ECSP982439A - DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEM - Google Patents
DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEMInfo
- Publication number
- ECSP982439A ECSP982439A ECSP982439A ECSP982439A EC SP982439 A ECSP982439 A EC SP982439A EC SP982439 A ECSP982439 A EC SP982439A EC SP982439 A ECSP982439 A EC SP982439A
- Authority
- EC
- Ecuador
- Prior art keywords
- antibiotics
- compounds
- derivatives
- siderophores
- conjugates
- Prior art date
Links
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a novedosos derivados de benzoxazindiona de la fórmula general I, y sus conjugados con sustancia activa, por ejemplo antibióticos. Los compuestos de la presente invención constituyen derivados heterocíclicos protegidos de catecol y son eficaces como sideróforos frente a cepas bacterianas gram negativas, particularmente Pseudomonáceas, cepas E.coli y Salmonella. Los mismos en forma de us conjugados con sustancia activas, por ejemplo antibióticos (conjugados antibióticos sideróforos) pueden introducir estos antibióticos en la célula bacteriana y aumentar o ampliar su eficacia antibacteriana en parte también frente a otras cepas bacterianas resistentes a otras B-lactamas. Además dichos compuestos son adecuados como formas premedicamentosas potenciales como quelatantes del hierro para la utilización en afecciones causadas por perturbaciones de metabolismo del hierro. La aplicación de la invención puede tener lugar en investigación farmacéutica, industria y agricultura. Fórmula I (gráfico), en donde R1 representa H o carboxialquilo, R2 representa H, alquilo o fenilo y R3 representa diversos grupos ácidos derivados de aminoácidos, depéptidos e hidrazonas o sus conjugados con sustancias activas, por ejemplo antibióticos. Dichos compuestos pueden existir en forma de ácidos libres, de sus sales o como ésteres fácilmente desdoblables.The invention relates to novel benzoxazindione derivatives of the general formula I, and their conjugates with active substance, for example antibiotics. The compounds of the present invention constitute catechol protected heterocyclic derivatives and are effective as siderophores against gram negative bacterial strains, particularly Pseudomonaceae, E.coli strains and Salmonella. The same in the form of us conjugated with active substances, for example antibiotics (conjugated antibiotics siderophores) can introduce these antibiotics into the bacterial cell and increase or extend their antibacterial efficacy in part also against other bacterial strains resistant to other B-lactams. Furthermore such compounds are suitable as potential pre-drug forms as iron chelators for use in conditions caused by disturbances of iron metabolism. The application of the invention can take place in pharmaceutical research, industry and agriculture. Formula I (graph), wherein R1 represents H or carboxyalkyl, R2 represents H, alkyl or phenyl and R3 represents various acid groups derived from amino acids, peptides and hydrazones or their conjugates with active substances, for example antibiotics. Said compounds can exist in the form of free acids, their salts or as easily cleavable esters.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP982439 ECSP982439A (en) | 1998-03-04 | 1998-03-04 | DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ECSP982439 ECSP982439A (en) | 1998-03-04 | 1998-03-04 | DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEM |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP982439A true ECSP982439A (en) | 1999-01-19 |
Family
ID=42043361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSP982439 ECSP982439A (en) | 1998-03-04 | 1998-03-04 | DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEM |
Country Status (1)
Country | Link |
---|---|
EC (1) | ECSP982439A (en) |
-
1998
- 1998-03-04 EC ECSP982439 patent/ECSP982439A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ID21897A (en) | ACID B-SULFONYL HYDROXYCAMM AS A MATERIAL HANDLING MATRIX METALOPROTEINASE | |
BR9810137A (en) | Compound, pharmaceutical composition and method of treatment or prevention of a thromboembolic disorder | |
DE69418368D1 (en) | Borononic acid peptide derivatives with protease inhibiting activity, their production process and pharmaceutical compositions containing them | |
MY109846A (en) | Dual inhibitors of no synthase and cyclooxygenase, process for their preparation and therapeutical compositions containing them | |
BR9303235A (en) | COMPOUNDS AND PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL FORMULATION, METHOD FOR COMBATING BACTERIA AND METHOD FOR TREATING BACTERIAL INFECTIONS | |
PT97500A (en) | PRODUCTION PROCESS OF LIPOSOMES AND PHARMACEUTICAL PREPARATIONS CONTAINING THOSE LIPOSOMES | |
TR200001330T2 (en) | Oxazolidinone derivatives and pharmaceutical compositions | |
AR010125A1 (en) | DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND DRUGS THAT CONTAIN THEM | |
BR0015177A (en) | benzoic acid esters of oxazolidinones having a hydroxyacetylpiperazine substituent | |
ECSP982439A (en) | DERIVATIVES OF BENZOXAZINDIONA, APPLICATION OF THE SAME AND MEDICINES THAT CONTAIN THEM | |
DK183789D0 (en) | 2-ALKYL-3-BENZOYLBENZOFURANES AND MEDICINES CONTAINING THESE | |
JOP20220158A1 (en) | Novel Amino Aryl Derivative Useful as Diacylglycerol Acyltransferase 2 Inhibitor and Use Thereof | |
FI91076C (en) | Process for the preparation of antibiotic C63 amide derivative of 34-de (acetylglucosaminyl) -34-deoxyticoplanins | |
AR008391A1 (en) | DERIVATIVES OF CATECOL, ITS THERAPEUTIC APPLICATION AND MEDICINES THAT CONTAIN THEM | |
MX15635A (en) | CYCLOMETHYLENE-1,2-DICARBOXYLIC ACID AMIDES AND THE PROCEDURE FOR THEIR PREPARATION. | |
BR9509889A (en) | Compounded pharmaceutical composition and processes to inhibit beta-lactamases and to increase the biological attractiveness of a beta-lactam type antibiotic | |
IT1216104B (en) | PEPTIDES WITH PHARMACEUTICAL ACTIVITY. | |
AR020587A1 (en) | METHOD FOR THE PROPHYLAXIS OR TREATMENT OF A BACTERIAL INFECTION IN MAMMALS, USE OF AN INJIBITOR OF NITRICAL SYNTHETIC OXIDE FOR THE MANUFACTURE OF MEDICINES AND PHARMACEUTICAL FORMULATION | |
MX9305523A (en) | IMPROVED CHEMOTHERAPEUTIC COMPOSITIONS AGAINST MICROBIAL INFECTIONS IN FISH, THE REPAIR AND USE OF THE SAME. | |
WO2002085841A3 (en) | Substituted catechol derivatives derived from polybasic secondary amino acids, method for production and use thereof | |
IT1223302B (en) | SULPHONAMIDE COMPOUNDS DERIVED INHIBITORS OF THE ALDOSE-REDUCTASE ENZYMATIC SYSTEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
US3794723A (en) | Complexes of phosphanilic acid and 9-amino-3-nitroacridine useful as antifungal or antibacterial agents | |
ATE58129T1 (en) | COMPOUNDS SIMILAR TO ANTIBIOTIC TAN-749 AND THEIR PRODUCTION. | |
Nuţă et al. | In vitro evaluation of the antibacterial and antifungal activity of some new N-(2-dialkylaminoethyl) benzanilides | |
ECSP972161A (en) | NEW SYNTHETIC DERIVATIVES OF CATECOL |