EE200200472A - Galenic dosage form for sustained release oral administration of molsidomine - Google Patents
Galenic dosage form for sustained release oral administration of molsidomineInfo
- Publication number
- EE200200472A EE200200472A EEP200200472A EEP200200472A EE200200472A EE 200200472 A EE200200472 A EE 200200472A EE P200200472 A EEP200200472 A EE P200200472A EE P200200472 A EEP200200472 A EE P200200472A EE 200200472 A EE200200472 A EE 200200472A
- Authority
- EE
- Estonia
- Prior art keywords
- molsidomine
- hours
- released
- angina
- release oral
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The present invention relates to a novel sustained-release oral galenical form of molsidomine for the treatment of all forms of angina attack (angina of effort, spastic angina, mixed angina). According to the invention, this novel galenical form contains a therapeutically effective amount of molsidomine or one of its active metabolites and has an in vitro dissolution rate [measured spectrophotometrically at 286 or 311 nm by the method described in the European Pharmacopoeia, 3rd edition (or USP XXIV), at 50 rpm, in 500 ml of a 0.1 N HCl medium, at 37° C.] of: 15 to 25% of molsidomine released after 1 hour, 20 to 35% of molsidomine released after 2 hours, 50 to 65% of molsidomine released after 6 hours, 75 to 95% of molsidomine released after 12 hours, >85% of molsidomine released after 18 hours and >90% of molsidomine released after 24 hours, the plasma peak of molsidomine obtained in vivo occurring 2.5 to 5 hours, preferably 3 to 4 hours, following the administration of said form, and having a value of between 25 and 40 ng/ml of plasma. Application: therapeutics industry.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0002307A FR2805462B1 (en) | 2000-02-24 | 2000-02-24 | NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE |
| PCT/EP2001/002055 WO2001062256A1 (en) | 2000-02-24 | 2001-02-22 | Novel galenical form for oral administration with prolonged release of molsidomine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200200472A true EE200200472A (en) | 2003-12-15 |
| EE05098B1 EE05098B1 (en) | 2008-12-15 |
Family
ID=8847342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200200472A EE05098B1 (en) | 2000-02-24 | 2001-02-22 | Molsidomine extended release oral galenic dosage form |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US7767227B2 (en) |
| EP (1) | EP1265614B1 (en) |
| JP (1) | JP4945043B2 (en) |
| KR (1) | KR100814191B1 (en) |
| CN (1) | CN100396284C (en) |
| AT (1) | ATE296632T1 (en) |
| AU (2) | AU2001240653B9 (en) |
| BE (1) | BE1013487A3 (en) |
| BG (1) | BG66111B1 (en) |
| BR (1) | BRPI0108041B8 (en) |
| CA (1) | CA2400886C (en) |
| CZ (1) | CZ301993B6 (en) |
| DE (1) | DE60111196T2 (en) |
| DZ (1) | DZ3273A1 (en) |
| EE (1) | EE05098B1 (en) |
| ES (1) | ES2241803T3 (en) |
| FR (1) | FR2805462B1 (en) |
| HK (1) | HK1050138B (en) |
| HR (1) | HRP20020692B1 (en) |
| HU (1) | HU229799B1 (en) |
| IL (2) | IL151205A0 (en) |
| IS (1) | IS2446B (en) |
| MA (1) | MA25576A1 (en) |
| MD (1) | MD3119C2 (en) |
| MX (1) | MXPA02008262A (en) |
| NO (1) | NO329495B1 (en) |
| NZ (1) | NZ520691A (en) |
| OA (1) | OA12183A (en) |
| PL (1) | PL201631B1 (en) |
| PT (1) | PT1265614E (en) |
| RS (1) | RS50291B (en) |
| RU (1) | RU2263506C2 (en) |
| SK (1) | SK286313B6 (en) |
| UA (1) | UA73972C2 (en) |
| WO (1) | WO2001062256A1 (en) |
| ZA (1) | ZA200206042B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2805462B1 (en) * | 2000-02-24 | 2003-08-15 | Therabel Res | NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE |
| US7803402B2 (en) * | 2002-07-06 | 2010-09-28 | Sanjeev Khandelwal | Pharmaceutical preparations |
| FR2868314B1 (en) * | 2004-04-05 | 2008-10-24 | Therabel Pharmaceuticals Ltd | NOVEL THERAPEUTIC USE OF MOLSIDOMIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
| EP2468269A1 (en) | 2010-11-26 | 2012-06-27 | Universitätsklinikum Münster | Nitric oxide donors in therapy of nitric oxide deficiency-induced disturbances of cerebral microcirculation |
| BE1028879B1 (en) | 2020-12-11 | 2022-07-12 | Europharmaceuticals | Molsidomine Sustained-Release Tablet |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3522191A1 (en) * | 1985-06-21 | 1987-01-15 | Cassella Ag | PHOTOSTABILIZATION OF SYDNONIMINES |
| CN1006522B (en) * | 1986-04-30 | 1990-01-24 | 田道制药有限公司 | Method for preparing sustained release preparation |
| HU210921B (en) * | 1990-03-28 | 1995-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them |
| HU211648A9 (en) * | 1990-03-28 | 1995-12-28 | Chinoin Gyogyszer Es Vegyeszet | Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same |
| DE4140192C2 (en) * | 1991-12-05 | 1996-02-29 | Alfatec Pharma Gmbh | Sol-controlled gelatin-based thermocolloid matrix for peroral sustained release forms |
| DE59408793D1 (en) * | 1993-05-11 | 1999-11-11 | Hoechst Ag | Galenic preparations from Molsidomin |
| JPH09503997A (en) * | 1993-07-08 | 1997-04-22 | シグナス，インコーポレイテッド | Monolithic matrix transdermal delivery system |
| IT1266565B1 (en) * | 1993-07-22 | 1997-01-09 | Ct Lab Farm Srl | PHARMACEUTICAL COMPOSITIONS WITH CONTROLLED RELEASE ON THE BASIS OF ONE OR MORE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE RANGE-HYDROXY-BUTYRIC ACID. |
| HU218280B (en) * | 1994-04-26 | 2000-07-28 | Cyclodextrin inclusion complexes containing sin-1a which are stable intheir solid state, process for their preparation and pharmaceutical compositions containing the comlexes | |
| DE4443105C2 (en) * | 1994-12-03 | 1997-03-13 | Hoechst Ag | Process for the production of tablets containing molsidomine |
| JPH09114680A (en) * | 1995-10-19 | 1997-05-02 | Fuji Xerox Co Ltd | Sequence controller |
| IT1282576B1 (en) * | 1996-02-06 | 1998-03-31 | Jagotec Ag | PHARMACEUTICAL TABLET SUITABLE TO GIVE THE ACTIVE SUBSTANCE IN SUBSEQUENT AND PREDETERMINABLE TIMES |
| PE57198A1 (en) * | 1996-03-25 | 1998-10-10 | American Home Prod | PROLONGED RELEASE FORMULA |
| JP2002522354A (en) * | 1997-09-19 | 2002-07-23 | シャイア ラボラトリーズ，インコーポレイテッド | Solid solution beadlets |
| FR2775188B1 (en) * | 1998-02-23 | 2001-03-09 | Lipha | IMMEDIATE RELEASE ORAL EXTENDED RELEASE GALENIC FORM COMPRISING AN ABSORPTION PROMOTING AGENT AND USE OF THE ABSORPTION PROMOTING AGENT |
| FR2805462B1 (en) * | 2000-02-24 | 2003-08-15 | Therabel Res | NEW ORAL GALENIC FORM WITH EXTENDED RELEASE OF MOLSIDOMINE |
-
2000
- 2000-02-24 FR FR0002307A patent/FR2805462B1/en not_active Expired - Lifetime
-
2001
- 2001-02-22 IL IL15120501A patent/IL151205A0/en active IP Right Grant
- 2001-02-22 WO PCT/EP2001/002055 patent/WO2001062256A1/en active IP Right Grant
- 2001-02-22 UA UA2002086983A patent/UA73972C2/en unknown
- 2001-02-22 ES ES01911692T patent/ES2241803T3/en not_active Expired - Lifetime
- 2001-02-22 DE DE60111196T patent/DE60111196T2/en not_active Expired - Lifetime
- 2001-02-22 AU AU2001240653A patent/AU2001240653B9/en not_active Expired
- 2001-02-22 RS YUP-622/02A patent/RS50291B/en unknown
- 2001-02-22 SK SK1220-2002A patent/SK286313B6/en not_active IP Right Cessation
- 2001-02-22 JP JP2001561321A patent/JP4945043B2/en not_active Expired - Lifetime
- 2001-02-22 KR KR1020027010441A patent/KR100814191B1/en active IP Right Grant
- 2001-02-22 CN CNB018052592A patent/CN100396284C/en not_active Expired - Lifetime
- 2001-02-22 NZ NZ520691A patent/NZ520691A/en not_active IP Right Cessation
- 2001-02-22 AU AU4065301A patent/AU4065301A/en active Pending
- 2001-02-22 PL PL357550A patent/PL201631B1/en unknown
- 2001-02-22 CZ CZ20022876A patent/CZ301993B6/en not_active IP Right Cessation
- 2001-02-22 AT AT01911692T patent/ATE296632T1/en active
- 2001-02-22 EE EEP200200472A patent/EE05098B1/en unknown
- 2001-02-22 BR BRPI0108041A patent/BRPI0108041B8/en not_active IP Right Cessation
- 2001-02-22 US US10/182,718 patent/US7767227B2/en not_active Expired - Fee Related
- 2001-02-22 MD MDA20020212A patent/MD3119C2/en active IP Right Grant
- 2001-02-22 DZ DZ013273A patent/DZ3273A1/en active
- 2001-02-22 EP EP01911692A patent/EP1265614B1/en not_active Expired - Lifetime
- 2001-02-22 RU RU2002121503/15A patent/RU2263506C2/en active
- 2001-02-22 PT PT01911692T patent/PT1265614E/en unknown
- 2001-02-22 OA OA1200200258A patent/OA12183A/en unknown
- 2001-02-22 BE BE2001/0121A patent/BE1013487A3/en not_active IP Right Cessation
- 2001-02-22 HU HU0300607A patent/HU229799B1/en unknown
- 2001-02-22 MX MXPA02008262A patent/MXPA02008262A/en active IP Right Grant
- 2001-02-22 CA CA2400886A patent/CA2400886C/en not_active Expired - Lifetime
-
2002
- 2002-07-29 ZA ZA200206042A patent/ZA200206042B/en unknown
- 2002-08-06 MA MA26765A patent/MA25576A1/en unknown
- 2002-08-12 IL IL151205A patent/IL151205A/en unknown
- 2002-08-14 IS IS6504A patent/IS2446B/en unknown
- 2002-08-22 BG BG107027A patent/BG66111B1/en unknown
- 2002-08-22 HR HR20020692A patent/HRP20020692B1/en not_active IP Right Cessation
- 2002-08-23 NO NO20024043A patent/NO329495B1/en not_active IP Right Cessation
-
2003
- 2003-03-27 HK HK03102218.9A patent/HK1050138B/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20101231 |