EE200000239A - Novel methylenebisphosphonic acid derivatives - Google Patents
Novel methylenebisphosphonic acid derivativesInfo
- Publication number
- EE200000239A EE200000239A EEP200000239A EEP200000239A EE200000239A EE 200000239 A EE200000239 A EE 200000239A EE P200000239 A EEP200000239 A EE P200000239A EE P200000239 A EEP200000239 A EE P200000239A EE 200000239 A EE200000239 A EE 200000239A
- Authority
- EE
- Estonia
- Prior art keywords
- acid derivatives
- methylenebisphosphonic acid
- novel methylenebisphosphonic
- novel
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI974001A FI104901B (en) | 1997-10-20 | 1997-10-20 | New methylene bisphosphonic acid derivatives |
PCT/FI1998/000814 WO1999020634A1 (en) | 1997-10-20 | 1998-10-20 | Novel methylenebisphosphonic acid derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200000239A true EE200000239A (en) | 2001-08-15 |
EE04061B1 EE04061B1 (en) | 2003-06-16 |
Family
ID=8549759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200000239A EE04061B1 (en) | 1997-10-20 | 1998-10-20 | Methylenebisphosphonic acid derivatives |
Country Status (19)
Country | Link |
---|---|
US (1) | US6326363B1 (en) |
EP (1) | EP1032578A1 (en) |
JP (1) | JP2001520232A (en) |
KR (1) | KR20010031269A (en) |
CN (1) | CN1147497C (en) |
AU (1) | AU740355B2 (en) |
BG (1) | BG104452A (en) |
BR (1) | BR9813102A (en) |
CA (1) | CA2306080A1 (en) |
EE (1) | EE04061B1 (en) |
FI (1) | FI104901B (en) |
HU (1) | HUP0004386A3 (en) |
IL (1) | IL135639A0 (en) |
NO (1) | NO20002006L (en) |
NZ (1) | NZ504390A (en) |
PL (1) | PL340055A1 (en) |
RU (1) | RU2205833C2 (en) |
TR (1) | TR200001055T2 (en) |
WO (1) | WO1999020634A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO313180B1 (en) * | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Visiting alpha particles emitting radiopharmaceuticals |
US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
US8288545B2 (en) * | 2006-07-21 | 2012-10-16 | Glsynthesis Inc. | Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use |
US8575127B2 (en) | 2008-11-20 | 2013-11-05 | Glsynthesis Inc. | Antithrombotic diadenosine tetraphosphates and related analogs |
CN107011380A (en) * | 2016-01-28 | 2017-08-04 | 臧伟 | A kind of diphosphonic acid derivative and containing diphosphonic acid derivative composition treatment fracture application |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4447256A (en) | 1977-07-20 | 1984-05-08 | Nissan Chemical Industries, Ltd. | N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same |
DE2758580A1 (en) | 1977-12-29 | 1979-07-05 | Hoechst Ag | PROCESS FOR PRODUCTION OF PHOSPHINE AND PHOSPHONIC ACID ANHYDRIDES |
US4973576A (en) | 1987-03-10 | 1990-11-27 | Yamanouchi Pharmaceutical Co., Ltd. | Bisphophonic acid derivatives and pharmaceutical compositions containing the same |
US4933472A (en) | 1988-04-08 | 1990-06-12 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted aminomethylenebis(phosphonic acid) derivatives |
EP0356866A3 (en) | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphorus-containing squalene synthetase inhibitors and method |
FI83421C (en) * | 1989-06-21 | 1991-07-10 | Huhtamaeki Oy | FOERFARANDE FOER FRAMSTAELLNING AV FARMAKOLOGISKT ANVAENDBARA METYLENBISFOSFONSYRADERIVAT. |
DE69023844T2 (en) | 1989-09-06 | 1996-06-20 | Merck & Co Inc | Acyloxymethyl ester of bisphonic acids as bone resorption inhibitors. |
FI89365C (en) * | 1990-12-20 | 1993-09-27 | Leiras Oy | PROCEDURE FOR THE FRAMEWORK OF THE PHARMACOLOGICAL PROCEDURE OF METHYLENBISPHOSPHONYRADERIVAT |
FI89366C (en) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Process for the preparation of novel pharmacologically useful methylenebisphosphonic acid derivatives |
FI89364C (en) * | 1990-12-20 | 1993-09-27 | Leiras Oy | FRUIT PROCESSING FOR METHYLENBISPHOSPHONE PHARMACEUTICALS, PHARMACOLOGICAL PROPERTIES |
JP3141028B2 (en) | 1991-04-06 | 2001-03-05 | アストラ・フアーマシユウテイカルズ・リミテツド | ATP analog |
TW237386B (en) | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
PL175623B1 (en) * | 1993-02-10 | 1999-01-29 | Astra Pharma Prod | N-alkyl-2-substituted atp analogues |
US5462932A (en) | 1994-05-17 | 1995-10-31 | Merck & Co., Inc. | Oral liquid alendronate formulations |
-
1997
- 1997-10-20 FI FI974001A patent/FI104901B/en not_active IP Right Cessation
-
1998
- 1998-10-20 US US09/529,826 patent/US6326363B1/en not_active Expired - Lifetime
- 1998-10-20 JP JP2000516975A patent/JP2001520232A/en not_active Withdrawn
- 1998-10-20 EP EP98949022A patent/EP1032578A1/en not_active Withdrawn
- 1998-10-20 KR KR1020007004256A patent/KR20010031269A/en not_active Application Discontinuation
- 1998-10-20 CA CA002306080A patent/CA2306080A1/en not_active Abandoned
- 1998-10-20 TR TR2000/01055T patent/TR200001055T2/en unknown
- 1998-10-20 RU RU2000112534/04A patent/RU2205833C2/en not_active IP Right Cessation
- 1998-10-20 BR BR9813102-8A patent/BR9813102A/en not_active IP Right Cessation
- 1998-10-20 WO PCT/FI1998/000814 patent/WO1999020634A1/en not_active Application Discontinuation
- 1998-10-20 CN CNB988103710A patent/CN1147497C/en not_active Expired - Fee Related
- 1998-10-20 PL PL98340055A patent/PL340055A1/en unknown
- 1998-10-20 EE EEP200000239A patent/EE04061B1/en not_active IP Right Cessation
- 1998-10-20 AU AU95437/98A patent/AU740355B2/en not_active Ceased
- 1998-10-20 NZ NZ504390A patent/NZ504390A/en unknown
- 1998-10-20 HU HU0004386A patent/HUP0004386A3/en unknown
- 1998-10-20 IL IL13563998A patent/IL135639A0/en unknown
-
2000
- 2000-04-17 NO NO20002006A patent/NO20002006L/en not_active Application Discontinuation
- 2000-05-17 BG BG104452A patent/BG104452A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU9543798A (en) | 1999-05-10 |
WO1999020634A1 (en) | 1999-04-29 |
HUP0004386A2 (en) | 2001-04-28 |
US6326363B1 (en) | 2001-12-04 |
NO20002006L (en) | 2000-06-15 |
EE04061B1 (en) | 2003-06-16 |
CA2306080A1 (en) | 1999-04-29 |
CN1276793A (en) | 2000-12-13 |
BG104452A (en) | 2000-12-29 |
JP2001520232A (en) | 2001-10-30 |
PL340055A1 (en) | 2001-01-15 |
FI104901B (en) | 2000-04-28 |
TR200001055T2 (en) | 2000-09-21 |
FI974001A0 (en) | 1997-10-20 |
IL135639A0 (en) | 2001-05-20 |
AU740355B2 (en) | 2001-11-01 |
RU2205833C2 (en) | 2003-06-10 |
FI974001A (en) | 1999-04-21 |
NZ504390A (en) | 2001-10-26 |
EP1032578A1 (en) | 2000-09-06 |
BR9813102A (en) | 2000-08-22 |
KR20010031269A (en) | 2001-04-16 |
CN1147497C (en) | 2004-04-28 |
HUP0004386A3 (en) | 2002-08-28 |
NO20002006D0 (en) | 2000-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20041020 |