ECSP992828A - BENZOSULFONE DERIVATIVES - Google Patents
BENZOSULFONE DERIVATIVESInfo
- Publication number
- ECSP992828A ECSP992828A ECSP992828A ECSP992828A EC SP992828 A ECSP992828 A EC SP992828A EC SP992828 A ECSP992828 A EC SP992828A EC SP992828 A ECSP992828 A EC SP992828A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- hydrogen
- amino
- trifluoromethyl
- phenyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- -1 piperazinyl Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
El presente invento se refiere a nuevos compuestos de la fórmula general (gráfico), en donde R1 es hidrógeno; R2 es hidrógeno, trifluorometilo o alquilo inferior; R3 es hidrógeno o amino; o R1 y R2 o R3 y R2 tomados conjuntamnete son -CH=CH-CH=CH-; Z es pirimidin-4-ilo, piridin-4-ilo, piridin-2-ilo o fenilo; R4 y R5 son cada uno, independientemente, hidrógeno, alquilo inferior, trifluorometilo, halógeno, alcoxilo inferior, nitrilo, amino, alquil-amino inferior, di-alquil-amino inferior, piperazinilo, morfolinilo, pirrolidinilo, vinilo, cicloalquilo de C3-C6, cicloalquenilo de C3-C6, t-butiletinilo, hidroxialquiletinilo, fenil-etinilo, naftilo, tiofenilo o fenilo, que puede estar sustituido por halógeno, alcoxilo inferior, alquilo inferior, trifluorometilo o nitro o un grupo -NH(CH2)nNR6R7, -N(CH3)(CH2)nNR6R7, -NH(CH2)n-morfolin-4-ilo o -NH(CH2)nOH; n es 2-4 R6 y R7 son cada uno, independientemente, hidrógeno o alquilo inferior, y a sus sales farmacéuticamente aceptables. Se ha encontrado que los compuestos de fórmula I poseen una afinidad selectiva a los receptores de 5HT-6.The present invention relates to novel compounds of the general formula (graph), wherein R1 is hydrogen; R2 is hydrogen, trifluoromethyl or lower alkyl; R3 is hydrogen or amino; or R1 and R2 or R3 and R2 taken together are -CH = CH-CH = CH-; Z is pyrimidin-4-yl, pyridin-4-yl, pyridin-2-yl or phenyl; R4 and R5 are each independently hydrogen, lower alkyl, trifluoromethyl, halogen, lower alkoxy, nitrile, amino, lower alkyl amino, di-lower alkyl amino, piperazinyl, morpholinyl, pyrrolidinyl, vinyl, C3-C6 cycloalkyl , C3-C6-cycloalkenyl, t-butylethynyl, hydroxyalkylethynyl, phenyl-ethynyl, naphthyl, thiophenyl or phenyl, which may be substituted by halogen, lower alkoxy, lower alkyl, trifluoromethyl or nitro or a -NH (CH2) nNR6R7 group, - N (CH3) (CH2) nNR6R7, -NH (CH2) n-morpholin-4-yl or -NH (CH2) nOH; n is 2-4 R6 and R7 are each, independently, hydrogen or lower alkyl, and their pharmaceutically acceptable salts. The compounds of formula I have been found to possess selective affinity for 5HT-6 receptors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992828 ECSP992828A (en) | 1999-01-15 | 1999-01-15 | BENZOSULFONE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992828 ECSP992828A (en) | 1999-01-15 | 1999-01-15 | BENZOSULFONE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP992828A true ECSP992828A (en) | 2000-08-18 |
Family
ID=42043821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP992828 ECSP992828A (en) | 1999-01-15 | 1999-01-15 | BENZOSULFONE DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP992828A (en) |
-
1999
- 1999-01-15 EC ECSP992828 patent/ECSP992828A/en unknown
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