ECSP982560A - 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED - Google Patents
4,5 DIARILIMIDAZOLES 2- SUBSTITUTEDInfo
- Publication number
- ECSP982560A ECSP982560A ECSP982560A ECSP982560A EC SP982560 A ECSP982560 A EC SP982560A EC SP982560 A ECSP982560 A EC SP982560A EC SP982560 A ECSP982560 A EC SP982560A
- Authority
- EC
- Ecuador
- Prior art keywords
- substituted
- substituent
- diseases
- thioryl
- aryltelide
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se proporciona 4,5 -diarilimidazoles 2-sustituidos novedoso, en donde: i) el átomo de nitrógeno en la posición 1 está sustituido por un sustituyente que contiene trialquilsililo, o ii) el sustituyente en la posición es arilalquilo, arillsulfonio, tiorilo, arilseleno, arilteluro, cicloalquilo, cicloalquenilo, alquilcicloalquilo, alquilcicloalquenio, amino o hidrazino, o N-heterociclilo mono o bicíclico, en donde el anillo que contiene N tiene seis miembros del anillo en particular compuesto de la fórmula I (gráfico), en donde R1,R2,R3 y R4 son como se definieron, en forma libre o de sal de adición de ácido farmacéuticamente aceptable o de éster fisiológicamente disociable, que tienen actividad inhibidora de quinasa p38 MAP (quinasa de Proteína Activada por Mitógeno). Los compuestos se utilizan como productos farmacéuticos para el tratamiento de enfermedades mediadas por TNF alfa I1-1 tales como artritis reumatoide y enfermedades del metabolismo óseo, por ejemplo osteoporosis.Novel 2-substituted 4,5-diarylimidazoles are provided, wherein: i) the nitrogen atom at the 1-position is substituted by a trialkylsilyl-containing substituent, or ii) the substituent at the position is arylalkyl, arylsulfonium, thioryl, arylselene , aryltelide, cycloalkyl, cycloalkenyl, alkylcycloalkyl, alkylcycloalkenium, amino or hydrazino, or mono- or bicyclic N-heterocyclyl, wherein the N-containing ring has six ring members in particular compound of formula I (graph), wherein R1, R2, R3 and R4 are as defined, in free or pharmaceutically acceptable acid addition or physiologically dissociable ester addition form, having inhibitory activity of p38 MAP kinase (Mitogen Activated Protein kinase). The compounds are used as pharmaceuticals for the treatment of TNF alpha I1-1 mediated diseases such as rheumatoid arthritis and bone metabolism diseases, for example osteoporosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982560A true ECSP982560A (en) | 1999-02-11 |
Family
ID=42043480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982560 ECSP982560A (en) | 1998-06-26 | 1998-06-26 | 4,5 DIARILIMIDAZOLES 2- SUBSTITUTED |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982560A (en) |
-
1998
- 1998-06-26 EC ECSP982560 patent/ECSP982560A/en unknown
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