EE05037B1 - Thiazolo (4,5-d) pyrimidine compounds, process for their preparation and pharmaceutical composition containing them - Google Patents

Thiazolo (4,5-d) pyrimidine compounds, process for their preparation and pharmaceutical composition containing them

Info

Publication number
EE05037B1
EE05037B1 EEP200200174A EEP200200174A EE05037B1 EE 05037 B1 EE05037 B1 EE 05037B1 EE P200200174 A EEP200200174 A EE P200200174A EE P200200174 A EEP200200174 A EE P200200174A EE 05037 B1 EE05037 B1 EE 05037B1
Authority
EE
Estonia
Prior art keywords
preparation
thiazolo
pharmaceutical composition
composition containing
pyrimidine compounds
Prior art date
Application number
EEP200200174A
Other languages
Estonian (et)
Inventor
Andrew Willis Paul
Victor Bonnert Roger
Fraser Hunt Simon
Alistair Stewart Walters Iain
Original Assignee
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Limited filed Critical Astrazeneca Uk Limited
Publication of EE200200174A publication Critical patent/EE200200174A/en
Publication of EE05037B1 publication Critical patent/EE05037B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy. <CHEM>The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy for treating chemokine mediated disease. <CHEM>
EEP200200174A 1999-10-01 2000-09-26 Thiazolo (4,5-d) pyrimidine compounds, process for their preparation and pharmaceutical composition containing them EE05037B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9903544A SE9903544D0 (en) 1999-10-01 1999-10-01 Novel compounds
PCT/GB2000/003692 WO2001025242A1 (en) 1999-10-01 2000-09-26 Novel thiazolo(4,5-d)pyrimidine compounds

Publications (2)

Publication Number Publication Date
EE200200174A EE200200174A (en) 2003-04-15
EE05037B1 true EE05037B1 (en) 2008-06-16

Family

ID=20417218

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200174A EE05037B1 (en) 1999-10-01 2000-09-26 Thiazolo (4,5-d) pyrimidine compounds, process for their preparation and pharmaceutical composition containing them

Country Status (27)

Country Link
US (3) US6790850B1 (en)
EP (2) EP1348709B1 (en)
JP (1) JP4824889B2 (en)
KR (1) KR100765051B1 (en)
CN (1) CN1210279C (en)
AT (2) ATE384068T1 (en)
AU (1) AU777872B2 (en)
BR (1) BR0014334A (en)
CA (1) CA2385269C (en)
CZ (1) CZ20021113A3 (en)
DE (2) DE60037836T2 (en)
DK (1) DK1222195T3 (en)
EE (1) EE05037B1 (en)
ES (2) ES2298451T3 (en)
HK (1) HK1052009A1 (en)
HU (1) HUP0204246A3 (en)
IL (2) IL148910A0 (en)
IS (1) IS2229B (en)
MX (1) MXPA02003263A (en)
NO (1) NO327706B1 (en)
NZ (1) NZ517880A (en)
PT (1) PT1222195E (en)
SE (1) SE9903544D0 (en)
TW (1) TWI260324B (en)
UA (1) UA73521C2 (en)
WO (1) WO2001025242A1 (en)
ZA (1) ZA200202380B (en)

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GB2359551A (en) 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives
SE0003828D0 (en) 2000-10-20 2000-10-20 Astrazeneca Ab Novel compounds
SE0101322D0 (en) * 2001-04-12 2001-04-12 Astrazeneca Ab Novel compounds
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GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
WO2004013141A1 (en) 2002-08-06 2004-02-12 Astrazeneca Ab Condensed pyridines and pyrimidines with tie2 (tek) activity
EP1539713B1 (en) 2002-08-24 2007-12-19 Astrazeneca AB Pyrimidine derivatives as modulators of chemokine receptor activity
GB0221829D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
GB0221828D0 (en) * 2002-09-20 2002-10-30 Astrazeneca Ab Novel compound
US20070142386A1 (en) * 2003-10-07 2007-06-21 Astrazeneca New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1
GB0328243D0 (en) * 2003-12-05 2004-01-07 Astrazeneca Ab Methods
EP1809624B1 (en) 2004-08-28 2013-11-20 AstraZeneca AB Pyrimidine sulphonamide derivatives as chemokine receptor modulators
WO2006064228A2 (en) * 2004-12-17 2006-06-22 Astrazeneca Ab Thiazolopyramidine compounds for the modulation of chemokine receptor activity
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UA90707C2 (en) * 2005-04-06 2010-05-25 Астразенека Аб Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives
TW200820973A (en) 2006-09-29 2008-05-16 Astrazeneca Ab Novel compounds 480
AR071036A1 (en) * 2008-03-26 2010-05-19 Astrazeneca Ab DERIVATIVES 5, 7-DISUSTITUTES OF [1, 3] TIAZOLO [4, 5-D] PIRIMIDIN-2 (3H) -ONA, A PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS AND ITS USE IN THE TREATMENT OF DISEASES MEDIATED BY THE CX3CR1 RECEIVER.
CN101671336B (en) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 Aromatic heterocyclic pyridine derivatives and analogs and preparation method and application thereof
CN101899058B (en) * 2010-05-24 2012-05-23 中国人民解放军第四军医大学 Method for preparing thiazolopyrimidine compound, thiazolopyrimidine compound and application thereof
EP3011012B1 (en) 2013-06-18 2018-09-12 New York University Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
CN105683202B (en) * 2013-08-02 2019-05-10 Syntrix生物系统公司 A kind of boronic acid compounds
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
WO2018073248A1 (en) 2016-10-17 2018-04-26 Icm (Institut Du Cerveau Et De La Moelle Épinière) Prognosis of demyelinating diseases patients and treatment thereof
CN110172067B (en) * 2019-04-11 2021-06-15 河南科技大学第一附属医院 Thiazole medicine molecule with bactericidal activity and preparation method thereof

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Also Published As

Publication number Publication date
EP1348709A3 (en) 2003-11-19
EP1348709A2 (en) 2003-10-01
HK1052009A1 (en) 2003-08-29
CN1210279C (en) 2005-07-13
ES2213043T3 (en) 2004-08-16
ATE257838T1 (en) 2004-01-15
NO327706B1 (en) 2009-09-14
EP1222195A1 (en) 2002-07-17
EE200200174A (en) 2003-04-15
CN1402730A (en) 2003-03-12
AU7304900A (en) 2001-05-10
MXPA02003263A (en) 2002-09-30
DE60007768T2 (en) 2004-12-02
NO20021448D0 (en) 2002-03-22
IL148910A (en) 2006-10-31
JP2003511384A (en) 2003-03-25
PL365778A1 (en) 2005-01-10
HUP0204246A3 (en) 2006-01-30
KR20020032635A (en) 2002-05-03
AU777872B2 (en) 2004-11-04
IS6306A (en) 2002-03-18
NO20021448L (en) 2002-05-22
SE9903544D0 (en) 1999-10-01
US6790850B1 (en) 2004-09-14
DK1222195T3 (en) 2004-04-19
ZA200202380B (en) 2003-10-29
DE60007768D1 (en) 2004-02-19
US20040224961A1 (en) 2004-11-11
BR0014334A (en) 2002-06-11
ES2298451T3 (en) 2008-05-16
US8143261B2 (en) 2012-03-27
CZ20021113A3 (en) 2002-06-12
KR100765051B1 (en) 2007-10-09
US20090281123A1 (en) 2009-11-12
EP1348709B1 (en) 2008-01-16
CA2385269A1 (en) 2001-04-12
HUP0204246A2 (en) 2003-04-28
JP4824889B2 (en) 2011-11-30
PT1222195E (en) 2004-05-31
WO2001025242A1 (en) 2001-04-12
EP1222195B1 (en) 2004-01-14
DE60037836D1 (en) 2008-03-06
IS2229B (en) 2007-04-15
DE60037836T2 (en) 2009-01-15
NZ517880A (en) 2003-09-26
CA2385269C (en) 2010-08-17
IL148910A0 (en) 2002-09-12
TWI260324B (en) 2006-08-21
ATE384068T1 (en) 2008-02-15
UA73521C2 (en) 2005-08-15

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