ECSP993273A - FARNESILO PROTEIN TRANSFERASE INHIBITORS - Google Patents
FARNESILO PROTEIN TRANSFERASE INHIBITORSInfo
- Publication number
- ECSP993273A ECSP993273A ECSP993273A ECSP993273A EC SP993273 A ECSP993273 A EC SP993273A EC SP993273 A ECSP993273 A EC SP993273A EC SP993273 A ECSP993273 A EC SP993273A
- Authority
- EC
- Ecuador
- Prior art keywords
- group
- protein transferase
- farnesilo
- compounds
- disclosed
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000003558 transferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000004202 carbamide Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen compuestos que tiene la fórmula (gráfico), en la cual R13 representa un anillo imidazol; R14 representa un grupo carbamato, urea, amida o sulfonamida; R8 representa H, cuando la cadena alquilo entre el grupo amida y el grupo R13 imidazol está sustituido, o R8 representa un sustituyente tal como arilalquilo, heteroarilalquilo o cicloalquilo, y los sustituyentes remanentes son tal como se definen aqui. También se describen compuestos en los cuales R8 es H, y la cadena alquilo entre el grupo amida y el grupo imidazol R13 está no sustituido. Se describe también un método para tratar cáncer y un método para inhibir la transferasa de proteina farnesilo usando los compuestos descriptos.Compounds are described having the formula (graph), in which R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H, when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl, and the remaining substituents are as defined herein. Also disclosed are compounds in which R8 is H, and the alkyl chain between the amide group and the imidazole group R13 is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993273 ECSP993273A (en) | 1999-12-16 | 1999-12-16 | FARNESILO PROTEIN TRANSFERASE INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993273 ECSP993273A (en) | 1999-12-16 | 1999-12-16 | FARNESILO PROTEIN TRANSFERASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993273A true ECSP993273A (en) | 2000-08-18 |
Family
ID=42044262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993273 ECSP993273A (en) | 1999-12-16 | 1999-12-16 | FARNESILO PROTEIN TRANSFERASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993273A (en) |
-
1999
- 1999-12-16 EC ECSP993273 patent/ECSP993273A/en unknown
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