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Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
La presente invención se refiere a un compuesto de la fórmula I (grágico), en donde R es adamantilo sustituido; y n es de 0 a 3; en forma libre o en forma de sal de adición de ácido. Los compuestos de la fórmula I inhiben la actividad de DPP-IV(peptidiasa de dipeptidilo-IV). Por consiguiente, se indican para utilizarse como productos farmacéuticos en la inhibición de DPP-IV, y en el tratamiento de condiciones mediadas por DPP-IV, tales como diabetes mellitus no dependientes de insulina, artritis, obesidad, osteoporosis, y otras condiciones de tolerancia deteriorada a la glucosa.The present invention relates to a compound of formula I (magical), wherein R is substituted adamantyl; and n is 0 to 3; in free form or in the form of an acid addition salt. The compounds of formula I inhibit the activity of DPP-IV (dipeptidyl-IV peptidiase). Accordingly, they are indicated for use as pharmaceuticals in the inhibition of DPP-IV, and in the treatment of conditions mediated by DPP-IV, such as non-insulin dependent diabetes mellitus, arthritis, obesity, osteoporosis, and other conditions of tolerance. impaired glucose.
COMPOUNDS DERIVED FROM ALQUILARILO; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; AND USE FOR THE TREATMENT AND / OR PROFILAXIS OF OBESITY AND RELATED DISORDERS.
process for the synthesis of (1s) -4,5-dimethoxy-1- (methylaminomethyl) benzocyclobutane and its addition salts, and application to the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid
COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL
Compound, process to produce the same, pharmaceutical composition, use of the compound, processes to inhibit the production of nitric oxide and / or cytokine in mammals, and to prevent or treat heart disease, autoimmune disease or septic shock in mammals, and, for medications
Process for the preparation of the compound, compound, pharmaceutical composition, use of the compounds, and, process for the preparation of the compounds