reacting a 1-thienyl:oxy-2,3-epoxypropane with an amine

Also Published As

Publication number Publication date
DE3065087D1 (en) 1983-11-03
JPS5695187A (en) 1981-08-01
EP0030688A2 (en) 1981-06-24
US4329352A (en) 1982-05-11
ZA807789B (en) 1982-01-27
EP0030688B1 (en) 1983-09-28
CA1155851A (en) 1983-10-25
ATE4808T1 (en) 1983-10-15
DE2950064A1 (en) 1981-06-19

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