EP0002655B2 - Method for the surface treatment of a contact lens - Google Patents
Method for the surface treatment of a contact lens Download PDFInfo
- Publication number
- EP0002655B2 EP0002655B2 EP78100646A EP78100646A EP0002655B2 EP 0002655 B2 EP0002655 B2 EP 0002655B2 EP 78100646 A EP78100646 A EP 78100646A EP 78100646 A EP78100646 A EP 78100646A EP 0002655 B2 EP0002655 B2 EP 0002655B2
- Authority
- EP
- European Patent Office
- Prior art keywords
- gas discharge
- contact lens
- process according
- container
- contact lenses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2011/00—Optical elements, e.g. lenses, prisms
Definitions
- the invention relates to a method according to the preamble of claim 1.
- the thickness of the deposits essentially depends on the production of the valley of the eye by the wearer of the contact lenses. Since it has so far not been possible to prevent the deposition of contaminants in the case of the contact lenses mentioned, the contact lens wearer must remove the contact lenses contaminated by deposits and clean them with suitable lens cleaning agents, which is at least annoying for the contact lens wearer.
- the invention has for its object to provide a method according to the preamble of claim 1, which leads to contact lens surfaces on which impurities, in particular proteins and lipids, are deposited to a lesser extent.
- This object is achieved in that the contact lens is exposed to a gas discharge in a pure oxygen atmosphere after polishing.
- Publication FR-A-2111959 describes a method for treating the surface of silicone rubber bodies, in which the bodies are briefly exposed to a cold inert gas plasma and are then kept under ambient conditions for at least four hours. After that, they should surprisingly be less prone to pollution; The influence of the ambient conditions is particularly important for this, since the plasma treatment alone does not have the desired effect.
- the surface treatment of the contact lens is preferably carried out in the oxygen atmosphere by means of a direct current discharge.
- the contact lens is introduced into a container which is evacuated, flooded with oxygen and then set to a pressure of preferably equal to or less than 10 torr before the gas discharge is initiated.
- a pressure of 0.01 torr is particularly favorable.
- the current is preferably in the range from 10 to 100 mA and the voltage is preferably in the range from 200 to 1000 V.
- the device shown comprises a container 10 made of glass, which can be closed in a gas-tight manner by a closure cover 12 and a stopper 14.
- a glass slide 16 on which the contact lenses 18 to be treated lie, is arranged inside the container.
- two electrodes 20 and 22, preferably designed as plates, which are above and below. of the slide are arranged and extend at least over its length. The holders for the slide and the electrodes are not shown.
- Each electrode 20 or 22 is connected to a voltage source 28 via a conductor 24 or 26 which is led through the wall of the container and by means of which a controllable voltage can be applied to the electrodes.
- a first connection pipe 30 and a second connection pipe 32 lead through the plug 14.
- the first connection pipe 30 is connected via a line 36 with a shut-off valve 38 to a vacuum pump 40.
- the pressure inside the container 10 can be measured by means of a vacuum meter 42 connected to the line 36.
- a ventilation valve 43 is also connected to line 36.
- the second connecting pipe 32 is connected via a line 44 with a shut-off valve 46 to an oxygen source 48.
- the contact lenses 18 are placed on the specimen slide 16 and inserted into the container 10.
- the container 10 is evacuated by means of the vacuum pump 40 when the shut-off valve 38 ′ and the shut-off valve 46 and ventilation valve 43 are open.
- the shutoff valve 38 is closed and the shutoff valve 46 is opened so that oxygen from the oxygen source 48 in the container 10 flows.
- the pressure of the oxygen atmosphere in the container 10 is then reduced to a suitable value equal to or less than 10 Torr by means of the vacuum pump 40.
- the shut-off valve 38 is also closed and the vacuum pump 40 is switched off.
- a voltage sufficient for glow discharge is then applied to the electrodes 20 and 22 by means of the voltage source 28, so that the gas filling in the container is ionized and the surfaces of the contact lenses 18 are exposed to the ion and electron current between the electrodes.
- this plasma treatment also surprisingly reduces the affinity for impurities, in particular lipids and proteins.
- the desired effect already occurs with short-term plasma treatment of the contact lenses. Good results are achieved with a treatment time of 15 minutes with a discharge current of 30 mA, a discharge voltage of 600 V and a vacuum of 0.5 Torr.
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Eyeglasses (AREA)
- Surface Treatment Of Optical Elements (AREA)
Description
Die Erfindung bezieht sich auf ein Verfahren gemäß dem Oberbegriff von Patentanspruch 1.The invention relates to a method according to the preamble of claim 1.
Bei harten Kontaktlinsen aus Polymethylmethacrylat-Homopolymer oder Celluloseacetobutyrat-Homopolymer und auch bei weichen Kontaktlinsen aus hydrophilem Material, beispielsweise Polyhema (Polyhydroxyäthylmethacrylat), das dehydratisiert hart ist, kommt es während des Tragens der Kontaktlinsen zu Ablagerungen von Verunreinigungen auf den Oberflächen der Kontaktlinse. Diese Verunreinigungen, die aus anorganischen und organischen Stoffen, insbesondere Proteinen und Lipiden, bestehen, beeinträchtigen die Sicht und verringern bei weichen Kontaktlinsen die Gasdurchlässigkeit, was wiederum die Zeitdauer verringert, während der die Kontaktlinse beschwerdefrei getragen werden kann.In the case of hard contact lenses made of polymethyl methacrylate homopolymer or cellulose acetobutyrate homopolymer and also in the case of soft contact lenses made of hydrophilic material, for example polyhema (polyhydroxyethyl methacrylate), which is dehydrated hard, contaminants are deposited on the surfaces of the contact lens when the contact lenses are worn. These contaminants, which consist of inorganic and organic substances, in particular proteins and lipids, impair the view and reduce the gas permeability in the case of soft contact lenses, which in turn reduces the length of time during which the contact lens can be worn without symptoms.
Die Stärke der Ablagerungen hängt im wesentlichen von der Tälgproduktion des Auges des Trägers der Kontaktlinsen ab. Da es bisher nicht möglich ist, bei den genannten Kontaktlinsen der Ablagerung von Verunreinigungen vorzubeugen, muß der Kontaktlinsenträger die durch Ablagerungen verunreinigten Kontaktlinsen herausnehmen und mit geeigneten Linsenreinigungsmitteln reinigen, was für den Kontaktlinsenträger zumindest lästig ist.The thickness of the deposits essentially depends on the production of the valley of the eye by the wearer of the contact lenses. Since it has so far not been possible to prevent the deposition of contaminants in the case of the contact lenses mentioned, the contact lens wearer must remove the contact lenses contaminated by deposits and clean them with suitable lens cleaning agents, which is at least annoying for the contact lens wearer.
Der Erfindung liegt die Aufgabe zugrunde, ein Verfahren gemäß dem Oberbegriff von Patentanspruch 1 zu schaffen, das zu Kontaktlinsenoberflächen führt, an denen sich Verunreinigungen, insbesondere Proteine und Lipide, in geringerem Maß ablagern.The invention has for its object to provide a method according to the preamble of claim 1, which leads to contact lens surfaces on which impurities, in particular proteins and lipids, are deposited to a lesser extent.
Diese Aufgabe wird erfindungsgemäß dadurch gelöst, daß die Kontaktlinse nach dem Polieren einer Gasentladung in einer reinen Sauerstoffatmosphäre ausgesetzt wird.This object is achieved in that the contact lens is exposed to a gas discharge in a pure oxygen atmosphere after polishing.
Es hat sich gezeigt, daß die Behandlung der Kontaktlinse im Sauerstoffplasma zu verringerter Ablagerung von Verunreinigungen führt. Dies ist um so überraschender, als angenommen werden mußte, daß die Behandlung von Kontaktlinsenoberflächen durch eine Gasentladung, die an sich bei Kontaktlinsen aus PMMA zur Verbesserung der Benetzbarkeit bekannt ist (DE-C-1255950) und im bekannten Fall beispielsweise in Wasserdampf oder Wasserstoffperoxid erfolgt, parallel zur stärkeren Hydrophilie auch stärkere Adsorption von Verunreinigungen hervorruft. Die Gründe für die überraschende Verringerung der Adsorption durch Sauerstoffplasmabehandlung von harten und hydrophilen weichen Kontaktlinsen sind bisher nicht eindeutig geklärt.It has been shown that the treatment of the contact lens in the oxygen plasma leads to reduced deposition of impurities. This is all the more surprising since it had to be assumed that the treatment of contact lens surfaces by a gas discharge, which is known per se for contact lenses made of PMMA to improve wettability (DE-C-1255950) and, in the known case, takes place, for example, in water vapor or hydrogen peroxide , parallel to the stronger hydrophilicity also causes stronger adsorption of impurities. The reasons for the surprising reduction in adsorption by oxygen plasma treatment of hard and hydrophilic soft contact lenses have not yet been clearly clarified.
In der Veröffentlichung FR-A-2111959 wird ein Verfahren zur Behandlung der Oberfläche von Silikonkautschukkörpern beschrieben, bei dem die Körper kurzzeitig einem kalten Inertgasplasma ausgesetzt werden und dann während zumindest vier Stunden unter Umgebungsbedingungen gehalten werden. Danach sollen sie überraschenderweise weniger zur Verschmutzung neigen ; wichtig hierfür ist besonders die Einwirkung der Umgebungsbedingungen, da die Plasmabehandlung allein die gewünschte Wirkung nicht hat.Publication FR-A-2111959 describes a method for treating the surface of silicone rubber bodies, in which the bodies are briefly exposed to a cold inert gas plasma and are then kept under ambient conditions for at least four hours. After that, they should surprisingly be less prone to pollution; The influence of the ambient conditions is particularly important for this, since the plasma treatment alone does not have the desired effect.
Vorzugsweise erfolgt die Oberflächenbehandlung der Kontaktlinse in der Sauerstoffatmosphäre durch eine Gleichstromentladung. Dazu wird die Kontaktlinse in einen Behälter eingebracht, der evakuiert wird, mit Sauerstoff durchflutet wird und dann auf einen Druck von vorzugsweise gleich oder kleiner 10 Torr eingestellt wird, bevor die Gasentladung eingeleitet wird. Besonders günstig ist ein Druck von 0,01 Torr. Während der Gasentladung liegt der Strom vorzugsweise im Bereich von 10 bis 100 mA und die Spannung vorzugsweise im Bereich von 200 bis 1000 V.The surface treatment of the contact lens is preferably carried out in the oxygen atmosphere by means of a direct current discharge. For this purpose, the contact lens is introduced into a container which is evacuated, flooded with oxygen and then set to a pressure of preferably equal to or less than 10 torr before the gas discharge is initiated. A pressure of 0.01 torr is particularly favorable. During the gas discharge, the current is preferably in the range from 10 to 100 mA and the voltage is preferably in the range from 200 to 1000 V.
Ein Ausführungsbeispiel der Erfindung wird im folgenden unter Bezugnahme auf die einzige Figur erläutert, die schematisch und teilweise in Schnittdarstellung eine Vorrichtung zur Durchführung des Verfahrens zeigt.An embodiment of the invention is explained below with reference to the single figure, which shows schematically and partially in section a device for performing the method.
Die dargestellte Vorrichtung umfaßt einen Behälter 10 aus Glas, der durch einen Verschlußdeckel 12 und einen Stopfen 14 gasdicht abschließbar ist. Innerhalb des Behälters ist ein als Glasgitter ausgebildeter Objektträger 16 angeordnet, auf dem die zu behandelnden Kontaktlinsen 18 liegen. Ferner befinden sich innerhalb des Behälters 10 zwei vorzugsweise als Platten ausgebildete Elektroden 20 und 22, die oberhalb bzw. underhalb. des Objektträgers angeordnet sind und sich zumindest über dessen Länge erstrecken. Die Halterungen für den Objektträger und die Elektroden sind nicht dargestellt.The device shown comprises a
Jede Elektrode 20 bzw. 22 ist über einen durch die Wand des Behälters geführten Leiter 24 bzw. 26 mit einer Spannungsquelle 28 verbunden, mittels der an die Elektroden eine steuerbare Spannung angelegt werden kann.Each
Durch den Stopfen 14 führen ein erstes Anschlußrohr 30 und ein zweites Anschlußrohr 32. Das erste Anschlußrohr 30 ist über eine Leitung 36 mit einem Absperrventil 38 an eine Vakuumpumpe 40 angeschlossen. Der Druck im Inneren des Behälters 10 kann mittels eines an die Leitung 36 angeschlossenen Vakuummeters 42 gemessen werden. An die Leitung 36 ist ferner ein Belüftungsventil 43 angeschlossen. Das zweite Anschlußrohr 32 ist über eine Leitung 44 mit einem Absperrventil 46 an eine Sauerstoffquelle 48 angeschlossen.A
Nach der Formgebung der Kontaktlinsen 18 und nachdem sie abschließend poliert worden sind, werden die Kontaktlinsen 18 auf den Objektträger 16 gelegt und in den Behälter 10 eingeführt. Nachdem der Behälter 10 mittels des Verschlußdeckels 12 geschlossen worden ist, wird bei geöffnetem Absperrventil 38' und geschlossenem Absperrventil 46 und Belüftungsventil 43 der Behälter 10 mittels der Vakuumpumpe 40 evakuiert. Danach wird das Absperrventil 38 geschlossen und das Absperrventil 46 geöffnet, so daß Sauerstoff aus der Sauerstoffquelle 48 in den Behälter 10 strömt. Nach erneutem Umschalten beider Absperrventile wird dann der Druck der Sauerstoffatmosphäre im Behälter 10 mittels der Vakuumpumpe 40 auf einen geeigneten Wert gleich oder kleiner 10 Torr gesenkt. Sobald das gewünschte Vakuum erreicht ist, wird auch das Absperrventil 38 geschlossen und die Vakuumpumpe 40 abgeschaltet. Mittels der Spannungsquelle 28 wird dann an die Elektroden 20 und 22 eine zur Glimmentladung ausreichende Spannung angelegt, so daß die Gasfüllung im Behälter ionisiert wird und die Oberflächen der Kontaktlinsen 18 dem lonen- und Elektronenstrom zwischen den Elektroden ausgesetzt sind. Diese Plasmabehandlung bewirkt außer der Bildung von die Hydrophilie erhöhenden polaren OH-Gruppen im Oberflächenbereich der Kontaktlinsen auch die überraschende Verringerung der Affinität für Verunreinigungen, insbesondere Lipide und Proteine. Nach Beendigung der Plasmabehandlung wird der Behälter 10 über das Belüftungsventil 43 belüftet, wonach die Kontaktlinsen aus dem Behälter entnommen werden.After the shaping of the
Der gewünschte Effekt tritt bereits bei kurzzeitiger Plasmabehandlung der Kontaktlinsen auf. Gute Ergebnisse werden bei einer Behandlungsdauer von 15 min bei einem Entladestrom von 30 mA, einer Entladespannung von 600 V und einem Vakuum von 0,5 Torr erzielt.The desired effect already occurs with short-term plasma treatment of the contact lenses. Good results are achieved with a treatment time of 15 minutes with a discharge current of 30 mA, a discharge voltage of 600 V and a vacuum of 0.5 Torr.
Die Möglichkeiten zur Durchführung des Verfahrens sind allerdings nicht auf die vorstehend genannten Werte und die vorstehend beschriebene Vorrichtung und ihre Funktionsweise beschränkt.However, the possibilities for carrying out the method are not limited to the values mentioned above and the device described above and their mode of operation.
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2756114 | 1977-12-16 | ||
DE2756114A DE2756114B1 (en) | 1977-12-16 | 1977-12-16 | Process for the surface treatment of a hard or dehydrated hydrophilic contact lens |
Publications (4)
Publication Number | Publication Date |
---|---|
EP0002655A2 EP0002655A2 (en) | 1979-07-11 |
EP0002655A3 EP0002655A3 (en) | 1979-08-08 |
EP0002655B1 EP0002655B1 (en) | 1982-01-20 |
EP0002655B2 true EP0002655B2 (en) | 1986-06-18 |
Family
ID=6026298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP78100646A Expired EP0002655B2 (en) | 1977-12-16 | 1978-08-11 | Method for the surface treatment of a contact lens |
Country Status (5)
Country | Link |
---|---|
US (1) | US4214014A (en) |
EP (1) | EP0002655B2 (en) |
DE (2) | DE2756114B1 (en) |
ES (1) | ES473524A1 (en) |
IT (1) | IT1099708B (en) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2483310A1 (en) * | 1980-05-29 | 1981-12-04 | Fibar Ste Civile Immob | TREATMENT PROCESS FOR MAKING HYDROPHILIC CONTACT LENSES HYDROPHILIC |
US5326584A (en) * | 1989-04-24 | 1994-07-05 | Drexel University | Biocompatible, surface modified materials and method of making the same |
US5080924A (en) * | 1989-04-24 | 1992-01-14 | Drexel University | Method of making biocompatible, surface modified materials |
JP2846343B2 (en) * | 1989-06-14 | 1999-01-13 | 株式会社メニコン | Surface treatment method for oxygen-permeable rigid contact lenses |
US5258127A (en) * | 1990-07-27 | 1993-11-02 | Pall Corporation | Leucocyte depleting filter device and method of use |
US5158718A (en) * | 1990-08-02 | 1992-10-27 | Pilkington Visioncare, Inc. | Contact lens casting |
EP0604590B1 (en) * | 1991-09-11 | 1999-03-17 | Pall Corporation | Gas plasma treated porous medium and method of separation using same |
US5443743A (en) * | 1991-09-11 | 1995-08-22 | Pall Corporation | Gas plasma treated porous medium and method of separation using same |
US5364662A (en) * | 1992-08-14 | 1994-11-15 | Medtronic, Inc. | Surface treatment of silicone rubber |
PT648243E (en) * | 1993-04-30 | 2000-06-30 | Alcon Lab Inc | METHOD FOR REDUCING THE STICKY QUALITY OF ACRYLIC MOLECULAR POLYMERS |
US5484549A (en) * | 1993-08-30 | 1996-01-16 | Ecolab Inc. | Potentiated aqueous ozone cleaning composition for removal of a contaminating soil from a surface |
US5567444A (en) * | 1993-08-30 | 1996-10-22 | Ecolab Inc. | Potentiated aqueous ozone cleaning and sanitizing composition for removal of a contaminating soil from a surface |
US7468398B2 (en) | 1994-09-06 | 2008-12-23 | Ciba Vision Corporation | Extended wear ophthalmic lens |
US5760100B1 (en) * | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
US5630946A (en) * | 1995-02-15 | 1997-05-20 | Pall Corporation | Method for processing a biological fluid including leukocyte removal in an extracorporeal circuit |
US5882739A (en) * | 1996-04-30 | 1999-03-16 | Whirlpool Corporation | Methods for improved drying performance of a dishwasher and resulting products thereof |
US6348507B1 (en) | 1998-05-05 | 2002-02-19 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses |
CA2328897A1 (en) | 1998-05-05 | 1999-11-11 | Bausch & Lomb Incorporated | Plasma surface treatment of silicone hydrogel contact lenses |
US6964731B1 (en) * | 1998-12-21 | 2005-11-15 | Cardinal Cg Company | Soil-resistant coating for glass surfaces |
US6974629B1 (en) * | 1999-08-06 | 2005-12-13 | Cardinal Cg Company | Low-emissivity, soil-resistant coating for glass surfaces |
US6660365B1 (en) | 1998-12-21 | 2003-12-09 | Cardinal Cg Company | Soil-resistant coating for glass surfaces |
US6213604B1 (en) | 1999-05-20 | 2001-04-10 | Bausch & Lomb Incorporated | Plasma surface treatment of silicone hydrogel contact lenses with a flexible carbon coating |
US6200626B1 (en) | 1999-05-20 | 2001-03-13 | Bausch & Lomb Incorporated | Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization |
US6630243B2 (en) * | 1999-05-20 | 2003-10-07 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating |
US6514438B1 (en) | 1999-12-21 | 2003-02-04 | Bausch & Lomb Incorporated | Pulse extraction of ocular medical devices |
US6543984B1 (en) | 2000-03-31 | 2003-04-08 | Bausch & Lomb Incorporated | Lens transfer method and devices |
US6428839B1 (en) | 2000-06-02 | 2002-08-06 | Bausch & Lomb Incorporated | Surface treatment of medical device |
DE60107461T2 (en) * | 2000-10-24 | 2005-05-12 | Bausch & Lomb Inc. | USE OF CATIONIC POLYSACCHARIDES FOR THE PREVENTION OF BACTERIAL APPLICATIONS |
US6702983B2 (en) | 2001-05-15 | 2004-03-09 | Bausch & Lomb Incorporated | Low ionic strength method and composition for reducing bacterial attachment to biomaterials |
US6958169B2 (en) * | 2002-12-17 | 2005-10-25 | Bausch & Lomb Incorporated | Surface treatment of medical device |
US7250197B2 (en) * | 2003-08-25 | 2007-07-31 | Bausch & Lomb Incorporated | Plasma treatment of contact lens and IOL |
WO2005063646A1 (en) | 2003-12-22 | 2005-07-14 | Cardinal Cg Company | Graded photocatalytic coatings |
DE602005003234T2 (en) | 2004-07-12 | 2008-08-28 | Cardinal Cg Co., Eden Prairie | MAINTENANCE-FREE COATINGS |
US7923114B2 (en) | 2004-12-03 | 2011-04-12 | Cardinal Cg Company | Hydrophilic coatings, methods for depositing hydrophilic coatings, and improved deposition technology for thin films |
US8092660B2 (en) | 2004-12-03 | 2012-01-10 | Cardinal Cg Company | Methods and equipment for depositing hydrophilic coatings, and deposition technologies for thin films |
US20060122560A1 (en) * | 2004-12-07 | 2006-06-08 | Robert Burgmeier | Medical devices and processes for preparing same |
US20070048349A1 (en) * | 2005-08-29 | 2007-03-01 | Bausch & Lomb Incorporated | Surface-modified medical devices and methods of making |
US7390863B2 (en) * | 2005-08-30 | 2008-06-24 | Bausch & Lomb Incorporated | Polymeric materials having enhanced ion and water transport property and medical devices comprising same |
US20070122540A1 (en) * | 2005-11-29 | 2007-05-31 | Bausch & Lomb Incorporated | Coatings on ophthalmic lenses |
US20070120279A1 (en) * | 2005-11-29 | 2007-05-31 | Bausch & Lomb Incorporated | Method for coating lens material |
US7989094B2 (en) * | 2006-04-19 | 2011-08-02 | Cardinal Cg Company | Opposed functional coatings having comparable single surface reflectances |
US20080002146A1 (en) * | 2006-06-28 | 2008-01-03 | Stachowski Mark J | Biocompatible, surface modified materials |
US20080011599A1 (en) | 2006-07-12 | 2008-01-17 | Brabender Dennis M | Sputtering apparatus including novel target mounting and/or control |
US7625598B2 (en) * | 2006-12-15 | 2009-12-01 | Bausch & Lomb Incorporated | Silicone contact lenses with wrinkled surface |
US20080142038A1 (en) * | 2006-12-15 | 2008-06-19 | Bausch & Lomb Incorporated | Surface treatment of medical devices |
ATE491479T1 (en) * | 2006-12-15 | 2011-01-15 | Bausch & Lomb | SURFACE TREATMENT OF BIOMEDICAL DEVICES |
US20080143955A1 (en) * | 2006-12-15 | 2008-06-19 | Bausch & Lomb Incorporated | Silicone Contact Lenses with Silicate Coating |
US20080206481A1 (en) * | 2007-02-26 | 2008-08-28 | Bausch & Lomb Incorporated | Silicone contact lenses with wrinkled surface |
WO2009036284A1 (en) | 2007-09-14 | 2009-03-19 | Cardinal Cg Company | Low-maintenance coatings, and methods for producing low-maintenance coatings |
US20090111942A1 (en) * | 2007-10-25 | 2009-04-30 | Bausch & Lomb Incorporated | Method for Making Surface Modified Biomedical Devices |
WO2009079224A2 (en) * | 2007-12-14 | 2009-06-25 | Bausch & Lomb Incorporated | Surface modified biomedical devices |
WO2009079223A1 (en) * | 2007-12-14 | 2009-06-25 | Bausch & Lomb Incorporated | Surface modified biomedical devices |
JP2011507563A (en) * | 2007-12-14 | 2011-03-10 | ボーシュ アンド ローム インコーポレイティド | Biomedical devices |
WO2009149827A1 (en) * | 2008-05-27 | 2009-12-17 | Ao Technology Ag | Polymer surface modification |
US8454689B2 (en) * | 2008-12-30 | 2013-06-04 | Bausch & Lomb Incorporated | Brush copolymers |
US20100168851A1 (en) * | 2008-12-30 | 2010-07-01 | David Paul Vanderbilt | Surface Modified Biomedical Devices |
US8419792B2 (en) | 2008-12-30 | 2013-04-16 | Bausch & Lomb Incorporated | Brush copolymers |
TW201200345A (en) | 2010-06-25 | 2012-01-01 | Carnehammer Lars Bertil | Surface treatment of rubber using low pressure plasma |
US8798332B2 (en) | 2012-05-15 | 2014-08-05 | Google Inc. | Contact lenses |
US8857981B2 (en) | 2012-07-26 | 2014-10-14 | Google Inc. | Facilitation of contact lenses with capacitive sensors |
US9158133B1 (en) | 2012-07-26 | 2015-10-13 | Google Inc. | Contact lens employing optical signals for power and/or communication |
US9523865B2 (en) | 2012-07-26 | 2016-12-20 | Verily Life Sciences Llc | Contact lenses with hybrid power sources |
US9298020B1 (en) | 2012-07-26 | 2016-03-29 | Verily Life Sciences Llc | Input system |
US8919953B1 (en) | 2012-08-02 | 2014-12-30 | Google Inc. | Actuatable contact lenses |
US9696564B1 (en) | 2012-08-21 | 2017-07-04 | Verily Life Sciences Llc | Contact lens with metal portion and polymer layer having indentations |
US9111473B1 (en) | 2012-08-24 | 2015-08-18 | Google Inc. | Input system |
US8820934B1 (en) | 2012-09-05 | 2014-09-02 | Google Inc. | Passive surface acoustic wave communication |
US20140192315A1 (en) | 2012-09-07 | 2014-07-10 | Google Inc. | In-situ tear sample collection and testing using a contact lens |
US9398868B1 (en) | 2012-09-11 | 2016-07-26 | Verily Life Sciences Llc | Cancellation of a baseline current signal via current subtraction within a linear relaxation oscillator-based current-to-frequency converter circuit |
US10010270B2 (en) | 2012-09-17 | 2018-07-03 | Verily Life Sciences Llc | Sensing system |
US9326710B1 (en) | 2012-09-20 | 2016-05-03 | Verily Life Sciences Llc | Contact lenses having sensors with adjustable sensitivity |
US8870370B1 (en) | 2012-09-24 | 2014-10-28 | Google Inc. | Contact lens that facilitates antenna communication via sensor impedance modulation |
US8960898B1 (en) | 2012-09-24 | 2015-02-24 | Google Inc. | Contact lens that restricts incoming light to the eye |
US20140088372A1 (en) | 2012-09-25 | 2014-03-27 | Google Inc. | Information processing method |
US8979271B2 (en) | 2012-09-25 | 2015-03-17 | Google Inc. | Facilitation of temperature compensation for contact lens sensors and temperature sensing |
US8989834B2 (en) | 2012-09-25 | 2015-03-24 | Google Inc. | Wearable device |
US8821811B2 (en) | 2012-09-26 | 2014-09-02 | Google Inc. | In-vitro contact lens testing |
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US9063351B1 (en) | 2012-09-28 | 2015-06-23 | Google Inc. | Input detection system |
US8965478B2 (en) | 2012-10-12 | 2015-02-24 | Google Inc. | Microelectrodes in an ophthalmic electrochemical sensor |
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US20140209481A1 (en) | 2013-01-25 | 2014-07-31 | Google Inc. | Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement |
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US3677877A (en) * | 1970-10-30 | 1972-07-18 | Dow Corning | Article of silicone rubber having surfaces resistant to dirt pick-up |
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IT1099708B (en) | 1985-09-28 |
IT7828786A0 (en) | 1978-10-16 |
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