ECSP982607A - OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM - Google Patents
OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEMInfo
- Publication number
- ECSP982607A ECSP982607A ECSP982607A ECSP982607A EC SP982607 A ECSP982607 A EC SP982607A EC SP982607 A ECSP982607 A EC SP982607A EC SP982607 A ECSP982607 A EC SP982607A
- Authority
- EC
- Ecuador
- Prior art keywords
- group
- oligo
- ch2ch2
- alkylene
- agents
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con oligo-tiofenos de la fórmula general I: (gráfico), en donde A es un grupo -CH2-CO, CH2CH2-CO- ó CH=CH-CO; B es un grupo 2-tienilo o fenilo sustituido por un grupo R, o es una aminoácido natural o sintético ligado al grupo A través de su N- terminal; ó A-B es un grupo -CH2CH2-NH-A-A, en donde el grupo -A,A es un residuo de aminoácido natural o sintético enlazado con el grupo CH2CH2-NH- a través de su carboxi terminal. R es hidrógeno o un grupo cloro, bromo, yodo, fluoro, alquilo (C1-44), alquileno (C1-C4)-COOR, alquileno (C1-C4)-NR2; ó alquileno (C1-C4)-NHCOR. R es hidrógeno o un grupo alquilo (C1-C4), isómeros de los mismos, y sales de los mismos con ácidos y bases farmacéuticamente aceptables. También se reinvindica el uso de los compuestos de fórmula (I) como inhibidores de la unión del uPA al receptor específico UPAR, en particular su aplicación como agentes antitumorales y antimetastáticos.The present invention relates to oligo-thiophenes of the general formula I: (graph), wherein A is a group -CH2-CO, CH2CH2-CO- or CH = CH-CO; B is a 2-thienyl or phenyl group substituted by an R group, or is a natural or synthetic amino acid linked to group A through its N-terminus; or A-B is a group -CH2CH2-NH-A-A, where the group -A, A is a natural or synthetic amino acid residue linked to the group CH2CH2-NH- through its carboxy terminal. R is hydrogen or a chlorine, bromine, iodine, fluoro, (C1-44) alkyl, (C1-C4) alkylene -COOR, (C1-C4) alkylene -NR2 group; or (C1-C4) alkylene -NHCOR. R is hydrogen or a (C1-C4) alkyl group, isomers thereof, and salts thereof with pharmaceutically acceptable acids and bases. The use of the compounds of formula (I) as inhibitors of uPA binding to the specific UPAR receptor is also claimed, in particular their application as antitumor and antimetastatic agents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP982607 ECSP982607A (en) | 1998-07-29 | 1998-07-29 | OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP982607 ECSP982607A (en) | 1998-07-29 | 1998-07-29 | OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP982607A true ECSP982607A (en) | 1999-05-06 |
Family
ID=42043528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP982607 ECSP982607A (en) | 1998-07-29 | 1998-07-29 | OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP982607A (en) |
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1998
- 1998-07-29 EC ECSP982607 patent/ECSP982607A/en unknown
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