ECSP982607A - OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM - Google Patents

OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

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Publication number
ECSP982607A
ECSP982607A ECSP982607A ECSP982607A EC SP982607 A ECSP982607 A EC SP982607A EC SP982607 A ECSP982607 A EC SP982607A EC SP982607 A ECSP982607 A EC SP982607A
Authority
EC
Ecuador
Prior art keywords
group
oligo
ch2ch2
alkylene
agents
Prior art date
Application number
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Spanish (es)
Inventor
Domenico Roberto Di
Cillis Gianpiero De
Bernhard Koning
Gerd Zimmermann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Priority to ECSP982607 priority Critical patent/ECSP982607A/en
Publication of ECSP982607A publication Critical patent/ECSP982607A/en

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Abstract

La presente invención se relaciona con oligo-tiofenos de la fórmula general I: (gráfico), en donde A es un grupo -CH2-CO, CH2CH2-CO- ó CH=CH-CO; B es un grupo 2-tienilo o fenilo sustituido por un grupo R, o es una aminoácido natural o sintético ligado al grupo A través de su N- terminal; ó A-B es un grupo -CH2CH2-NH-A-A, en donde el grupo -A,A es un residuo de aminoácido natural o sintético enlazado con el grupo CH2CH2-NH- a través de su carboxi terminal. R es hidrógeno o un grupo cloro, bromo, yodo, fluoro, alquilo (C1-44), alquileno (C1-C4)-COOR, alquileno (C1-C4)-NR2; ó alquileno (C1-C4)-NHCOR. R es hidrógeno o un grupo alquilo (C1-C4), isómeros de los mismos, y sales de los mismos con ácidos y bases farmacéuticamente aceptables. También se reinvindica el uso de los compuestos de fórmula (I) como inhibidores de la unión del uPA al receptor específico UPAR, en particular su aplicación como agentes antitumorales y antimetastáticos.The present invention relates to oligo-thiophenes of the general formula I: (graph), wherein A is a group -CH2-CO, CH2CH2-CO- or CH = CH-CO; B is a 2-thienyl or phenyl group substituted by an R group, or is a natural or synthetic amino acid linked to group A through its N-terminus; or A-B is a group -CH2CH2-NH-A-A, where the group -A, A is a natural or synthetic amino acid residue linked to the group CH2CH2-NH- through its carboxy terminal. R is hydrogen or a chlorine, bromine, iodine, fluoro, (C1-44) alkyl, (C1-C4) alkylene -COOR, (C1-C4) alkylene -NR2 group; or (C1-C4) alkylene -NHCOR. R is hydrogen or a (C1-C4) alkyl group, isomers thereof, and salts thereof with pharmaceutically acceptable acids and bases. The use of the compounds of formula (I) as inhibitors of uPA binding to the specific UPAR receptor is also claimed, in particular their application as antitumor and antimetastatic agents.

ECSP982607 1998-07-29 1998-07-29 OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM ECSP982607A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP982607 ECSP982607A (en) 1998-07-29 1998-07-29 OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP982607 ECSP982607A (en) 1998-07-29 1998-07-29 OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Publications (1)

Publication Number Publication Date
ECSP982607A true ECSP982607A (en) 1999-05-06

Family

ID=42043528

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP982607 ECSP982607A (en) 1998-07-29 1998-07-29 OLIGO TIOFENOS USEFUL AS ANTIMETASTIC AGENTS, A METHOD FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM

Country Status (1)

Country Link
EC (1) ECSP982607A (en)

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