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Pirroles sustituidos de fórmula (gráfico), en la que R1 es hidrógeno y R2 es metilo o R1 es metilo y R2 es hidrógeno o R1 es hidroximetilo y R2 es metilo asi como profármacos farmacéuticamente aceptables o sales farmacéuticamente aceptables de los mismos son agentes antiproliferativos útiles en el tratamiento del cáncer.Substituted pyrroles of formula (graph), wherein R1 is hydrogen and R2 is methyl or R1 is methyl and R2 is hydrogen or R1 is hydroxymethyl and R2 is methyl as well as pharmaceutically acceptable prodrugs or pharmaceutically acceptable salts thereof are useful antiproliferative agents in the treatment of cancer.