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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Las composiciones de nefazodona de liberación prolongada, que contienen clorhidrato de nefazodona, polímeros de gelificación iónico y no iónico, un agente hidrofilico insoluble, y excipíentes opcionales farmacéuticamente aceptables, demuestran liberación de la nefazodona, modulada por el pH. Estas composiciones son formuladas en formas de dosis unitaria para la administración oral mejorada. Los mejoramientos comprenden un perfil prolongado de liberación del fármaco, proporcionando niveles comparativos de nefazodona con respecto a las formas de dosificación de liberación inmediata y, además, que demuestran la falta de un efecto por alimento.Nefazodone extended-release compositions, containing nefazodone hydrochloride, ionic and nonionic gelling polymers, an insoluble hydrophilic agent, and pharmaceutically acceptable optional excipients, demonstrate pH-modulated release of nefazodone. These compositions are formulated in unit dose forms for improved oral administration. The enhancements comprise a prolonged drug release profile, providing comparative levels of nefazodone with respect to immediate release dosage forms, and further demonstrating the lack of an effect per food.
ECSP9929751999-06-021999-06-02
NEFAZODONE DOSAGE FORM
ECSP992975A
(en)
A CAPSULE THAT INCLUDES A SPONTANELY DISPERSABLE PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION, A SPONTANELY DISPERSABLE PHARMACEUTICAL COMPOSITION FOR THE ORAL ADMINISTRATION AND THE USE FOR THE PREPARATION OF A TREATMENT MEDICATION