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Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La presente invención se refiere aq los compuestos de la fórmula (T) (gráfico), donde R1 es fenilo, naftilo, 1,2,3,4-tetrahidronaftilo, (iso) quinolinilo, tetrahidro (iso) quinolinilo, 3,4-dihidro-1H-isoquinolinilo, cromanilo o el grupo alcanfor, cuyos grupos pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados entre (1-8C) alquilo ó (1-8C)alcoxi; R2 y R3 son independientemente H ó (1-8C) alquilo; R4 es (1-8C)alquilo ó (3-8C) alquilo; o R3 y R4 junto con el átomo de nitrógeno el cual están unidos, forman un anillo no aromático de 4-8 miembros que opcionalmente contiene otro heteroátomo, estando al anillo opcionalmente sustituido con (1-8C) alquilo ó SO2- (1-8C)alquilo]; Q es un espaciador que tiene una longitud de cadena de 10m a 70 átomos; y Z es un residuo de oligosacárido cargado negativamente que comprende de dos a seis unidades monosacáridos estando la carga compensada por contraiones cargados positivamente; O una sal farmacéuticamente aceptable del mismo o una prodroga del mismo. Los compuestos de la invención tienen actividad antitrombótica y pueden usarse para tratar o prevenir enfermedades relacionadas con la trombina. La presente invención se refiere a los compuestos de la fórmula (T)The present invention relates to q compounds of formula (T) (graph), where R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso) quinolinyl, tetrahydro (iso) quinolinyl, 3,4- dihydro-1H-isoquinolinyl, chromanyl or the camphor group, the groups of which may optionally be substituted with one or more substituents selected from (1-8C) alkyl or (1-8C) alkoxy; R2 and R3 are independently H or (1-8C) alkyl; R4 is (1-8C) alkyl or (3-8C) alkyl; or R3 and R4 together with the nitrogen atom to which they are attached, form a 4-8 membered non-aromatic ring optionally containing another heteroatom, the ring being optionally substituted with (1-8C) alkyl or SO2- (1-8C )I rent]; Q is a spacer having a chain length of 10m to 70 atoms; and Z is a negatively charged oligosaccharide residue comprising from two to six monosaccharide units with the charge being offset by positively charged counterions; Either a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention have antithrombotic activity and can be used to treat or prevent thrombin related diseases. The present invention relates to compounds of formula (T)
ECSP9930241999-06-171999-06-17
ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ECSP993024A
(en)
DERIVATIVES OF 2-ARIL-8-OXODIHIDROPURINE, PROCEDURES TO PREPARE THEM, INTERMEDIATE APPLICATION COMPOUNDS IN THESE PROCEDURES, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF STATES OF STATE.
DERIVATIVES OF 1-SULFONIL-TETRAHIDRO REPLACED KINOLINES, PHARMACEUTICAL COMPOSITIONS AND THE USE OF THE SAME FOR THE PREPARATION OF MEDICINES AS INHIBITORS OF THE SECRET RANGE
USE OF A TIAZOL COMPOUND THAT INCLUDES A TIAZOL DERIVATIVE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE PREVENTION AND TREATMENT OF DISEASES CAUSED BY THE NORMAL PRODUCTION OF CITOCINES AND / OR ACCELEATION OF THE ADHESION OF NEUTROPHILES AND / OR THE ABNORMAL PRODUCTION OF TNF-ALFA
IMINOAZUCARES RENTED TO PREVENT, REDUCE OR REVERT THE RESISTANCE TO MULTIDROGA IN THE CHEMOTHERAPEUTIC AND COMPOSITION PHARMACEUTICAL TREATMENT CONTAINING THEM.
DERIVED FROM ADAMANTANO, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR USE IN THERAPY, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF SUCH COMPOUND AND SUCH COMPOSITION AND INTERMEDIATE COMPOUNDS
COMPOUNDS OF 4-TETRAZOLIL-4-PHENYLPIPERIDINE AS AGONISTS OF OPIOID RECEIVERS AND THERAPEUTIC AGENTS FOR THE TREATMENT OF PAIN AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS AN ACTIVE PRINCIPLE IN COMBINATION WITH OTHER AGENTS.
4-AMINOPIRIDE [2,3-D] PIRIMIDINE 5,7-DISSTITUTED COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME FOR LAMANUFACTURE OF MEDICINES, A PROCEDURE FOR THEIR PREPARATION.