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Se describen derivados de cefalosporina de fórmula general (gráfico), en donde R es un residuo orgánico de peso molecular no superior a 400 unido al átomo de azufre adyacente a través de un carbono y que está formado por átomos de carbono, hidrógeno, opcionalmente oxígeno, azufre, nitrógeno y/o halógeno; R1 es hidrógeno, alquilo inferior o fenilo; y A es un átomo de nitrógeno secundario, terciario o cuaternario unido directamente al grupo propenilo y sustituido por un residuo orgánico de peso molecular no superior a 400 que está formado por átomos de carbono, hidrógeno, opcionalmente oxígeno, azufre, nitrógeno y/o halógeno, asi como a ésteres fácilmente hidrolizables de los mismos, sales farmacéuticamente aceptables de dichos compuestos e hidratos de los compuestos de fórmula I y de sus éteres y sales. Se describe también un proceso para fabricación, inetermedios útiles en la misma, medicamentos que contienen los productos finales y el uso de estos últimos para el tratamiento y profilaxis de enfermedades infecciosas o para la fabricación de medicamentos.Cephalosporin derivatives of the general formula (graph) are described, in which R is an organic residue with a molecular weight of not more than 400 attached to the adjacent sulfur atom through a carbon and consisting of carbon atoms, hydrogen, optionally oxygen , sulfur, nitrogen and / or halogen; R1 is hydrogen, lower alkyl, or phenyl; and A is a secondary, tertiary or quaternary nitrogen atom directly attached to the propenyl group and substituted by an organic residue of a molecular weight not exceeding 400 that is formed by carbon, hydrogen, optionally oxygen, sulfur, nitrogen and / or halogen atoms , as well as easily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their ethers and salts. Also described is a process for manufacturing, useful intermediates therein, drugs containing the final products and the use of the latter for the treatment and prophylaxis of infectious diseases or for the manufacture of drugs.
ECSP9930311999-06-221999-06-22
DERIVATIVES OF PROPENYL CEPHALOSPORIN
ECSP993031A
(en)
A COMPOUND, WHICH IS A DERIVATIVE OF BENZOHETEROCICLICO DISTAMICINA, ITS USE, A PROCEDURE TO PRODUCE IT AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES IT
DECAHIDRO-ISOQUINOLINAS, A PROCESS FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
ANTI-TUMOR AND ANTIVIRAL RENTAL AGENTS, PROCEDURE FOR THEIR PREPARATION, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH AGENTS.
(4-piperidinyl)-1h-2-benzopyran derivatives useful as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same
CEFALOSPORINE DERIVATIVES, DRUGS CONTAINING THEM, PROCEDURE FOR THE MANUFACTURE OF SUCH DERIVATIVES AND USEFUL COMPOUNDS AS INTERMEDIARIES TO PREPARE SUCH DERIVATIVES