ECSP982550A - DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA - Google Patents

DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA

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Publication number
ECSP982550A
ECSP982550A ECSP982550A ECSP982550A EC SP982550 A ECSP982550 A EC SP982550A EC SP982550 A ECSP982550 A EC SP982550A EC SP982550 A ECSP982550 A EC SP982550A
Authority
EC
Ecuador
Prior art keywords
lower alkyl
phenyl
proviso
sulfonamido
imidazoline
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Richard Leo Cournoyer
Paul Francis Keitz
Counde O'yang
Dennis Mitsugu Yasuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP982550 priority Critical patent/ECSP982550A/en
Publication of ECSP982550A publication Critical patent/ECSP982550A/en

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Abstract

La presente invención se refiere a nuevos compuestos representados por la fórmula: (gráfico), en donde A R1q(R3R60N)m(Z) (NR2)n; m y q son cada uno 0 ó 1, con la condición de que cuando q es 1, m es 0 y cuando q es 0, m es 1; Z es C=0, m es 1; X es -NH-, -CH2- ó -OCH2-, Y es 2-imidazolina, 2-oxazolina, 2-tiazolina ó 4-imidazol; R1 es H, alquilo inferior o fenilo, con la condición de que cuando R1 es H, m es 1; R2, R3 y R60 son cado uno independientemente H, alquilo inferior, o fenilo; R4,R5,R6 y R7 son cada uno independientemente hidrógeno, alquilo inferior, -CF3-, alcoxilo inferior, halógeno, fenilo, alquenilo inferior, hidroxilo, (alquilo inferior)sulfonamido ó cicloalquilo inferior, en donde R2 y R7 opcionalmente pueden ser tomados juntos para formar un alquileno o alquenileno de 2 a 3 átomos de carbono en un anillo de 5 ó 6 miembros sin sustituir u opcionalmente sustituido, en donde los sustituyentes opcionales en el anillo son halo, alquilo inferior, ó -CN, con la condición de que cuando R7 es hedroxilo o (alquilo inferior)sulfonamido, entonces X no es -NH- cuando Y es 2-imidazolina. Los compuestos incluyen las sales farmacéuticamente aceptables de los anteriores. En la fórmula anterior A puede ser, por ejemplo (R1SO2NR2), (R3R60NSO2NR2), ó (R3R60NCONR2). La invención incluye también el empleo de los compuestos anteriores y composiciones que los contienen como alfa A/1L agonistas en el tratamiento de varios estados de enfermedad tales como la incontinencia urinaria, congestión nasal, priapismo, depresión, ansiedad, demencia, senilidad, deficiencias de la atención y razonamiento de la enfermedad de Alzheimer, y trastornos de la alimentación como la obesidad, bulimia y anorexia.The present invention relates to new compounds represented by the formula: (graph), where A R1q (R3R60N) m (Z) (NR2) n; m and q are each 0 or 1, with the proviso that when q is 1, m is 0 and when q is 0, m is 1; Z is C = 0, m is 1; X is -NH-, -CH2- or -OCH2-, Y is 2-imidazoline, 2-oxazoline, 2-thiazoline or 4-imidazole; R1 is H, lower alkyl or phenyl, with the proviso that when R1 is H, m is 1; R2, R3 and R60 are each independently H, lower alkyl, or phenyl; R4, R5, R6 and R7 are each independently hydrogen, lower alkyl, -CF3-, lower alkoxy, halogen, phenyl, lower alkenyl, hydroxyl, (lower alkyl) sulfonamido or cycloalkyl lower, wherein R2 and R7 can optionally be taken together to form a 2 to 3 carbon alkylene or alkenylene in an unsubstituted or optionally substituted 5- or 6-membered ring, wherein the optional substituents on the ring are halo, lower alkyl, or -CN, with the proviso that that when R7 is hedroxy or (lower alkyl) sulfonamido, then X is not -NH- when Y is 2-imidazoline. The compounds include the pharmaceutically acceptable salts of the above. In the above formula A can be, for example (R1SO2NR2), (R3R60NSO2NR2), or (R3R60NCONR2). The invention also includes the use of the above compounds and compositions containing them as alpha A / 1L agonists in the treatment of various disease states such as urinary incontinence, nasal congestion, priapism, depression, anxiety, dementia, senility, deficiencies of the attention and reasoning of Alzheimer's disease, and eating disorders such as obesity, bulimia and anorexia.

ECSP982550 1998-06-22 1998-06-22 DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA ECSP982550A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP982550 ECSP982550A (en) 1998-06-22 1998-06-22 DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP982550 ECSP982550A (en) 1998-06-22 1998-06-22 DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA

Publications (1)

Publication Number Publication Date
ECSP982550A true ECSP982550A (en) 1999-01-26

Family

ID=42043470

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP982550 ECSP982550A (en) 1998-06-22 1998-06-22 DERIVATIVES OF PHENYL AND AMINOPHENYL - ALKYLSULPHONAMIDES AND UREA

Country Status (1)

Country Link
EC (1) ECSP982550A (en)

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