ECSP993070A - HIGH-AFFINITY LEAGUES FOR THE NOCICEPTINE ORL 1 RECEPTOR - Google Patents
HIGH-AFFINITY LEAGUES FOR THE NOCICEPTINE ORL 1 RECEPTORInfo
- Publication number
- ECSP993070A ECSP993070A ECSP993070A ECSP993070A EC SP993070 A ECSP993070 A EC SP993070A EC SP993070 A ECSP993070 A EC SP993070A EC SP993070 A ECSP993070 A EC SP993070A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- heterocycloalkyl
- heteroaryl
- Prior art date
Links
Landscapes
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nuevos compuestos de fórmula (gráfico), o una sal o solvato de los mismos, farmacéuticamente aceptable en los cuales: la linea de puntos representa un doble enlace opcional; X1 es H, alquilo, cicloalquilo, arilo, heteroarilo, heterocicloalquilo o heterociclilo benzofusionado opcionalmente sustituidos; X2 es H, -CH=, -CN, amino, alquilo o arilo opcionalmente sustituido; o X1 o X2 conjuntamente forman un grupo espiro heterociclilo opcionalmente benzofusionado. R1, R2, R3 y R4 son independientemente H o alquilo, o (R1 y R4) o (R2 y R3) o (R1 y R3) o (R2 y R4) conjuntamente pueden formar un puente alquileno de 1 a 3 átomos de carbono; Z1 es alquilo, arilo, heteroarilo, cicloalquilo o heterocicloalquilo opcionalmente sustituido o -CO2(alquilo o amino substituido) o CN, Z2 es H o Z1; Z3 es H o alquilo; o Z1, Z2 y Z3 conjuntamente con el carbon al cual están unidos forman anillos biciclicos saturados o insaturados; composiciones farmacéuticas que incluyen los mismos y el uso de dichos compuestos como inhibidores, receptores de nociceptina útiles para el tratamiento, ansiedad, tos, asma, depresión y abuso de alcohol.Novel compounds of formula (graph), or a pharmaceutically acceptable salt or solvate thereof in which: the dotted line represents an optional double bond; X1 is optionally substituted H, alkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl or heterocyclyl; X2 is H, -CH =, -CN, amino, alkyl or optionally substituted aryl; or X1 or X2 together form an optionally benzofused spiro heterocyclyl group. R1, R2, R3 and R4 are independently H or alkyl, or (R1 and R4) or (R2 and R3) or (R1 and R3) or (R2 and R4) together can form an alkylene bridge of 1 to 3 carbon atoms ; Z1 is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl or -CO2 (alkyl or substituted amino) or CN, Z2 is H or Z1; Z3 is H or alkyl; or Z1, Z2 and Z3 together with the carbon to which they are attached form saturated or unsaturated bicyclic rings; Pharmaceutical compositions including the same and the use of said compounds as inhibitors, nociceptin receptors useful for the treatment, anxiety, cough, asthma, depression and alcohol abuse.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993070 ECSP993070A (en) | 1999-07-26 | 1999-07-26 | HIGH-AFFINITY LEAGUES FOR THE NOCICEPTINE ORL 1 RECEPTOR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993070 ECSP993070A (en) | 1999-07-26 | 1999-07-26 | HIGH-AFFINITY LEAGUES FOR THE NOCICEPTINE ORL 1 RECEPTOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993070A true ECSP993070A (en) | 1999-09-09 |
Family
ID=42044057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993070 ECSP993070A (en) | 1999-07-26 | 1999-07-26 | HIGH-AFFINITY LEAGUES FOR THE NOCICEPTINE ORL 1 RECEPTOR |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993070A (en) |
-
1999
- 1999-07-26 EC ECSP993070 patent/ECSP993070A/en unknown
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