ECSP993138A - CONTROLLED DRUG DELIVERY SYSTEM ORALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROL - Google Patents
CONTROLLED DRUG DELIVERY SYSTEM ORALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROLInfo
- Publication number
- ECSP993138A ECSP993138A ECSP993138A ECSP993138A EC SP993138 A ECSP993138 A EC SP993138A EC SP993138 A ECSP993138 A EC SP993138A EC SP993138 A ECSP993138 A EC SP993138A
- Authority
- EC
- Ecuador
- Prior art keywords
- drug
- optionally
- pharmaceutical composition
- delivery system
- drug delivery
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición farmacéutica en forma de tabletas o cápsulas provee una combinación de control temporal y espacial de liberación de una droga a un paciente para resultados terapéuticos efectivos. La composición farmacéutica comprende una droga, un componente generaddor de gas, un agente dilatador, un agwente viscoso, y opcionalmente un polímero formador de gel. El agente dilatador pertenence a un grupo de compuestos conocidos como superdesintegradores (por ejemplo: la polivinilpirrolidona de enlace cruzado o la carboximetilcelulosa de sodio). Inicialmente el agente viscoso y luego el polímero formador de gel, forman una matriz de gel hidratada que ocluye el gas, causando que la tableta o cápsula flten para ser retenidas en el estomago o en la parte alta del intestino delgado (control espacial). Al mismo tiempo la matriz de gel hidratado crea un camino de difusión tortyuoso para la droga, lo que resulta en una liberación sostenida de la droga (control temporal). Una formulación, preferida, de ciprofloxacin administarda una sola vez el dia comprende 69.9% de base de ciprofloxacin 0.34% de alginato de sodio, 1.03% de goma jántica, 13.7% de bicarbonato de sodio, 12.1% de polivinilpirrolidona de enlace cruzado, y opcionalmente otros excipientes farmacéuticos, la formulación está en forma de tabletas recubiertas o no, o en cápsulas.A pharmaceutical composition in the form of tablets or capsules provides a combination of temporal and spatial control of drug release to a patient for effective therapeutic results. The pharmaceutical composition comprises a drug, a gas generating component, a dilating agent, a viscous solvent, and optionally a gel-forming polymer. The dilating agent belongs to a group of compounds known as super-disintegrators (for example: cross-linked polyvinylpyrrolidone or sodium carboxymethyl cellulose). Initially the viscous agent and then the gel-forming polymer, form a hydrated gel matrix that occludes the gas, causing the tablet or capsule to float to be retained in the stomach or upper part of the small intestine (spatial control). At the same time the hydrated gel matrix creates a tortuous diffusion path for the drug, resulting in a sustained release of the drug (temporary control). A preferred formulation of ciprofloxacin administered once a day comprises 69.9% ciprofloxacin base, 0.34% sodium alginate, 1.03% gum semantics, 13.7% sodium bicarbonate, 12.1% cross-linked polyvinylpyrrolidone, and optionally Other pharmaceutical excipients, the formulation is in the form of coated or uncoated tablets, or capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993138 ECSP993138A (en) | 1999-09-14 | 1999-09-14 | CONTROLLED DRUG DELIVERY SYSTEM ORALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROL |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993138 ECSP993138A (en) | 1999-09-14 | 1999-09-14 | CONTROLLED DRUG DELIVERY SYSTEM ORALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993138A true ECSP993138A (en) | 2000-05-08 |
Family
ID=42044126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993138 ECSP993138A (en) | 1999-09-14 | 1999-09-14 | CONTROLLED DRUG DELIVERY SYSTEM ORALLY ADMINISTERED, PROVIDING TEMPORARY AND SPACE CONTROL |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993138A (en) |
-
1999
- 1999-09-14 EC ECSP993138 patent/ECSP993138A/en unknown
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